Last update:
Sat Aug 31 12:17:35 MDT 2024
Patricia Melloy and
Shu Shen and
Erin White and
J. Richard McIntosh and
Mark D. Rose Nuclear fusion during yeast mating
occurs by a three-step pathway . . . . . 659
Chiara Francavilla and
Paola Cattaneo and
Vladimir Berezin and
Elisabeth Bock and
Diletta Ami and
Ario de Marco and
Gerhard Christofori and
Ugo Cavallaro The binding of NCAM to FGFR1 induces a
specific cellular response mediated by
receptor trafficking . . . . . . . . . . 1101
Xiaodong Fang and
Jianying Luo and
Ryuichi Nishihama and
Carsten Wloka and
Christopher Dravis and
Mirko Travaglia and
Masayuki Iwase and
Elizabeth A. Vallen and
Erfei Bi Biphasic targeting and cleavage furrow
ingression directed by the tail of a
myosin II . . . . . . . . . . . . . . . 1333
Emmanuel Dornier and
Franck Coumailleau and
Jean-François Ottavi and
Julien Moretti and
Claude Boucheix and
Philippe Mauduit and
François Schweisguth and
Eric Rubinstein TspanC8 tetraspanins regulate
ADAM10/Kuzbanian trafficking and promote
Notch activation in flies and mammals 481
Mitch Leslie TCAF1 puts a chill on prostate cancer ??
Mitch Leslie Actin is good at long division . . . . . ??
Mitch Leslie No substitute for $ \beta $3 integrin ??
Mitch Leslie BRWD1 shows its gender bias . . . . . . 3
Caitlin Sedwick Julia von Blume: Sorting through the
trans-Golgi . . . . . . . . . . . . . . 4
Ben Short TUNEL vision spots apoptotic cells . . . 7
Alan Hall Celebrating the first 60 years of The
Journal of Cell Biology . . . . . . . . 9
Wakam Chang and
Howard J. Worman and
Gregg G. Gundersen Accessorizing and anchoring the LINC
complex for multifunctionality . . . . . 11
Nazila Daneshjou and
Nathan Sieracki and
Geerten P. van Nieuw Amerongen and
Daniel E. Conway and
Martin A. Schwartz and
Yulia A. Komarova and
Asrar B. Malik Rac1 functions as a reversible tension
modulator to stabilize VE-cadherin
trans-interaction . . . . . . . . . . . 23
Jennifer C. Harr and
Teresa Romeo Luperchio and
Xianrong Wong and
Erez Cohen and
Sarah J. Wheelan and
Karen L. Reddy Directed targeting of chromatin to the
nuclear lamina is mediated by chromatin
state and A-type lamins . . . . . . . . 33
Shrivatsav Pattabiraman and
Claudia Baumann and
Daniela Guisado and
John J. Eppig and
John C. Schimenti and
Rabindranath De La Fuente Mouse BRWD1 is critical for spermatid
postmeiotic transcription and female
meiotic chromosome stability . . . . . . 53
Joachim Neller and
Alexander Dünkler and
Reinhild Rösler and
Nils Johnsson A protein complex containing Epo1p
anchors the cortical endoplasmic
reticulum to the yeast bud tip . . . . . 71
Dimitra Gkika and
Loic Lemonnier and
George Shapovalov and
Dmitri Gordienko and
Céline Poux and
Michela Bernardini and
Alexandre Bokhobza and
Gabriel Bidaux and
Cindy Degerny and
Kathye Verreman and
Basma Guarmit and
Mohamed Benahmed and
Yvan de Launoit and
Rene J. M. Bindels and
Alessandra Fiorio Pla and
Natalia Prevarskaya TRP channel--associated factors are a
novel protein family that regulates
TRPM8 trafficking and activity . . . . . 89
Sunan Li and
Shan Xu and
Brian A. Roelofs and
Liron Boyman and
W. Jonathan Lederer and
Hiromi Sesaki and
Mariusz Karbowski Transient assembly of F-actin on the
outer mitochondrial membrane contributes
to mitochondrial fission . . . . . . . . 109
Wei Zou and
Steven L. Teitelbaum Absence of Dap12 and the $ \alpha $ v$
\beta $3 integrin causes severe
osteopetrosis . . . . . . . . . . . . . 125
Mitch Leslie NIK flips the switch on Arp2/3 . . . . . ??
Mitch Leslie Mannose $6$-phosphate steers B cells on
the right course . . . . . . . . . . . . ??
Mitch Leslie Erv41--Erv46 complex recaptures wayward
ER proteins . . . . . . . . . . . . . . ??
Mitch Leslie Putting a kink in a familiar control
loop . . . . . . . . . . . . . . . . . . 139
Kendall Powell Cole Haynes: On the trail of
mitochondrial dysfunction . . . . . . . 140
Margaret L. Gardel Moving beyond molecular mechanisms . . . 143
Olivier Hyrien Peaks cloaked in the mist: The landscape
of mammalian replication origins . . . . 147
Lawrence L. LeClaire and
Manish Rana and
Martin Baumgartner and
Diane L. Barber The Nck-interacting kinase NIK increases
Arp2/3 complex activity by
phosphorylating the Arp2 subunit . . . . 161
Takanobu Otomo and
Michaela Schweizer and
Katrin Kollmann and
Valéa Schumacher and
Nicole Muschol and
Eva Tolosa and
Hans-Willi Mittrücker and
Thomas Braulke Mannose 6 phosphorylation of lysosomal
enzymes controls B cell functions . . . 171
Soonjoung Kim and
Hongtao Yu Multiple assembly mechanisms anchor the
KMN spindle checkpoint platform at human
mitotic kinetochores . . . . . . . . . . 181
Aya Shibuya and
Neil Margulis and
Romain Christiano and
Tobias C. Walther and
Charles Barlowe The Erv41--Erv46 complex serves as a
retrograde receptor to retrieve escaped
ER proteins . . . . . . . . . . . . . . 197
Seiichi Uchimura and
Takashi Fujii and
Hiroko Takazaki and
Rie Ayukawa and
Yosuke Nishikawa and
Itsushi Minoura and
You Hachikubo and
Genji Kurisu and
Kazuo Sutoh and
Takahide Kon and
Keiichi Namba and
Etsuko Muto A flipped ion pair at the
dynein--microtubule interface is
critical for dynein motility and ATPase
activation . . . . . . . . . . . . . . . 211
Julie M. Craft and
J. Aaron Harris and
Sebastian Hyman and
Peter Kner and
Karl F. Lechtreck Tubulin transport by IFT is upregulated
during ciliary growth by a
cilium-autonomous mechanism . . . . . . 223
Antoine Ducuing and
Charlotte Keeley and
Bertrand Mollereau and
Stéphane Vincent A DPP-mediated feed-forward loop
canalizes morphogenesis during
\bionameDrosophila dorsal closure . . . 239
Eva Szabo and
Yuanyuan Qiu and
Shairaz Baksh and
Marek Michalak and
Michal Opas Calreticulin inhibits commitment to
adipocyte differentiation . . . . . . . 249
Ben Short Misdirection leads the way to vesicle
transport proteins . . . . . . . . . . . ??
Ben Short Nup82 complex puts the P in NPC . . . . ??
Ben Short Dense collagen kindles invadopodia
formation . . . . . . . . . . . . . . . ??
Ben Short A Ror recruit to mammary gland
development . . . . . . . . . . . . . . 253
Caitlin Sedwick Cayetano González: Mothers, daughters,
stemness, and cancer . . . . . . . . . . 254
Ben Short Mapping out the nuclear pore complex . . 257
William S. Trimble and
Sergio Grinstein Barriers to the free diffusion of
proteins and lipids in the plasma
membrane . . . . . . . . . . . . . . . . 259
Marvin Bentley and
Helena Decker and
Julie Luisi and
Gary Banker A novel assay reveals preferential
binding between Rabs, kinesins, and
specific endosomal subpopulations . . . 273
Monika Gaik and
Dirk Flemming and
Alexander von Appen and
Panagiotis Kastritis and
Norbert Mücke and
Jessica Fischer and
Philipp Stelter and
Alessandro Ori and
Khanh Huy Bui and
Jochen Baßler and
Elisar Barbar and
Martin Beck and
Ed Hurt Structural basis for assembly and
function of the Nup82 complex in the
nuclear pore scaffold . . . . . . . . . 283
Françoise M. Roelants and
Brooke M. Su and
Joachim von Wulffen and
Subramaniam Ramachandran and
Elodie Sartorel and
Amy E. Trott and
Jeremy Thorner Protein kinase Gin4 negatively regulates
flippase function and controls plasma
membrane asymmetry . . . . . . . . . . . 299
Cristina Colombelli and
Marilena Palmisano and
Yael Eshed-Eisenbach and
Desirée Zambroni and
Ernesto Pavoni and
Cinzia Ferri and
Stefania Saccucci and
Sophie Nicole and
Raija Soininen and
Karen K. McKee and
Peter D. Yurchenco and
Elior Peles and
Lawrence Wrabetz and
M. Laura Feltri Perlecan is recruited by dystroglycan to
nodes of Ranvier and binds the
clustering molecule gliomedin . . . . . 313
Vira V. Artym and
Stephen Swatkoski and
Kazue Matsumoto and
Catherine B. Campbell and
Ryan J. Petrie and
Emilios K. Dimitriadis and
Xin Li and
Susette C. Mueller and
Thomas H. Bugge and
Marjan Gucek and
Kenneth M. Yamada Dense fibrillar collagen is a potent
inducer of invadopodia via a specific
signaling network . . . . . . . . . . . 331
Kevin Roarty and
Amy N. Shore and
Chad J. Creighton and
Jeffrey M. Rosen Ror2 regulates branching,
differentiation, and actin-cytoskeletal
dynamics within the mammary epithelium 351
Margaret C. Wright and
Erin G. Reed-Geaghan and
Alexa M. Bolock and
Tomoyuki Fujiyama and
Mikio Hoshino and
Stephen M. Maricich Unipotent, Atoh1$^+$ progenitors
maintain the Merkel cell population in
embryonic and adult mice . . . . . . . . 367
Ben Short Asterless amplifies Plk4 . . . . . . . . ??
Ben Short When centromeres fill in for telomeres ??
Ben Short Mitofusin 2 keeps the respiratory chain
on Q . . . . . . . . . . . . . . . . . . ??
Ben Short Actin works both sides of the
immunological synapse . . . . . . . . . 383
Kendall Powell Thoru Pederson: Spotting novel roles for
the nucleolus . . . . . . . . . . . . . 384
Graham Warren In praise of other model organisms . . . 387
Alaina H. Willet and
Nathan A. McDonald and
K. Adam Bohnert and
Michelle A. Baird and
John R. Allen and
Michael W. Davidson and
Kathleen L. Gould The F--BAR Cdc15 promotes contractile
ring formation through the direct
recruitment of the formin Cdc12 . . . . 391
Joseph E. Klebba and
Brian J. Galletta and
Jonathan Nye and
Karen M. Plevock and
Daniel W. Buster and
Natalie A. Hollingsworth and
Kevin C. Slep and
Nasser M. Rusan and
Gregory C. Rogers Two Polo-like kinase 4 binding domains
in Asterless perform distinct roles in
regulating kinase stability . . . . . . 401
Alex Fennell and
Alfonso Fernández-Álvarez and
Kazunori Tomita and
Julia Promisel Cooper Telomeres and centromeres have
interchangeable roles in promoting
meiotic spindle formation . . . . . . . 415
Arnaud Mourier and
Elisa Motori and
Tobias Brandt and
Marie Lagouge and
Ilian Atanassov and
Anne Galinier and
Gunter Rappl and
Susanne Brodesser and
Kjell Hultenby and
Christoph Dieterich and
Nils-Göran Larsson Mitofusin 2 is required to maintain
mitochondrial coenzyme Q levels . . . . 429
Heath E. Johnson and
Samantha J. King and
Sreeja B. Asokan and
Jeremy D. Rotty and
James E. Bear and
Jason M. Haugh F-actin bundles direct the initiation
and orientation of lamellipodia through
adhesion-based signaling . . . . . . . . 443
William A. Comrie and
Shuixing Li and
Sarah Boyle and
Janis K. Burkhardt The dendritic cell cytoskeleton promotes
T cell adhesion and activation by
constraining ICAM-1 mobility . . . . . . 457
William A. Comrie and
Alexander Babich and
Janis K. Burkhardt F-actin flow drives affinity maturation
and spatial organization of LFA-1 at the
immunological synapse . . . . . . . . . 475
Mitch Leslie Sall4 won't give stem cells a break . . ??
Mitch Leslie Desmoplakin's tail gets the message . . ??
Mitch Leslie A fresh start for stalled forks . . . . 495
Caitlin Sedwick Rick Horwitz: Words do not suffice . . . 496
Ben Short Assessing actin's growth rate . . . . . 499
Joseph M. Rutkowski and
Jennifer H. Stern and
Philipp E. Scherer The cell biology of fat expansion . . . 501
Jianhua Xiong and
Dilyana Todorova and
Ning-Yuan Su and
Jinchul Kim and
Pei-Jen Lee and
Zhouxin Shen and
Steven P. Briggs and
Yang Xu Stemness factor Sall4 is required for
DNA damage response in embryonic stem
cells . . . . . . . . . . . . . . . . . 513
Glennis A. Logsdon and
Evelyne J. Barrey and
Emily A. Bassett and
Jamie E. DeNizio and
Lucie Y. Guo and
Tanya Panchenko and
Jennine M. Dawicki-McKenna and
Patrick Heun and
Ben E. Black Both tails and the centromere targeting
domain of CENP--A are required for
centromere establishment . . . . . . . . 521
ChangHwan Lee and
Patricia Occhipinti and
Amy S. Gladfelter PolyQ-dependent RNA--protein assemblies
control symmetry breaking . . . . . . . 533
Saravanabhavan Thangavel and
Matteo Berti and
Maryna Levikova and
Cosimo Pinto and
Shivasankari Gomathinayagam and
Marko Vujanovic and
Ralph Zellweger and
Hayley Moore and
Eu Han Lee and
Eric A. Hendrickson and
Petr Cejka and
Sheila Stewart and
Massimo Lopes and
Alessandro Vindigni DNA2 drives processing and restart of
reversed replication forks in human
cells . . . . . . . . . . . . . . . . . 545
Ralph Zellweger and
Damian Dalcher and
Karun Mutreja and
Matteo Berti and
Jonas A. Schmid and
Raquel Herrador and
Alessandro Vindigni and
Massimo Lopes Rad51-mediated replication fork reversal
is a global response to genotoxic
treatments in human cells . . . . . . . 563
Gabriella Viero and
Lorenzo Lunelli and
Andrea Passerini and
Paolo Bianchini and
Robert J. Gilbert and
Paola Bernab\`o and
Toma Tebaldi and
Alberto Diaspro and
Cecilia Pederzolli and
Alessandro Quattrone Three distinct ribosome assemblies
modulated by translation are the
building blocks of polysomes . . . . . . 581
Lauren V. Albrecht and
Lichao Zhang and
Jeffrey Shabanowitz and
Enkhsaikhan Purevjav and
Jeffrey A. Towbin and
Donald F. Hunt and
Kathleen J. Green GSK3- and PRMT-1-dependent modifications
of desmoplakin control
desmoplakin--cytoskeleton dynamics . . . 597
Byung Min Chung and
Artem Arutyunov and
Erika Ilagan and
Nu Yao and
Marsha Wills-Karp and
Pierre A. Coulombe Regulation of C--X--C chemokine gene
expression by keratin 17 and hnRNP K in
skin tumor keratinocytes . . . . . . . . 613
Maria S. Ioannou and
Emily S. Bell and
Martine Girard and
Mathilde Chaineau and
Jason N. R. Hamlin and
Mark Daubaras and
Anie Monast and
Morag Park and
Louis Hodgson and
Peter S. McPherson DENND2B activates Rab13 at the leading
edge of migrating cells and promotes
metastatic behavior . . . . . . . . . . 629
Ben Short LSR puts its seal on brain endothelial
cells . . . . . . . . . . . . . . . . . ??
Ben Short NORE1A erects a senescence barrier to
tumorigenesis . . . . . . . . . . . . . ??
Ben Short Hedgehog induces a gut reaction . . . . ??
Ben Short Adding complexity to the nuclear pore
complex . . . . . . . . . . . . . . . . 651
Kendall Powell Johanna Ivaska: Finding opposing forces
in integrins . . . . . . . . . . . . . . 652
Bas van Steensel A short guide to technology development
in cell biology . . . . . . . . . . . . 655
David G. Wilkinson Balancing cell behavior at boundaries 659
Nicolas Tavernier and
Anna Noatynska and
Costanza Panbianco and
Lisa Martino and
Lucie Van Hove and
Françoise Schwager and
Thibaut Léger and
Monica Gotta and
Lionel Pintard Cdk1 phosphorylates SPAT-1/Bora to
trigger PLK-1 activation and drive
mitotic entry in \bionameC. elegans
embryos . . . . . . . . . . . . . . . . 661
J. Sebastian Gomez-Cavazos and
Martin W. Hetzer The nucleoporin gp210/Nup210 controls
muscle differentiation by regulating
nuclear envelope/ER homeostasis . . . . 671
Wenjing Li and
Peishan Yi and
Guangshuo Ou Somatic CRISPR--Cas9--induced mutations
reveal roles of embryonically essential
dynein chains in \bionameCaenorhabditis
elegans cilia . . . . . . . . . . . . . 683
Suzanna L. Prosser and
Ciaran G. Morrison Centrin2 regulates CP110 removal in
primary cilium formation . . . . . . . . 693
Fabien Sohet and
Christina Lin and
Roeben N. Munji and
Seo Yeon Lee and
Nadine Ruderisch and
Allison Soung and
Thomas D. Arnold and
Nikita Derugin and
Zinaida S. Vexler and
Frances T. Yen and
Richard Daneman LSR\slash angulin-1 is a tricellular
tight junction protein involved in
blood--brain barrier formation . . . . . 703
Céline Reyes and
Céline Serrurier and
Tiphaine Gauthier and
Yannick Gachet and
Sylvie Tournier Aurora B prevents chromosome arm
separation defects by promoting telomere
dispersion and disjunction . . . . . . . 713
Christopher L. Lord and
Benjamin L. Timney and
Michael P. Rout and
Susan R. Wente Altering nuclear pore complex function
impacts longevity and mitochondrial
function in \bionameS. cerevisiae . . . 729
Homa Ghalei and
Franz X. Schaub and
Joanne R. Doherty and
Yoshihiko Noguchi and
William R. Roush and
John L. Cleveland and
M. Elizabeth Stroupe and
Katrin Karbstein Hrr25/CK1$ \delta $-directed release of
Ltv1 from pre-40S ribosomes is necessary
for ribosome assembly and cell growth 745
Mathieu Ferron and
Julie Lacombe and
Amélie Germain and
Franck Oury and
Gérard Karsenty GGCX and VKORC1 inhibit osteocalcin
endocrine functions . . . . . . . . . . 761
Howard Donninger and
Diego F. Calvisi and
Thibaut Barnoud and
Jennifer Clark and
M. Lee Schmidt and
Michele D. Vos and
Geoffrey J. Clark NORE1A is a Ras senescence effector that
controls the apoptotic/senescent balance
of p53 via HIPK2 . . . . . . . . . . . . 777
Anna Brachet and
Stephanie Norwood and
Jos F. Brouwers and
Ernest Palomer and
J. Bernd Helms and
Carlos G. Dotti and
José A. Esteban LTP-triggered cholesterol redistribution
activates Cdc42 and drives AMPA receptor
synaptic delivery . . . . . . . . . . . 791
Aiguo Tian and
Qing Shi and
Alice Jiang and
Shuangxi Li and
Bing Wang and
Jin Jiang Injury-stimulated Hedgehog signaling
promotes regenerative proliferation of
\bionameDrosophila intestinal stem cells 807
Olga Tornavaca and
Minghao Chia and
Neil Dufton and
Lourdes Osuna Almagro and
Daniel E. Conway and
Anna M. Randi and
Martin A. Schwartz and
Karl Matter and
Maria S. Balda ZO-1 controls endothelial adherens
junctions, cell--cell tension,
angiogenesis, and barrier formation . . 821
Olivia Luu and
Erich W. Damm and
Serge E. Parent and
Debanjan Barua and
Tamara H. L. Smith and
Jason W. H. Wen and
Stephanie E. Lepage and
Martina Nagel and
Hady Ibrahim-Gawel and
Yunyun Huang and
Ashley E. E. Bruce and
Rudolf Winklbauer PAPC mediates self/non-self-distinction
during Snail1-dependent tissue
separation . . . . . . . . . . . . . . . 839
Marcel Reuter and
Alex Zelensky and
Ihor Smal and
Erik Meijering and
Wiggert A. van Cappellen and
H. Martijn de Gruiter and
Gijsbert J. van Belle and
Martin E. van Royen and
Adriaan B. Houtsmuller and
Jeroen Essers and
Roland Kanaar and
Claire Wyman BRCA2 diffuses as oligomeric clusters
with RAD51 and changes mobility after
DNA damage in live cells . . . . . . . . 857
Ramanjaneyulu Allam and
Michel H. Maillard and
Aubry Tardivel and
Vijaykumar Chennupati and
Hristina Bega and
Chi Wang Yu and
Dominique Velin and
Pascal Schneider and
Kendle M. Maslowski Epithelial NAIPs protect against colonic
tumorigenesis . . . . . . . . . . . . . ??
Ben Short Spindly gets a lipid link to
kinetochores . . . . . . . . . . . . . . ??
Mitch Leslie Stress granules ease the way for
metastasis . . . . . . . . . . . . . . . ??
Ben Short A POSH accent for synaptic growth . . . ??
Ben Short How VE-cadherin goes with the flow . . . 861
Caitlin Sedwick Chiara Zurzolo: GPI knows the way to go 862
Ben Short Damaged mitochondria get a Parkin ticket 865
Allison W. McClure and
Daniel J. Lew To avoid a mating mishap, yeast focus
and communicate . . . . . . . . . . . . 867
Michelle R. Bond and
John A. Hanover A little sugar goes a long way: The cell
biology of O--GlcNAc . . . . . . . . . . 869
Devinderjit K. Moudgil and
Nathan Westcott and
Jakub K. Famulski and
Kinjal Patel and
Dawn Macdonald and
Howard Hang and
Gordon K. T. Chan A novel role of farnesylation in
targeting a mitotic checkpoint protein,
human Spindly, to kinetochores . . . . . 881
Omaya Dudin and
Felipe O. Bendezú and
Raphael Groux and
Thierry Laroche and
Arne Seitz and
Sophie G. Martin A formin-nucleated actin aster
concentrates cell wall hydrolases for
cell fusion in fission yeast . . . . . . 897
Syam Prakash Somasekharan and
Amal El-Naggar and
Gabriel Leprivier and
Hongwei Cheng and
Shamil Hajee and
Thomas G. P. Grunewald and
Fan Zhang and
Tony Ng and
Olivier Delattre and
Valentina Evdokimova and
Yuzhuo Wang and
Martin Gleave and
Poul H. Sorensen YB-1 regulates stress granule formation
and tumor progression by translationally
activating G3BP1 . . . . . . . . . . . . 913
Ryan J. H. West and
Yubing Lu and
Bruno Marie and
Fen-Biao Gao and
Sean T. Sweeney Rab8, POSH, and TAK1 regulate synaptic
growth in a \bionameDrosophila model of
frontotemporal dementia . . . . . . . . 931
Zhonghua Hu and
Jun Zhao and
Tianyi Hu and
Yan Luo and
Jun Zhu and
Zheng Li miR-501-3p mediates the
activity-dependent regulation of the
expression of AMPA receptor subunit
GluA1 . . . . . . . . . . . . . . . . . 949
Michael Howell and
Howard Brickner and
Violaine D. Delorme-Walker and
Justin Choi and
Jean-Michel Saffin and
Daniel Miller and
Andreas Panopoulos and
Céline DerMardirossian and
Arun Fotedar and
Robert L. Margolis and
Rati Fotedar WISp39 binds phosphorylated Coronin 1B
to regulate Arp2/3 localization and
Cofilin-dependent motility . . . . . . . 961
Brian G. Coon and
Nicolas Baeyens and
Jinah Han and
Madhusudhan Budatha and
Tyler D. Ross and
Jennifer S. Fang and
Sanguk Yun and
Jeon-Leon Thomas and
Martin A. Schwartz Intramembrane binding of VE-cadherin to
VEGFR2 and VEGFR3 assembles the
endothelial mechanosensory complex . . . 975
Kyle M. Draheim and
Xiaofeng Li and
Rong Zhang and
Oriana S. Fisher and
Giulia Villari and
Titus J. Boggon and
David A. Calderwood CCM2--CCM3 interaction stabilizes their
protein expression and permits
endothelial network formation . . . . . 987
Dominique Siegenthaler and
Eva-Maria Enneking and
Eliza Moreno and
Jan Pielage L1CAM\slash Neuroglian controls the
axon--axon interactions establishing
layered and lobular mushroom body
architecture . . . . . . . . . . . . . . 1003
Ben Short Mismatch repair provides a security
patch for translesion synthesis . . . . ??
Ben Short For fission yeast nuclei, it takes two
to tango . . . . . . . . . . . . . . . . ??
Ben Short Tmem231 keeps cilia in the zone . . . . ??
Ben Short PI(4)P gets Sac-rificed in the name of
endocytic recycling . . . . . . . . . . 3
Kendall Powell Dyche Mullins: Finding filaments at the
fringes . . . . . . . . . . . . . . . . 4
Karen Mruk and
James K. Chen Thinking big with small molecules . . . 7
Aidan M. Fenix and
Dylan T. Burnette A small part of myosin IIB takes on a
big role in cell polarity . . . . . . . 11
Ira Tabas and
Guillermo García-Cardeña and
Gary K. Owens Recent insights into the cellular
biology of atherosclerosis . . . . . . . 13
Alba Juanes-Garcia and
Jessica R. Chapman and
Rocio Aguilar-Cuenca and
Cristina Delgado-Arevalo and
Jennifer Hodges and
Leanna A. Whitmore and
Jeffrey Shabanowitz and
Donald F. Hunt and
Alan Rick Horwitz and
Miguel Vicente-Manzanares A regulatory motif in nonmuscle myosin
II--B regulates its role in migratory
front--back polarity . . . . . . . . . . 23
Anastasia Tsaalbi-Shtylik and
Cristina Ferrás and
Bea Pauw and
Giel Hendriks and
Piya Temviriyanukul and
Leone Carlée and
Fabienne Calléja and
Sandrine van Hees and
Jun-Ichi Akagi and
Shigenori Iwai and
Fumio Hanaoka and
Jacob G. Jansen and
Niels de Wind Excision of translesion synthesis errors
orchestrates responses to
helix-distorting DNA lesions . . . . . . 33
Kathleen Scheffler and
Refael Minnes and
Vincent Fraisier and
Anne Paoletti and
Phong T. Tran Microtubule minus end motors kinesin-14
and dynein drive nuclear congression in
parallel pathways . . . . . . . . . . . 47
Xia Feng and
Pierre A. Coulombe A role for disulfide bonding in keratin
intermediate filament organization and
dynamics in skin keratinocytes . . . . . 59
Ana\"\is Aulas and
Guillaume Caron and
Christos G. Gkogkas and
Nguyen-Vi Mohamed and
Laurie Destroismaisons and
Nahum Sonenberg and
Nicole Leclerc and
J. Alex Parker and
Christine Vande Velde G3BP1 promotes stress-induced RNA
granule interactions to preserve
polyadenylated mRNA . . . . . . . . . . 73
Fubito Nakatsu and
Mirko Messa and
Ramiro Nández and
Heather Czapla and
Yixiao Zou and
Stephen M. Strittmatter and
Pietro De Camilli Sac2\slash INPP5F is an inositol
$4$-phosphatase that functions in the
endocytic pathway . . . . . . . . . . . 85
FoSheng Hsu and
Fenghua Hu and
Yuxin Mao Spatiotemporal control of
phosphatidylinositol $4$-phosphate by
Sac2 regulates endocytic recycling . . . 97
Kei Okatsu and
Fumika Koyano and
Mayumi Kimura and
Hidetaka Kosako and
Yasushi Saeki and
Keiji Tanaka and
Noriyuki Matsuda Phosphorylated ubiquitin chain is the
genuine Parkin receptor . . . . . . . . 111
Elle C. Roberson and
William E. Dowdle and
Aysegul Ozanturk and
Francesc R. Garcia-Gonzalo and
Chunmei Li and
Jan Halbritter and
Nadia Elkhartoufi and
Jonathan D. Porath and
Heidi Cope and
Allison Ashley-Koch and
Simon Gregory and
Sophie Thomas and
John A. Sayer and
Sophie Saunier and
Edgar A. Otto and
Nicholas Katsanis and
Erica E. Davis and
Tania Attié-Bitach and
Friedhelm Hildebrandt and
Michel R. Leroux and
Jeremy F. Reiter TMEM231, mutated in orofaciodigital and
Meckel syndromes, organizes the ciliary
transition zone . . . . . . . . . . . . 129
Bo-Ra Na and
Hye-Ran Kim and
Indre Piragyte and
Hyun-Mee Oh and
Min-Sung Kwon and
Uroos Akber and
Hyun-Su Lee and
Do-Sim Park and
Woo Keun Song and
Zee-Yong Park and
Sin-Hyeog Im and
Mun-Chual Rho and
Young-Min Hyun and
Minsoo Kim and
Chang-Duk Jun TAGLN2 regulates T cell activation by
stabilizing the actin cytoskeleton at
the immunological synapse . . . . . . . 143
David J. Barry and
Charlotte H. Durkin and
Jasmine V. Abella and
Michael Way Open source software for quantification
of cell migration, protrusions, and
fluorescence intensities . . . . . . . . 163
Nazila Daneshjou and
Nathan Sieracki and
Geerten P. van Nieuw Amerongen and
Daniel E. Conway and
Martin A. Schwartz and
Yulia A. Komarova and
Asrar B. Malik Rac1 functions as a reversible tension
modulator to stabilize VE-cadherin
trans-interaction . . . . . . . . . . . 181
Mitch Leslie TRAMM makes an unscheduled stop during
mitosis . . . . . . . . . . . . . . . . ??
Mitch Leslie Mitotic proteins take on editorial
duties . . . . . . . . . . . . . . . . . ??
Mitch Leslie MLCK stops cells from going full frontal ??
Mitch Leslie Sugar saps FOXO1's healing power . . . . 185
Caitlin Sedwick Matthew Rasband: Zen and the art of
axonal maintenance . . . . . . . . . . . 186
Caitlin Sedwick Demystifying Aurora B . . . . . . . . . 189
Kenneth M. Yamada and
Alan Hall Reproducibility and cell biology . . . . 191
Daniel H. Madsen and
Thomas H. Bugge The source of matrix-degrading enzymes
in human cancer: Problems of research
reproducibility and possible solutions 195
Rizaldy P. Scott and
Susan E. Quaggin The cell biology of renal filtration . . 199
Kelly E. Miller and
Rebecca Heald Glutamylation of Nap1 modulates histone
H1 dynamics and chromosome condensation
in \bionameXenopus . . . . . . . . . . . 211
Miroslav P. Milev and
Benedeta Hasaj and
Djenann Saint-Dic and
Sary Snounou and
Qingchuan Zhao and
Michael Sacher TRAMM\slash TrappC12 plays a role in
chromosome congression, kinetochore
stability, and CENP--E recruitment . . . 221
Yihan Wan and
Xiaobin Zheng and
Haiyang Chen and
Yuxuan Guo and
Hao Jiang and
Xiaonan He and
Xueliang Zhu and
Yixian Zheng Splicing function of mitotic regulators
links R-loop--mediated DNA damage to
tumor cell killing . . . . . . . . . . . 235
Ping Li and
Yize Shao and
Hui Jin and
Hong-Guo Yu Ndj1, a telomere-associated protein,
regulates centrosome separation in
budding yeast meiosis . . . . . . . . . 247
Gregor Habeck and
Felix A. Ebner and
Hiroko Shimada-Kreft and
Stefan G. Kreft The yeast ERAD--C ubiquitin ligase Doa10
recognizes an intramembrane degron . . . 261
Sunny S. Lou and
Alba Diz-Muñoz and
Orion D. Weiner and
Daniel A. Fletcher and
Julie A. Theriot Myosin light chain kinase regulates cell
polarization independently of membrane
tension or Rho kinase . . . . . . . . . 275
Chenying Zhang and
Bhaskar Ponugoti and
Chen Tian and
Fanxing Xu and
Rohinton Tarapore and
Angelika Batres and
Sarah Alsadun and
Jason Lim and
Guangyu Dong and
Dana T. Graves FOXO1 differentially regulates both
normal and diabetic wound healing . . . 289
Daisuke Nanba and
Fujio Toki and
Sota Tate and
Matome Imai and
Natsuki Matsushita and
Ken Shiraishi and
Koji Sayama and
Hiroshi Toki and
Shigeki Higashiyama and
Yann Barrandon Cell motion predicts human epidermal
stemness . . . . . . . . . . . . . . . . 305
Ben Short Hsp72 gives spindles a fiber supplement ??
Ben Short Axonal autophagosomes use a rideshare
service . . . . . . . . . . . . . . . . ??
Ben Short Rab27a builds a platform for HIV-1 . . . ??
Ben Short SUN protection for the skin . . . . . . 319
Kendall Powell Petra Schwille: Taking a minimalist
approach to membranes . . . . . . . . . 320
Satyajit Mayor The shifting geography and language of
cell biology . . . . . . . . . . . . . . 323
Bernhard Nieswandt and
Simon Stritt Megakaryocyte rupture for acute platelet
needs . . . . . . . . . . . . . . . . . 327
Magdalena Bezanilla and
Amy S. Gladfelter and
David R. Kovar and
Wei-Lih Lee Cytoskeletal dynamics: a view from the
membrane . . . . . . . . . . . . . . . . 329
Suzanna L. Prosser and
Navdeep K. Sahota and
Laurence Pelletier and
Ciaran G. Morrison and
Andrew M. Fry Nek5 promotes centrosome integrity in
interphase and loss of centrosome
cohesion in mitosis . . . . . . . . . . 339
Laura O'Regan and
Josephina Sampson and
Mark W. Richards and
Axel Knebel and
Daniel Roth and
Fiona E. Hood and
Anne Straube and
Stephen J. Royle and
Richard Bayliss and
Andrew M. Fry Hsp72 is targeted to the mitotic spindle
by Nek6 to promote K-fiber assembly and
mitotic progression . . . . . . . . . . 349
Kirk W. Donovan and
Anthony Bretscher Head-to-tail regulation is critical for
the in vivo function of myosin V . . . . 359
Katharina Grikscheit and
Tanja Frank and
Ying Wang and
Robert Grosse Junctional actin assembly is mediated by
Formin-like 2 downstream of Rac1 . . . . 367
Xiu-Tang Cheng and
Bing Zhou and
Mei-Yao Lin and
Qian Cai and
Zu-Hang Sheng Axonal autophagosomes recruit dynein for
retrograde transport through fusion with
late endosomes . . . . . . . . . . . . . 377
Rafael Lucena and
Noah Dephoure and
Steve P. Gygi and
Douglas R. Kellogg and
Victor A. Tallada and
Rafael R. Daga and
Juan Jimenez Nucleocytoplasmic transport in the
midzone membrane domain controls yeast
mitotic spindle disassembly . . . . . . 387
Rachel M. Stewart and
Amanda E. Zubek and
Kathryn A. Rosowski and
Sarah M. Schreiner and
Valerie Horsley and
Megan C. King Nuclear--cytoskeletal linkages
facilitate cross talk between the
nucleus and intercellular adhesions . . 403
Keith A. Vossel and
Jordan C. Xu and
Vira Fomenko and
Takashi Miyamoto and
Elsa Suberbielle and
Joseph A. Knox and
Kaitlyn Ho and
Daniel H. Kim and
Gui-Qiu Yu and
Lennart Mucke Tau reduction prevents A$ \beta
$-induced axonal transport deficits by
blocking activation of GSK3$ \beta $ . . 419
Pehuén Pereyra Gerber and
Mercedes Cabrini and
Carolina Jancic and
Luciana Paoletti and
Claudia Banchio and
Catalina von Bilderling and
Lorena Sigaut and
Lía I. Pietrasanta and
Gabriel Duette and
Eric O. Freed and
Genevieve de Saint Basile and
Catarina Ferreira Moita and
Luis Ferreira Moita and
Sebastian Amigorena and
Philippe Benaroch and
Jorge Geffner and
Matías Ostrowski Rab27a controls HIV-1 assembly by
regulating plasma membrane levels of
phosphatidylinositol 4,5-bisphosphate 435
Satoshi Nishimura and
Mika Nagasaki and
Shinji Kunishima and
Akira Sawaguchi and
Asuka Sakata and
Hiroyasu Sakaguchi and
Tsukasa Ohmori and
Ichiro Manabe and
Joseph E. Italiano and
Tomiko Ryu and
Naoya Takayama and
Issei Komuro and
Takashi Kadowaki and
Koji Eto and
Ryozo Nagai IL-1$ \alpha $ induces thrombopoiesis
through megakaryocyte rupture in
response to acute platelet needs . . . . 453
Rana Amini and
Eugénie Goupil and
Sara Labella and
Monique Zetka and
Amy S. Maddox and
Jean-Claude Labbé and
Nicolas T. Chartier \bionameC. elegans Anillin proteins
regulate intercellular bridge stability
and germline syncytial organization . . 467
Ben Short Ltc1 gets added to the ER's contacts . . ??
Ben Short A stem cell niche shows self-restraint ??
Ben Short A SMRTer way to track molecules . . . . ??
Ben Short Dimerization dictates the message . . . 471
Caitlin Sedwick Eva Nogales: See how they run . . . . . 472
Ben Short VEGF tips its hand in angiogenesis . . . 474
Chris Marshall From RAS to RHO: The making of the great
cell biologist Alan Hall (1952--2015) 481
Kevin P. Schoenfelder and
Donald T. Fox The expanding implications of polyploidy 485
Silvia Tietz and
Britta Engelhardt Brain barriers: Crosstalk between
complex tight junctions and adherens
junctions . . . . . . . . . . . . . . . 493
Taekyung Kim and
Mark W. Moyle and
Pablo Lara-Gonzalez and
Christian De Groot and
Karen Oegema and
Arshad Desai Kinetochore-localized BUB-1/BUB-3
complex promotes anaphase onset in
\bionameC. elegans . . . . . . . . . . . 507
Yang Yang and
Dai Tsuchiya and
Soni Lacefield Bub3 promotes Cdc20-dependent activation
of the APC/C in \bionameS. cerevisiae 519
Shuoshuo Wang and
Adriana Reuveny and
Talila Volk Nesprin provides elastic properties to
muscle nuclei by cooperating with
spectraplakin and EB1 . . . . . . . . . 529
Andrew Murley and
Reta D. Sarsam and
Alexandre Toulmay and
Justin Yamada and
William A. Prinz and
Jodi Nunnari Ltc1 is an ER-localized sterol
transporter and a component of
ER--mitochondria and ER--vacuole
contacts . . . . . . . . . . . . . . . . 539
Masashi Yukawa and
Chiho Ikebe and
Takashi Toda The Msd1--Wdr8--Pkl1 complex anchors
microtubule minus ends to fission yeast
spindle pole bodies . . . . . . . . . . 549
Megan K. Dennis and
Adriana R. Mantegazza and
Olivia L. Snir and
Dani\`ele Tenza and
Amanda Acosta-Ruiz and
Cédric Delevoye and
Richard Zorger and
Anand Sitaram and
Wilfredo de Jesus-Rojas and
Keerthana Ravichandran and
John Rux and
Elena V. Sviderskaya and
Dorothy C. Bennett and
Graça Raposo and
Michael S. Marks and
Subba Rao Gangi Setty BLOC-2 targets recycling endosomal
tubules to melanosomes for cargo
delivery . . . . . . . . . . . . . . . . 563
Stephan Wilmes and
Oliver Beutel and
Zhi Li and
Véronique François-Newton and
Christian P. Richter and
Dennis Janning and
Cindy Kroll and
Patrizia Hanhart and
Katharina Hötte and
Changjiang You and
Gilles Uzé and
Sandra Pellegrini and
Jacob Piehler Receptor dimerization dynamics as a
regulatory valve for plasticity of type
I interferon signaling . . . . . . . . . 579
Lichao Luo and
Huashan Wang and
Chao Fan and
Sen Liu and
Yu Cai Wnt ligands regulate Tkv expression to
constrain Dpp activity in the
\bionameDrosophila ovarian stem cell
niche . . . . . . . . . . . . . . . . . 595
Carlas S. Smith and
Stephan Preibisch and
Aviva Joseph and
Sara Abrahamsson and
Bernd Rieger and
Eugene Myers and
Robert H. Singer and
David Grunwald Nuclear accessibility of $ \beta $-actin
mRNA is measured by $3$D single-molecule
real-time tracking . . . . . . . . . . . 609
Gregor Habeck and
Felix A. Ebner and
Hiroko Shimada-Kreft and
Stefan G. Kreft The yeast ERAD--C ubiquitin ligase Doa10
recognizes an intramembrane degron . . . 621
Mitch Leslie Splicing reverses protein's function . . ??
Mitch Leslie A Hedgehog inhibitor gets around . . . . ??
Mitch Leslie Neurons join forces to push ahead . . . ??
Mitch Leslie How chromosomes shrink to fit . . . . . 625
Kendall Powell Junjie Hu: Shape-shifting in the
endoplasmic reticulum . . . . . . . . . 626
Elaine Fuchs Cell biology: More than skin deep . . . 629
Jonas Helma and
M. Cristina Cardoso and
Serge Muyldermans and
Heinrich Leonhardt Nanobodies and recombinant binders in
cell biology . . . . . . . . . . . . . . 633
Anne-Marie Ladouceur and
Jonas F. Dorn and
Paul S. Maddox Mitotic chromosome length scales in
response to both cell and nuclear size 645
Anshul Rana and
Michelle Yen and
Amir Masoud Sadaghiani and
Seth Malmersjö and
Chan Young Park and
Ricardo E. Dolmetsch and
Richard S. Lewis Alternative splicing converts STIM2 from
an activator to an inhibitor of
store-operated calcium channels . . . . 653
Olaya Llano and
Sergey Smirnov and
Shetal Soni and
Andrey Golubtsov and
Isabelle Guillemin and
Pirta Hotulainen and
Igor Medina and
Hans Gerd Nothwang and
Claudio Rivera and
Anastasia Ludwig KCC2 regulates actin dynamics in
dendritic spines via interaction with $
\beta $-PIX . . . . . . . . . . . . . . 671
Rosemarie Ungricht and
Michael Klann and
Peter Horvath and
Ulrike Kutay Diffusion and retention are major
determinants of protein targeting to the
inner nuclear membrane . . . . . . . . . 687
Andrea Boni and
Antonio Z. Politi and
Petr Strnad and
Wanqing Xiang and
M. Julius Hossain and
Jan Ellenberg Live imaging and modeling of inner
nuclear membrane targeting reveals its
molecular requirements in mammalian
cells . . . . . . . . . . . . . . . . . 705
Chuan-Ming Xie and
Dongping Wei and
Lili Zhao and
Sylvie Marchetto and
Lin Mei and
Jean-Paul Borg and
Yi Sun Erbin is a novel substrate of the Sag-$
\beta $TrCP E3 ligase that regulates
Kras$^{\rm G12D}$-induced skin
tumorigenesis . . . . . . . . . . . . . 721
Alexander M. Holtz and
Samuel C. Griffiths and
Samantha J. Davis and
Benjamin Bishop and
Christian Siebold and
Benjamin L. Allen Secreted HHIP1 interacts with heparan
sulfate and regulates Hedgehog ligand
localization and function . . . . . . . 739
Jian Jiang and
Zheng-hong Zhang and
Xiao-bin Yuan and
Mu-ming Poo Spatiotemporal dynamics of traction
forces show three contraction centers in
migratory neurons . . . . . . . . . . . 759
Ben Short GMF$ \beta $ prunes actin branches . . . 776
Ben Short Building a bridge to a new spindle pole
body . . . . . . . . . . . . . . . . . . ??
Ben Short P2X4 promotes lysosome fusion . . . . . ??
Ben Short Kinases KISS and tell . . . . . . . . . ??
Caitlin Sedwick Elena Gracheva: Ion channels run hot and
cold . . . . . . . . . . . . . . . . . . 778
Ben Short The first buds of Cdc42 . . . . . . . . 780
Lilian T. Lamech and
Cole M. Haynes The unpredictability of prolonged
activation of stress response pathways 781
Frederick G. Westhorpe and
Colin J. Fuller and
Aaron F. Straight A cell-free CENP--A assembly system
defines the chromatin requirements for
centromere maintenance . . . . . . . . . 789
Elizabeth M. Haynes and
Sreeja B. Asokan and
Samantha J. King and
Heath E. Johnson and
Jason M. Haugh and
James E. Bear GMF$ \beta $ controls branched actin
content and lamellipodial retraction in
fibroblasts . . . . . . . . . . . . . . 803
Vladimir A. Volkov and
Paula M. Grissom and
Vladimir K. Arzhanik and
Anatoly V. Zaytsev and
Kutralanathan Renganathan and
Tristan McClure-Begley and
William M. Old and
Natalie Ahn and
J. Richard McIntosh Centromere protein F includes two sites
that couple efficiently to
depolymerizing microtubules . . . . . . 813
Stella Aronov and
Saray Dover-Biterman and
Edith Suss-Toby and
Michael Shmoish and
Lea Duek and
Mordechai Choder Pheromone-encoding mRNA is transported
to the yeast mating projection by
specific RNP granules . . . . . . . . . 829
Christian Seybold and
Menattallah Elserafy and
Diana Rüthnick and
Musa Ozboyaci and
Annett Neuner and
Benjamin Flottmann and
Mike Heilemann and
Rebecca C. Wade and
Elmar Schiebel Kar1 binding to Sfi1 C-terminal regions
anchors the SPB bridge to the nuclear
envelope . . . . . . . . . . . . . . . . 843
Tyler C. Moyer and
Kevin M. Clutario and
Bramwell G. Lambrus and
Vikas Daggubati and
Andrew J. Holland Binding of STIL to Plk4 activates kinase
activity to promote centriole assembly 863
Qi Cao and
Xi Zoë Zhong and
Yuanjie Zou and
Ruth Murrell-Lagnado and
Michael X. Zhu and
Xian-Ping Dong Calcium release through P2X4 activates
calmodulin to promote endolysosomal
membrane fusion . . . . . . . . . . . . 879
Mutsuki Amano and
Tomonari Hamaguchi and
Md. Hasanuzzaman Shohag and
Kei Kozawa and
Katsuhiro Kato and
Xinjian Zhang and
Yoshimitsu Yura and
Yoshiharu Matsuura and
Chikako Kataoka and
Tomoki Nishioka and
Kozo Kaibuchi Kinase-interacting substrate screening
is a novel method to identify kinase
substrates . . . . . . . . . . . . . . . 895
Mitch Leslie Bleach at the roots of mitotic
progression . . . . . . . . . . . . . . ??
Mitch Leslie p53 censuses centrosomes . . . . . . . . ??
Mitch Leslie Even killers recycle . . . . . . . . . . ??
Mitch Leslie Cilia drop anchor . . . . . . . . . . . 3
Kendall Powell Sally Horne--Badovinac: Taking a spin
around morphogenesis . . . . . . . . . . 4
Wendy S. Garrett From cell biology to the microbiome: an
intentional infinite loop . . . . . . . 7
Michael Thumm and
Mikael Simons Myelinophagy: Schwann cells dine in . . 9
Kerstin Klare and
John R. Weir and
Federica Basilico and
Tomasz Zimniak and
Lucia Massimiliano and
Nina Ludwigs and
Franz Herzog and
Andrea Musacchio CENP-C is a blueprint for constitutive
centromere--associated network assembly
within human kinetochores . . . . . . . 11
Jung Mi Lim and
Kyung S. Lee and
Hyun Ae Woo and
Dongmin Kang and
Sue Goo Rhee Control of the pericentrosomal H$_2$
O$_2$ level by peroxiredoxin I is
critical for mitotic progression . . . . 23
Clementine Schouteden and
Daniel Serwas and
Mate Palfy and
Alexander Dammermann The ciliary transition zone functions in
cell adhesion but is dispensable for
axoneme assembly in \bionameC. elegans 35
Melpomeni Platani and
Laura Trinkle-Mulcahy and
Michael Porter and
A. Arockia Jeyaprakash and
William C. Earnshaw Mio depletion links mTOR regulation to
Aurora A and Plk1 activation at mitotic
centrosomes . . . . . . . . . . . . . . 45
Bramwell G. Lambrus and
Yumi Uetake and
Kevin M. Clutario and
Vikas Daggubati and
Michael Snyder and
Greenfield Sluder and
Andrew J. Holland p53 protects against genome instability
following centriole duplication failure 63
Dorothy A. Lerit and
Holly A. Jordan and
John S. Poulton and
Carey J. Fagerstrom and
Brian J. Galletta and
Mark Peifer and
Nasser M. Rusan Interphase centrosome organization by
the PLP--Cnn scaffold is required for
centrosome function . . . . . . . . . . 79
Damien Laporte and
Fabien Courtout and
Beno\^\it Pinson and
Jim Dompierre and
Bénédicte Salin and
Lysiane Brocard and
Isabelle Sagot A stable microtubule array drives
fission yeast polarity reestablishment
upon quiescence exit . . . . . . . . . . 99
Misty R. Marshall and
Varsha Pattu and
Mahantappa Halimani and
Monika Maier-Peuschel and
Martha-Lena Müller and
Ute Becherer and
Wanjin Hong and
Markus Hoth and
Thomas Tschernig and
Yenan T. Bryceson and
Jens Rettig VAMP8-dependent fusion of recycling
endosomes with the plasma membrane
facilitates T lymphocyte cytotoxicity 135
Jose A. Gomez-Sanchez and
Lucy Carty and
Marta Iruarrizaga-Lejarreta and
Marta Palomo-Irigoyen and
Marta Varela-Rey and
Megan Griffith and
Janina Hantke and
Nuria Macias-Camara and
Mikel Azkargorta and
Igor Aurrekoetxea and
Virginia Gutiérrez De Juan and
Harold B. J. Jefferies and
Patricia Aspichueta and
Félix Elortza and
Ana M. Aransay and
María L. Martínez-Chantar and
Frank Baas and
José M. Mato and
Rhona Mirsky and
Ashwin Woodhoo and
Kristján R. Jessen Schwann cell autophagy, myelinophagy,
initiates myelin clearance from injured
nerves . . . . . . . . . . . . . . . . . 153
Jochen Baßler and
Helge Paternoga and
Iris Holdermann and
Matthias Thoms and
Sander Granneman and
Clara Barrio-Garcia and
Afua Nyarko and
Woonghee Lee and
Gunter Stier and
Sarah A. Clark and
Daniel Schraivogel and
Martina Kallas and
Roland Beckmann and
David Tollervey and
Elisar Barbar and
Irmi Sinning and
Ed Hurt A network of assembly factors is
involved in remodeling rRNA elements
during preribosome maturation . . . . . 169
Ben Short Spindle assembly at a BRISC pace . . . . ??
Ben Short Ribosomes have a NAC for nascent chain
processing . . . . . . . . . . . . . . . ??
Ben Short Cadherin clusters solidify adhesions . . ??
Ben Short A timeline for exocytosis . . . . . . . 173
Caitlin Sedwick Feng Shao: Getting a sense for the
defense . . . . . . . . . . . . . . . . 174
Caitlin Sedwick A spotlight on chromatin choreography 176
Susan A. Gerbi Beginning at the end: DNA replication
within the telomere . . . . . . . . . . 177
Kirk W. Donovan and
Anthony Bretscher Tracking individual secretory vesicles
during exocytosis reveals an ordered and
regulated process . . . . . . . . . . . 181
William C. Drosopoulos and
Settapong T. Kosiyatrakul and
Carl L. Schildkraut BLM helicase facilitates telomere
replication during leading strand
synthesis of telomeres . . . . . . . . . 191
Kaowen Yan and
Li Li and
Xiaojian Wang and
Ruisha Hong and
Ying Zhang and
Hua Yang and
Ming Lin and
Sha Zhang and
Qihua He and
Duo Zheng and
Jun Tang and
Yuxin Yin and
Genze Shao The deubiquitinating enzyme complex
BRISC is required for proper mitotic
spindle assembly in mammalian cells . . 209
Karen A. Newell-Litwa and
Mathilde Badoual and
Hannelore Asmussen and
Heather Patel and
Leanna Whitmore and
Alan Rick Horwitz ROCK1 and 2 differentially regulate
actomyosin organization to drive cell
and synaptic polarity . . . . . . . . . 225
Anke Treuner-Lange and
Eric Macia and
Mathilde Guzzo and
Edina Hot and
Laura M. Faure and
Beata Jakobczak and
Leon Espinosa and
Damien Alcor and
Adrien Ducret and
Daniela Keilberg and
Jean Philippe Castaing and
Sandra Lacas Gervais and
Michel Franco and
Lotte Sògaard-Andersen and
Tâm Mignot The small G-protein MglA connects to the
MreB actin cytoskeleton at bacterial
focal adhesions . . . . . . . . . . . . 243
Adebowale O. Bamidele and
Kimberly N. Kremer and
Petra Hirsova and
Ian C. Clift and
Gregory J. Gores and
Daniel D. Billadeau and
Karen E. Hedin IQGAP1 promotes CXCR4 chemokine receptor
function and trafficking via EEA-1$^+$
endosomes . . . . . . . . . . . . . . . 257
Juan Wang and
Saralin Davis and
Shekar Menon and
Jinzhong Zhang and
Jingzhen Ding and
Serena Cervantes and
Elizabeth Miller and
Yu Jiang and
Susan Ferro-Novick Ypt1/Rab1 regulates Hrr25/CK1$ \delta $
kinase activity in ER--Golgi traffic and
macroautophagy . . . . . . . . . . . . . 273
Yvonne Nyathi and
Martin R. Pool Analysis of the interplay of protein
biogenesis factors at the ribosome exit
site reveals new role for NAC . . . . . 287
Maria J. Gomez-Lamarca and
Laura A. Snowdon and
Ekatarina Seib and
Thomas Klein and
Sarah J. Bray Rme-8 depletion perturbs Notch recycling
and predisposes to pathogenic signaling 303
Ihor Yakymovych and
Mariya Yakymovych and
Guangxiang Zang and
Yabing Mu and
Anders Bergh and
Maréne Landström and
Carl-Henrik Heldin CIN85 modulates TGF$ \beta $ signaling
by promoting the presentation of TGF$
\beta $ receptors on the cell surface 319
Pierre-Olivier Strale and
Laurence Duchesne and
Grégoire Peyret and
Lorraine Montel and
Thao Nguyen and
Evelyn Png and
Robert Tampé and
Sergey Troyanovsky and
Sylvie Hénon and
Benoit Ladoux and
René-Marc M\`ege The formation of ordered nanoclusters
controls cadherin anchoring to actin and
cell--cell contact fluidity . . . . . . 333
Marie-Thér\`ese Prospéri and
Priscilla Lépine and
Florent Dingli and
Perrine Paul-Gilloteaux and
René Martin and
Damarys Loew and
Hans-Joachim Knölker and
Evelyne Coudrier Myosin 1b functions as an effector of
EphB signaling to control cell repulsion 347
Ben Short Chromosome search and rescue . . . . . . ??
Ben Short SNAREs share atlastin's burden . . . . . ??
Ben Short Integrin signaling tranquilizes Hippo ??
Ben Short Actin hotspots blaze a trail along axons 365
Kendall Powell Jan van Deursen: From knockout pioneer
to antiaging innovator . . . . . . . . . 366
David R. Sherwood A developmental biologist's
``outside-the-cell'' thinking . . . . . 369
Jingyan Fu and
Minglei Bian and
Guangwei Xin and
Zhaoxuan Deng and
Jia Luo and
Xiao Guo and
Hao Chen and
Yao Wang and
Qing Jiang and
Chuanmao Zhang TPX2 phosphorylation maintains metaphase
spindle length by regulating microtubule
flux . . . . . . . . . . . . . . . . . . 373
Anjana Badrinarayanan and
Tung B. K. Le and
Michael T. Laub Rapid pairing and resegregation of
distant homologous loci enables
double-strand break repair in bacteria 385
Archan Ganguly and
Yong Tang and
Lina Wang and
Kelsey Ladt and
Jonathan Loi and
Bénédicte Dargent and
Christophe Leterrier and
Subhojit Roy A dynamic formin-dependent deep F-actin
network in axons . . . . . . . . . . . . 401
Yutaka Matsubayashi and
Camilla Coulson-Gilmer and
Tom H. Millard Endocytosis-dependent coordination of
multiple actin regulators is required
for wound healing . . . . . . . . . . . 419
Catherine L. Nezich and
Chunxin Wang and
Adam I. Fogel and
Richard J. Youle MiT\slash TFE transcription factors are
activated during mitophagy downstream of
Parkin and Atg5 . . . . . . . . . . . . 435
Miriam Lee and
Young-Joon Ko and
Yeojin Moon and
Minsoo Han and
Hyung-Wook Kim and
Sung Haeng Lee and
KyeongJin Kang and
Youngsoo Jun SNAREs support atlastin-mediated
homotypic ER fusion in
\bionameSaccharomyces cerevisiae . . . . 451
Chin-Hsien Lin and
Hsun Li and
Yi-Nan Lee and
Ying-Ju Cheng and
Ruey-Meei Wu and
Cheng-Ting Chien Lrrk regulates the dynamic profile of
dendritic Golgi outposts through the
golgin Lava lamp . . . . . . . . . . . . 471
Shiya Cheng and
Kun Wang and
Wei Zou and
Rui Miao and
Yaling Huang and
Haibin Wang and
Xiaochen Wang PtdIns(4,5)P$_2$ and PtdIns3P coordinate
to regulate phagosomal sealing for
apoptotic cell clearance . . . . . . . . 485
Nam-Gyun Kim and
Barry M. Gumbiner Adhesion to fibronectin regulates Hippo
signaling via the FAK--Src--PI3K pathway 503
Maria Gomez-Lamarca and
Laura Amy Snowdon and
Ekatarina Seib and
Thomas Klein and
Sarah Bray Rme-8 depletion perturbs Notch recycling
and predisposes to pathogenic signaling 517
Ruchi Saraya and
Arjen M. Krikken and
Marten Veenhuis and
Ida J. van der Klei Peroxisome reintroduction in Hansenula
polymorpha requires Pex25 and Rho1 . . . 519
Ben Short Mdm1 helps the ER and vacuole stay in
touch . . . . . . . . . . . . . . . . . ??
Ben Short miR-7 loss is hard to stomach . . . . . ??
Ben Short Gauging Gag assembly . . . . . . . . . . ??
Ben Short The tension mounts at centromeric loops 523
Caitlin Sedwick Elias Spiliotis: Septins set it up . . . 524
Ben Short The spindle plays both ends . . . . . . 526
Edward Courchaine and
Karla M. Neugebauer Paraspeckles: Paragons of functional
aggregation . . . . . . . . . . . . . . 527
Sven Hennig and
Geraldine Kong and
Taro Mannen and
Agata Sadowska and
Simon Kobelke and
Amanda Blythe and
Gavin J. Knott and
K. Swaminathan Iyer and
Diwei Ho and
Estella A. Newcombe and
Kana Hosoki and
Naoki Goshima and
Tetsuya Kawaguchi and
Danny Hatters and
Laura Trinkle-Mulcahy and
Tetsuro Hirose and
Charles S. Bond and
Archa H. Fox Prion-like domains in RNA binding
proteins are essential for building
subnuclear paraspeckles . . . . . . . . 529
W. Mike Henne and
Lu Zhu and
Zsolt Balogi and
Christopher Stefan and
Jeffrey A. Pleiss and
Scott D. Emr Mdm1\slash Snx13 is a novel
ER--endolysosomal interorganelle
tethering protein . . . . . . . . . . . 541
Josh Lawrimore and
Paula A. Vasquez and
Michael R. Falvo and
Russell M. Taylor and
Leandra Vicci and
Elaine Yeh and
M. Gregory Forest and
Kerry Bloom DNA loops generate intracentromere
tension in mitosis . . . . . . . . . . . 553
Rune Troelsgaard Pedersen and
Thomas Kruse and
Jakob Nilsson and
Vibe H. Oestergaard and
Michael Lisby TopBP1 is required at mitosis to reduce
transmission of DNA damage to G1
daughter cells . . . . . . . . . . . . . 565
Dustin G. Thomas and
Aishwarya Yenepalli and
Celine Marie Denais and
Andrew Rape and
Jordan R. Beach and
Yu-li Wang and
William P. Schiemann and
Harihara Baskaran and
Jan Lammerding and
Thomas T. Egelhoff Non-muscle myosin IIB is critical for
nuclear translocation during $3$D
invasion . . . . . . . . . . . . . . . . 583
Mei Jiang and
Julian Esteve-Rudd and
Vanda S. Lopes and
Tanja Diemer and
Concepción Lillo and
Agrani Rump and
David S. Williams Microtubule motors transport phagosomes
in the RPE, and lack of KLC1 leads to
AMD-like pathogenesis . . . . . . . . . 595
Xiao-Di Zhao and
Yuan-Yuan Lu and
Hao Guo and
Hua-Hong Xie and
Li-Jie He and
Gao-Fei Shen and
Jin-Feng Zhou and
Ting Li and
Si-Jun Hu and
Lin Zhou and
Ya-Nan Han and
Shu-Li Liang and
Xin Wang and
Kai-Chun Wu and
Yong-Quan Shi and
Yong-Zhan Nie and
Dai-Ming Fan MicroRNA-7\slash NF-$ \kappa $B
signaling regulatory feedback circuit
regulates gastric carcinogenesis . . . . 613
Jelle Hendrix and
Viola Baumgärtel and
Waldemar Schrimpf and
Sergey Ivanchenko and
Michelle A. Digman and
Enrico Gratton and
Hans-Georg Kräusslich and
Barbara Müller and
Don C. Lamb Live-cell observation of cytosolic HIV-1
assembly onset reveals RNA-interacting
Gag oligomers . . . . . . . . . . . . . 629
Chi-Shuo Chen and
Soonjin Hong and
Indrajyoti Indra and
Alina P. Sergeeva and
Regina B. Troyanovsky and
Lawrence Shapiro and
Barry Honig and
Sergey M. Troyanovsky $ \alpha $-Catenin--mediated cadherin
clustering couples cadherin and actin
dynamics . . . . . . . . . . . . . . . . 647
Yusuke Kubo and
Kentarou Baba and
Michinori Toriyama and
Takunori Minegishi and
Tadao Sugiura and
Satoshi Kozawa and
Kazushi Ikeda and
Naoyuki Inagaki Shootin1--cortactin interaction mediates
signal--force transduction for axon
outgrowth . . . . . . . . . . . . . . . 663
Yutaka Matsubayashi and
Camilla Coulson-Gilmer and
Tom H. Millard Endocytosis-dependent coordination of
multiple actin regulators is required
for wound healing . . . . . . . . . . . 677
Mitch Leslie Starving tumors eat metabolic enzyme . . ??
Mitch Leslie Phospholipid prunes actin branches . . . ??
Mitch Leslie Hsc70's trip to the tip . . . . . . . . ??
Mitch Leslie Mast cells get all touchy-feely . . . . 683
Kendall Powell Nick Lane: Unearthing the first cellular
innovations . . . . . . . . . . . . . . 684
Petra Schwille Jump-starting life? Fundamental aspects
of synthetic biology . . . . . . . . . . 687
Paul S. Maddox and
Anne-Marie Ladouceur Concentrating on the mitotic spindle . . 691
Nina Schweizer and
Nisha Pawar and
Matthias Weiss and
Helder Maiato An organelle-exclusion envelope assists
mitosis and underlies distinct molecular
crowding in the spindle region . . . . . 695
Hong-guang Xia and
Ayaz Najafov and
Jiefei Geng and
Lorena Galan-Acosta and
Xuemei Han and
Yuan Guo and
Bing Shan and
Yaoyang Zhang and
Erik Norberg and
Tao Zhang and
Lifeng Pan and
Junli Liu and
Jonathan L. Coloff and
Dimitry Ofengeim and
Hong Zhu and
Kejia Wu and
Yu Cai and
John R. Yates and
Zhengjiang Zhu and
Junying Yuan and
Helin Vakifahmetoglu-Norberg Degradation of HK2 by chaperone-mediated
autophagy promotes metabolic catastrophe
and cell death . . . . . . . . . . . . . 705
Alice Parisi and
Floriane Lacour and
Lorenzo Giordani and
Sabine Colnot and
Pascal Maire and
Fabien Le Grand APC is required for muscle stem cell
proliferation and skeletal muscle tissue
repair . . . . . . . . . . . . . . . . . 717
Xiaolong Zhuo and
Xiao Guo and
Xiaoyan Zhang and
Guihua Jing and
Yao Wang and
Qiang Chen and
Qing Jiang and
Junjun Liu and
Chuanmao Zhang Usp16 regulates kinetochore localization
of Plk1 to promote proper chromosome
alignment in mitosis . . . . . . . . . . 727
Takashi Watanabe and
Mai Kakeno and
Toshinori Matsui and
Ikuko Sugiyama and
Nariko Arimura and
Kenji Matsuzawa and
Aya Shirahige and
Fumiyoshi Ishidate and
Tomoki Nishioka and
Shinichiro Taya and
Mikio Hoshino and
Kozo Kaibuchi TTBK2 with EB1/3 regulates microtubule
dynamics in migrating cells through
KIF2A phosphorylation . . . . . . . . . 737
Nan Hyung Hong and
Aidong Qi and
Alissa M. Weaver PI(3,5)P$_2$ controls endosomal branched
actin dynamics by regulating
cortactin--actin interactions . . . . . 753
Norbert Bencsik and
Zsófia Szíber and
Hanna Liliom and
Krisztián Tárnok and
Sándor Borbély and
Márton Gulyás and
Anikó Rátkai and
Attila Sz\Hucs and
Diána Hazai-Novák and
Kornelia Ellwanger and
Bence Rácz and
Klaus Pfizenmaier and
Angelika Hausser and
Katalin Schlett Protein kinase D promotes
plasticity-induced F-actin stabilization
in dendritic spines and regulates memory
formation . . . . . . . . . . . . . . . 771
Marion Gabel and
Franck Delavoie and
Valérie Demais and
Cathy Royer and
Yannick Bailly and
Nicolas Vitale and
Marie-France Bader and
Sylvette Chasserot-Golaz Annexin A2-dependent actin bundling
promotes secretory granule docking to
the plasma membrane and exocytosis . . . 785
Miranda V. Hunter and
Donghoon M. Lee and
Tony J. C. Harris and
Rodrigo Fernandez-Gonzalez Polarized E-cadherin endocytosis directs
actomyosin remodeling during embryonic
wound repair . . . . . . . . . . . . . . 801
Jonathan DeGeer and
Andrew Kaplan and
Pierre Mattar and
Morgane Morabito and
Ursula Stochaj and
Timothy E. Kennedy and
Anne Debant and
Michel Cayouette and
Alyson E. Fournier and
Nathalie Lamarche-Vane Hsc70 chaperone activity underlies Trio
GEF function in axon growth and guidance
induced by netrin-1 . . . . . . . . . . 817
Harriet P. Lo and
Susan J. Nixon and
Thomas E. Hall and
Belinda S. Cowling and
Charles Ferguson and
Garry P. Morgan and
Nicole L. Schieber and
Manuel A. Fernandez-Rojo and
Michele Bastiani and
Matthias Floetenmeyer and
Nick Martel and
Jocelyn Laporte and
Paul F. Pilch and
Robert G. Parton The caveolin--cavin system plays a
conserved and critical role in
mechanoprotection of skeletal muscle . . 833
Amanda Carroll-Portillo and
Judy L. Cannon and
Joost te Riet and
Anna Holmes and
Yuko Kawakami and
Toshiaki Kawakami and
Alessandra Cambi and
Diane S. Lidke Mast cells and dendritic cells form
synapses that facilitate antigen
transfer for T cell activation . . . . . 851
Ben Short Myelin goes to great pains to regulate
NGF . . . . . . . . . . . . . . . . . . ??
Ben Short Inflammation gets TRIM'd back by
autophagy . . . . . . . . . . . . . . . ??
Ben Short Progranulin takes an alternate route to
lysosomes . . . . . . . . . . . . . . . ??
Ben Short Kinetochores expand their reach . . . . 867
Caitlin Sedwick Jeffrey Fredberg: Flow under pressure 868
Ben Short Sorting out endosome form and function 870
Barry J. Thompson and
Erik Sahai MST kinases in development and disease 871
Alexander B. Lang and
Arun T. John Peter and
Peter Walter and
Beno\^\it Kornmann ER-mitochondrial junctions can be
bypassed by dominant mutations in the
endosomal protein Vps13 . . . . . . . . 883
H.-Christian von Büdingen and
Feng Mei and
Ariele Greenfield and
Sarah Jahn and
Yun-An A. Shen and
Hugh H. Reid and
David D. McKemy and
Jonah R. Chan The myelin oligodendrocyte glycoprotein
directly binds nerve growth factor to
modulate central axon circuitry . . . . 891
David J. Wynne and
Hironori Funabiki Kinetochore function is controlled by a
phospho-dependent coexpansion of inner
and outer components . . . . . . . . . . 899
Amy A. Connolly and
Kenji Sugioka and
Chien-Hui Chuang and
Joshua B. Lowry and
Bruce Bowerman KLP-7 acts through the Ndc80 complex to
limit pole number in \bionameC. elegans
oocyte meiotic spindle assembly . . . . 917
Kim Pham and
Raz Shimoni and
Mirren Charnley and
Mandy J. Ludford-Menting and
Edwin D. Hawkins and
Kelly Ramsbottom and
Jane Oliaro and
David Izon and
Stephen B. Ting and
Joseph Reynolds and
Grant Lythe and
Carmen Molina-Paris and
Heather Melichar and
Ellen Robey and
Patrick O. Humbert and
Min Gu and
Sarah M. Russell Asymmetric cell division during T cell
development controls downstream fate . . 933
F.-Nora Vögtle and
Michael Keller and
Asli A. Taskin and
Susanne E. Horvath and
Xue Li Guan and
Claudia Prinz and
Magdalena Opali\'nska and
Carina Zorzin and
Martin van der Laan and
Markus R. Wenk and
Rolf Schubert and
Nils Wiedemann and
Martin Holzer and
Chris Meisinger The fusogenic lipid phosphatidic acid
promotes the biogenesis of mitochondrial
outer membrane protein Ugo1 . . . . . . 951
Liming Yan and
Sha Sun and
Wei Wang and
Juanming Shi and
Xiaoyu Hu and
Shiyan Wang and
Dan Su and
Zihe Rao and
Junjie Hu and
Zhiyong Lou Structures of the yeast dynamin-like
GTPase Sey1p provide insight into
homotypic ER fusion . . . . . . . . . . 961
Tomonori Kimura and
Ashish Jain and
Seong Won Choi and
Michael A. Mandell and
Kate Schroder and
Terje Johansen and
Vojo Deretic TRIM-mediated precision autophagy
targets cytoplasmic regulators of innate
immunity . . . . . . . . . . . . . . . . 973
Xiaolai Zhou and
Lirong Sun and
Francisco Bastos de Oliveira and
Xiaoyang Qi and
William J. Brown and
Marcus B. Smolka and
Ying Sun and
Fenghua Hu Prosaposin facilitates
sortilin-independent lysosomal
trafficking of progranulin . . . . . . . 991
Gianluca Fulgenzi and
Francesco Tomassoni-Ardori and
Lucia Babini and
Jodi Becker and
Colleen Barrick and
Sandrine Puverel and
Lino Tessarollo BDNF modulates heart contraction force
and long-term homeostasis through
truncated TrkB.T1 receptor activation 1003
Nikki R. Paul and
Jennifer L. Allen and
Anna Chapman and
Maria Morlan-Mairal and
Egor Zindy and
Guillaume Jacquemet and
Laura Fernandez del Ama and
Nermina Ferizovic and
David M. Green and
Jonathan D. Howe and
Elisabeth Ehler and
Adam Hurlstone and
Patrick T. Caswell $ \alpha $5$ \beta $1 integrin recycling
promotes Arp2/3-independent cancer cell
invasion via the formin FHOD3 . . . . . 1013
Pierre-Olivier Strale and
Laurence Duchesne and
Grégoire Peyret and
Lorraine Montel and
Thao Nguyen and
Evelyn Png and
Robert Tampé and
Sergey Troyanovsky and
Sylvie Hénon and
Benoit Ladoux and
René-Marc M\`ege The formation of ordered nanoclusters
controls cadherin anchoring to actin and
cell--cell contact fluidity . . . . . . 1033
Caitlin Sedwick Glia hold it together . . . . . . . . . ??
Caitlin Sedwick Mitochondria sense the way forward . . . ??
Caitlin Sedwick Clearing the way for efficient stem cell
differentiation . . . . . . . . . . . . ??
Caitlin Sedwick Glycolytic cancer cells splice their way
out of trouble . . . . . . . . . . . . . 1037
Kendall Powell Nihal Altan--Bonnet: Tracking viruses
that hijack membranes . . . . . . . . . 1038
Marcos Gonzalez-Gaitan and
Aurélien Roux When cell biology meets theory . . . . . 1041
Lena-Sophie Wenz and
Lars Ellenrieder and
Jian Qiu and
Maria Bohnert and
Nicole Zufall and
Martin van der Laan and
Nikolaus Pfanner and
Nils Wiedemann and
Thomas Becker Sam37 is crucial for formation of the
mitochondrial TOM--SAM supercomplex,
thereby promoting $ \beta $-barrel
biogenesis . . . . . . . . . . . . . . . 1047
Lucas J. M. Bruurs and
Lisa Donker and
Susan Zwakenberg and
Fried J. Zwartkruis and
Harry Begthel and
A. S. Knisely and
George Posthuma and
Stan F. J. van de Graaf and
Coen C. Paulusma and
Johannes L. Bos ATP8B1-mediated spatial organization of
Cdc42 signaling maintains singularity
during enterocyte polarization . . . . . 1055
Julie M. Bianchini and
Khameeka N. Kitt and
Martijn Gloerich and
Sabine Pokutta and
William I. Weis and
W. James Nelson Reevaluating $ \alpha $E-catenin monomer
and homodimer functions by
characterizing E-cadherin/$ \alpha
$E-catenin chimeras . . . . . . . . . . 1065
Ryan B. MacDonald and
Owen Randlett and
Julia Oswald and
Takeshi Yoshimatsu and
Kristian Franze and
William A. Harris Müller glia provide essential tensile
strength to the developing retina . . . 1075
Anne Pacquelet and
Perrine Uhart and
Jean-Pierre Tassan and
Grégoire Michaux PAR-4 and anillin regulate myosin to
coordinate spindle and furrow position
during asymmetric division . . . . . . . 1085
Hongying Gang and
Rimpy Dhingra and
Junjun Lin and
Yan Hai and
Yaron Aviv and
Victoria Margulets and
Mohammad Hamedani and
Thatchawan Thanasupawat and
Etienne Leygue and
Thomas Klonisch and
James R. Davie and
Lorrie A. Kirshenbaum PDK2-mediated alternative splicing
switches Bnip3 from cell death to cell
survival . . . . . . . . . . . . . . . . 1101
Neil J. Grimsey and
Berenice Aguilar and
Thomas H. Smith and
Phillip Le and
Amanda L. Soohoo and
Manojkumar A. Puthenveedu and
Victor Nizet and
JoAnn Trejo Ubiquitin plays an atypical role in
GPCR-induced p38 MAP kinase activation
on endosomes . . . . . . . . . . . . . . 1117
Seigo Terawaki and
Voahirana Camosseto and
Francesca Prete and
Till Wenger and
Alexia Papadopoulos and
Christiane Rondeau and
Alexis Combes and
Christian Rodriguez Rodrigues and
Thien-Phong Vu Manh and
Mathieu Fallet and
Luc English and
Rodrigo Santamaria and
Ana R. Soares and
Tobias Weil and
Hamida Hammad and
Michel Desjardins and
Jean-Pierre Gorvel and
Manuel A. S. Santos and
Evelina Gatti and
Philippe Pierre RUN and FYVE domain-containing protein 4
enhances autophagy and lysosome
tethering in response to Interleukin-4 1133
Yi Bao and
Carola Ledderose and
Amelie F. Graf and
Bianca Brix and
Theresa Birsak and
Albert Lee and
Jingping Zhang and
Wolfgang G. Junger mTOR and differential activation of
mitochondria orchestrate neutrophil
chemotaxis . . . . . . . . . . . . . . . 1153
Anthony Leyme and
Arthur Marivin and
Lorena Perez-Gutierrez and
Lien T. Nguyen and
Mikel Garcia-Marcos Integrins activate trimeric G proteins
via the nonreceptor protein GIV/Girdin 1165
Sylvain Bessonnard and
Daniel Mesnard and
Daniel B. Constam PC7 and the related proteases Furin and
Pace4 regulate E-cadherin function
during blastocyst formation . . . . . . 1185
Sandeep Gopal and
Pernille Sògaard and
Hinke A. B. Multhaupt and
Csilla Pataki and
Elena Okina and
Xiaojie Xian and
Mikael E. Pedersen and
Troy Stevens and
Oliver Griesbeck and
Pyong Woo Park and
Roger Pocock and
John R. Couchman Transmembrane proteoglycans control
stretch-activated channels to set
cytosolic calcium levels . . . . . . . . 1199
Juan I. Ernesto and
Mariana Weigel Muñoz and
María A. Battistone and
Gustavo Vasen and
Pablo Martínez-López and
Gerardo Orta and
Dulce Figueiras-Fierro and
José L. De la Vega-Beltran and
Ignacio A. Moreno and
Héctor A. Guidobaldi and
Laura Giojalas and
Alberto Darszon and
Débora J. Cohen and
Patricia S. Cuasnicú CRISP1 as a novel CatSper regulator that
modulates sperm motility and orientation
during fertilization . . . . . . . . . . 1213
Victor Briz and
Yan Liu and
Guoqi Zhu and
Xiaoning Bi and
Michel Baudry A novel form of synaptic plasticity in
field CA3 of hippocampus requires GPER1
activation and BDNF release . . . . . . 1225
Ine Vandersmissen and
Sander Craps and
Maarten Depypere and
Giulia Coppiello and
Nick van Gastel and
Frederik Maes and
Geert Carmeliet and
Jan Schrooten and
Elizabeth A. V. Jones and
Lieve Umans and
Roland Devlieger and
Michel Koole and
Olivier Gheysens and
An Zwijsen and
Xabier L. Aranguren and
Aernout Luttun Endothelial Msx1 transduces hemodynamic
changes into an arteriogenic remodeling
response . . . . . . . . . . . . . . . . 1239
Sundari Chetty and
Elise N. Engquist and
Elie Mehanna and
Kathy O. Lui and
Alexander M. Tsankov and
Douglas A. Melton A Src inhibitor regulates the cell cycle
of human pluripotent stem cells and
improves directed differentiation . . . 1257
Caitlin Sedwick mTORC2 tips the balance in cell survival ??
Caitlin Sedwick Chaperones caught partying with prions ??
Caitlin Sedwick Growing up and growing pores in myoblast
fusion . . . . . . . . . . . . . . . . . ??
Caitlin Sedwick Thy-1: Shade and sun for integrin
signaling . . . . . . . . . . . . . . . 3
Caitlin Sedwick Lin He: ``Junk'' DNA isn't . . . . . . . 4
Ben Short Lamellipodial actin branches out . . . . 6
Hao Jiang and
Xiaonan He and
Di Feng and
Xueliang Zhu and
Yixian Zheng RanGTP aids anaphase entry through
Ubr5-mediated protein turnover . . . . . 7
Benjamin Woods and
Chun-Chen Kuo and
Chi-Fang Wu and
Trevin R. Zyla and
Daniel J. Lew Polarity establishment requires
localized activation of Cdc42 . . . . . 19
Vincent Hyenne and
Ahmet Apaydin and
David Rodriguez and
Coralie Spiegelhalter and
Sarah Hoff-Yoessle and
Maxime Diem and
Saurabh Tak and
Olivier Lefebvre and
Yannick Schwab and
Jacky G. Goetz and
Michel Labouesse RAL-1 controls multivesicular body
biogenesis and exosome secretion . . . . 27
Sujash S. Chatterjee and
Abil Saj and
Tenzin Gocha and
Matthew Murphy and
Foster C. Gonsalves and
Xiaoqian Zhang and
Penelope Hayward and
Betül Akgöl Oksuz and
Steven S. Shen and
Aviv Madar and
Alfonso Martinez Arias and
Ramanuj DasGupta Inhibition of $ \beta $--catenin--TCF1
interaction delays differentiation of
mouse embryonic stem cells . . . . . . . 39
Jade P. X. Cheng and
Carolina Mendoza-Topaz and
Gillian Howard and
Jessica Chadwick and
Elena Shvets and
Andrew S. Cowburn and
Benjamin J. Dunmore and
Alexi Crosby and
Nicholas W. Morrell and
Benjamin J. Nichols Caveolae protect endothelial cells from
membrane rupture during increased
cardiac output . . . . . . . . . . . . . 53
Petra Björk and
Jan-Olov Persson and
Lars Wieslander Intranuclear binding in space and time
of exon junction complex and NXF1 to
premRNPs/mRNPs in vivo . . . . . . . . . 63
Vittoria Pagliarini and
Laura Pelosi and
Maria Blaire Bustamante and
Annalisa Nobili and
Maria Grazia Berardinelli and
Marcello D'Amelio and
Antonio Musar\`o and
Claudio Sette SAM68 is a physiological regulator of
SMN2 splicing in spinal muscular atrophy 77
Patrick Kuhn and
Albena Draycheva and
Andreas Vogt and
Narcis-Adrian Petriman and
Lukas Sturm and
Friedel Drepper and
Bettina Warscheid and
Wolfgang Wintermeyer and
Hans-Georg Koch Ribosome binding induces repositioning
of the signal recognition particle
receptor on the translocon . . . . . . . 91
Zhipeng Zou and
Juan Chen and
Anling Liu and
Xuan Zhou and
Qiancheng Song and
Chunhong Jia and
Zhenguo Chen and
Jun Lin and
Cuilan Yang and
Ming Li and
Yu Jiang and
Xiaochun Bai mTORC2 promotes cell survival through
c--Myc-dependent up-regulation of E2F1 105
Inna Kalaidzidis and
Marta Miaczynska and
Marta Brewi\'nska-Olchowik and
Anna Hupalowska and
Charles Ferguson and
Robert G. Parton and
Yannis Kalaidzidis and
Marino Zerial APPL endosomes are not obligatory
endocytic intermediates but act as
stable cargo-sorting compartments . . . 123
Jonathan O'Driscoll and
Daniel Clare and
Helen Saibil Prion aggregate structure in yeast cells
is determined by the Hsp104-Hsp110
disaggregase machinery . . . . . . . . . 145
Sei Yoshida and
Regina Pacitto and
Yao Yao and
Ken Inoki and
Joel A. Swanson Growth factor signaling to mTORC1 by
amino acid--laden macropinosomes . . . . 159
Vincent F. Fiore and
Patrick W. Strane and
Anton V. Bryksin and
Eric S. White and
James S. Hagood and
Thomas H. Barker Conformational coupling of integrin and
Thy-1 regulates Fyn priming and
fibroblast mechanotransduction . . . . . 173
Nagaraju Dhanyasi and
Dagan Segal and
Eyal Shimoni and
Vera Shinder and
Ben-Zion Shilo and
K. VijayRaghavan and
Eyal D. Schejter Surface apposition and multiple cell
contacts promote myoblast fusion in
\bionameDrosophila flight muscles . . . 191
Ben Short sisRNAs engage with their hosts . . . . ??
Ben Short Num1 relieves dynein's inhibitions . . . ??
Ben Short Trypanosomes show their commitment . . . ??
Ben Short Merlin casts its spell on the cortical
cytoskeleton . . . . . . . . . . . . . . 207
Kendall Powell Francesca Peri: Micromanaging the lives
of microglia . . . . . . . . . . . . . . 208
Justin W. Taraska Cell biology of the future:
Nanometer-scale cellular cartography . . 211
Stefan Linder MT1-MMP: Endosomal delivery drives
breast cancer metastasis . . . . . . . . 215
Evan Heller and
Elaine Fuchs Tissue patterning and cellular mechanics 219
Tisha Bohr and
Christian R. Nelson and
Erin Klee and
Needhi Bhalla Spindle assembly checkpoint proteins
regulate and monitor meiotic synapsis in
\bionameC. elegans . . . . . . . . . . . 233
Jun Wei Pek and
Ismail Osman and
Mandy Li-Ian Tay and
Ruther Teo Zheng Stable intronic sequence RNAs have
possible regulatory roles in
\bionameDrosophila melanogaster . . . . 243
Tasuku Konno and
Eduardo Pinho Melo and
Carlos Lopes and
Ilir Mehmeti and
Sigurd Lenzen and
David Ron and
Edward Avezov ERO1-independent production of H$_2$
O$_2$ within the endoplasmic reticulum
fuels Prdx4-mediated oxidative protein
folding . . . . . . . . . . . . . . . . 253
Vineet Choudhary and
Namrata Ojha and
Andy Golden and
William A. Prinz A conserved family of proteins
facilitates nascent lipid droplet
budding from the ER . . . . . . . . . . 261
Wei Dong and
Xuejing Zhang and
Weijie Liu and
Yi-jiun Chen and
Juan Huang and
Erin Austin and
Alicia M. Celotto and
Wendy Z. Jiang and
Michael J. Palladino and
Yu Jiang and
Gerald R. V. Hammond and
Yang Hong A conserved polybasic domain mediates
plasma membrane targeting of Lgl and its
regulation by hypoxia . . . . . . . . . 273
Emily H. Stoops and
Michael Hull and
Christina Olesen and
Kavita Mistry and
Jennifer L. Harder and
Felix Rivera-Molina and
Derek Toomre and
Michael J. Caplan The periciliary ring in polarized
epithelial cells is a hot spot for
delivery of the apical protein gp135 . . 287
Hui-Ju Yang and
Haruhiko Asakawa and
Tokuko Haraguchi and
Yasushi Hiraoka Nup132 modulates meiotic spindle
attachment in fission yeast by
regulating kinetochore assembly . . . . 295
Lindsay G. Lammers and
Steven M. Markus The dynein cortical anchor Num1
activates dynein motility by relieving
Pac1/LIS1-mediated inhibition . . . . . 309
Vladimir Jovasevic and
Mojgan H. Naghavi and
Derek Walsh Microtubule plus end--associated
CLIP-170 initiates HSV-1 retrograde
transport in primary human cells . . . . 323
Valentina Marchesin and
Antonio Castro-Castro and
Catalina Lodillinsky and
Alessia Castagnino and
Joanna Cyrta and
Hél\`ene Bonsang-Kitzis and
Laetitia Fuhrmann and
Marie Irondelle and
Elvira Infante and
Guillaume Montagnac and
Fabien Reyal and
Anne Vincent-Salomon and
Philippe Chavrier ARF6-JIP3\slash 4 regulate endosomal
tubules for MT1-MMP exocytosis in cancer
invasion . . . . . . . . . . . . . . . . 339
Audrey Dumas and
Gabrielle Lê-Bury and
Florence Marie-Ana\"\is and
Floriane Herit and
Julie Mazzolini and
Thomas Guilbert and
Pierre Bourdoncle and
David G. Russell and
Serge Benichou and
Ahmed Zahraoui and
Florence Niedergang The HIV-1 protein Vpr impairs phagosome
maturation by controlling
microtubule-dependent trafficking . . . 359
Uwe Richter and
Taina Lahtinen and
Paula Marttinen and
Fumi Suomi and
Brendan J. Battersby Quality control of mitochondrial protein
synthesis is required for membrane
integrity and cell fitness . . . . . . . 373
Christine Chiasson-MacKenzie and
Zachary S. Morris and
Quentin Baca and
Brett Morris and
Joanna K. Coker and
Rossen Mirchev and
Anne E. Jensen and
Thomas Carey and
Shannon L. Stott and
David E. Golan and
Andrea I. McClatchey NF2\slash Merlin mediates
contact-dependent inhibition of EGFR
mobility and internalization via
cortical actomyosin . . . . . . . . . . 391
Nivetha Kannan and
Vivian W. Tang Synaptopodin couples epithelial
contractility to $ \alpha
$-actinin-$4$-dependent junction
maturation . . . . . . . . . . . . . . . 407
Jieyan V. Chen and
Ling-Rong Kao and
Swadhin C. Jana and
Elena Sivan-Loukianova and
Susana Mendonça and
Oscar A. Cabrera and
Priyanka Singh and
Clemens Cabernard and
Daniel F. Eberl and
Monica Bettencourt-Dias and
Timothy L. Megraw Rootletin organizes the ciliary rootlet
to achieve neuron sensory function in
\bionameDrosophila . . . . . . . . . . . 435
Maria Rosa Domingo-Sananes and
Balazs Szö\Hor and
Michael A. J. Ferguson and
Michael D. Urbaniak and
Keith R. Matthews Molecular control of irreversible
bistability during trypanosome
developmental commitment . . . . . . . . 455
Zhong Liu and
Guohua Zhong and
Phing Chian Chai and
Lichao Luo and
Sen Liu and
Ying Yang and
Gyeong-Hun Baeg and
Yu Cai Coordinated niche-associated signals
promote germline homeostasis in the
\bionameDrosophila ovary . . . . . . . . 469
Ben Short TRIMming $ \gamma $-actin levels
improves the memory . . . . . . . . . . ??
Ben Short Special delivery to the apical membrane ??
Ben Short Notch commandeers COMMD9 for endosomal
sorting . . . . . . . . . . . . . . . . ??
Ben Short Solidifying the view of RNP dynamics . . 487
Caitlin Sedwick Anne Brunet: Gracefully studying how we
age . . . . . . . . . . . . . . . . . . 488
Ben Short SUMO enters the ring . . . . . . . . . . 490
Edward N. Pugh Photoreceptor disc morphogenesis: The
classical evagination model prevails . . 491
Jin-Dong Ding and
Raquel Y. Salinas and
Vadim Y. Arshavsky Discs of mammalian rod photoreceptors
form through the membrane evagination
mechanism . . . . . . . . . . . . . . . 495
Christian R. Nelson and
Tom Hwang and
Pin-Hsi Chen and
Needhi Bhalla TRIP13$^{\rm PCH - 2}$ promotes Mad2
localization to unattached kinetochores
in the spindle checkpoint response . . . 503
Nicolas Derive and
Cedric Landmann and
Emilie Montembault and
Marie-Charlotte Claverie and
Priscillia Pierre-Elies and
Damien Goutte-Gattat and
Nabila Founounou and
Derek McCusker and
Anne Royou Bub3--BubR1-dependent sequestration of
Cdc20$^{\rm Fizzy}$ at DNA breaks
facilitates the correct segregation of
broken chromosomes . . . . . . . . . . . 517
Elisa Cesarini and
Chiara Mozzetta and
Fabrizia Marullo and
Francesco Gregoretti and
Annagiusi Gargiulo and
Marta Columbaro and
Alice Cortesi and
Laura Antonelli and
Simona Di Pelino and
Stefano Squarzoni and
Daniela Palacios and
Alessio Zippo and
Beatrice Bodega and
Gennaro Oliva and
Chiara Lanzuolo Lamin A/C sustains PcG protein
architecture, maintaining
transcriptional repression at target
genes . . . . . . . . . . . . . . . . . 533
Anna M. Schulz and
Susanne Stutte and
Sebastian Hogl and
Nancy Luckashenak and
Diana Dudziak and
Céline Leroy and
Ignasi Forné and
Axel Imhof and
Stephan A. Müller and
Cord H. Brakebusch and
Stefan F. Lichtenthaler and
Thomas Brocker Cdc42-dependent actin dynamics controls
maturation and secretory activity of
dendritic cells . . . . . . . . . . . . 553
Joerg Schreiber and
Marlene J. Végh and
Julia Dawitz and
Tim Kroon and
Maarten Loos and
Dorthe Labonté and
Ka Wan Li and
Pim Van Nierop and
Michiel T. Van Diepen and
Chris I. De Zeeuw and
Matthias Kneussel and
Rhiannon M. Meredith and
August B. Smit and
Ronald E. Van Kesteren Ubiquitin ligase TRIM3 controls
hippocampal plasticity and learning by
regulating synaptic $ \gamma $-actin
levels . . . . . . . . . . . . . . . . . 569
Georg F. Vogel and
Katharina M. C. Klee and
Andreas R. Janecke and
Thomas Müller and
Michael W. Hess and
Lukas A. Huber Cargo-selective apical exocytosis in
epithelial cells is conducted by Myo5B,
Slp4a, Vamp7, and Syntaxin 3 . . . . . . 587
Haiying Li and
Yeon Koo and
Xicheng Mao and
Luis Sifuentes-Dominguez and
Lindsey L. Morris and
Da Jia and
Naoteru Miyata and
Rebecca A. Faulkner and
Jan M. van Deursen and
Marc Vooijs and
Daniel D. Billadeau and
Bart van de Sluis and
Ondine Cleaver and
Ezra Burstein Endosomal sorting of Notch receptors
through COMMD9-dependent pathways
modulates Notch signaling . . . . . . . 605
Hyojin Park and
Sungwoon Lee and
Pravesh Shrestha and
Jihye Kim and
Jeong Ae Park and
Yeongrim Ko and
Young Ho Ban and
Dae-Young Park and
Sang-Jun Ha and
Gou Young Koh and
Victor Sukbong Hong and
Naoki Mochizuki and
Young-Myeong Kim and
Weontae Lee and
Young-Guen Kwon AMIGO2, a novel membrane anchor of PDK1,
controls cell survival and angiogenesis
via Akt activation . . . . . . . . . . . 619
Ming Li and
Tatsuhiro Koshi and
Scott D. Emr Membrane-anchored ubiquitin ligase
complex is required for the turnover of
lysosomal membrane proteins . . . . . . 639
Pranav Ullal and
Nathan A. McDonald and
Jun-Song Chen and
Libera Lo Presti and
Rachel H. Roberts-Galbraith and
Kathleen L. Gould and
Sophie G. Martin The DYRK-family kinase Pom1
phosphorylates the F--BAR protein Cdc15
to prevent division at cell poles . . . 653
Xia Gao and
Aman S. Bali and
Scott H. Randell and
Brigid L. M. Hogan GRHL2 coordinates regeneration of a
polarized mucociliary epithelium from
basal stem cells . . . . . . . . . . . . 669
Charlotte Guetta-Terrier and
Pascale Monzo and
Jie Zhu and
Hongyan Long and
Lakshmi Venkatraman and
Yue Zhou and
PeiPei Wang and
Sing Yian Chew and
Alexander Mogilner and
Benoit Ladoux and
Nils C. Gauthier Protrusive waves guide $3$D cell
migration along nanofibers . . . . . . . 683
Arnaud Hubstenberger and
Cristiana Cameron and
Scott L. Noble and
Sean Keenan and
Thomas C. Evans Modifiers of solid RNP granules control
normal RNP dynamics and mRNA activity in
early development . . . . . . . . . . . 703
Aurélie Ladang and
Francesca Rapino and
Lukas C. Heukamp and
Lars Tharun and
Kateryna Shostak and
Damien Hermand and
Sylvain Delaunay and
Iva Klevernic and
Zheshen Jiang and
Nicolas Jacques and
Diane Jamart and
Valérie Migeot and
Alexandra Florin and
Serkan Göktuna and
Brigitte Malgrange and
Owen J. Sansom and
Laurent Nguyen and
Reinhard Büttner and
Pierre Close and
Alain Chariot Elp3 drives Wnt-dependent tumor
initiation and regeneration in the
intestine . . . . . . . . . . . . . . . ??
Claudia X. Dominguez and
Robert A. Amezquita and
Tianxia Guan and
Heather D. Marshall and
Nikhil S. Joshi and
Steven H. Kleinstein and
Susan M. Kaech The transcription factors ZEB2 and T-bet
cooperate to program cytotoxic T cell
terminal differentiation in response to
LCMV viral infection . . . . . . . . . . ??
Kyla D. Omilusik and
J. Adam Best and
Bingfei Yu and
Steven Goossens and
Alexander Weidemann and
Jessica V. Nguyen and
Eve Seuntjens and
Agata Stryjewska and
Christiane Zweier and
Rahul Roychoudhuri and
Luca Gattinoni and
Lynne M. Bird and
Yujiro Higashi and
Hisato Kondoh and
Danny Huylebroeck and
Jody Haigh and
Ananda W. Goldrath Transcriptional repressor ZEB2 promotes
terminal differentiation of CD8$^+$
effector and memory T cell populations
during infection . . . . . . . . . . . . ??
Mary J. van Helden and
Steven Goossens and
Cécile Daussy and
Anne-Laure Mathieu and
Fabrice Faure and
Antoine Marçais and
Niels Vandamme and
Natalie Farla and
Katia Mayol and
Sébastien Viel and
Sophie Degouve and
Emilie Debien and
Eve Seuntjens and
Andrea Conidi and
Julie Chaix and
Philippe Mangeot and
Simon de Bernard and
Laurent Buffat and
Jody Haigh and
Danny Huylebroeck and
Bart N. Lambrecht and
Geert Berx and
Thierry Walzer Terminal NK cell maturation is
controlled by concerted actions of T-bet
and Zeb2 and is essential for melanoma
rejection . . . . . . . . . . . . . . . ??
Mitch Leslie Balanced mitochondria behave better . . ??
Mitch Leslie KDM4B doesn't leave a mark . . . . . . . ??
Mitch Leslie TDP-43 crosses the divide . . . . . . . ??
Mitch Leslie How the optic tectum stacks up . . . . . 719
Caitlin Sedwick Thomas Pucadyil: Piecing together
membrane fission . . . . . . . . . . . . 720
John D. Aitchison and
Michael P. Rout The interactome challenge . . . . . . . 729
Evgeny Zatulovskiy and
Jan M. Skotheim Mitosis is swell . . . . . . . . . . . . 733
Marisa M. Faraldo and
Marina A. Glukhova Regulating the regulator: Numb acts
upstream of p53 to control mammary stem
and progenitor cell . . . . . . . . . . 737
Xu Cao and
Yanshan Fang Transducing oxidative stress to death
signals in neurons . . . . . . . . . . . 741
Scott C. Rosenberg and
Kevin D. Corbett The multifaceted roles of the HORMA
domain in cellular signaling . . . . . . 745
Sungmin Son and
Joon Ho Kang and
Seungeun Oh and
Marc W. Kirschner and
T. J. Mitchison and
Scott Manalis Resonant microchannel volume and mass
measurements show that suspended cells
swell during mitosis . . . . . . . . . . 757
Ewa Zlotek-Zlotkiewicz and
Sylvain Monnier and
Giovanni Cappello and
Mael Le Berre and
Matthieu Piel Optical volume and mass measurements
show that mammalian cells swell during
mitosis . . . . . . . . . . . . . . . . 765
Satoshi Ninagawa and
Tetsuya Okada and
Yoshiki Sumitomo and
Satoshi Horimoto and
Takehiro Sugimoto and
Tokiro Ishikawa and
Shunichi Takeda and
Takashi Yamamoto and
Tadashi Suzuki and
Yukiko Kamiya and
Koichi Kato and
Kazutoshi Mori Forcible destruction of severely
misfolded mammalian glycoproteins by the
non-glycoprotein ERAD pathway . . . . . 775
Wing-Kit Leung and
Neil Humphryes and
Negar Afshar and
Bilge Argunhan and
Yaroslav Terentyev and
Tomomi Tsubouchi and
Hideo Tsubouchi The synaptonemal complex is assembled by
a polySUMOylation-driven feedback
mechanism in yeast . . . . . . . . . . . 785
Hsiuchen Chen and
Shuxun Ren and
Clary Clish and
Mohit Jain and
Vamsi Mootha and
J. Michael McCaffery and
David C. Chan Titration of mitochondrial fusion
rescues Mff-deficient cardiomyopathy . . 795
Sharon R. Cooper and
Michelle R. Emond and
Phan Q. Duy and
Brandon G. Liebau and
Marc A. Wolman and
James D. Jontes Protocadherins control the modular
assembly of neuronal columns in the
zebrafish optic tectum . . . . . . . . . 807
Rosa A. Uribe and
Ailín L. Buzzi and
Marianne E. Bronner and
Pablo H. Strobl-Mazzulla Histone demethylase KDM4B regulates otic
vesicle invagination via epigenetic
control of Dlx3 expression . . . . . . . 815
Alexandra Grippa and
Laura Buxó and
Gabriel Mora and
Charlotta Funaya and
Fatima-Zahra Idrissi and
Francesco Mancuso and
Raul Gomez and
Júlia Muntany\`a and
Eduard Sabidó and
Pedro Carvalho The seipin complex Fld1/Ldb16 stabilizes
ER--lipid droplet contact sites . . . . 829
Daniela Tosoni and
Silvia Zecchini and
Marco Coazzoli and
Ivan Colaluca and
Giovanni Mazzarol and
Alicia Rubio and
Michele Caccia and
Emanuele Villa and
Olav Zilian and
Pier Paolo Di Fiore and
Salvatore Pece The Numb/p53 circuitry couples
replicative self-renewal and tumor
suppression in mammary epithelial cells 845
Anna E. Dart and
Gary M. Box and
William Court and
Madeline E. Gale and
John P. Brown and
Sarah E. Pinder and
Suzanne A. Eccles and
Claire M. Wells PAK4 promotes kinase-independent
stabilization of RhoU to modulate cell
adhesion . . . . . . . . . . . . . . . . 863
Shuji Wakatsuki and
Akiko Furuno and
Makiko Ohshima and
Toshiyuki Araki Oxidative stress-dependent
phosphorylation activates ZNRF1 to
induce neuronal/axonal degeneration . . 881
Marisa S. Feiler and
Benjamin Strobel and
Axel Freischmidt and
Anika M. Helferich and
Julia Kappel and
Bryson M. Brewer and
Deyu Li and
Dietmar R. Thal and
Paul Walther and
Albert C. Ludolph and
Karin M. Danzer and
Jochen H. Weishaupt TDP-43 is intercellularly transmitted
across axon terminals . . . . . . . . . 897
Simon J. Ittig and
Christoph Schmutz and
Christoph A. Kasper and
Marlise Amstutz and
Alexander Schmidt and
Lo\"\ic Sauteur and
M. Alessandra Vigano and
Shyan Huey Low and
Markus Affolter and
Guy R. Cornelis and
Erich A. Nigg and
Cécile Arrieumerlou A bacterial type III secretion-based
protein delivery tool for broad
applications in cell biology . . . . . . 913
Nivetha Kannan and
Vivian W. Tang Correction: Synaptopodin couples
epithelial contractility to $ \alpha
$-actinin-$4$-dependent junction
maturation . . . . . . . . . . . . . . . 933
Ben Short A vitamin supplement for remyelination ??
Ben Short Splicing limits the spread of Crumbs . . ??
Ben Short Ephrin-A3 typecasts muscle fibers . . . ??
Ben Short How the spindle keeps its focus . . . . 937
Karen Blum Marcos Sotomayor: Listening in on the
cadherin family's secrets . . . . . . . 938
Caitlin Sedwick How stressed cells triage mRNAs . . . . 940
Yinling Hu A feedforward loop of NLRC5
(de)ubiquitination keeps IKK-NF-$ \kappa
$B in check . . . . . . . . . . . . . . 941
Sofia C. Guimaraes and
Martin Schuster and
Ewa Bielska and
Gulay Dagdas and
Sreedhar Kilaru and
Ben R. A. Meadows and
Michael Schrader and
Gero Steinberg Peroxisomes, lipid droplets, and
endoplasmic reticulum ``hitchhike'' on
motile early endosomes . . . . . . . . . 945
K\`evin Knoops and
Rinse de Boer and
Anita Kram and
Ida J. van der Klei Yeast pex1 cells contain peroxisomal
ghosts that import matrix proteins upon
reintroduction of Pex1 . . . . . . . . . 955
Takayuki Yasunaga and
Sylvia Hoff and
Christoph Schell and
Martin Helmstädter and
Oliver Kretz and
Sebastian Kuechlin and
Toma A. Yakulov and
Christina Engel and
Barbara Müller and
Robert Bensch and
Olaf Ronneberger and
Tobias B. Huber and
Soeren S. Lienkamp and
Gerd Walz The polarity protein Inturned links
NPHP4 to Daam1 to control the subapical
actin network in multiciliated cells . . 963
Alerie Guzman de la Fuente and
Oihana Errea and
Peter van Wijngaarden and
Ginez A. Gonzalez and
Christophe Kerninon and
Andrew A. Jarjour and
Hilary J. Lewis and
Clare A. Jones and
Brahim Nait-Oumesmar and
Chao Zhao and
Jeffrey K. Huang and
Charles ffrench-Constant and
Robin J. M. Franklin Vitamin D receptor--retinoid X receptor
heterodimer signaling regulates
oligodendrocyte progenitor cell
differentiation . . . . . . . . . . . . 975
Todd Schoborg and
Allison L. Zajac and
Carey J. Fagerstrom and
Rodrigo X. Guillen and
Nasser M. Rusan An Asp--CaM complex is required for
centrosome--pole cohesion and centrosome
inheritance in neural stem cells . . . . 987
Ami Ito and
Gohta Goshima Microcephaly protein Asp focuses the
minus ends of spindle microtubules at
the pole and within the spindle . . . . 999
Athea Vichas and
Matthew T. Laurie and
Jennifer A. Zallen The Ski2-family helicase Obelus
regulates Crumbs alternative splicing
and cell polarity . . . . . . . . . . . 1011
Qingcai Meng and
Chunmei Cai and
Tingzhe Sun and
Qianliang Wang and
Weihong Xie and
Rongfu Wang and
Jun Cui Reversible ubiquitination shapes NLRC5
function and modulates NF-$ \kappa $B
activation switch . . . . . . . . . . . 1025
Alison M. Motley and
Paul C. Galvin and
Lakhan Ekal and
James M. Nuttall and
Ewald H. Hettema Reevaluation of the role of Pex1 and
dynamin-related proteins in peroxisome
membrane biogenesis . . . . . . . . . . 1041
Vinod Kumar and
Jamal-Eddine Bouameur and
Janina Bär and
Robert H. Rice and
Hue-Tran Hornig-Do and
Dennis R. Roop and
Nicole Schwarz and
Susanne Brodesser and
Sören Thiering and
Rudolf E. Leube and
Rudolf J. Wiesner and
Preethi Vijayaraj and
Christina B. Brazel and
Sandra Heller and
Hans Binder and
Henry Löffler-Wirth and
Peter Seibel and
Thomas M. Magin A keratin scaffold regulates epidermal
barrier formation, mitochondrial lipid
composition, and activity . . . . . . . 1057
Danny A. Stark and
Nathan J. Coffey and
Hannah R. Pancoast and
Laura L. Arnold and
J. Peyton D. Walker and
Joanne Vallée and
Richard Robitaille and
Michael L. Garcia and
D. D. W. Cornelison Ephrin-A3 promotes and maintains slow
muscle fiber identity during postnatal
development and reinnervation . . . . . 1077
Jonathon A. Ditlev and
Paul J. Michalski and
Greg Huber and
Gonzalo M. Rivera and
William A. Mohler and
Leslie M. Loew and
Bruce J. Mayer Correction: Stoichiometry of
Nck-dependent actin polymerization in
living cells . . . . . . . . . . . . . . 1095
Ben Short A cohort study of kinetochore proteins ??
Ben Short Secretase complexes let it RIP . . . . . ??
Ben Short B cell, heal thyself . . . . . . . . . . ??
Ben Short mRNAs scan themselves out . . . . . . . 1099
Karen Blum Rosa Puertollano: The importance of
recycling cellular trash . . . . . . . . 1100
Rebecca Heald and
Alexey Khodjakov Thirty years of search and capture: The
complex simplicity of mitotic spindle
assembly . . . . . . . . . . . . . . . . 1103
A. Agata G\luszek and
C. Fiona Cullen and
Wenjing Li and
Rachel A. Battaglia and
Sarah J. Radford and
Mariana F. Costa and
Kim S. McKim and
Gohta Goshima and
Hiroyuki Ohkura The microtubule catastrophe promoter
Sentin delays stable
kinetochore--microtubule attachment in
oocytes . . . . . . . . . . . . . . . . 1113
Carlas Smith and
Azra Lari and
Carina Patrizia Derrer and
Anette Ouwehand and
Ammeret Rossouw and
Maximiliaan Huisman and
Thomas Dange and
Mark Hopman and
Aviva Joseph and
Daniel Zenklusen and
Karsten Weis and
David Grunwald and
Ben Montpetit In vivo single-particle imaging of
nuclear mRNA export in budding yeast
demonstrates an essential role for
Mex67p . . . . . . . . . . . . . . . . . 1121
Mark-Albert Saroufim and
Pierre Bensidoun and
Pascal Raymond and
Samir Rahman and
Matthew R. Krause and
Marlene Oeffinger and
Daniel Zenklusen The nuclear basket mediates perinuclear
mRNA scanning in budding yeast . . . . . 1131
Itaru Samejima and
Christos Spanos and
Flavia de Lima Alves and
Tetsuya Hori and
Marinela Perpelescu and
Juan Zou and
Juri Rappsilber and
Tatsuo Fukagawa and
William C. Earnshaw Whole-proteome genetic analysis of
dependencies in assembly of a vertebrate
kinetochore . . . . . . . . . . . . . . 1141
Allen C. Chen and
Sumin Kim and
Nina Shepardson and
Sarvagna Patel and
Soyon Hong and
Dennis J. Selkoe Physical and functional interaction
between the $ \alpha $- and $ \gamma
$-secretases: a new model of regulated
intramembrane proteolysis . . . . . . . 1157
Costanza Giampietro and
Andrea Disanza and
Luca Bravi and
Miriam Barrios-Rodiles and
Monica Corada and
Emanuela Frittoli and
Cecilia Savorani and
Maria Grazia Lampugnani and
Barbara Boggetti and
Carien Niessen and
Jeff L. Wrana and
Giorgio Scita and
Elisabetta Dejana The actin-binding protein EPS8 binds
VE-cadherin and modulates YAP
localization and signaling . . . . . . . 1177
Heather Miller and
Thiago Castro-Gomes and
Matthias Corrotte and
Christina Tam and
Timothy K. Maugel and
Norma W. Andrews and
Wenxia Song Lipid raft-dependent plasma membrane
repair interferes with the activation of
B lymphocytes . . . . . . . . . . . . . 1193
Mitch Leslie Cdc55 keeps Rho1 focused on growth . . . ??
Mitch Leslie All-access coverage for neurites
showcases their subtleties . . . . . . . ??
Mitch Leslie Epithelia prefer their ECM firm and
easily digested . . . . . . . . . . . . ??
Mitch Leslie Taking the stress out of replication . . 3
Caitlin Sedwick Sharon Dent: The unfolding SAGA of
chromatin-modifying proteins . . . . . . 4
Robert V. Farese and
Tobias C. Walther Lipid droplets go nuclear . . . . . . . 7
Idan Cohen and
Elena Ezhkova Cbx4: a new guardian of p63's domain of
epidermal control . . . . . . . . . . . 9
Benoit Chabot and
Lulzim Shkreta Defective control of pre--messenger RNA
splicing in human disease . . . . . . . 13
Yuki Ohsaki and
Takeshi Kawai and
Yukichika Yoshikawa and
Jinglei Cheng and
Eija Jokitalo and
Toyoshi Fujimoto PML isoform II plays a critical role in
nuclear lipid droplet formation . . . . 29
Shawn N. Jordan and
Tim Davies and
Yelena Zhuravlev and
Julien Dumont and
Mimi Shirasu-Hiza and
Julie C. Canman Cortical PAR polarity proteins promote
robust cytokinesis during asymmetric
cell division . . . . . . . . . . . . . 39
Erin M. Jonasson and
Valentina Rossio and
Riko Hatakeyama and
Mitsuhiro Abe and
Yoshikazu Ohya and
Satoshi Yoshida Zds1\slash Zds2--PP2A$^{\rm Cdc55}$
complex specifies signaling output from
Rho1 GTPase . . . . . . . . . . . . . . 51
Saskia Hoffmann and
Stine Smedegaard and
Kyosuke Nakamura and
Gulnahar B. Mortuza and
Markus Räschle and
Alain Ibañez de Opakua and
Yasuyoshi Oka and
Yunpeng Feng and
Francisco J. Blanco and
Matthias Mann and
Guillermo Montoya and
Anja Groth and
Simon Bekker-Jensen and
Niels Mailand TRAIP is a PCNA-binding ubiquitin ligase
that protects genome stability after
replication stress . . . . . . . . . . . 63
Andrei N. Mardaryev and
Bo Liu and
Valentina Rapisarda and
Krzysztof Poterlowicz and
Igor Malashchuk and
Jana Rudolf and
Andrey A. Sharov and
Colin A. Jahoda and
Michael Y. Fessing and
Salvador A. Benitah and
Guo-Liang Xu and
Vladimir A. Botchkarev Cbx4 maintains the epithelial lineage
identity and cell proliferation in the
developing stratified epithelium . . . . 77
Ludovico Fusco and
Riwal Lefort and
Kevin Smith and
Fethallah Benmansour and
German Gonzalez and
Caterina Barillari and
Bernd Rinn and
François Fleuret and
Pascal Fua and
Olivier Pertz Computer vision profiling of neurite
outgrowth dynamics reveals
spatiotemporal modularity of Rho GTPase
signaling . . . . . . . . . . . . . . . 91
Nduka O. Enemchukwu and
Ricardo Cruz-Acuña and
Tom Bongiorno and
Christopher T. Johnson and
José R. García and
Todd Sulchek and
Andrés J. García Synthetic matrices reveal contributions
of ECM biophysical and biochemical
properties to epithelial morphogenesis 113
Mitch Leslie The long and short of OPA1 . . . . . . . ??
Mitch Leslie Ubiquitylation leaves Nup60 a basket
case . . . . . . . . . . . . . . . . . . ??
Mitch Leslie Using speckles to spot protein dynamics ??
Mitch Leslie Making sure late endosomes are on time 127
Kendall Powell Jeremy Nance: Charting gastrulation's
gyrations . . . . . . . . . . . . . . . 128
Subhojit Roy Waves, rings, and trails: The scenic
landscape of axonal actin . . . . . . . 131
Lana M. Pollock and
Shih-Wei Chou and
Brian M. McDermott My oh my(osin): Insights into how
auditory hair cells count, measure, and
shape . . . . . . . . . . . . . . . . . 135
Sergio Simoes and
Ulrich Tepass Muscle versus Snail: Muscle wins . . . . 139
Elena Scarpa and
Roberto Mayor Collective cell migration in development 143
Anne Korwitz and
Carsten Merkwirth and
Ricarda Richter-Dennerlein and
Simon E. Tröder and
Hans-Georg Sprenger and
Pedro M. Quirós and
Carlos López-Otín and
Elena I. Rugarli and
Thomas Langer Loss of OMA1 delays neurodegeneration by
preventing stress-induced OPA1
processing in mitochondria . . . . . . . 157
Carlos A. Niño and
David Guet and
Alexandre Gay and
Sergine Brutus and
Frédéric Jourquin and
Shweta Mendiratta and
Jean Salamero and
Vincent Géli and
Catherine Dargemont Posttranslational marks control
architectural and functional plasticity
of the nuclear pore complex basket . . . 167
Kai Liu and
Youli Jian and
Xiaojuan Sun and
Chengkui Yang and
Zhiyang Gao and
Zhili Zhang and
Xuezhao Liu and
Yang Li and
Jing Xu and
Yudong Jing and
Shohei Mitani and
Sudan He and
Chonglin Yang Negative regulation of
phosphatidylinositol $3$-phosphate
levels in early-to-late endosome
conversion . . . . . . . . . . . . . . . 181
Cédric Plutoni and
Elsa Bazellieres and
Ma\"\ilys Le Borgne-Rochet and
Franck Comunale and
Agusti Brugues and
Martial Séveno and
Damien Planchon and
Sylvie Thuault and
Nathalie Morin and
Stéphane Bodin and
Xavier Trepat and
Cécile Gauthier-Rouvi\`ere P-cadherin promotes collective cell
migration via a Cdc42-mediated increase
in mechanical forces . . . . . . . . . . 199
Mo Weng and
Eric Wieschaus Myosin-dependent remodeling of adherens
junctions protects junctions from
Snail-dependent disassembly . . . . . . 219
Andrea Lelli and
Vincent Michel and
Jacques Boutet de Monvel and
Matteo Cortese and
Montserrat Bosch-Grau and
Asadollah Aghaie and
Isabelle Perfettini and
Typhaine Dupont and
Paul Avan and
Aziz El-Amraoui and
Christine Petit Class III myosins shape the auditory
hair bundles by limiting microvilli and
stereocilia growth . . . . . . . . . . . 231
António J. Pereira and
Paulo Aguiar and
Michael Belsley and
Helder Maiato Inducible fluorescent speckle microscopy 245
Ben Short PxdA helps peroxisomes hitch a ride . . ??
Ben Short Yeast chromatin takes global action on
carbon . . . . . . . . . . . . . . . . . ??
Ben Short Sorting out peroxisome biogenesis . . . ??
Ben Short Mapping the kinetochore Delta . . . . . 259
Caitlin Sedwick Needhi Bhalla: Chromosomes do the most
amazing things . . . . . . . . . . . . . 260
Yi Liu and
Marcus B. Smolka TOPBP1 takes RADical command in
recombinational DNA repair . . . . . . . 263
Pieta K. Mattila and
Facundo D. Batista and
Bebhinn Treanor Dynamics of the actin cytoskeleton
mediates receptor cross talk: an
emerging concept in tuning receptor
signaling . . . . . . . . . . . . . . . 267
Pavel Moudry and
Kenji Watanabe and
Kamila M. Wolanin and
Jirina Bartkova and
Isabel E. Wassing and
Sugiko Watanabe and
Robert Strauss and
Rune Troelsgaard Pedersen and
Vibe H. Oestergaard and
Michael Lisby and
Miguel Andújar-Sánchez and
Apolinar Maya-Mendoza and
Fumiko Esashi and
Jiri Lukas and
Jiri Bartek TOPBP1 regulates RAD51 phosphorylation
and chromatin loading and determines
PARP inhibitor sensitivity . . . . . . . 281
John Salogiannis and
Martin J. Egan and
Samara L. Reck-Peterson Peroxisomes move by hitchhiking on early
endosomes using the novel linker protein
PxdA . . . . . . . . . . . . . . . . . . 289
Atsuhiro Nakajo and
Shin-ichiro Yoshimura and
Hiroko Togawa and
Masataka Kunii and
Tomohiko Iwano and
Ayaka Izumi and
Yuria Noguchi and
Ayako Watanabe and
Ayako Goto and
Toshiro Sato and
Akihiro Harada EHBP1L1 coordinates Rab8 and Bin1 to
regulate apical-directed transport in
polarized epithelial cells . . . . . . . 297
Valentin Magidson and
Jie He and
Jeffrey G. Ault and
Christopher B. O'Connell and
Nachen Yang and
Irina Tikhonenko and
Bruce F. McEwen and
Haixin Sui and
Alexey Khodjakov Unattached kinetochores rather than
intrakinetochore tension arrest mitosis
in taxol-treated cells . . . . . . . . . 307
Elisa Dultz and
Harianto Tjong and
Elodie Weider and
Mareike Herzog and
Barry Young and
Christiane Brune and
Daniel Müllner and
Christopher Loewen and
Frank Alber and
Karsten Weis Global reorganization of budding yeast
chromosome conformation in different
physiological conditions . . . . . . . . 321
Gaurav Agrawal and
Scott N. Fassas and
Zhi-Jie Xia and
Suresh Subramani Distinct requirements for intra--ER
sorting and budding of peroxisomal
membrane proteins from the ER . . . . . 335
Edward R. Horton and
Jonathan D. Humphries and
Ben Stutchbury and
Guillaume Jacquemet and
Christoph Ballestrem and
Simon T. Barry and
Martin J. Humphries Modulation of FAK and Src adhesion
signaling occurs independently of
adhesion complex composition . . . . . . 349
Ben Short Ndel1 keeps cilia retracted . . . . . . ??
Ben Short Disrupted desmosomes drive fibrosis . . ??
Ben Short Ataxin-3 phosphorylation protects
neurons . . . . . . . . . . . . . . . . ??
Ben Short Lymphocytes shrink to stay fit . . . . . 367
Kendall Powell Elisabetta Dejana: Probing the vagaries
of vessels . . . . . . . . . . . . . . . 368
Pieterjan Dierickx and
Linda W. Van Laake Muscle-on-chip: an in vitro model for
donor--host cardiomyocyte coupling . . . 371
Karen A. Newell-Litwa Breaking down to build up: Neuroligin's
C-terminal domain strengthens the
synapse . . . . . . . . . . . . . . . . 375
Prashant Mishra and
David C. Chan Metabolic regulation of mitochondrial
dynamics . . . . . . . . . . . . . . . . 379
Yvonne Aratyn-Schaus and
Francesco S. Pasqualini and
Hongyan Yuan and
Megan L. McCain and
George J. C. Ye and
Sean P. Sheehy and
Patrick H. Campbell and
Kevin Kit Parker Coupling primary and stem cell-derived
cardiomyocytes in an in vitro model of
cardiac cell therapy . . . . . . . . . . 389
Tomas Aparicio and
Richard Baer and
Max Gottesman and
Jean Gautier MRN, CtIP, and BRCA1 mediate repair of
topoisomerase II--DNA adducts . . . . . 399
Hironori Inaba and
Hidemasa Goto and
Kousuke Kasahara and
Kanako Kumamoto and
Shigenobu Yonemura and
Akihito Inoko and
Shotaro Yamano and
Hideki Wanibuchi and
Dongwei He and
Naoki Goshima and
Tohru Kiyono and
Shinji Hirotsune and
Masaki Inagaki Ndel1 suppresses ciliogenesis in
proliferating cells by regulating the
trichoplein--Aurora A pathway . . . . . 409
Adi D. Dubash and
Chen Y. Kam and
Brian A. Aguado and
Dipal M. Patel and
Mario Delmar and
Lonnie D. Shea and
Kathleen J. Green Plakophilin-2 loss promotes TGF-$ \beta
$1/p38 MAPK-dependent fibrotic gene
expression in cardiomyocytes . . . . . . 425
Vivian C. Hecht and
Lucas B. Sullivan and
Robert J. Kimmerling and
Dong-Hwee Kim and
Aaron M. Hosios and
Max A. Stockslager and
Mark M. Stevens and
Joon Ho Kang and
Denis Wirtz and
Matthew G. Vander Heiden and
Scott R. Manalis Biophysical changes reduce energetic
demand in growth factor--deprived
lymphocytes . . . . . . . . . . . . . . 439
An Liu and
Zikai Zhou and
Rui Dang and
Yuehua Zhu and
Junxia Qi and
Guiqin He and
Celeste Leung and
Daniel Pak and
Zhengping Jia and
Wei Xie Neuroligin 1 regulates spines and
synaptic plasticity via
LIMK1/cofilin-mediated actin
reorganization . . . . . . . . . . . . . 449
Carlos A. Matos and
Clévio Nóbrega and
Susana R. Louros and
Bruno Almeida and
Elisabete Ferreiro and
Jorge Valero and
Luís Pereira de Almeida and
Sandra Macedo-Ribeiro and
Ana Luísa Carvalho Ataxin-3 phosphorylation decreases
neuronal defects in spinocerebellar
ataxia type 3 models . . . . . . . . . . 465
Ben Short Mitochondrial fission is crucial for
cristae remodeling . . . . . . . . . . . ??
Ben Short p62 aggregation is a problem for neural
stem cells . . . . . . . . . . . . . . . ??
Ben Short NBR1 helps autophagosomes take a bite
out of focal adhesions . . . . . . . . . ??
Ben Short Switching septins spurs sporulation . . 483
Caitlin Sedwick Jessica Feldman: Microtubule-organizing
function dives off centrosomes . . . . . 484
Tomke Stürner and
Gaia Tavosanis Rotating for elongation: Fat2 whips for
the race . . . . . . . . . . . . . . . . 487
E. B. Frankel and
Anjon Audhya Burning cellular bridges: Two pathways
to the big breakup . . . . . . . . . . . 491
Gerard M. J. Beaudoin Mosaic cellular patterning in the nose:
Adhesion molecules give their two scents 495
Liliane Christ and
Eva M. Wenzel and
Knut Liestòl and
Camilla Raiborg and
Coen Campsteijn and
Harald Stenmark ALIX and ESCRT-I/II function as parallel
ESCRT-III recruiters in cytokinetic
abscission . . . . . . . . . . . . . . . 499
Galo Garcia and
Gregory C. Finnigan and
Lydia R. Heasley and
Sarah M. Sterling and
Adeeti Aggarwal and
Chad G. Pearson and
Eva Nogales and
Michael A. McMurray and
Jeremy Thorner Assembly, molecular organization, and
membrane-binding properties of
development-specific septins . . . . . . 515
Hidenori Otera and
Non Miyata and
Osamu Kuge and
Katsuyoshi Mihara Drp1-dependent mitochondrial fission via
MiD49/51 is essential for apoptotic
cristae remodeling . . . . . . . . . . . 531
Chenran Wang and
Song Chen and
Syn Yeo and
Gizem Karsli-Uzunbas and
Eileen White and
Noboru Mizushima and
Herbert W. Virgin and
Jun-Lin Guan Elevated p62/SQSTM1 determines the fate
of autophagy-deficient neural stem cells
by increasing superoxide . . . . . . . . 545
Sayaka Katsunuma and
Hisao Honda and
Tomoyasu Shinoda and
Yukitaka Ishimoto and
Takaki Miyata and
Hiroshi Kiyonari and
Takaya Abe and
Ken-ichi Nibu and
Yoshimi Takai and
Hideru Togashi Synergistic action of nectins and
cadherins generates the mosaic cellular
pattern of the olfactory epithelium . . 561
Candia M. Kenific and
Samantha J. Stehbens and
Juliet Goldsmith and
Andrew M. Leidal and
Nathalie Faure and
Jordan Ye and
Torsten Wittmann and
Jayanta Debnath NBR1 enables autophagy-dependent focal
adhesion turnover . . . . . . . . . . . 577
Anna Julia Squarr and
Klaus Brinkmann and
Baoyu Chen and
Tim Steinbacher and
Klaus Ebnet and
Michael K. Rosen and
Sven Bogdan Fat2 acts through the WAVE regulatory
complex to drive collective cell
migration during tissue rotation . . . . 591
Ben Short Three speeds of gene repositioning . . . ??
Ben Short ROBO-cop protects cells from stiff
environment . . . . . . . . . . . . . . ??
Ben Short Decrypting a collagen's role in
schizophrenia . . . . . . . . . . . . . ??
Ben Short Survival of the fattest . . . . . . . . 607
Caitlin Sedwick Jim Kadonaga: Exploring transcription
and chromatin . . . . . . . . . . . . . 608
Alexis A. Jourdain and
Erik Boehm and
Kinsey Maundrell and
Jean-Claude Martinou Mitochondrial RNA granules:
Compartmentalizing mitochondrial gene
expression . . . . . . . . . . . . . . . 611
Joseph R. Marquardt and
Harold A. Fisk ARHGEF17 sets the timer for retention of
Mps1 at kinetochores . . . . . . . . . . 615
Swetha Gowrishankar and
Shawn M. Ferguson Lysosomes relax in the cellular suburbs 617
Ariadna P. Velázquez and
Takashi Tatsuta and
Ruben Ghillebert and
Ingmar Drescher and
Martin Graef Lipid droplet--mediated ER homeostasis
regulates autophagy and cell survival
during starvation . . . . . . . . . . . 621
Carlo Randise-Hinchliff and
Robert Coukos and
Varun Sood and
Michael Chas Sumner and
Stefan Zdraljevic and
Lauren Meldi Sholl and
Donna Garvey Brickner and
Sara Ahmed and
Lauren Watchmaker and
Jason H. Brickner Strategies to regulate transcription
factor--mediated gene positioning and
interchromosomal clustering at the
nuclear periphery . . . . . . . . . . . 633
Mayumi Isokane and
Thomas Walter and
Robert Mahen and
Bianca Nijmeijer and
Jean-Karim Hériché and
Kota Miura and
Stefano Maffini and
Miroslav Penchev Ivanov and
Tomoya S. Kitajima and
Jan-Michael Peters and
Jan Ellenberg ARHGEF17 is an essential spindle
assembly checkpoint factor that targets
Mps1 to kinetochores . . . . . . . . . . 647
Keng Chen and
Chwee Tat Koe and
Zhanyuan Benny Xing and
Xiaolin Tian and
Fabrizio Rossi and
Cheng Wang and
Quan Tang and
Wenhui Zong and
Wan Jin Hong and
Reshma Taneja and
Fengwei Yu and
Cayetano Gonzalez and
Chunlai Wu and
Sharyn Endow and
Hongyan Wang Arl2- and Msps-dependent microtubule
growth governs asymmetric division . . . 661
Danielle E. Johnson and
Philip Ostrowski and
Valentin Jaumouillé and
Sergio Grinstein The position of lysosomes within the
cell determines their luminal pH . . . . 677
Laure Fourel and
Anne Valat and
Eva Faurobert and
Raphael Guillot and
Ingrid Bourrin-Reynard and
Kefeng Ren and
Laurence Lafanech\`ere and
Emmanuelle Planus and
Catherine Picart and
Corinne Albiges-Rizo $ \beta $3 integrin--mediated spreading
induced by matrix-bound BMP-2 controls
Smad signaling in a
stiffness-independent manner . . . . . . 693
Lily Thao-Nhi Le and
Oscar Cazares and
Janna K. Mouw and
Sharmila Chatterjee and
Hector Macias and
Angel Moran and
Jillian Ramos and
Patricia J. Keely and
Valerie M. Weaver and
Lindsay Hinck Loss of miR-203 regulates cell shape and
matrix adhesion through ROBO1/Rac/FAK in
response to stiffness . . . . . . . . . 707
Jianmin Su and
Jiang Chen and
Kumiko Lippold and
Aboozar Monavarfeshani and
Gabriela Lizana Carrillo and
Rachel Jenkins and
Michael A. Fox Collagen-derived matricryptins promote
inhibitory nerve terminal formation in
the developing neocortex . . . . . . . . 721
Taekyung Kim and
Mark W. Moyle and
Pablo Lara-Gonzalez and
Christian De Groot and
Karen Oegema and
Arshad Desai Correction: Kinetochore-localized
BUB-1/BUB-3 complex promotes anaphase
onset in \bionameC. elegans . . . . . . 737
Kai Liu and
Youli Jian and
Xiaojuan Sun and
Chengkui Yang and
Zhiyang Gao and
Zhili Zhang and
Xuezhao Liu and
Yang Li and
Jing Xu and
Yudong Jing and
Shohei Mitani and
Sudan He and
Chonglin Yang Correction: Negative regulation of
phosphatidylinositol $3$-phosphate
levels in early-to-late endosome
conversion . . . . . . . . . . . . . . . 739
Ben Short MLL5 limits PLK1 aggregation . . . . . . ??
Ben Short A switch for stress granule assembly . . ??
Ben Short How Gpr161 exits from cilia . . . . . . ??
Ben Short How asters find their center . . . . . . 743
Kendall Powell Sophie Dumont: Mastering the uncanny
mechanics of living systems . . . . . . 744
Simon Cabello and
Yannick Gachet and
Sylvie Tournier Cutting edge science: Laser surgery
illuminates viscoelasticity of merotelic
kinetochores . . . . . . . . . . . . . . 747
Ju Youn Kim and
Samie R. Jaffrey Separating neuronal compartments gives
clues as to local effect of ubiquitin
conjugates in synaptogenesis . . . . . . 751
Emyr Lloyd-Evans On the move, lysosomal CAX drives
Ca$^{2+}$ transport and motility . . . . 755
Marie-Hél\`ene Verlhac Mother centrioles are kicked out so that
starfish zygote can grow . . . . . . . . 759
Serge Dmitrieff and
François Nédélec Amplification of actin polymerization
forces . . . . . . . . . . . . . . . . . 763
Gheorghe Cojoc and
Emanuele Roscioli and
Lijuan Zhang and
Alfonso García-Ulloa and
Jagesh V. Shah and
Michael W. Berns and
Nenad Pavin and
Daniela Cimini and
Iva M. Toli\'c and
Juraj Gregan Laser microsurgery reveals conserved
viscoelastic behavior of the kinetochore 767
Hirokazu Tanimoto and
Akatsuki Kimura and
Nicolas Minc Shape--motion relationships of centering
microtubule asters . . . . . . . . . . . 777
Maria J. Pinto and
Pedro L. Alves and
Luís Martins and
Joana R. Pedro and
Hyun R. Ryu and
Noo Li Jeon and
Anne M. Taylor and
Ramiro D. Almeida The proteasome controls presynaptic
differentiation through modulation of an
on-site pool of polyubiquitinated
conjugates . . . . . . . . . . . . . . . 789
Manuela Melchionda and
Jon K. Pittman and
Roberto Mayor and
Sandip Patel Ca$^{2+}$ /H$^+$ exchange by acidic
organelles regulates cell migration in
vivo . . . . . . . . . . . . . . . . . . 803
Joana Borrego-Pinto and
Kálmán Somogyi and
Matthia A. Karreman and
Julia König and
Thomas Müller-Reichert and
Mónica Bettencourt-Dias and
Pierre Gönczy and
Yannick Schwab and
Péter Lénárt Distinct mechanisms eliminate mother and
daughter centrioles in meiosis of
starfish oocytes . . . . . . . . . . . . 815
Wei Zhao and
Jie Liu and
Xiaoming Zhang and
Lih-Wen Deng MLL5 maintains spindle bipolarity by
preventing aberrant cytosolic
aggregation of PLK1 . . . . . . . . . . 829
Nancy Kedersha and
Marc D. Panas and
Christopher A. Achorn and
Shawn Lyons and
Sarah Tisdale and
Tyler Hickman and
Marshall Thomas and
Judy Lieberman and
Gerald M. McInerney and
Pavel Ivanov and
Paul Anderson G3BP--Caprin1--USP10 complexes mediate
stress granule condensation and
associate with 40S subunits . . . . . . 845
Kasturi Pal and
Sun-hee Hwang and
Bandarigoda Somatilaka and
Hemant Badgandi and
Peter K. Jackson and
Kathryn DeFea and
Saikat Mukhopadhyay Smoothened determines $ \beta
$-arrestin--mediated removal of the G
protein--coupled receptor Gpr161 from
the primary cilium . . . . . . . . . . . 861
Vinod Kumar and
Jamal-Eddine Bouameur and
Janina Bär and
Robert H. Rice and
Hue-Tran Hornig-Do and
Dennis R. Roop and
Nicole Schwarz and
Susanne Brodesser and
Sören Thiering and
Rudolf E. Leube and
Rudolf J. Wiesner and
Preethi Vijayaraj and
Christina B. Brazel and
Sandra Heller and
Hans Binder and
Henry Löffler-Wirth and
Peter Seibel and
Thomas M. Magin Correction: A keratin scaffold regulates
epidermal barrier formation,
mitochondrial lipid composition, and
activity . . . . . . . . . . . . . . . . 877
Chenran Wang and
Song Chen and
Syn Yeo and
Gizem Karsli-Uzunbas and
Eileen White and
Noboru Mizushima and
Herbert W. Virgin and
Jun-Lin Guan Correction: Elevated p62/SQSTM1
determines the fate of
autophagy-deficient neural stem cells by
increasing superoxide . . . . . . . . . 879
Hong-guang Xia and
Ayaz Najafov and
Jiefei Geng and
Lorena Galan-Acosta and
Xuemei Han and
Yuan Guo and
Bing Shan and
Yaoyang Zhang and
Erik Norberg and
Tao Zhang and
Lifeng Pan and
Junli Liu and
Jonathan L. Coloff and
Dimitry Ofengeim and
Hong Zhu and
Kejia Wu and
Yu Cai and
John R. Yates and
Zhengjiang Zhu and
Junying Yuan and
Helin Vakifahmetoglu-Norberg Correction: Degradation of HK2 by
chaperone-mediated autophagy promotes
metabolic catastrophe and cell death . . 881
Anna Julia Squarr and
Klaus Brinkmann and
Baoyu Chen and
Tim Steinbacher and
Klaus Ebnet and
Michael K. Rosen and
Sven Bogdan Correction: Fat2 acts through the WAVE
regulatory complex to drive collective
cell migration during tissue rotation 883
Ben Short Arf6 wins the MVP award . . . . . . . . 2
Caitlin Sedwick Maya Schuldiner: The systems that define
us . . . . . . . . . . . . . . . . . . . 3
Damián Lobato-Márquez and
Serge Mostowy Septins recognize micron-scale membrane
curvature . . . . . . . . . . . . . . . 5
Ting Zhang and
Yihong Ye Doa1 is a MAD adaptor for Cdc48 . . . . 7
Erika Gucciardo and
Mohammad Mobashir and
Kaisa Lehti Proactive for invasion: Reuse of matrix
metalloproteinase for structural memory 11
Konstantin Licht and
Michael F. Jantsch Rapid and dynamic transcriptome
regulation by RNA editing and RNA
modifications . . . . . . . . . . . . . 15
Andrew A. Bridges and
Maximilian S. Jentzsch and
Patrick W. Oakes and
Patricia Occhipinti and
Amy S. Gladfelter Micron-scale plasma membrane curvature
is recognized by the septin cytoskeleton 23
Eamonn J. Dickson and
Jill B. Jensen and
Oscar Vivas and
Martin Kruse and
Alexis E. Traynor-Kaplan and
Bertil Hille Dynamic formation of ER--PM junctions
presents a lipid phosphatase to regulate
phosphoinositides . . . . . . . . . . . 33
Xi Wu and
Lanlan Li and
Hui Jiang Doa1 targets ubiquitinated substrates
for mitochondria-associated degradation 49
Shyam Srivats and
Dilshan Balasuriya and
Mathias Pasche and
Gerard Vistal and
J. Michael Edwardson and
Colin W. Taylor and
Ruth D. Murrell-Lagnado Sigma1 receptors inhibit store-operated
Ca$^{2+}$ entry by attenuating coupling
of STIM1 to Orai1 . . . . . . . . . . . 65
Ari Hashimoto and
Tsukasa Oikawa and
Shigeru Hashimoto and
Hirokazu Sugino and
Ayumu Yoshikawa and
Yutaro Otsuka and
Haruka Handa and
Yasuhito Onodera and
Jin-Min Nam and
Chitose Oneyama and
Masato Okada and
Mitsunori Fukuda and
Hisataka Sabe P53- and mevalonate pathway-driven
malignancies require Arf6 for metastasis
and drug resistance . . . . . . . . . . 81
Kamila Bledzka and
Katarzyna Bialkowska and
Khalid Sossey-Alaoui and
Julia Vaynberg and
Elzbieta Pluskota and
Jun Qin and
Edward F. Plow Kindlin-2 directly binds actin and
regulates integrin outside-in signaling 97
Karim El Azzouzi and
Christiane Wiesner and
Stefan Linder Metalloproteinase MT1-MMP islets act as
memory devices for podosome reemergence 109
Andrew W. Grenfell and
Magdalena Strzelecka and
Marina E. Crowder and
Kara J. Helmke and
Anne-Lore Schlaitz and
Rebecca Heald A versatile multivariate image analysis
pipeline reveals features of
\bionameXenopus extract spindles . . . . 127
Lucia D'Amico and
Sahil Mahajan and
Aude-Helene Capietto and
Zhengfeng Yang and
Ali Zamani and
Biancamaria Ricci and
David B. Bumpass and
Melissa A. Meyer and
Xinming Su and
Andrea Wang-Gillam and
Kathy N. Weilbaecher and
Sheila Ann Stewart and
David DeNardo and
Roberta Faccio Dickkopf-related protein 1 (Dkk1)
regulates the accumulation and function
of myeloid derived suppressor cells in
cancer . . . . . . . . . . . . . . . . . ??
Elisha de Valle and
George Grigoriadis and
Lorraine A. O'Reilly and
Simon N. Willis and
Mhairi J. Maxwell and
Lynn M. Corcoran and
Evelyn Tsantikos and
Jasper K. S. Cornish and
Kirsten A. Fairfax and
Ajithkumar Vasanthakumar and
Mark A. Febbraio and
Margaret L. Hibbs and
Marc Pellegrini and
Ashish Banerjee and
Philip D. Hodgkin and
Axel Kallies and
Fabienne Mackay and
Andreas Strasser and
Steve Gerondakis and
Raffi Gugasyan NF$ \kappa $B1 is essential to prevent
the development of multiorgan
autoimmunity by limiting IL-6 production
in follicular B cells . . . . . . . . . ??
Ben Short Slit holds a strange attraction for
filopodia . . . . . . . . . . . . . . . 138
Kendall Powell Martin Jonikas: Bringing high-throughput
genetics to photosynthesis . . . . . . . 139
Jodi Nunnari and
Rebecca Alvania Doing what we do best, only better . . . 141
Anja Schneider and
Mikael Simons Catching filopodia: Exosomes surf on
fast highways to enter cells . . . . . . 143
Nico P. Dantuma and
Florian A. Salomons Ubiquitin versus misfolding: The minimal
requirements for inclusion body
formation . . . . . . . . . . . . . . . 147
Jeff Hardin Regulating cell--cell junctions from A
to Z . . . . . . . . . . . . . . . . . . 151
Dustin Green and
Xinzhong Dong The cell biology of acute itch . . . . . 155
Kenneth R. Pryde and
Heather L. Smith and
Kai-Yin Chau and
Anthony H. V. Schapira PINK1 disables the anti-fission
machinery to segregate damaged
mitochondria for mitophagy . . . . . . . 163
Wolf Heusermann and
Justin Hean and
Dominic Trojer and
Emmanuelle Steib and
Stefan von Bueren and
Alexandra Graff-Meyer and
Christel Genoud and
Katrin Martin and
Nicolas Pizzato and
Johannes Voshol and
David V. Morrissey and
Samir E. L. Andaloussi and
Matthew J. Wood and
Nicole C. Meisner-Kober Exosomes surf on filopodia to enter
cells at endocytic hot spots, traffic
within endosomes, and are targeted to
the ER . . . . . . . . . . . . . . . . . 173
Ekaterina Gracheva and
Shalaka Chitale and
Thomas Wilhelm and
Alexander Rapp and
Jonathan Byrne and
Jens Stadler and
Rebeca Medina and
M. Cristina Cardoso and
Holger Richly ZRF1 mediates remodeling of E3 ligases
at DNA lesion sites during nucleotide
excision repair . . . . . . . . . . . . 185
Arlise Andress and
Yanxia Bei and
Bryan R. Fonslow and
Ritika Giri and
Yilong Wu and
John R. Yates and
Richard W. Carthew Spindle-E cycling between nuage and
cytoplasm is controlled by Qin and PIWI
proteins . . . . . . . . . . . . . . . . 201
Emma G. Sturgill and
Stephen R. Norris and
Yan Guo and
Ryoma Ohi Kinesin-5 inhibitor resistance is driven
by kinesin-12 . . . . . . . . . . . . . 213
Kirill Bersuker and
Michael Brandeis and
Ron R. Kopito Protein misfolding specifies recruitment
to cytoplasmic inclusion bodies . . . . 229
Wangsun Choi and
Bipul R. Acharya and
Grégoire Peyret and
Marc-Antoine Fardin and
René-Marc M\`ege and
Benoit Ladoux and
Alpha S. Yap and
Alan S. Fanning and
Mark Peifer Remodeling the zonula adherens in
response to tension and the role of
afadin in this response . . . . . . . . 243
Russell E. McConnell and
J. Edward van Veen and
Marina Vidaki and
Adam V. Kwiatkowski and
Aaron S. Meyer and
Frank B. Gertler A requirement for filopodia extension
toward Slit during Robo-mediated axon
repulsion . . . . . . . . . . . . . . . 261
Joana Capote and
Irina Kramerova and
Leonel Martinez and
Sylvia Vetrone and
Elisabeth R. Barton and
H. Lee Sweeney and
M. Carrie Miceli and
Melissa J. Spencer Osteopontin ablation ameliorates
muscular dystrophy by shifting
macrophages to a pro-regenerative
phenotype . . . . . . . . . . . . . . . 275
Ben Short Neurons let it slide . . . . . . . . . . 290
Kendall Powell Eugenia Piddini: Chasing how cells
outcompete one another . . . . . . . . . 291
Anna Akhmanova and
Sander van den Heuvel Tipping the spindle into the right
position . . . . . . . . . . . . . . . . 293
Suzanne R. Pfeffer Lipoprotein secretion: It takes two to
TANGO . . . . . . . . . . . . . . . . . 297
Maria S. Ioannou and
Peter S. McPherson Rab-mediated membrane trafficking and
the control of epithelial cell polarity 301
Alvaro H. Crevenna and
Birgit Blank and
Andreas Maiser and
Derya Emin and
Jens Prescher and
Gisela Beck and
Christine Kienzle and
Kira Bartnik and
Bianca Habermann and
Mehrshad Pakdel and
Heinrich Leonhardt and
Don C. Lamb and
Julia von Blume Secretory cargo sorting by
Ca$^{2+}$-dependent Cab45
oligomerization at the trans-Golgi
network . . . . . . . . . . . . . . . . 305
David M. Kern and
Peter K. Nicholls and
David C. Page and
Iain M. Cheeseman A mitotic SKAP isoform regulates spindle
positioning at astral microtubule plus
ends . . . . . . . . . . . . . . . . . . 315
Anand N. Rao and
Aditi Falnikar and
Eileen T. O'Toole and
Mary K. Morphew and
Andreas Hoenger and
Michael W. Davidson and
Xiaobing Yuan and
Peter W. Baas Sliding of centrosome-unattached
microtubules defines key features of
neuronal phenotype . . . . . . . . . . . 329
António J. M. Santos and
Cristina Nogueira and
Maria Ortega-Bellido and
Vivek Malhotra TANGO1 and Mia2/cTAGE5 (TALI) cooperate
to export bulky pre-chylomicrons/VLDLs
from the endoplasmic reticulum . . . . . 343
Paulina S. Mrozowska and
Mitsunori Fukuda Regulation of podocalyxin trafficking by
Rab small GTPases in $2$D and $3$D
epithelial cell cultures . . . . . . . . 355
Abhishek Kumar and
Mingxing Ouyang and
Koen Van den Dries and
Ewan James McGhee and
Keiichiro Tanaka and
Marie D. Anderson and
Alexander Groisman and
Benjamin T. Goult and
Kurt I. Anderson and
Martin A. Schwartz Talin tension sensor reveals novel
features of focal adhesion force
transmission and mechanosensitivity . . 371
Beatriz Marcos-Ramiro and
Diego García-Weber and
Susana Barroso and
Jorge Feito and
María C. Ortega and
Eva Cernuda-Morollón and
Natalia Reglero-Real and
Laura Fernández-Martín and
Maria C. Durán and
Miguel A. Alonso and
Isabel Correas and
Susan Cox and
Anne J. Ridley and
Jaime Millán RhoB controls endothelial barrier
recovery by inhibiting Rac1 trafficking
to the cell border . . . . . . . . . . . 385
Ben Short Chloride helps collagen build its
network . . . . . . . . . . . . . . . . 404
Shawn Jordan Heike Folsch: Peeling back the layers 405
Timothy S. Catlett and
Timothy M. Gomez Division of labor in the growth cone by
DSCR1 . . . . . . . . . . . . . . . . . 407
Robert G. Kelly How Mesp1 makes a move . . . . . . . . . 411
Chenshu Liu and
Yinghui Mao Diaphanous formin mDia2 regulates
CENP--A levels at centromeres . . . . . 415
Melissa C. Pamula and
Shih-Chieh Ti and
Tarun M. Kapoor The structured core of human $ \beta $
tubulin confers isotype-specific
polymerization properties . . . . . . . 425
Brian J. Galletta and
Katherine C. Jacobs and
Carey J. Fagerstrom and
Nasser M. Rusan Asterless is required for centriole
length control and sperm development . . 435
Wei Wang and
Asit Rai and
Eun-Mi Hur and
Zeev Smilansky and
Karen T. Chang and
Kyung-Tai Min DSCR1 is required for both axonal growth
cone extension and steering . . . . . . 451
Giuseppe Chiapparo and
Xionghui Lin and
Fabienne Lescroart and
Samira Chabab and
Catherine Paulissen and
Lorenzo Pitisci and
Antoine Bondue and
Cédric Blanpain Mesp1 controls the speed, polarity, and
directionality of cardiovascular
progenitor migration . . . . . . . . . . 463
Christopher F. Cummings and
Vadim Pedchenko and
Kyle L. Brown and
Selene Colon and
Mohamed Rafi and
Celestial Jones-Paris and
Elena Pokydeshava and
Min Liu and
Jose C. Pastor-Pareja and
Cody Stothers and
Isi A. Ero-Tolliver and
A. Scott McCall and
Roberto Vanacore and
Gautam Bhave and
Samuel Santoro and
Timothy S. Blackwell and
Roy Zent and
Ambra Pozzi and
Billy G. Hudson Extracellular chloride signals collagen
IV network assembly during basement
membrane formation . . . . . . . . . . . 479
Emmanuel Dornier and
Franck Coumailleau and
Jean-François Ottavi and
Julien Moretti and
Claude Boucheix and
Philippe Mauduit and
François Schweisguth and
Eric Rubinstein Correction: TspanC8 tetraspanins
regulate ADAM10/Kuzbanian trafficking
and promote Notch activation in flies
and mammals . . . . . . . . . . . . . . 495
Ben Short Telomeres come up short in heart
regeneration . . . . . . . . . . . . . . 497
Shawn Jordan Fred Chang: The shape of things to come 498
Michael L. Dustin and
Lance C. Kam Tapping out a mechanical code for T cell
triggering . . . . . . . . . . . . . . . 501
Marianne E. Bronner How inhibitory cues can both constrain
and promote cell migration . . . . . . . 505
Iain A. Sawyer and
Miroslav Dundr Nuclear bodies: Built to boost . . . . . 509
Holly A. Ping and
Lauren M. Kraft and
WeiTing Chen and
Amy E. Nilles and
Laura L. Lackner Num1 anchors mitochondria to the plasma
membrane via two domains with different
lipid binding specificities . . . . . . 513
Mari J. Aaltonen and
Jonathan R. Friedman and
Christof Osman and
Bénédicte Salin and
Jean-Paul di Rago and
Jodi Nunnari and
Thomas Langer and
Takashi Tatsuta MICOS and phospholipid transfer by
Ups2--Mdm35 organize membrane lipid
synthesis in mitochondria . . . . . . . 525
Kenneth H. Hu and
Manish J. Butte T cell activation requires force
generation . . . . . . . . . . . . . . . 535
András Szabó and
Manuela Melchionda and
Giancarlo Nastasi and
Mae L. Woods and
Salvatore Campo and
Roberto Perris and
Roberto Mayor In vivo confinement promotes collective
migration of neural crest cells . . . . 543
Deirdre C. Tatomer and
Esteban Terzo and
Kaitlin P. Curry and
Harmony Salzler and
Ivan Sabath and
Grzegorz Zapotoczny and
Daniel J. McKay and
Zbigniew Dominski and
William F. Marzluff and
Robert J. Duronio Concentrating pre-mRNA processing
factors in the histone locus body
facilitates efficient histone mRNA
biogenesis . . . . . . . . . . . . . . . 557
Esther Aix and
Óscar Gutiérrez-Gutiérrez and
Carlota Sánchez-Ferrer and
Tania Aguado and
Ignacio Flores Postnatal telomere dysfunction induces
cardiomyocyte cell-cycle arrest through
p21 activation . . . . . . . . . . . . . 571
Christos Petropoulos and
Christiane Oddou and
Anouk Emadali and
Edwige Hiriart-Bryant and
Cyril Boyault and
Eva Faurobert and
Scott Vande Pol and
Joo-ri Kim-Kaneyama and
Alexandra Kraut and
Yohann Coute and
Marc Block and
Corinne Albiges-Rizo and
Olivier Destaing Roles of paxillin family members in
adhesion and ECM degradation coupling at
invadosomes . . . . . . . . . . . . . . 585
Ben Short Untangling Topo II's function at mitotic
centromeres . . . . . . . . . . . . . . 601
Shawn Jordan Claudine Kraft: a hunger for
understanding . . . . . . . . . . . . . 602
Zairan Liu and
Orion D. Weiner Positioning the cleavage furrow: All you
need is Rho . . . . . . . . . . . . . . 605
Paul T. Conduit Microtubule organization: a complex
solution . . . . . . . . . . . . . . . . 609
Camilla Raiborg and
Harald Stenmark Plasma membrane repairs by small GTPase
Rab3a . . . . . . . . . . . . . . . . . 613
Deepika Sharma and
Thirumala-Devi Kanneganti The cell biology of inflammasomes:
Mechanisms of inflammasome activation
and regulation . . . . . . . . . . . . . 617
Marisa Encarnação and
Lília Espada and
Cristina Escrevente and
Denisa Mateus and
José Ramalho and
Xavier Michelet and
Inês Santarino and
Victor W. Hsu and
Michael B. Brenner and
Duarte C. Barral and
Otília V. Vieira A Rab3a-dependent complex essential for
lysosome positioning and plasma membrane
repair . . . . . . . . . . . . . . . . . 631
Elizabeth Wagner and
Michael Glotzer Local RhoA activation induces
cytokinetic furrows independent of
spindle position and cell cycle stage 641
Heather Edgerton and
Marnie Johansson and
Daniel Keifenheim and
Soumya Mukherjee and
Jeremy M. Chacón and
Jeff Bachant and
Melissa K. Gardner and
Duncan J. Clarke A noncatalytic function of the
topoisomerase II CTD in Aurora B
recruitment to inner centromeres during
mitosis . . . . . . . . . . . . . . . . 651
Makoto M. Yoshida and
Lily Ting and
Steven P. Gygi and
Yoshiaki Azuma SUMOylation of DNA topoisomerase II$
\alpha $ regulates histone H3 kinase
Haspin and H3 phosphorylation in mitosis 665
Andrew Muroyama and
Lindsey Seldin and
Terry Lechler Divergent regulation of functionally
distinct $ \gamma $-tubulin complexes
during differentiation . . . . . . . . . 679
Natalia Sikorska and
Leticia Lemus and
Auxiliadora Aguilera-Romero and
Javier Manzano-Lopez and
Howard Riezman and
Manuel Muñiz and
Veit Goder Limited ER quality control for
GPI-anchored proteins . . . . . . . . . 693
Alexis R. Demonbreun and
Mattia Quattrocelli and
David Y. Barefield and
Madison V. Allen and
Kaitlin E. Swanson and
Elizabeth M. McNally An actin-dependent annexin complex
mediates plasma membrane repair in
muscle . . . . . . . . . . . . . . . . . 705
Ben Short Insulin sends SEC16A packing . . . . . . 1
Shawn Jordan Megan King: a force to be reckoned with 2
Elena B. Pasquale Exosomes expand the sphere of influence
of Eph receptors and ephrins . . . . . . 5
Bruno Mesmin Mitochondrial lipid transport and
biosynthesis: a complex balance . . . . 9
Chin-Chi Chen and
Barbara G. Mellone Chromatin assembly: Journey to the
CENter of the chromosome . . . . . . . . 13
Kyle M. Trudeau and
Aaron H. Colby and
Jialiu Zeng and
Guy Las and
Jiazuo H. Feng and
Mark W. Grinstaff and
Orian S. Shirihai Lysosome acidification by photoactivated
nanoparticles restores autophagy under
lipotoxicity . . . . . . . . . . . . . . 25
Jingyi Gong and
Roman Körner and
Louise Gaitanos and
Rüdiger Klein Exosomes mediate cell
contact--independent ephrin--Eph
signaling during axon guidance . . . . . 35
Taro Mannen and
Seisuke Yamashita and
Kozo Tomita and
Naoki Goshima and
Tetsuro Hirose The Sam68 nuclear body is composed of
two RNase-sensitive substructures joined
by the adaptor HNRNPL . . . . . . . . . 45
Joanne Bruno and
Alexandria Brumfield and
Natasha Chaudhary and
David Iaea and
Timothy E. McGraw SEC16A is a RAB10 effector required for
insulin-stimulated GLUT4 trafficking in
adipocytes . . . . . . . . . . . . . . . 61
Non Miyata and
Yasunori Watanabe and
Yasushi Tamura and
Toshiya Endo and
Osamu Kuge Phosphatidylserine transport by
Ups2--Mdm35 in respiration-active
mitochondria . . . . . . . . . . . . . . 77
Ellen J. Ezratty and
H. Amalia Pasolli and
Elaine Fuchs A Presenilin-2--ARF4 trafficking axis
modulates Notch signaling during
epidermal differentiation . . . . . . . 89
Bing Zhou and
Panpan Yu and
Mei-Yao Lin and
Tao Sun and
Yanmin Chen and
Zu-Hang Sheng Facilitation of axon regeneration by
enhancing mitochondrial transport and
rescuing energy deficits . . . . . . . . 103
Ben Short Mitotic cells get a stress test . . . . 121
Shawn Jordan Cliff Brangwynne: All the right
materials . . . . . . . . . . . . . . . 122
Giusi Caldieri and
Sara Sigismund Spatial resolution of cAMP signaling by
soluble adenylyl cyclase . . . . . . . . 125
Lahiru Gangoda and
Suresh Mathivanan Cortactin enhances exosome secretion
without altering cargo . . . . . . . . . 129
Andrew W. Grenfell and
Rebecca Heald and
Magdalena Strzelecka Mitotic noncoding RNA processing
promotes kinetochore and spindle
assembly in \bionameXenopus . . . . . . 133
Bramwell G. Lambrus and
Vikas Daggubati and
Yumi Uetake and
Phillip M. Scott and
Kevin M. Clutario and
Greenfield Sluder and
Andrew J. Holland A USP28--53BP1--p53--p21 signaling axis
arrests growth after centrosome loss or
prolonged mitosis . . . . . . . . . . . 143
Franz Meitinger and
John V. Anzola and
Manuel Kaulich and
Amelia Richardson and
Joshua D. Stender and
Christopher Benner and
Christopher K. Glass and
Steven F. Dowdy and
Arshad Desai and
Andrew K. Shiau and
Karen Oegema 53BP1 and USP28 mediate p53 activation
and G1 arrest after centrosome loss or
extended mitotic duration . . . . . . . 155
Qing Tang and
Neil Billington and
Elena B. Krementsova and
Carol S. Bookwalter and
Matthew Lord and
Kathleen M. Trybus A single-headed fission yeast myosin V
transports actin in a
tropomyosin-dependent manner . . . . . . 167
Carolina Inda and
Paula A. dos Santos Claro and
Juan J. Bonfiglio and
Sergio A. Senin and
Giuseppina Maccarrone and
Christoph W. Turck and
Susana Silberstein Different cAMP sources are critically
involved in G protein--coupled receptor
CRHR1 signaling . . . . . . . . . . . . 181
Seema Sinha and
Daisuke Hoshino and
Nan Hyung Hong and
Kellye C. Kirkbride and
Nathan E. Grega-Larson and
Motoharu Seiki and
Matthew J. Tyska and
Alissa M. Weaver Cortactin promotes exosome secretion by
controlling branched actin dynamics . . 197
Andrea V. Cantú and
Svetlana Altshuler-Keylin and
Diana J. Laird Discrete somatic niches coordinate
proliferation and migration of
primordial germ cells via Wnt signaling 215
Abhishek Kumar and
Mingxing Ouyang and
Koen Van den Dries and
Ewan James McGhee and
Keiichiro Tanaka and
Marie D. Anderson and
Alexander Groisman and
Benjamin T. Goult and
Kurt I. Anderson and
Martin A. Schwartz Correction: Talin tension sensor reveals
novel features of focal adhesion force
transmission and mechanosensitivity . . 231
Ben Short A program to reduce inequality . . . . . 233
Shawn Jordan Frederic Bard: The sweet side of traffic 234
Carolyn M. Ott Midbody remnant licenses primary cilia
formation in epithelial cells . . . . . 237
Gábor Juhász A mitochondrial-derived vesicle HOPS to
endolysosomes using Syntaxin-17 . . . . 241
Clare E. Futter and
Daniel F. Cutler Coming or going? Un--BLOC--ing delivery
and recycling pathways during melanosome
maturation . . . . . . . . . . . . . . . 245
Katherine R. Mattaini and
Mark R. Sullivan and
Matthew G. Vander Heiden The importance of serine metabolism in
cancer . . . . . . . . . . . . . . . . . 249
Miguel Bernabé-Rubio and
Germán Andrés and
Javier Casares-Arias and
Jaime Fernández-Barrera and
Laura Rangel and
Natalia Reglero-Real and
David C. Gershlick and
José J. Fernández and
Jaime Millán and
Isabel Correas and
David G. Miguez and
Miguel A. Alonso Novel role for the midbody in primary
ciliogenesis by polarized epithelial
cells . . . . . . . . . . . . . . . . . 259
Gian-Luca McLelland and
Sydney A. Lee and
Heidi M. McBride and
Edward A. Fon Syntaxin-17 delivers
PINK1/Parkin-dependent mitochondrial
vesicles to the endolysosomal system . . 275
Megan K. Dennis and
Cédric Delevoye and
Amanda Acosta-Ruiz and
Ilse Hurbain and
Maryse Romao and
Geoffrey G. Hesketh and
Philip S. Goff and
Elena V. Sviderskaya and
Dorothy C. Bennett and
J. Paul Luzio and
Thierry Galli and
David J. Owen and
Graça Raposo and
Michael S. Marks BLOC-1 and BLOC-3 regulate VAMP7 cycling
to and from melanosomes via distinct
tubular transport carriers . . . . . . . 293
Courtney M. Schroeder and
Ronald D. Vale Assembly and activation of
dynein--dynactin by the cargo adaptor
protein Hook3 . . . . . . . . . . . . . 309
Hai H. Le and
Monika Looney and
Benjamin Strauss and
Michael Bloodgood and
Antony M. Jose Tissue homogeneity requires inhibition
of unequal gene silencing during
development . . . . . . . . . . . . . . 319
Thomas G. McWilliams and
Alan R. Prescott and
George F. G. Allen and
Jevgenia Tamjar and
Michael J. Munson and
Calum Thomson and
Miratul M. K. Muqit and
Ian G. Ganley mito -QC illuminates mitophagy and
mitochondrial architecture in vivo . . . 333
Joshua P. Ferguson and
Nathan M. Willy and
Spencer P. Heidotting and
Scott D. Huber and
Matthew J. Webber and
Comert Kural Deciphering dynamics of
clathrin-mediated endocytosis in a
living organism . . . . . . . . . . . . 347
Ben Short Cells set sail after lifting anchor from
Myo1E . . . . . . . . . . . . . . . . . 359
Shawn Jordan Hari Shroff: Taking a closer look . . . 360
Dejana Mokranjac Mitochondrial protein import: an
unexpected disulfide bond . . . . . . . 363
Michiel Krols and
Geert Bultynck and
Sophie Janssens ER--Mitochondria contact sites: a new
regulator of cellular calcium flux comes
into play . . . . . . . . . . . . . . . 367
Kate O'Connor-Giles Toll-tally tubular: a newly identified
Toll-like receptor--FoxO pathway
regulates dynamics of the neuronal
microtubule network . . . . . . . . . . 371
Iris K. Jarsch and
Frederic Daste and
Jennifer L. Gallop Membrane curvature in cell biology: an
integration of molecular mechanisms . . 375
Kirsty J. McMillan and
Matthew Gallon and
Adam P. Jellett and
Thomas Clairfeuille and
Frances C. Tilley and
Ian McGough and
Chris M. Danson and
Kate J. Heesom and
Kevin A. Wilkinson and
Brett M. Collins and
Peter J. Cullen Atypical parkinsonism--associated
retromer mutant alters endosomal sorting
of specific cargo proteins . . . . . . . 389
Vaclav Urban and
Jana Dobrovolna and
Daniela Hühn and
Jana Fryzelkova and
Jiri Bartek and
Pavel Janscak RECQ5 helicase promotes resolution of
conflicts between replication and
transcription in human cells . . . . . . 401
Ajay Ramesh and
Valentina Peleh and
Sonia Martinez-Caballero and
Florian Wollweber and
Frederik Sommer and
Martin van der Laan and
Michael Schroda and
R. Todd Alexander and
María Luisa Campo and
Johannes M. Herrmann A disulfide bond in the TIM23 complex is
crucial for voltage gating and
mitochondrial protein import . . . . . . 417
Arun Raturi and
Tomás Gutiérrez and
Carolina Ortiz-Sandoval and
Araya Ruangkittisakul and
Maria Sol Herrera-Cruz and
Jeremy P. Rockley and
Kevin Gesson and
Dimitar Ourdev and
Phing-How Lou and
Eliana Lucchinetti and
Nasser Tahbaz and
Michael Zaugg and
Shairaz Baksh and
Klaus Ballanyi and
Thomas Simmen TMX1 determines cancer cell metabolism
as a thiol-based modulator of
ER--mitochondria Ca$^{2+}$ flux . . . . 433
Mo Zhou and
Heidi Wiener and
Wenjuan Su and
Yong Zhou and
Caroline Liot and
Ian Ahearn and
John F. Hancock and
Mark R. Philips VPS35 binds farnesylated N--Ras in the
cytosol to regulate N--Ras trafficking 445
Colleen N. McLaughlin and
Inna V. Nechipurenko and
Nan Liu and
Heather T. Broihier A Toll receptor-FoxO pathway represses
Pavarotti/MKLP1 to promote microtubule
dynamics in motoneurons . . . . . . . . 459
Susumu Tanimura and
Junya Hashizume and
Naoya Arichika and
Kazushi Watanabe and
Kaname Ohyama and
Kohsuke Takeda and
Michiaki Kohno ERK signaling promotes cell motility by
inducing the localization of myosin 1E
to lamellipodial tips . . . . . . . . . 475
Ben Short Tracking CRISPR targeting . . . . . . . 491
Shawn Jordan Richard Cheney: Life on the move . . . . 492
Jessica L. Teo and
Alpha S. Yap Cycling Rho for tissue contraction . . . 495
Gislene Pereira and
Elmar Schiebel Mitotic exit: Determining the PP2A
dephosphorylation program . . . . . . . 499
Tina Solvik and
Jayanta Debnath At the crossroads of autophagy and
infection: Noncanonical roles for ATG
proteins in viral replication . . . . . 503
Isabelle Tardieux and
Jake Baum Reassessing the mechanics of parasite
motility and host-cell invasion . . . . 507
Lee Dolat and
Elias T. Spiliotis Septins promote macropinosome maturation
and traffic to the lysosome by
facilitating membrane fusion . . . . . . 517
Hanhui Ma and
Li-Chun Tu and
Ardalan Naseri and
Maximiliaan Huisman and
Shaojie Zhang and
David Grunwald and
Thoru Pederson CRISPR-Cas9 nuclear dynamics and target
recognition in living cells . . . . . . 529
Michael J. Cundell and
Lukas H. Hutter and
Ricardo Nunes Bastos and
Elena Poser and
James Holder and
Shabaz Mohammed and
Bela Novak and
Francis A. Barr A PP2A--B55 recognition signal controls
substrate dephosphorylation kinetics
during mitotic exit . . . . . . . . . . 539
Thomas Jungas and
Renaud T. Perchey and
Mohamad Fawal and
Caroline Callot and
Carine Froment and
Odile Burlet-Schiltz and
Arnaud Besson and
Alice Davy Eph-mediated tyrosine phosphorylation of
citron kinase controls abscission . . . 555
Elisa Herawati and
Daisuke Taniguchi and
Hatsuho Kanoh and
Kazuhiro Tateishi and
Shuji Ishihara and
Sachiko Tsukita Multiciliated cell basal bodies align in
stereotypical patterns coordinated by
the apical cytoskeleton . . . . . . . . 571
Maria Losada-Perez and
Neale Harrison and
Alicia Hidalgo Molecular mechanism of central nervous
system repair by the \bionameDrosophila
NG2 homologue kon-tiki . . . . . . . . . 587
Frank M. Mason and
Shicong Xie and
Claudia G. Vasquez and
Michael Tworoger and
Adam C. Martin RhoA GTPase inhibition organizes
contraction during epithelial
morphogenesis . . . . . . . . . . . . . 603
Mario Mauthe and
Martijn Langereis and
Jennifer Jung and
Xingdong Zhou and
Alex Jones and
Wienand Omta and
Sharon A. Tooze and
Björn Stork and
Sòren Riis Paludan and
Tero Ahola and
Dave Egan and
Christian Behrends and
Michal Mokry and
Cornelis de Haan and
Frank van Kuppeveld and
Fulvio Reggiori An siRNA screen for ATG protein
depletion reveals the extent of the
unconventional functions of the
autophagy proteome in virus replication 619
Mitch Leslie ER membrane puts up barriers in
\bionameC. elegans . . . . . . . . . . . 637
Melina Casadio and
Shawn Jordan Julie Forman--Kay: Dynamic views on
protein structure . . . . . . . . . . . 638
Mugdha Deshpande and
Avital A. Rodal Beyond the SNARE: Munc18-1 chaperones $
\alpha $-synuclein . . . . . . . . . . . 641
Amnon Sharir and
Ophir D. Klein Watching a deep dive: Live imaging
provides lessons about tooth
invagination . . . . . . . . . . . . . . 645
Hema V. Pingali and
Angela K. Hilliker A beacon in the cytoplasm: Tracking
translation of single mRNAs . . . . . . 649
Chun-Yan Lim and
Roberto Zoncu The lysosome as a command-and-control
center for cellular metabolism . . . . . 653
Zuo Yen Lee and
Manoël Prouteau and
Monica Gotta and
Yves Barral Compartmentalization of the endoplasmic
reticulum in the early \bionameC.
elegans embryos . . . . . . . . . . . . 665
Graeme Sargent and
Tim van Zutphen and
Tatiana Shatseva and
Ling Zhang and
Valeria Di Giovanni and
Robert Bandsma and
Peter Kijun Kim PEX2 is the E3 ubiquitin ligase required
for pexophagy during starvation . . . . 677
Dante Lepore and
Olya Spassibojko and
Gabrielle Pinto and
Ruth N. Collins Cell cycle-dependent phosphorylation of
Sec4p controls membrane deposition
during cytokinesis . . . . . . . . . . . 691
Ye Jin Chai and
Emma Sierecki and
Vanesa M. Tomatis and
Rachel S. Gormal and
Nichole Giles and
Isabel C. Morrow and
Di Xia and
Jürgen Götz and
Robert G. Parton and
Brett M. Collins and
Yann Gambin and
Frédéric A. Meunier Munc18-1 is a molecular chaperone for $
\alpha $-synuclein, controlling its
self-replicating aggregation . . . . . . 705
Charles V. Rajadurai and
Serhiy Havrylov and
Paula P. Coelho and
Colin D. H. Ratcliffe and
Kossay Zaoui and
Bruce H. Huang and
Anie Monast and
Naila Chughtai and
Veena Sangwan and
Frank B. Gertler and
Peter M. Siegel and
Morag Park 5'-Inositol phosphatase SHIP2 recruits
Mena to stabilize invadopodia for cancer
cell invasion . . . . . . . . . . . . . 719
Thomas N. Gaitanos and
Jorg Koerner and
Ruediger Klein Tiam--Rac signaling mediates
trans-endocytosis of ephrin receptor
EphB2 and is important for cell
repulsion . . . . . . . . . . . . . . . 735
Laura Ahtiainen and
Isa Uski and
Irma Thesleff and
Marja L. Mikkola Early epithelial signaling center
governs tooth budding morphogenesis . . 753
Xavier Pichon and
Amandine Bastide and
Adham Safieddine and
Racha Chouaib and
Aubin Samacoits and
Eugenia Basyuk and
Marion Peter and
Florian Mueller and
Edouard Bertrand Visualization of single endogenous
polysomes reveals the dynamics of
translation in live human cells . . . . 769
Andrew W. Grenfell and
Rebecca Heald and
Magdalena Strzelecka Correction: Mitotic noncoding RNA
processing promotes kinetochore and
spindle assembly in \bionameXenopus . . 783
Mitch Leslie Why endosomes recycle GPCRs . . . . . . 785
Shawn Jordan David Spector: Coordinating gene
expression in space and time . . . . . . 786
Shi-Bin Hu and
Run-Wen Yao and
Ling-Ling Chen Shedding light on paraspeckle structure
by super-resolution microscopy . . . . . 789
Claudio A. Franco and
Holger Gerhardt Blood flow boosts BMP signaling to keep
vessels in shape . . . . . . . . . . . . 793
Shanna Lynn Bowman and
Daniel John Shiwarski and
Manojkumar A. Puthenveedu Distinct G protein--coupled receptor
recycling pathways allow spatial control
of downstream G protein signaling . . . 797
Nicolas Baeyens and
Bruno Larrivée and
Roxana Ola and
Brielle Hayward-Piatkowskyi and
Alexandre Dubrac and
Billy Huang and
Tyler D. Ross and
Brian G. Coon and
Elizabeth Min and
Maya Tsarfati and
Haibin Tong and
Anne Eichmann and
Martin A. Schwartz Defective fluid shear stress
mechanotransduction mediates hereditary
hemorrhagic telangiectasia . . . . . . . 807
Jason A. West and
Mari Mito and
Satoshi Kurosaka and
Toru Takumi and
Chiharu Tanegashima and
Takeshi Chujo and
Kaori Yanaka and
Robert E. Kingston and
Tetsuro Hirose and
Charles Bond and
Archa Fox and
Shinichi Nakagawa Structural, super-resolution microscopy
analysis of paraspeckle nuclear body
organization . . . . . . . . . . . . . . 817
Anupam Das and
Sagarika Nag and
Anne B. Mason and
Margarida M. Barroso Endosome--mitochondria interactions are
modulated by iron release from
transferrin . . . . . . . . . . . . . . 831
Ravikiran Kasula and
Ye Jin Chai and
Adekunle T. Bademosi and
Callista B. Harper and
Rachel S. Gormal and
Isabel C. Morrow and
Eric Hosy and
Brett M. Collins and
Daniel Choquet and
Andreas Papadopulos and
Frédéric A. Meunier The Munc18-1 domain 3a hinge-loop
controls syntaxin-1A nanodomain assembly
and engagement with the SNARE complex
during secretory vesicle priming . . . . 847
Fabien Binamé and
Aurélien Bidaud-Meynard and
Laure Magnan and
Léo Piquet and
Bertille Montibus and
Anne Chabadel and
Frédéric Saltel and
Valérie Lagrée and
Violaine Moreau Cancer-associated mutations in the
protrusion-targeting region of
p190RhoGAP impact tumor cell migration 859
Jennifer Vieillard and
Marie Paschaki and
Jean-Luc Duteyrat and
Céline Augi\`ere and
Elisabeth Cortier and
Jean-André Lapart and
Joëlle Thomas and
Bénédicte Durand Transition zone assembly and its
contribution to axoneme formation in
\bionameDrosophila male germ cells . . . 875
Ben Short A reason to avoid SNAP judgments . . . . 1
Kimberly Siletti Ana-Maria Lennon-Duménil: a dynamic
career . . . . . . . . . . . . . . . . . 2
Jan Lammerding and
Katarina Wolf Nuclear envelope rupture: Actin fibers
are putting the squeeze on the nucleus 5
Yu-Mei Huang and
Matthew N. Rasband Organization of the axon initial
segment: Actin like a fence . . . . . . 9
Philipp Niethammer Neutrophil mechanotransduction: a GEF to
sense fluid shear stress . . . . . . . . 13
Amandine Chaix and
Amir Zarrinpar and
Satchidananda Panda The circadian coordination of cell
biology . . . . . . . . . . . . . . . . 15
Emily M. Hatch and
Martin W. Hetzer Nuclear envelope rupture is induced by
actin-based nucleus confinement . . . . 27
David Albrecht and
Christian M. Winterflood and
Mohsen Sadeghi and
Thomas Tschager and
Frank Noé and
Helge Ewers Nanoscopic compartmentalization of
membrane protein motion at the axon
initial segment . . . . . . . . . . . . 37
Alexander P. Nesmith and
Matthew A. Wagner and
Francesco S. Pasqualini and
Blakely B. O'Connor and
Mark J. Pincus and
Paul R. August and
Kevin Kit Parker A human in vitro model of Duchenne
muscular dystrophy muscle formation and
contractility . . . . . . . . . . . . . 47
Benjamin L. Timney and
Barak Raveh and
Roxana Mironska and
Jill M. Trivedi and
Seung Joong Kim and
Daniel Russel and
Susan R. Wente and
Andrej Sali and
Michael P. Rout Simple rules for passive diffusion
through the nuclear pore complex . . . . 57
Patrick M. Redli and
Ivana Gasic and
Patrick Meraldi and
Erich A. Nigg and
Anna Santamaria The Ska complex promotes Aurora B
activity to ensure chromosome
biorientation . . . . . . . . . . . . . 77
Keiji Uematsu and
Fumihiko Okumura and
Syunsuke Tonogai and
Akiko Joo-Okumura and
Dawit Hailu Alemayehu and
Akihiko Nishikimi and
Yoshinori Fukui and
Kunio Nakatsukasa and
Takumi Kamura ASB7 regulates spindle dynamics and
genome integrity by targeting DDA3 for
proteasomal degradation . . . . . . . . 95
Noah Fine and
Ioannis D. Dimitriou and
Jacob Rullo and
María José Sandí and
Björn Petri and
Jack Haitsma and
Hisham Ibrahim and
Jose La Rose and
Michael Glogauer and
Paul Kubes and
Myron Cybulsky and
Robert Rottapel GEF-H1 is necessary for neutrophil shear
stress--induced migration during
inflammation . . . . . . . . . . . . . . 107
Masataka Kunii and
Mica Ohara-Imaizumi and
Noriko Takahashi and
Masaki Kobayashi and
Ryosuke Kawakami and
Yasumitsu Kondoh and
Takeshi Shimizu and
Siro Simizu and
Bangzhong Lin and
Kazuto Nunomura and
Kyota Aoyagi and
Mitsuyo Ohno and
Masaki Ohmuraya and
Takashi Sato and
Shin-ichiro Yoshimura and
Ken Sato and
Reiko Harada and
Yoon-Jeong Kim and
Hiroyuki Osada and
Tomomi Nemoto and
Haruo Kasai and
Tadahiro Kitamura and
Shinya Nagamatsu and
Akihiro Harada Opposing roles for SNAP23 in secretion
in exocrine and endocrine pancreatic
cells . . . . . . . . . . . . . . . . . 121
Ben Short How morphine tips the synaptic balance 139
Marie Anne O'Donnell Katja Röper: Deciphering tissue origami 140
Michael Brandeis Slip slidin' away of mitosis with
CRL2$^{\rm Zyg11}$ . . . . . . . . . . . 143
Jeremy N. Kay Radial migration: Retinal neurons hold
on for the ride . . . . . . . . . . . . 147
Riju S. Balachandran and
Cassandra S. Heighington and
Natalia G. Starostina and
James W. Anderson and
David L. Owen and
Srividya Vasudevan and
Edward T. Kipreos The ubiquitin ligase CRL2$^{\rm ZYG11}$
targets cyclin B1 for degradation in a
conserved pathway that facilitates
mitotic slippage . . . . . . . . . . . . 151
Yuan Li and
Baohui Chen and
Wei Zou and
Xin Wang and
Yanwei Wu and
Dongfeng Zhao and
Yanan Sun and
Yubing Liu and
Lianwan Chen and
Long Miao and
Chonglin Yang and
Xiaochen Wang The lysosomal membrane protein SCAV-3
maintains lysosome integrity and adult
longevity . . . . . . . . . . . . . . . 167
Lili Zhu and
Aurora Gomez-Duran and
Gabriele Saretzki and
Shibo Jin and
Katarzyna Tilgner and
Dario Melguizo-Sanchis and
Georgios Anyfantis and
Jumana Al-Aama and
Ludovic Vallier and
Patrick Chinnery and
Majlinda Lako and
Lyle Armstrong The mitochondrial protein CHCHD2 primes
the differentiation potential of human
induced pluripotent stem cells to
neuroectodermal lineages . . . . . . . . 187
Isabelle Munoz and
Luca Danelli and
Julien Claver and
Nicolas Goudin and
Mathieu Kurowska and
Iris Karina Madera-Salcedo and
Jian-Dong Huang and
Alain Fischer and
Claudia González-Espinosa and
Geneviéve de Saint Basile and
Ulrich Blank and
Gaël Ménasché Kinesin-1 controls mast cell
degranulation and anaphylaxis through
PI3K-dependent recruitment to the
granular Slp3/Rab27b complex . . . . . . 203
Audrey K. O'Neill and
Abigail A. Kindberg and
Terren K. Niethamer and
Andrew R. Larson and
Hsin-Yi Henry Ho and
Michael E. Greenberg and
Jeffrey O. Bush Unidirectional Eph/ephrin signaling
creates a cortical actomyosin
differential to drive cell segregation 217
Sara Monaco and
Beate Jahraus and
Yvonne Samstag and
Hilmar Bading Nuclear calcium is required for human T
cell activation . . . . . . . . . . . . 231
Yu Cai and
Lu Yang and
Guoku Hu and
Xufeng Chen and
Fang Niu and
Li Yuan and
Han Liu and
Huangui Xiong and
Jyothi Arikkath and
Shilpa Buch Regulation of morphine-induced synaptic
alterations: Role of oxidative stress,
ER stress, and autophagy . . . . . . . . 245
Jaroslav Icha and
Christiane Kunath and
Mauricio Rocha-Martins and
Caren Norden Independent modes of ganglion cell
translocation ensure correct lamination
of the zebrafish retina . . . . . . . . 259
Merja Joensuu and
Pranesh Padmanabhan and
Nela Durisic and
Adekunle T. D. Bademosi and
Elizabeth Cooper-Williams and
Isabel C. Morrow and
Callista B. Harper and
WooRam Jung and
Robert G. Parton and
Geoffrey J. Goodhill and
Andreas Papadopulos and
Frédéric A. Meunier Subdiffractional tracking of
internalized molecules reveals
heterogeneous motion states of synaptic
vesicles . . . . . . . . . . . . . . . . 277
Ben Short A basic guide to stem cell
differentiation . . . . . . . . . . . . 293
Melina Casadio Fanni Gergely: Exploring centrosome
biology . . . . . . . . . . . . . . . . 294
Ana Guerrero and
Jesús Gil HMGB2 holds the key to the
senescence-associated secretory
phenotype . . . . . . . . . . . . . . . 297
Adam C. Martin Embryonic ring closure: Actomyosin rings
do the two-step . . . . . . . . . . . . 301
Kevin C. Slep A microtubule dynamics reconstitutional
convention . . . . . . . . . . . . . . . 305
Mingxue Gu and
Haoxing Xu A painful TR(i)P to lysosomes . . . . . 309
Marc D. Panas and
Pavel Ivanov and
Paul Anderson Mechanistic insights into mammalian
stress granule dynamics . . . . . . . . 313
Katherine M. Aird and
Osamu Iwasaki and
Andrew V. Kossenkov and
Hideki Tanizawa and
Nail Fatkhutdinov and
Benjamin G. Bitler and
Linh Le and
Gretchen Alicea and
Ting-Lin Yang and
F. Brad Johnson and
Ken-ichi Noma and
Rugang Zhang HMGB2 orchestrates the chromatin
landscape of senescence-associated
secretory phenotype gene loci . . . . . 325
Zenghui Xue and
Anna Marie Sokac Back-to-back mechanisms drive actomyosin
ring closure during \bionameDrosophila
embryo cleavage . . . . . . . . . . . . 335
Bryne Ulmschneider and
Bree K. Grillo-Hill and
Marimar Benitez and
Dinara R. Azimova and
Diane L. Barber and
Todd G. Nystul Increased intracellular pH is necessary
for adult epithelial and embryonic stem
cell differentiation . . . . . . . . . . 345
Takashi Moriwaki and
Gohta Goshima Five factors can reconstitute all three
phases of microtubule polymerization
dynamics . . . . . . . . . . . . . . . . 357
Shujiang Shang and
Feipeng Zhu and
Bin Liu and
Zuying Chai and
Qihui Wu and
Meiqin Hu and
Yuan Wang and
Rong Huang and
Xiaoyu Zhang and
Xi Wu and
Lei Sun and
Yeshi Wang and
Li Wang and
Huadong Xu and
Sasa Teng and
Bing Liu and
Lianghong Zheng and
Chen Zhang and
Fukang Zhang and
Xinghua Feng and
Desheng Zhu and
Changhe Wang and
Tao Liu and
Michael X. Zhu and
Zhuan Zhou Intracellular TRPA1 mediates Ca$^{2+}$
release from lysosomes in dorsal root
ganglion neurons . . . . . . . . . . . . 369
Sricharan Murugesan and
Jinsung Hong and
Jason Yi and
Dong Li and
Jordan R. Beach and
Lin Shao and
John Meinhardt and
Grey Madison and
Xufeng Wu and
Eric Betzig and
John A. Hammer Formin-generated actomyosin arcs propel
T cell receptor microcluster movement at
the immune synapse . . . . . . . . . . . 383
Maryam Yousefi and
Ning Li and
Angela Nakauka-Ddamba and
Shan Wang and
Kimberly Davidow and
Jenna Schoenberger and
Zhengquan Yu and
Shane T. Jensen and
Michael G. Kharas and
Christopher J. Lengner Msi RNA-binding proteins control reserve
intestinal stem cell quiescence . . . . 401
Mailin Julia Hamm and
Bettina Carmen Kirchmaier and
Wiebke Herzog Sema3d controls collective endothelial
cell migration by distinct mechanisms
via Nrp1 and PlxnD1 . . . . . . . . . . 415
Thomas N. Gaitanos and
Jorg Koerner and
Ruediger Klein Correction: Tiam--Rac signaling mediates
trans-endocytosis of ephrin receptor
EphB2 and is important for cell
repulsion . . . . . . . . . . . . . . . 431
Ben Short Rac and Rho compete to cooperate . . . . 433
Marie Anne O'Donnell Job Dekker: Hitting the scientific
hi--Cs . . . . . . . . . . . . . . . . . 434
Bogdan Beirowski and
Elisabetta Babetto and
Lawrence Wrabetz Axon degeneration: Linking axonal
bioenergetics to myelin . . . . . . . . 437
Hesso Farhan Regulation of EGFR surface levels by
COPII-dependent trafficking . . . . . . 441
Zhiqi Sun and
Shengzhen S. Guo and
Reinhard Fässler Integrin-mediated mechanotransduction 445
Brian A. Bayless and
Domenico F. Galati and
Anthony D. Junker and
Chelsea B. Backer and
Jacek Gaertig and
Chad G. Pearson Asymmetrically localized proteins
stabilize basal bodies against ciliary
beating forces . . . . . . . . . . . . . 457
Jocelyn F. Krey and
Evan S. Krystofiak and
Rachel A. Dumont and
Sarath Vijayakumar and
Dongseok Choi and
Francisco Rivero and
Bechara Kachar and
Sherri M. Jones and
Peter G. Barr-Gillespie Plastin 1 widens stereocilia by
transforming actin filament packing from
hexagonal to liquid . . . . . . . . . . 467
Emmanuel Martin and
Marie-Hél\`ene Ouellette and
Sarah Jenna Rac1\slash RhoA antagonism defines
cell-to-cell heterogeneity during
epidermal morphogenesis in nematodes . . 483
Laura L. Thomas and
J. Christopher Fromme GTPase cross talk regulates TRAPPII
activation of Rab11 homologues during
vesicle biogenesis . . . . . . . . . . . 499
Amit S. Joshi and
Xiaofang Huang and
Vineet Choudhary and
Tim P. Levine and
Junjie Hu and
William A. Prinz A family of membrane-shaping proteins at
ER subdomains regulates pre-peroxisomal
vesicle biogenesis . . . . . . . . . . . 515
Xinghua Yin and
Grahame J. Kidd and
Nobuhiko Ohno and
Guy A. Perkins and
Mark H. Ellisman and
Chinthasagar Bastian and
Sylvain Brunet and
Selva Baltan and
Bruce D. Trapp Proteolipid protein--deficient myelin
promotes axonal mitochondrial
dysfunction via altered metabolic
coupling . . . . . . . . . . . . . . . . 531
Sandra Scharaw and
Murat Iskar and
Alessandro Ori and
Gaelle Boncompain and
Vibor Laketa and
Ina Poser and
Emma Lundberg and
Franck Perez and
Martin Beck and
Peer Bork and
Rainer Pepperkok The endosomal transcriptional regulator
RNF11 integrates degradation and
transport of EGFR . . . . . . . . . . . 543
Tamako Nishimura and
Shoko Ito and
Hiroko Saito and
Sylvain Hiver and
Kenta Shigetomi and
Junichi Ikenouchi and
Masatoshi Takeichi DAAM1 stabilizes epithelial junctions by
restraining WAVE complex-dependent
lateral membrane motility . . . . . . . 559
Christine J. Smoyer and
Santharam S. Katta and
Jennifer M. Gardner and
Lynn Stoltz and
Scott McCroskey and
William D. Bradford and
Melainia McClain and
Sarah E. Smith and
Brian D. Slaughter and
Jay R. Unruh and
Sue L. Jaspersen Analysis of membrane proteins localizing
to the inner nuclear envelope in living
cells . . . . . . . . . . . . . . . . . 575
Xiaodong Fang and
Jianying Luo and
Ryuichi Nishihama and
Carsten Wloka and
Christopher Dravis and
Mirko Travaglia and
Masayuki Iwase and
Elizabeth A. Vallen and
Erfei Bi Correction: Biphasic targeting and
cleavage furrow ingression directed by
the tail of a myosin II . . . . . . . . 591
Ben Short GTSE1 leads cancer cells into CIN . . . 593
Melina Casadio Jim Bear: Delineating the mechanics of
cell migration . . . . . . . . . . . . . 594
Luke E. Formosa and
Michael T. Ryan Mitochondrial fusion: Reaching the end
of mitofusin's tether . . . . . . . . . 597
Martin Graef A dividing matter: Drp1/Dnm1-independent
mitophagy . . . . . . . . . . . . . . . 599
Babykumari Chitramuthu and
Andrew Bateman Progranulin and the receptor tyrosine
kinase EphA2, partners in crime? . . . . 603
Christian Henneberger and
Christian Steinhäuser Astrocytic TLR4 at the crossroads of
inflammation and seizure susceptibility 607
Isma Bennabi and
Marie-Emilie Terret and
Marie-Hél\`ene Verlhac Meiotic spindle assembly and chromosome
segregation in oocytes . . . . . . . . . 611
Yuanbo Qi and
Liming Yan and
Caiting Yu and
Xiangyang Guo and
Xin Zhou and
Xiaoyu Hu and
Xiaofang Huang and
Zihe Rao and
Zhiyong Lou and
Junjie Hu Structures of human mitofusin 1 provide
insight into mitochondrial tethering . . 621
Shweta Bendre and
Arnaud Rondelet and
Conrad Hall and
Nadine Schmidt and
Yu-Chih Lin and
Gary J. Brouhard and
Alexander W. Bird GTSE1 tunes microtubule stability for
chromosome alignment and segregation by
inhibiting the microtubule depolymerase
MCAK . . . . . . . . . . . . . . . . . . 631
Shun-ichi Yamashita and
Xiulian Jin and
Kentaro Furukawa and
Maho Hamasaki and
Akiko Nezu and
Hidenori Otera and
Tetsu Saigusa and
Tamotsu Yoshimori and
Yasuyoshi Sakai and
Katsuyoshi Mihara and
Tomotake Kanki Mitochondrial division occurs
concurrently with autophagosome
formation but independently of Drp1
during mitophagy . . . . . . . . . . . . 649
Jong Kook Park and
Han Peng and
Julia Katsnelson and
Wending Yang and
Nihal Kaplan and
Ying Dong and
Joshua Z. Rappoport and
CongCong He and
Robert M. Lavker MicroRNAs-103\slash 107 coordinately
regulate macropinocytosis and autophagy 667
Thomas Neill and
Simone Buraschi and
Atul Goyal and
Catherine Sharpe and
Elizabeth Natkanski and
Liliana Schaefer and
Andrea Morrione and
Renato V. Iozzo EphA2 is a functional receptor for the
growth factor progranulin . . . . . . . 687
Gun-Hee Lee and
Morihisa Fujita and
Katsuyoshi Takaoka and
Yoshiko Murakami and
Yoshitaka Fujihara and
Noriyuki Kanzawa and
Kei-ichi Murakami and
Eriko Kajikawa and
Yoko Takada and
Kazunobu Saito and
Masahito Ikawa and
Hiroshi Hamada and
Yusuke Maeda and
Taroh Kinoshita A GPI processing phospholipase A2,
PGAP6, modulates Nodal signaling in
embryos by shedding CRIPTO . . . . . . . 705
Yi Shen and
Huaping Qin and
Juan Chen and
Lingyan Mou and
Yang He and
Yixiu Yan and
Hang Zhou and
Ya Lv and
Zhong Chen and
Junlu Wang and
Yu-Dong Zhou Postnatal activation of TLR4 in
astrocytes promotes excitatory
synaptogenesis in hippocampal neurons 719
Andrew T. Schiffmacher and
Vivien Xie and
Lisa A. Taneyhill Cadherin-6B proteolysis promotes the
neural crest cell
epithelial-to-mesenchymal transition
through transcriptional regulation . . . 735
Ben Short Cytokinetic rings mind the gap . . . . . 749
Kimberly Siletti Rusty Gage: a plastic approach to
neuroscience . . . . . . . . . . . . . . 750
Nicola Silva and
Verena Jantsch UNC-84: ``LINC-ing'' chromosome movement
and double strand break repair . . . . . 753
Yan G. Zhao and
Hong Zhang ULK1 cycling: The ups and downs of the
autophagy response . . . . . . . . . . . 757
Sascha Martens No ATG8s, no problem? How LC3/GABARAP
proteins contribute to autophagy . . . . 761
Alex T. Ritter and
Ira Mellman Natural killer cell granules converge to
avoid collateral damage . . . . . . . . 765
Natalia Gomez-Navarro and
Elizabeth Miller Protein sorting at the ER--Golgi
interface . . . . . . . . . . . . . . . 769
Ariadne Vlahakis and
Nerea Lopez Muniozguren and
Ted Powers Calcium channel regulator Mid1 links
TORC2-mediated changes in mitochondrial
respiration to autophagy . . . . . . . . 779
Ana M. Silva and
Daniel S. Osório and
Antonio J. Pereira and
Helder Maiato and
Inês Mendes Pinto and
Boris Rubinstein and
Reto Gassmann and
Ivo Andreas Telley and
Ana Xavier Carvalho Robust gap repair in the contractile
ring ensures timely completion of
cytokinesis . . . . . . . . . . . . . . 789
Katherine S. Lawrence and
Erin C. Tapley and
Victor E. Cruz and
Qianyan Li and
Kayla Aung and
Kevin C. Hart and
Thomas U. Schwartz and
Daniel A. Starr and
JoAnne Engebrecht LINC complexes promote homologous
recombination in part through inhibition
of nonhomologous end joining . . . . . . 801
Tien-chen Lin and
Annett Neuner and
Dirk Flemming and
Peng Liu and
Takumi Chinen and
Ursula Jäkle and
Robert Arkowitz and
Elmar Schiebel MOZART1 and $ \gamma $-tubulin complex
receptors are both required to turn $
\gamma $-TuSC into an active microtubule
nucleation template . . . . . . . . . . 823
Francesca Nazio and
Marianna Carinci and
Cristina Valacca and
Pamela Bielli and
Flavie Strappazzon and
Manuela Antonioli and
Fabiola Ciccosanti and
Carlo Rodolfo and
Silvia Campello and
Gian Maria Fimia and
Claudio Sette and
Paolo Bonaldo and
Francesco Cecconi Fine-tuning of ULK1 mRNA and protein
levels is required for autophagy
oscillation . . . . . . . . . . . . . . 841
Thanh Ngoc Nguyen and
Benjamin Scott Padman and
Joanne Usher and
Viola Oorschot and
Georg Ramm and
Michael Lazarou Atg8 family LC3/GABARAP proteins are
crucial for autophagosome--lysosome
fusion but not autophagosome formation
during PINK1/Parkin mitophagy and
starvation . . . . . . . . . . . . . . . 857
Hsiang-Ting Hsu and
Emily M. Mace and
Alexandre F. Carisey and
Dixita I. Viswanath and
Athanasia E. Christakou and
Martin Wiklund and
Björn Önfelt and
Jordan S. Orange NK cells converge lytic granules to
promote cytotoxicity and prevent
bystander killing . . . . . . . . . . . 875
Ben Short Want to promote tissue growth? There's
an App for that! . . . . . . . . . . . . 1
Andrea Marat Andrew Ewald: Understanding cellular
cooperation . . . . . . . . . . . . . . 2
Brooke J. Bevis Susan Lindquist: Visionary scientist and
peerless mentor . . . . . . . . . . . . 5
Meredith N. Frazier and
Lauren P. Jackson Watching real-time endocytosis in living
cells . . . . . . . . . . . . . . . . . 9
Elisabeth Genot ARF1 at the crossroads of podosome
construction and function . . . . . . . 13
Paolo Pierobon and
Ana-Maria Lennon-Duménil To use or not to use the force: How B
lymphocytes extract surface-tethered
antigens . . . . . . . . . . . . . . . . 17
Simone Sidoli and
Katarzyna Kulej and
Benjamin A. Garcia Why proteomics is not the new genomics
and the future of mass spectrometry in
cell biology . . . . . . . . . . . . . . 21
Lukasz J. Bugaj and
Geoff P. O'Donoghue and
Wendell A. Lim Interrogating cellular perception and
decision making with optogenetic tools 25
Celeste M. Nelson From static to animated: Measuring
mechanical forces in tissues . . . . . . 29
Marina Simian and
Mina J. Bissell Organoids: a historical perspective of
thinking in three dimensions . . . . . . 31
Enrico Monachino and
Lisanne M. Spenkelink and
Antoine M. van Oijen Watching cellular machinery in action,
one molecule at a time . . . . . . . . . 41
Talley J. Lambert and
Jennifer C. Waters Navigating challenges in the application
of superresolution microscopy . . . . . 53
Ben T. Grys and
Dara S. Lo and
Nil Sahin and
Oren Z. Kraus and
Quaid Morris and
Charles Boone and
Brenda J. Andrews Machine learning and computer vision
approaches for phenotypic profiling . . 65
Melina Mathur and
Joy S. Xiang and
Christina D. Smolke Mammalian synthetic biology for studying
the cell . . . . . . . . . . . . . . . . 73
Alexander Benjamin Schendzielorz and
Christian Schulz and
Oleksandr Lytovchenko and
Anne Clancy and
Bernard Guiard and
Raffaele Ieva and
Martin van der Laan and
Peter Rehling Two distinct membrane
potential-dependent steps drive
mitochondrial matrix protein
translocation . . . . . . . . . . . . . 83
Ryan J. Petrie and
Heather M. Harlin and
Lulu I. T. Korsak and
Kenneth M. Yamada Activating the nuclear piston mechanism
of $3$D migration in tumor cells . . . . 93
Tetsuya Hori and
Naoko Kagawa and
Atsushi Toyoda and
Asao Fujiyama and
Sadahiko Misu and
Norikazu Monma and
Fumiaki Makino and
Kazuho Ikeo and
Tatsuo Fukagawa Constitutive centromere-associated
network controls centromere drift in
vertebrate cells . . . . . . . . . . . . 101
Min-Ji Kang and
Deepika Vasudevan and
Kwonyoon Kang and
Kyunggon Kim and
Jung-Eun Park and
Nan Zhang and
Xiaomei Zeng and
Thomas A. Neubert and
Michael T. Marr and
Hyung Don Ryoo 4E-BP is a target of the GCN2--ATF4
pathway during \bionameDrosophila
development and aging . . . . . . . . . 115
Li-Ka Liu and
Vineet Choudhary and
Alexandre Toulmay and
William A. Prinz An inducible ER--Golgi tether
facilitates ceramide transport to
alleviate lipotoxicity . . . . . . . . . 131
Hyo Kyun Chung and
Dongryeol Ryu and
Koon Soon Kim and
Joon Young Chang and
Yong Kyung Kim and
Hyon-Seung Yi and
Seul Gi Kang and
Min Jeong Choi and
Seong Eun Lee and
Saet-Byel Jung and
Min Jeong Ryu and
Soung Jung Kim and
Gi Ryang Kweon and
Hail Kim and
Jung Hwan Hwang and
Chul-Ho Lee and
Se-Jin Lee and
Christopher E. Wall and
Michael Downes and
Ronald M. Evans and
Johan Auwerx and
Minho Shong Growth differentiation factor 15 is a
myomitokine governing systemic energy
homeostasis . . . . . . . . . . . . . . 149
Zuzana Kadlecova and
Stephanie J. Spielman and
Dinah Loerke and
Aparna Mohanakrishnan and
Dana Kim Reed and
Sandra L. Schmid Regulation of clathrin-mediated
endocytosis by hierarchical allosteric
activation of AP2 . . . . . . . . . . . 167
Nisha Bte Mohd Rafiq and
Zi Zhao Lieu and
Tingting Jiang and
Cheng-han Yu and
Paul Matsudaira and
Gareth E. Jones and
Alexander D. Bershadsky Podosome assembly is controlled by the
GTPase ARF1 and its nucleotide exchange
factor ARNO . . . . . . . . . . . . . . 181
Tianliang Sun and
Lida Yang and
Harmandeep Kaur and
Jenny Pestel and
Mario Looso and
Hendrik Nolte and
Cornelius Krasel and
Daniel Heil and
Ramesh K. Krishnan and
Marie-Josée Santoni and
Jean-Paul Borg and
Moritz Bünemann and
Stefan Offermanns and
Jakub M. Swiercz and
Thomas Worzfeld A reverse signaling pathway downstream
of Sema4A controls cell migration via
Scrib . . . . . . . . . . . . . . . . . 199
Katelyn M. Spillane and
Pavel Tolar B cell antigen extraction is regulated
by physical properties of
antigen-presenting cells . . . . . . . . 217
Joseph J. Bruckner and
Hong Zhan and
Scott J. Gratz and
Monica Rao and
Fiona Ukken and
Gregory Zilberg and
Kate M. O'Connor-Giles Fife organizes synaptic vesicles and
calcium channels for high-probability
neurotransmitter release . . . . . . . . 231
Jennifer M. Dyson and
Sarah E. Conduit and
Sandra J. Feeney and
Sandra Hakim and
Tia DiTommaso and
Alex J. Fulcher and
Absorn Sriratana and
Georg Ramm and
Kristy A. Horan and
Rajendra Gurung and
Carol Wicking and
Ian Smyth and
Christina A. Mitchell INPP5E regulates
phosphoinositide-dependent cilia
transition zone function . . . . . . . . 247
Hitoshi Matakatsu and
Seth S. Blair and
Richard G. Fehon The palmitoyltransferase Approximated
promotes growth via the Hippo pathway by
palmitoylation of Fat . . . . . . . . . 265
Ben Short How the vasculature delivers lung
epithelia from an incorrect fate . . . . 2991
Marie Anne O'Donnell Margot Quinlan: Muscling in on oogenesis 2992
James E. Casanova and
Bettina Winckler A new Rab7 effector controls
phosphoinositide conversion in endosome
maturation . . . . . . . . . . . . . . . 2995
Nelson O. Gekara DNA damage-induced immune response:
Micronuclei provide key platform . . . . 2999
Mary Dasso Catch and release: 14-3-3 controls Ncd
in meiotic spindles . . . . . . . . . . 3003
Thomas D. Pollard Nine unanswered questions about
cytokinesis . . . . . . . . . . . . . . 3007
Annalisa Izzo and
Céline Ziegler-Birling and
Peter W. S. Hill and
Lydia Brondani and
Petra Hajkova and
Maria-Elena Torres-Padilla and
Robert Schneider Dynamic changes in H1 subtype
composition during epigenetic
reprogramming . . . . . . . . . . . . . 3017
Robin Beaven and
Ricardo Nunes Bastos and
Christos Spanos and
Pierre Romé and
C. Fiona Cullen and
Juri Rappsilber and
Régis Giet and
Gohta Goshima and
Hiroyuki Ohkura 14-3-3 regulation of Ncd reveals a new
mechanism for targeting proteins to the
spindle in oocytes . . . . . . . . . . . 3029
Chloe E. Snider and
Alaina H. Willet and
Jun-Song Chen and
Göker Arpa\ug and
Marija Zanic and
Kathleen L. Gould Phosphoinositide-mediated ring anchoring
resists perpendicular forces to promote
medial cytokinesis . . . . . . . . . . . 3041
Walter Huynh and
Ronald D. Vale Disease-associated mutations in human
BICD2 hyperactivate motility of
dynein--dynactin . . . . . . . . . . . . 3051
Lauren M. Kraft and
Laura L. Lackner Mitochondria-driven assembly of a
cortical anchor for mitochondria and
dynein . . . . . . . . . . . . . . . . . 3061
Antonis Kourtidis and
Brian Necela and
Wan-Hsin Lin and
Ruifeng Lu and
Ryan W. Feathers and
Yan W. Asmann and
E. Aubrey Thompson and
Panos Z. Anastasiadis Cadherin complexes recruit mRNAs and
RISC to regulate epithelial cell
signaling . . . . . . . . . . . . . . . 3073
Laura Soto Hinojosa and
Manuel Holst and
Christian Baarlink and
Robert Grosse MRTF transcription and Ezrin-dependent
plasma membrane blebbing are required
for entotic invasion . . . . . . . . . . 3087
Yang Yang and
Yanzhe Gao and
Liz Mutter-Rottmayer and
Anastasia Zlatanou and
Michael Durando and
Weimin Ding and
David Wyatt and
Dale Ramsden and
Yuki Tanoue and
Satoshi Tateishi and
Cyrus Vaziri DNA repair factor RAD18 and DNA
polymerase Pol$ \kappa $ confer
tolerance of oncogenic DNA replication
stress . . . . . . . . . . . . . . . . . 3097
Aaron R. Tipton and
Jonathan D. Wren and
John R. Daum and
Joseph C. Siefert and
Gary J. Gorbsky GTSE1 regulates spindle microtubule
dynamics to control Aurora B kinase and
Kif4A chromokinesin on chromosome arms 3117
Qing-Hua Zhang and
Wai Shan Yuen and
Deepak Adhikari and
Jennifer A. Flegg and
Greg FitzHarris and
Marco Conti and
Piotr Sicinski and
Ibtissem Nabti and
Petros Marangos and
John Carroll Cyclin A2 modulates
kinetochore--microtubule attachment in
meiosis II . . . . . . . . . . . . . . . 3133
Diego L. Lapetina and
Christopher Ptak and
Ulyss K. Roesner and
Richard W. Wozniak Yeast silencing factor Sir4 and a subset
of nucleoporins form a complex distinct
from nuclear pore complexes . . . . . . 3145
Xiaoyi Qu and
Feng Ning Yuan and
Carlo Corona and
Silvia Pasini and
Maria Elena Pero and
Gregg G. Gundersen and
Michael L. Shelanski and
Francesca Bartolini Stabilization of dynamic microtubules by
mDia1 drives Tau-dependent A$ \beta_{1 -
42} $ synaptotoxicity . . . . . . . . . 3161
Chao Yang and
Jingchao Wu and
Cecilia de Heus and
Ilya Grigoriev and
Nalan Liv and
Yao Yao and
Ihor Smal and
Erik Meijering and
Judith Klumperman and
Robert Z. Qi and
Anna Akhmanova EB1 and EB3 regulate microtubule minus
end organization and Golgi morphology 3179
Qiang Gao and
Derk D. Binns and
Lisa N. Kinch and
Nick V. Grishin and
Natalie Ortiz and
Xiao Chen and
Joel M. Goodman Pet10p is a yeast perilipin that
stabilizes lipid droplets and promotes
their assembly . . . . . . . . . . . . . 3199
Arun T. John Peter and
Beatrice Herrmann and
Diana Antunes and
Doron Rapaport and
Kai Stefan Dimmer and
Beno\^\it Kornmann Vps13-Mcp1 interact at
vacuole--mitochondria interfaces and
bypass ER--mitochondria contact sites 3219
Jonathon L. Burman and
Sarah Pickles and
Chunxin Wang and
Shiori Sekine and
Jose Norberto S. Vargas and
Zhe Zhang and
Alice M. Youle and
Catherine L. Nezich and
Xufeng Wu and
John A. Hammer and
Richard J. Youle Mitochondrial fission facilitates the
selective mitophagy of protein
aggregates . . . . . . . . . . . . . . . 3231
Andrey S. Selyunin and
Lakesla R. Iles and
Geoffrey Bartholomeusz and
Somshuvra Mukhopadhyay Genome-wide siRNA screen identifies
UNC50 as a regulator of Shiga toxin 2
trafficking . . . . . . . . . . . . . . 3249
Masahide Oku and
Yuichiro Maeda and
Yoko Kagohashi and
Takeshi Kondo and
Mai Yamada and
Toyoshi Fujimoto and
Yasuyoshi Sakai Evidence for ESCRT- and
clathrin-dependent microautophagy . . . 3263
Chris MacDonald and
Robert C. Piper Genetic dissection of early endosomal
recycling highlights a TORC1-independent
role for Rag GTPases . . . . . . . . . . 3275
Swetha Gowrishankar and
Yumei Wu and
Shawn M. Ferguson Impaired JIP3-dependent axonal lysosome
transport promotes amyloid plaque
pathology . . . . . . . . . . . . . . . 3291
Kai Liu and
Ruxiao Xing and
Youli Jian and
Zhiyang Gao and
Xinli Ma and
Xiaojuan Sun and
Yang Li and
Meng Xu and
Xin Wang and
Yudong Jing and
Weixiang Guo and
Chonglin Yang WDR91 is a Rab7 effector required for
neuronal development . . . . . . . . . . 3307
Maria Fiuza and
Christine M. Rostosky and
Gabrielle T. Parkinson and
Alexei M. Bygrave and
Nagaraj Halemani and
Marcio Baptista and
Ira Milosevic and
Jonathan G. Hanley PICK1 regulates AMPA receptor
endocytosis via direct interactions with
AP2 $ \alpha $-appendage and dynamin . . 3323
Rebecca McLennan and
Caleb M. Bailey and
Linus J. Schumacher and
Jessica M. Teddy and
Jason A. Morrison and
Jennifer C. Kasemeier-Kulesa and
Lauren A. Wolfe and
Madeline M. Gogol and
Ruth E. Baker and
Philip K. Maini and
Paul M. Kulesa DAN (NBL1) promotes collective neural
crest migration by restraining
uncontrolled invasion . . . . . . . . . 3339
Gongping Sun and
Elmer Guzman and
Varuzhan Balasanyan and
Christopher M. Conner and
Kirsten Wong and
Hongjun Robin Zhou and
Kenneth S. Kosik and
Denise J. Montell A molecular signature for anastasis,
recovery from the brink of apoptotic
cell death . . . . . . . . . . . . . . . 3355
Jiayi Yao and
Pierre J. Guihard and
Xiuju Wu and
Ana M. Blazquez-Medela and
Melissa J. Spencer and
Medet Jumabay and
Peter Tontonoz and
Alan M. Fogelman and
Kristina I. Boström and
Yucheng Yao Vascular endothelium plays a key role in
directing pulmonary epithelial cell
differentiation . . . . . . . . . . . . 3369
Guillaume Jacquemet and
Ilkka Paatero and
Alexandre F. Carisey and
Artur Padzik and
Jordan S. Orange and
Hellyeh Hamidi and
Johanna Ivaska FiloQuant reveals increased filopodia
density during breast cancer progression 3387
Vasja Urban\vci\vc and
Richard Butler and
Benjamin Richier and
Manuel Peter and
Julia Mason and
Frederick J. Livesey and
Christine E. Holt and
Jennifer L. Gallop Filopodyan: an open-source pipeline for
the analysis of filopodia . . . . . . . 3405
Paola Kuri and
Nicole L. Schieber and
Thomas Thumberger and
Joachim Wittbrodt and
Yannick Schwab and
Maria Leptin Correction: Dynamics of in vivo ASC
speck formation . . . . . . . . . . . . 3423
Ben Short A three-alarm signal for endocytosis? 3425
Marie Anne O'Donnell Ling-Ling Chen: Shaping a career in RNA
biology . . . . . . . . . . . . . . . . 3426
Luisa Robbez-Masson and
Christopher H. C. Tie and
Helen M. Rowe Cancer cells, on your histone marks, get
SETDB1, silence retrotransposons, and
go! . . . . . . . . . . . . . . . . . . 3429
John P. Chamberland and
Brigitte Ritter Retromer revisited: Evolving roles for
retromer in endosomal sorting . . . . . 3433
Laura Machesky and
Vania M. M. Braga So far, yet so close: $ \alpha $-Catenin
dimers help migrating cells get together 3437
Heidi K. Norton and
Jennifer E. Phillips-Cremins Crossed wires: $3$D genome misfolding in
human disease . . . . . . . . . . . . . 3441
Chih-Chia Chang and
Tzu-Lun Huang and
Yuta Shimamoto and
Su-Yi Tsai and
Kuo-Chiang Hsia Regulation of mitotic spindle assembly
factor NuMA by Importin-$ \beta $ . . . 3453
Ricardo M. Leitao and
Douglas R. Kellogg The duration of mitosis and daughter
cell size are modulated by nutrients in
budding yeast . . . . . . . . . . . . . 3463
Babet van der Vaart and
Josef Fischböck and
Christine Mieck and
Peter Pichler and
Karl Mechtler and
René H. Medema and
Stefan Westermann TORC1 signaling exerts spatial control
over microtubule dynamics by promoting
nuclear export of Stu2 . . . . . . . . . 3471
Vivien Krüger and
Thomas Becker and
Lars Becker and
Malayko Montilla-Martinez and
Lars Ellenrieder and
F.-Nora Vögtle and
Helmut E. Meyer and
Michael T. Ryan and
Nils Wiedemann and
Bettina Warscheid and
Nikolaus Pfanner and
Richard Wagner and
Chris Meisinger Identification of new channels by
systematic analysis of the mitochondrial
outer membrane . . . . . . . . . . . . . 3485
Ronald L. Neppl and
Chia-Ling Wu and
Kenneth Walsh lncRNA Chronos is an aging-induced
inhibitor of muscle hypertrophy . . . . 3497
Youmna Attieh and
Andrew G. Clark and
Carina Grass and
Sophie Richon and
Marc Pocard and
Pascale Mariani and
Nadia Elkhatib and
Timo Betz and
Basile Gurchenkov and
Danijela Matic Vignjevic Cancer-associated fibroblasts lead tumor
invasion through integrin-$ \beta
$3-dependent fibronectin assembly . . . 3509
Dharm S. Patel and
Sarah M. Misenko and
Joonyoung Her and
Samuel F. Bunting BLM helicase regulates DNA repair by
counteracting RAD51 loading at DNA
double-strand break sites . . . . . . . 3521
Trinna L. Cuellar and
Anna-Maria Herzner and
Xiaotian Zhang and
Yogesh Goyal and
Colin Watanabe and
Brad A. Friedman and
Vasantharajan Janakiraman and
Steffen Durinck and
Jeremy Stinson and
David Arnott and
Tommy K. Cheung and
Subhra Chaudhuri and
Zora Modrusan and
Jonas Martin Doerr and
Marie Classon and
Benjamin Haley Silencing of retrotransposons by SETDB1
inhibits the interferon response in
acute myeloid leukemia . . . . . . . . . 3535
Karthik Dhatchinamoorthy and
Manjunatha Shivaraju and
Jeffrey J. Lange and
Boris Rubinstein and
Jay R. Unruh and
Brian D. Slaughter and
Jennifer L. Gerton Structural plasticity of the living
kinetochore . . . . . . . . . . . . . . 3551
Leah Bury and
Paula A. Coelho and
Angela Simeone and
Samantha Ferries and
Claire E. Eyers and
Patrick A. Eyers and
Magdalena Zernicka-Goetz and
David M. Glover Plk4 and Aurora A cooperate in the
initiation of acentriolar spindle
assembly in mammalian oocytes . . . . . 3571
Silvia Salas-Pino and
Paola Gallardo and
Ramón R. Barrales and
Sigurd Braun and
Rafael R. Daga The fission yeast nucleoporin Alm1 is
required for proteasomal degradation of
kinetochore components . . . . . . . . . 3591
Larisa E. Kapinos and
Binlu Huang and
Chantal Rencurel and
Roderick Y. H. Lim Karyopherins regulate nuclear pore
complex barrier and transport function 3609
Shiteshu Shrimal and
Natalia A. Cherepanova and
Reid Gilmore DC2 and KCP2 mediate the interaction
between the oligosaccharyltransferase
and the ER translocon . . . . . . . . . 3625
Shuai Wang and
Chien-I. Yang and
Shu-ou Shan SecA mediates cotranslational targeting
and translocation of an inner membrane
protein . . . . . . . . . . . . . . . . 3639
Konstantin Feinberg and
Adelaida Kolaj and
Chen Wu and
Natalie Grinshtein and
Jonathan R. Krieger and
Michael F. Moran and
Lee L. Rubin and
Freda D. Miller and
David R. Kaplan A neuroprotective agent that inactivates
prodegenerative TrkA and preserves
mitochondria . . . . . . . . . . . . . . 3655
Arunas Kvainickas and
Ana Jimenez-Orgaz and
Heike Nägele and
Zehan Hu and
Jörn Dengjel and
Florian Steinberg Cargo-selective SNX--BAR proteins
mediate retromer trimer independent
retrograde transport . . . . . . . . . . 3677
Boris Simonetti and
Chris M. Danson and
Kate J. Heesom and
Peter J. Cullen Sequence-dependent cargo recognition by
SNX--BARs mediates retromer-independent
transport of CI--MPR . . . . . . . . . . 3695
Amandine Pitaval and
Fabrice Senger and
Gaëlle Letort and
Xavier Gidrol and
Laurent Guyon and
James Sillibourne and
Manuel Théry Microtubule stabilization drives $3$D
centrosome migration to initiate primary
ciliogenesis . . . . . . . . . . . . . . 3713
Yuliya Zilberman and
Joshua Abrams and
Dorian C. Anderson and
Jeremy Nance Cdc42 regulates junctional actin but not
cell polarization in the
\bionameCaenorhabditis elegans epidermis 3729
Frederic Daste and
Astrid Walrant and
Mikkel R. Holst and
Jonathan R. Gadsby and
Julia Mason and
Ji-Eun Lee and
Daniel Brook and
Marcel Mettlen and
Elin Larsson and
Steven F. Lee and
Richard Lundmark and
Jennifer L. Gallop Control of actin polymerization via the
coincidence of phosphoinositides and
high membrane curvature . . . . . . . . 3745
Megan N. Wood and
Noboru Ishiyama and
Indira Singaram and
Connie M. Chung and
Annette S. Flozak and
Alex Yemelyanov and
Mitsu Ikura and
Wonhwa Cho and
Cara J. Gottardi $ \alpha $-Catenin homodimers are
recruited to phosphoinositide-activated
membranes to promote adhesion . . . . . 3767
Ralph T. Böttcher and
Maik Veelders and
Pascaline Rombaut and
Jan Faix and
Marina Theodosiou and
Theresa E. Stradal and
Klemens Rottner and
Roy Zent and
Franz Herzog and
Reinhard Fässler Kindlin-2 recruits paxillin and Arp2/3
to promote membrane protrusions during
initial cell spreading . . . . . . . . . 3785
Begum Erdogan and
Mingfang Ao and
Lauren M. White and
Anna L. Means and
Bryson M. Brewer and
Lijie Yang and
M. Kay Washington and
Chanjuan Shi and
Omar E. Franco and
Alissa M. Weaver and
Simon W. Hayward and
Deyu Li and
Donna J. Webb Cancer-associated fibroblasts promote
directional cancer cell migration by
aligning fibronectin . . . . . . . . . . 3799
Tara Capece and
Brandon L. Walling and
Kihong Lim and
Kyun-Do Kim and
Seyeon Bae and
Hung-Li Chung and
David J. Topham and
Minsoo Kim A novel intracellular pool of LFA-1 is
critical for asymmetric CD8$^+$ T cell
activation and differentiation . . . . . 3817
Garret R. Anderson and
Stephan Maxeiner and
Richard Sando and
Theodoros Tsetsenis and
Robert C. Malenka and
Thomas C. Südhof Postsynaptic adhesion GPCR latrophilin-2
mediates target recognition in
entorhinal-hippocampal synapse assembly 3831
Francisco Lázaro-Diéguez and
Anne Müsch Cell--cell adhesion accounts for the
different orientation of columnar and
hepatocytic cell divisions . . . . . . . 3847
Matthew R. Avenarius and
Jocelyn F. Krey and
Rachel A. Dumont and
Clive P. Morgan and
Connor B. Benson and
Sarath Vijayakumar and
Christopher L. Cunningham and
Deborah I. Scheffer and
David P. Corey and
Ulrich Müller and
Sherri M. Jones and
Peter G. Barr-Gillespie Heterodimeric capping protein is
required for stereocilia length and
width regulation . . . . . . . . . . . . 3861
Patricia Melloy and
Shu Shen and
Erin White and
J. Richard McIntosh and
Mark D. Rose Correction: Nuclear fusion during yeast
mating occurs by a three-step pathway 3883
Jodi Nunnari and
Rebecca Alvania Introducing a new look for JCB . . . . . 3885
Ben Short UNC-45a helps cells manage their stress
levels . . . . . . . . . . . . . . . . . 3887
Marie Anne O'Donnell Nasser Rusan: Scoping out centrosomes 3889
Alejandra I. Romero-Morales and
Natalya A. Ortolano and
Vivian Gama Apical polarization and lumenogenesis:
The apicosome sheds new light . . . . . 3891
Alexandria Colaço and
Marja Jäättelä Ragulator --- a multifaceted regulator
of lysosomal signaling and trafficking 3895
Min Wu Pulses and waves of contractility . . . 3899
Simon Pan and
Jonah R. Chan Regulation and dysregulation of axon
infrastructure by myelinating glia . . . 3903
Hibiki Kawamata and
Giovanni Manfredi Proteinopathies and OXPHOS dysfunction
in neurodegenerative diseases . . . . . 3917
Elias Cornejo and
Philipp Schlaermann and
Shaeri Mukherjee How to rewire the host cell: a home
improvement guide for intracellular
bacteria . . . . . . . . . . . . . . . . 3931
Simon I. R. Lane and
Keith T. Jones Chromosome biorientation and APC
activity remain uncoupled in oocytes
with reduced volume . . . . . . . . . . 3949
Mitsutoshi Nakamura and
Jeffrey M. Verboon and
Susan M. Parkhurst Prepatterning by RhoGEFs governs Rho
GTPase spatiotemporal dynamics during
wound repair . . . . . . . . . . . . . . 3959
Jean A. Smith and
Allison E. Hall and
Mark D. Rose Membrane curvature directs the
localization of Cdc42p to novel foci
required for cell--cell fusion . . . . . 3971
Kenichiro Taniguchi and
Yue Shao and
Ryan F. Townshend and
Chari L. Cortez and
Clair E. Harris and
Sasha Meshinchi and
Sundeep Kalantry and
Jianping Fu and
K. Sue O'Shea and
Deborah L. Gumucio An apicosome initiates self-organizing
morphogenesis of human pluripotent stem
cells . . . . . . . . . . . . . . . . . 3981
Emily Yun-Chia Chang and
Carolina A. Novoa and
Maria J. Aristizabal and
Yan Coulombe and
Romulo Segovia and
Richa Chaturvedi and
Yaoqing Shen and
Christelle Keong and
Annie S. Tam and
Steven J. M. Jones and
Jean-Yves Masson and
Michael S. Kobor and
Peter C. Stirling RECQ-like helicases Sgs1 and BLM
regulate R-loop--associated genome
instability . . . . . . . . . . . . . . 3991
María Moriel-Carretero and
Sara Ovejero and
Marie Gérus-Durand and
Dimos Vryzas and
Angelos Constantinou Fanconi anemia FANCD2 and FANCI proteins
regulate the nuclear dynamics of
splicing factors . . . . . . . . . . . . 4007
Veena Mathew and
Annie S. Tam and
Karissa L. Milbury and
Analise K. Hofmann and
Christopher S. Hughes and
Gregg B. Morin and
Christopher J. R. Loewen and
Peter C. Stirling Selective aggregation of the splicing
factor Hsh155 suppresses splicing upon
genotoxic stress . . . . . . . . . . . . 4027
David Ribet and
Serena Boscaini and
Clothilde Cauvin and
Martin Siguier and
Serge Mostowy and
Arnaud Echard and
Pascale Cossart SUMOylation of human septins is critical
for septin filament bundling and
cytokinesis . . . . . . . . . . . . . . 4041
Jaakko I. Lehtimäki and
Aidan M. Fenix and
Tommi M. Kotila and
Giuseppe Balistreri and
Lassi Paavolainen and
Markku Varjosalo and
Dylan T. Burnette and
Pekka Lappalainen UNC-45a promotes myosin folding and
stress fiber assembly . . . . . . . . . 4053
Darko Stojkov and
Poorya Amini and
Kevin Oberson and
Christiane Sokollik and
Andrea Duppenthaler and
Hans-Uwe Simon and
Shida Yousefi ROS and glutathionylation balance
cytoskeletal dynamics in neutrophil
extracellular trap formation . . . . . . 4073
Ming-Xin An and
Si Li and
Han-Bing Yao and
Chao Li and
Jia-Mei Wang and
Jia Sun and
Xin-Yu Li and
Xiao-Na Meng and
Hua-Qin Wang BAG3 directly stabilizes Hexokinase 2
mRNA and promotes aerobic glycolysis in
pancreatic cancer cells . . . . . . . . 4091
Nina Judith Hos and
Raja Ganesan and
Saray Gutiérrez and
Deniz Hos and
Jennifer Klimek and
Zeinab Abdullah and
Martin Krönke and
Nirmal Robinson Type I interferon enhances necroptosis
of Salmonella Typhimurium--infected
macrophages by impairing antioxidative
stress responses . . . . . . . . . . . . 4107
Wei-Ke Ji and
Rajarshi Chakrabarti and
Xintao Fan and
Lori Schoenfeld and
Stefan Strack and
Henry N. Higgs Receptor-mediated Drp1 oligomerization
on endoplasmic reticulum . . . . . . . . 4123
Yu Chen and
David C. Gershlick and
Sang Yoon Park and
Juan S. Bonifacino Segregation in the Golgi complex
precedes export of endolysosomal
proteins in distinct transport carriers 4141
Junwan Fan and
Yaqing Wang and
Liang Liu and
Hongsheng Zhang and
Feng Zhang and
Lei Shi and
Mei Yu and
Fei Gao and
Zhiheng Xu cTAGE5 deletion in pancreatic $ \beta $
cells impairs proinsulin trafficking and
insulin biogenesis in mice . . . . . . . 4153
Helen Court and
Ian M. Ahearn and
Marc Amoyel and
Erika A. Bach and
Mark R. Philips Regulation of NOTCH signaling by RAB7
and RAB8 requires carboxyl methylation
by ICMT . . . . . . . . . . . . . . . . 4165
Jing Pu and
Tal Keren-Kaplan and
Juan S. Bonifacino A Ragulator--BORC interaction controls
lysosome positioning in response to
amino acid availability . . . . . . . . 4183
Przemyslaw A. Filipek and
Mariana E. G. de Araujo and
Georg F. Vogel and
Cedric H. De Smet and
Daniela Eberharter and
Manuele Rebsamen and
Elena L. Rudashevskaya and
Leopold Kremser and
Teodor Yordanov and
Philipp Tschaikner and
Barbara G. Fürnrohr and
Stefan Lechner and
Theresia Dunzendorfer-Matt and
Klaus Scheffzek and
Keiryn L. Bennett and
Giulio Superti-Furga and
Herbert H. Lindner and
Taras Stasyk and
Lukas A. Huber LAMTOR\slash Ragulator is a negative
regulator of Arl8b- and BORC-dependent
late endosomal positioning . . . . . . . 4199
Zhi Hong and
Nina Marie Pedersen and
Ling Wang and
Maria Lyngaas Torgersen and
Harald Stenmark and
Camilla Raiborg PtdIns3P controls mTORC1 signaling
through lysosomal positioning . . . . . 4217
Julia D. Romano and
Sabrina J. Nolan and
Corey Porter and
Karen Ehrenman and
Eric J. Hartman and
Ru-ching Hsia and
Isabelle Coppens The parasite Toxoplasma sequesters
diverse Rab host vesicles within an
intravacuolar network . . . . . . . . . 4235
Brajendra K. Tripathi and
Tiera Grant and
Xiaolan Qian and
Ming Zhou and
Philipp Mertins and
Dunrui Wang and
Alex G. Papageorge and
Sergey G. Tarasov and
Kent W. Hunter and
Steven A. Carr and
Douglas R. Lowy Receptor tyrosine kinase activation of
RhoA is mediated by AKT phosphorylation
of DLC1 . . . . . . . . . . . . . . . . 4255
Melanie Graessl and
Johannes Koch and
Abram Calderon and
Dominic Kamps and
Soumya Banerjee and
Tomá\vs Mazel and
Nina Schulze and
Jana Kathrin Jungkurth and
Rutuja Patwardhan and
Djamschid Solouk and
Nico Hampe and
Bernd Hoffmann and
Leif Dehmelt and
Perihan Nalbant An excitable Rho GTPase signaling
network generates dynamic subcellular
contraction patterns . . . . . . . . . . 4271
Caitlin W. Brown and
John J. Amante and
Hira Lal Goel and
Arthur M. Mercurio The $ \alpha $6$ \beta $4 integrin
promotes resistance to ferroptosis . . . 4287
Noémie Druelle and
Andhira Vieira and
Aidin Shabro and
Monica Courtney and
Magali Mondin and
Samah Rekima and
Tiziana Napolitano and
Serena Silvano and
Sergi Navarro-Sanz and
Biljana Hadzic and
Fabio Avolio and
Minoo Rassoulzadegan and
Herbert A. Schmid and
Ahmed Mansouri and
Patrick Collombat Ectopic expression of Pax4 in pancreatic
$ \delta $ cells results in $ \beta
$-like cell neogenesis . . . . . . . . . 4299
Shinichi Nakamuta and
Yu-Ting Yang and
Chia-Lin Wang and
Nicholas B. Gallo and
Jia-Ray Yu and
Yilin Tai and
Linda Van Aelst Dual role for DOCK7 in tangential
migration of interneuron precursors in
the postnatal forebrain . . . . . . . . 4313
Sara K. Donnelly and
Ramon Cabrera and
Serena P. H. Mao and
John R. Christin and
Bin Wu and
Wenjun Guo and
Jose Javier Bravo-Cordero and
John S. Condeelis and
Jeffrey E. Segall and
Louis Hodgson Rac3 regulates breast cancer invasion
and metastasis by controlling adhesion
and matrix degradation . . . . . . . . . 4331
Laura A. Wood and
Gabrielle Larocque and
Nicholas I. Clarke and
Sourav Sarkar and
Stephen J. Royle New tools for ``hot-wiring''
clathrin-mediated endocytosis with
temporal and spatial precision . . . . . 4351
Ben Short Merlin weaves its magic on peripheral
nerve repair . . . . . . . . . . . . . . 283
Melina Casadio Alberto Kornblihtt: Coupling alternative
splicing with transcription . . . . . . 284
Maya Schuldiner and
Einat Zalckvar Incredibly close --- A newly identified
peroxisome--ER contact site in humans 287
Aruni P. Senaratne and
Ines A. Drinnenberg All that is old does not wither:
Conservation of outer kinetochore
proteins across all eukaryotes? . . . . 291
Marcel A. T. M. van Vugt Shutting down the power supply for DNA
repair in cancer cells . . . . . . . . . 295
Margaret D. Myers and
Gregory S. Payne Vps13 and Cdc31/centrin: Puzzling
partners in membrane traffic . . . . . . 299
Vladimir Todorov and
Andreas Linkermann Back to the roots of regulated necrosis 303
Sangkyun Cho and
Jerome Irianto and
Dennis E. Discher Mechanosensing by the nucleus: From
pathways to scaling relationships . . . 305
Oguzhan Atay and
Jan M. Skotheim Spatial and temporal signal processing
and decision making by MAPK pathways . . 317
Joseph L. Costello and
Inês G. Castro and
Christian Hacker and
Tina A. Schrader and
Jeremy Metz and
Dagmar Zeuschner and
Afsoon S. Azadi and
Luis F. Godinho and
Victor Costina and
Peter Findeisen and
Andreas Manner and
Markus Islinger and
Michael Schrader ACBD5 and VAPB mediate membrane
associations between peroxisomes and the
ER . . . . . . . . . . . . . . . . . . . 331
Michael Ebner and
Benjamin Sinkovics and
Magdalena Szczygie\l and
Daniela Wolfschoon Ribeiro and
Ivan Yudushkin Localization of mTORC2 activity inside
cells . . . . . . . . . . . . . . . . . 343
Daniel Cirera-Salinas and
Jian Yu and
Maxime Bodak and
Richard P. Ngondo and
Kristina M. Herbert and
Constance Ciaudo Noncanonical function of DGCR8 controls
mESC exit from pluripotency . . . . . . 355
Rong Hua and
Derrick Cheng and
Étienne Coyaud and
Spencer Freeman and
Erminia Di Pietro and
Yuqing Wang and
Adriano Vissa and
Christopher M. Yip and
Gregory D. Fairn and
Nancy Braverman and
John H. Brumell and
William S. Trimble and
Brian Raught and
Peter K. Kim VAPs and ACBD5 tether peroxisomes to the
ER for peroxisome maintenance and lipid
homeostasis . . . . . . . . . . . . . . 367
Simon D'Archivio and
Bill Wickstead Trypanosome outer kinetochore proteins
suggest conservation of chromosome
segregation machinery across eukaryotes 379
Benjamin Alleva and
Nathan Balukoff and
Amy Peiper and
Sarit Smolikove Regulating chromosomal movement by the
cochaperone FKB-6 ensures timely pairing
and synapsis . . . . . . . . . . . . . . 393
Jia Qu and
Wenyi Sun and
Jie Zhong and
Hao Lv and
Mingrui Zhu and
Jun Xu and
Nan Jin and
Zuoquan Xie and
Minjia Tan and
Shu-Hai Lin and
Meiyu Geng and
Jian Ding and
Min Huang Phosphoglycerate mutase 1 regulates dNTP
pool and promotes homologous
recombination repair in cancer cells . . 409
Mithu De and
Austin N. Oleskie and
Mariam Ayyash and
Somnath Dutta and
Liliya Mancour and
Mohamed E. Abazeed and
Eddy J. Brace and
Georgios Skiniotis and
Robert S. Fuller The Vps13p--Cdc31p complex is directly
required for TGN late endosome transport
and TGN homotypic fusion . . . . . . . . 425
Amanda L. Neisch and
Thomas P. Neufeld and
Thomas S. Hays A STRIPAK complex mediates axonal
transport of autophagosomes and dense
core vesicles through PP2A regulation 441
Ayelén Mariana Distéfano and
María Victoria Martin and
Juan Pablo Córdoba and
Andrés Martín Bellido and
Sebastián D'Ippólito and
Silvana Lorena Colman and
Débora Soto and
Juan Alfredo Roldán and
Carlos Guillermo Bartoli and
Eduardo Julián Zabaleta and
Diego Fernando Fiol and
Brent R. Stockwell and
Scott J. Dixon and
Gabriela Carolina Pagnussat Heat stress induces ferroptosis-like
cell death in plants . . . . . . . . . . 463
Shuji Wakatsuki and
Shinji Tokunaga and
Megumi Shibata and
Toshiyuki Araki GSK3B-mediated phosphorylation of MCL1
regulates axonal autophagy to promote
Wallerian degeneration . . . . . . . . . 477
Thomas Mindos and
Xin-peng Dun and
Katherine North and
Robin D. S. Doddrell and
Alexander Schulz and
Philip Edwards and
James Russell and
Bethany Gray and
Sheridan L. Roberts and
Aditya Shivane and
Georgina Mortimer and
Melissa Pirie and
Nailing Zhang and
Duojia Pan and
Helen Morrison and
David B. Parkinson Merlin controls the repair capacity of
Schwann cells after injury by regulating
Hippo/YAP activity . . . . . . . . . . . 495
Bradlee Nelms and
Natasha Furtado Dalomba and
Wayne Lencer A targeted RNAi screen identifies
factors affecting diverse stages of
receptor-mediated transcytosis . . . . . 511
Ben Short Tubby proteins prove their adaptability 527
Marie Anne O'Donnell Erin Goley: Catching the bug for
studying the cytoskeleton . . . . . . . 528
Mary A. Logan Fragile phagocytes: FMRP positively
regulates engulfment activity . . . . . 531
Kenji Shimada and
Susan M. Gasser A game of musical chairs: Pro- and
anti-resection factors compete for
TOPBP1 binding after DNA damage . . . . 535
Nick R. Leslie Importin-11 keeps PTEN safe from harm 539
Daniel A. Starr and
Lesilee S. Rose TorsinA regulates the LINC to moving
nuclei . . . . . . . . . . . . . . . . . 543
Jerry Edward Chipuk and
Mark P. A. Luna-Vargas The peroxisomes strike BAK: Regulation
of peroxisome integrity by the Bcl-2
family . . . . . . . . . . . . . . . . . 547
Carles Cantó The heat shock factor HSF1 juggles
protein quality control and metabolic
regulation . . . . . . . . . . . . . . . 551
Xin Qi eIF2$ \alpha $ links mitochondrial
dysfunction to dendritic degeneration 555
Shaohe Wang and
Rei Sekiguchi and
William P. Daley and
Kenneth M. Yamada Patterned cell and matrix dynamics in
branching morphogenesis . . . . . . . . 559
Clari Valansi and
David Moi and
Evgenia Leikina and
Elena Matveev and
Martín Graña and
Leonid V. Chernomordik and
Héctor Romero and
Pablo S. Aguilar and
Benjamin Podbilewicz Arabidopsis HAP2/GCS1 is a gamete fusion
protein homologous to somatic and viral
fusogens . . . . . . . . . . . . . . . . 571
Thomas R. Lerner and
Sophie Borel and
Daniel J. Greenwood and
Urska Repnik and
Matthew R. G. Russell and
Susanne Herbst and
Martin L. Jones and
Lucy M. Collinson and
Gareth Griffiths and
Maximiliano G. Gutierrez Mycobacterium tuberculosis replicates
within necrotic human macrophages . . . 583
Reed M. O'Connor and
Elizabeth F. Stone and
Charlotte R. Wayne and
Emily V. Marcinkevicius and
Matt Ulgherait and
Rebecca Delventhal and
Meghan M. Pantalia and
Vanessa M. Hill and
Clarice G. Zhou and
Sophie McAllister and
Anna Chen and
Jennifer S. Ziegenfuss and
Wesley B. Grueber and
Julie C. Canman and
Mimi M. Shirasu-Hiza A \bionameDrosophila model of Fragile X
syndrome exhibits defects in
phagocytosis by innate immune cells . . 595
Yael Nechemia-Arbely and
Daniele Fachinetti and
Karen H. Miga and
Nikolina Sekulic and
Gautam V. Soni and
Dong Hyun Kim and
Adeline K. Wong and
Ah Young Lee and
Kristen Nguyen and
Cees Dekker and
Bing Ren and
Ben E. Black and
Don W. Cleveland Human centromeric CENP--A chromatin is a
homotypic, octameric nucleosome at all
cell cycle points . . . . . . . . . . . 607
Yi Liu and
José Renato Cussiol and
Diego Dibitetto and
Jennie Rae Sims and
Shyam Twayana and
Robert Samuel Weiss and
Raimundo Freire and
Federica Marini and
Achille Pellicioli and
Marcus Bustamante Smolka TOPBP1$^{\rm Dpb11}$ plays a conserved
role in homologous recombination DNA
repair through the coordinated
recruitment of 53BP1$^{Rad9}$ . . . . . 623
Muhan Chen and
Dawid G. Nowak and
Navneet Narula and
Brian Robinson and
Kaitlin Watrud and
Alexandra Ambrico and
Tali M. Herzka and
Martha E. Zeeman and
Matthias Minderer and
Wu Zheng and
Saya H. Ebbesen and
Kendra S. Plafker and
Carlos Stahlhut and
Victoria M. Y. Wang and
Lorna Wills and
Abu Nasar and
Mireia Castillo-Martin and
Carlos Cordon-Cardo and
John E. Wilkinson and
Scott Powers and
Raffaella Sordella and
Nasser K. Altorki and
Vivek Mittal and
Brendon M. Stiles and
Scott M. Plafker and
Lloyd C. Trotman The nuclear transport receptor
Importin-11 is a tumor suppressor that
maintains PTEN protein . . . . . . . . . 641
Cosmo A. Saunders and
Nathan J. Harris and
Patrick T. Willey and
Brian M. Woolums and
Yuexia Wang and
Alex J. McQuown and
Amy Schoenhofen and
Howard J. Worman and
William T. Dauer and
Gregg G. Gundersen and
G. W. Gant Luxton TorsinA controls TAN line assembly and
the retrograde flow of dorsal
perinuclear actin cables during rearward
nuclear movement . . . . . . . . . . . . 657
Désirée Schatton and
David Pla-Martin and
Marie-Charlotte Marx and
Henriette Hansen and
Arnaud Mourier and
Ivan Nemazanyy and
Alberto Pessia and
Peter Zentis and
Teresa Corona and
Vangelis Kondylis and
Esther Barth and
Astrid C. Schauss and
Vidya Velagapudi and
Elena I. Rugarli CLUH regulates mitochondrial metabolism
by controlling translation and decay of
target mRNAs . . . . . . . . . . . . . . 675
Melissa Vos and
Ann Geens and
Claudia Böhm and
Liesbeth Deaulmerie and
Jef Swerts and
Matteo Rossi and
Katleen Craessaerts and
Elvira P. Leites and
Philip Seibler and
Aleksandar Rakovic and
Thora Lohnau and
Bart De Strooper and
Sarah-Maria Fendt and
Vanessa A. Morais and
Christine Klein and
Patrik Verstreken Cardiolipin promotes electron transport
between ubiquinone and complex I to
rescue PINK1 deficiency . . . . . . . . 695
Ken-ichiro Hosoi and
Non Miyata and
Satoru Mukai and
Satomi Furuki and
Kanji Okumoto and
Emily H. Cheng and
Yukio Fujiki The VDAC2--BAK axis regulates
peroxisomal membrane permeability . . . 709
Aijun Qiao and
Xiongjie Jin and
Junfeng Pang and
Demetrius Moskophidis and
Nahid F. Mivechi The transcriptional regulator of the
chaperone response HSF1 controls hepatic
bioenergetics and protein homeostasis 723
Hemant B. Badgandi and
Sun-hee Hwang and
Issei S. Shimada and
Evan Loriot and
Saikat Mukhopadhyay Tubby family proteins are adapters for
ciliary trafficking of integral membrane
proteins . . . . . . . . . . . . . . . . 743
Lei Xiong and
Ji-Ung Jung and
Hao-Han Guo and
Jin-Xiu Pan and
Xiang-Dong Sun and
Lin Mei and
Wen-Cheng Xiong Osteoblastic Lrp4 promotes
osteoclastogenesis by regulating ATP
release and adenosine--A$_{2A}$ R
signaling . . . . . . . . . . . . . . . 761
Bryan Vander Lugt and
Jeremy Riddell and
Aly A. Khan and
Jason A. Hackney and
Justin Lesch and
Jason DeVoss and
Matthew T. Weirauch and
Harinder Singh and
Ira Mellman Transcriptional determinants of
tolerogenic and immunogenic states
during dendritic cell maturation . . . . 779
Mehri Moradi and
Rajeeve Sivadasan and
Lena Saal and
Patrick Lüningschrör and
Benjamin Dombert and
Reena Jagdish Rathod and
Daniela C. Dieterich and
Robert Blum and
Michael Sendtner Differential roles of $ \alpha $-, $
\beta $-, and $ \gamma $-actin in axon
growth and collateral branch formation
in motoneurons . . . . . . . . . . . . . 793
Taiichi Tsuyama and
Asako Tsubouchi and
Tadao Usui and
Hiromi Imamura and
Tadashi Uemura Mitochondrial dysfunction induces
dendritic loss via eIF2$ \alpha $
phosphorylation . . . . . . . . . . . . 815
David Labrousse-Arias and
Emma Martínez-Alonso and
María Corral-Escariz and
Raquel Bienes-Martínez and
Jaime Berridy and
Leticia Serrano-Oviedo and
Elisa Conde and
María-Laura García-Bermejo and
José M. Giménez-Bachs and
Antonio S. Salinas-Sánchez and
Ricardo Sánchez-Prieto and
Masahiro Yao and
Marina Lasa and
María J. Calzada VHL promotes immune response against
renal cell carcinoma via NF-$ \kappa
$B-dependent regulation of VCAM-1 . . . 835
Pranav Ullal and
Nathan A. McDonald and
Jun-Song Chen and
Libera Lo Presti and
Rachel H. Roberts-Galbraith and
Kathleen L. Gould and
Sophie G. Martin Retraction: The DYRK-family kinase Pom1
phosphorylates the F--BAR Cdc15 to
prevent division at cell poles . . . . . 849
Ben Short ELKS1 helps neuronal synapses diversify 851
Kimberly Siletti Roop Mallik: From machines to molecular
motors . . . . . . . . . . . . . . . . . 852
Toni McHugh and
Julie P. I. Welburn Dynein at kinetochores: Making the
connection . . . . . . . . . . . . . . . 855
Benjamin S. Glick New insights into protein secretion:
TANGO1 runs rings around the COPII coat 859
Sarah-Maria Fendt and
Patrik Verstreken Neurons eat glutamate to stay alive . . 863
Emmanuel Dornier and
Jim C. Norman Tensin links energy metabolism to
extracellular matrix assembly . . . . . 867
Christian Eggeling and
Simon J. Davis Macrophages: micromanagers of
antagonistic signaling nanoclusters . . 871
Paula Martínez and
Maria A. Blasco Telomere-driven diseases and
telomere-targeting therapies . . . . . . 875
Daryna Tarasenko and
Mariam Barbot and
Daniel C. Jans and
Benjamin Kroppen and
Boguslawa Sadowski and
Gudrun Heim and
Wiebke Möbius and
Stefan Jakobs and
Michael Meinecke The MICOS component Mic60 displays a
conserved membrane-bending activity that
is necessary for normal cristae
morphology . . . . . . . . . . . . . . . 889
Ishier Raote and
Maria Ortega Bellido and
Marinella Pirozzi and
Chong Zhang and
David Melville and
Seetharaman Parashuraman and
Timo Zimmermann and
Vivek Malhotra TANGO1 assembles into rings around COPII
coats at ER exit sites . . . . . . . . . 901
Sarah Fink and
Kira Turnbull and
Arshad Desai and
Christopher S. Campbell An engineered minimal chromosomal
passenger complex reveals a role for
INCENP/Sli15 spindle association in
chromosome biorientation . . . . . . . . 911
Michael S. Wheelock and
David J. Wynne and
Boo Shan Tseng and
Hironori Funabiki Dual recognition of chromatin and
microtubules by INCENP is important for
mitotic progression . . . . . . . . . . 925
José B. Gama and
Cláudia Pereira and
Patrícia A. Simões and
Ricardo Celestino and
Rita M. Reis and
Daniel J. Barbosa and
Helena R. Pires and
Cátia Carvalho and
João Amorim and
Ana X. Carvalho and
Dhanya K. Cheerambathur and
Reto Gassmann Molecular mechanism of dynein
recruitment to kinetochores by the
Rod--Zw10--Zwilch complex and Spindly 943
Shyamal Mosalaganti and
Jenny Keller and
Anika Altenfeld and
Michael Winzker and
Pascaline Rombaut and
Michael Saur and
Arsen Petrovic and
Annemarie Wehenkel and
Sabine Wohlgemuth and
Franziska Müller and
Stefano Maffini and
Tanja Bange and
Franz Herzog and
Herbert Waldmann and
Stefan Raunser and
Andrea Musacchio Structure of the RZZ complex and
molecular basis of its interaction with
Spindly . . . . . . . . . . . . . . . . 961
Raymundo Alfaro-Aco and
Akanksha Thawani and
Sabine Petry Structural analysis of the role of TPX2
in branching microtubule nucleation . . 983
Patricia L. Yeyati and
Rachel Schiller and
Girish Mali and
Ioannis Kasioulis and
Akane Kawamura and
Ian R. Adams and
Christopher Playfoot and
Nick Gilbert and
Veronica van Heyningen and
Jimi Wills and
Alex von Kriegsheim and
Andrew Finch and
Juro Sakai and
Christopher J. Schofield and
Ian J. Jackson and
Pleasantine Mill KDM3A coordinates actin dynamics with
intraflagellar transport to regulate
cilia stability . . . . . . . . . . . . 999
Kyota Yasuda and
Sarah F. Clatterbuck-Soper and
Meredith E. Jackrel and
James Shorter and
Stavroula Mili FUS inclusions disrupt RNA localization
by sequestering kinesin-1 and inhibiting
microtubule detyrosination . . . . . . . 1015
Min Liu and
Zhi Feng and
Hongmei Ke and
Ying Liu and
Tianhui Sun and
Jianli Dai and
Wenhong Cui and
José Carlos Pastor-Pareja Tango1 spatially organizes ER exit sites
to control ER export . . . . . . . . . . 1035
Rituraj Marwaha and
Subhash B. Arya and
Divya Jagga and
Harmeet Kaur and
Amit Tuli and
Mahak Sharma The Rab7 effector PLEKHM1 binds Arl8b to
promote cargo traffic to lysosomes . . . 1051
Suvagata Roy Chowdhury and
Anastasija Reimer and
Malvika Sharan and
Vera Kozjak-Pavlovic and
Ana Eulalio and
Bhupesh K. Prusty and
Martin Fraunholz and
Karthika Karunakaran and
Thomas Rudel \bionameChlamydia preserves the
mitochondrial network necessary for
replication via microRNA-dependent
inhibition of fission . . . . . . . . . 1071
Ajit S. Divakaruni and
Martina Wallace and
Caodu Buren and
Kelly Martyniuk and
Alexander Y. Andreyev and
Edward Li and
Jerel A. Fields and
Thekla Cordes and
Ian J. Reynolds and
Brenda L. Bloodgood and
Lynn A. Raymond and
Christian M. Metallo and
Anne N. Murphy Inhibition of the mitochondrial pyruvate
carrier protects from excitotoxic
neuronal death . . . . . . . . . . . . . 1091
Maria Georgiadou and
Johanna Lilja and
Guillaume Jacquemet and
Camilo Guzmán and
Maria Rafaeva and
Charlotte Alibert and
Yan Yan and
Pranshu Sahgal and
Martina Lerche and
Jean-Baptiste Manneville and
Tomi P. Mäkelä and
Johanna Ivaska AMPK negatively regulates
tensin-dependent integrin activity . . . 1107
Filipa B. Lopes and
\vStefan Bálint and
Salvatore Valvo and
James H. Felce and
Edith M. Hessel and
Michael L. Dustin and
Daniel M. Davis Membrane nanoclusters of Fc$ \gamma $RI
segregate from inhibitory SIRP$ \alpha $
upon activation of human macrophages . . 1123
Hiroshi Kawabe and
Miso Mitkovski and
Pascal S. Kaeser and
Johannes Hirrlinger and
Felipe Opazo and
Dennis Nestvogel and
Stefan Kalla and
Anna Fejtova and
Sophie E. Verrier and
Simon R. Bungers and
Benjamin H. Cooper and
Frederique Varoqueaux and
Yun Wang and
Ralf B. Nehring and
Eckart D. Gundelfinger and
Christian Rosenmund and
Silvio O. Rizzoli and
Thomas C. Südhof and
Jeong-Seop Rhee and
Nils Brose ELKS1 localizes the synaptic vesicle
priming protein bMunc13-2 to a specific
subset of active zones . . . . . . . . . 1143
Jason R. Plemel and
Andrew V. Caprariello and
Michael B. Keough and
Tyler J. Henry and
Shigeki Tsutsui and
Tak H. Chu and
Geert J. Schenk and
Roel Klaver and
V. Wee Yong and
Peter K. Stys Unique spectral signatures of the
nucleic acid dye acridine orange can
distinguish cell death by apoptosis and
necroptosis . . . . . . . . . . . . . . 1163
Masanao Kinoshita and
Kenichi G. N. Suzuki and
Nobuaki Matsumori and
Misa Takada and
Hikaru Ano and
Kenichi Morigaki and
Mitsuhiro Abe and
Asami Makino and
Toshihide Kobayashi and
Koichiro M. Hirosawa and
Takahiro K. Fujiwara and
Akihiro Kusumi and
Michio Murata Raft-based sphingomyelin interactions
revealed by new fluorescent
sphingomyelin analogs . . . . . . . . . 1183
Hiroshi Kawabe and
Miso Mitkovski and
Pascal S. Kaeser and
Johannes Hirrlinger and
Felipe Opazo and
Dennis Nestvogel and
Stefan Kalla and
Anna Fejtova and
Sophie E. Verrier and
Simon R. Bungers and
Benjamin H. Cooper and
Frederique Varoqueaux and
Yun Wang and
Ralf B. Nehring and
Eckart D. Gundelfinger and
Christian Rosenmund and
Silvio O. Rizzoli and
Thomas C. Südhof and
Jeong-Seop Rhee and
Nils Brose Correction: ELKS1 localizes the synaptic
vesicle priming protein bMunc13-2 to a
specific subset of active zones . . . . 1205
Ben Short The signal hypothesis matures with age 1207
Timothy K. Spencer Antonina Roll--Mecak: Decoding the
secrets of tubulin complexity . . . . . 1208
Christina L. Vizcarra and
Margot E. Quinlan Actin filament assembly by bacterial
factors VopL/F: Which end is up? . . . . 1211
Clara Sidor and
Katja Röper Squeezing out in a ``tug of war'': The
role of myosin in neural stem cell
delamination . . . . . . . . . . . . . . 1215
Shradha Das and
Elisabeth Knust Stardust, the Janus-faced partner of
Crumbs . . . . . . . . . . . . . . . . . 1219
Austin B. Keeler and
Christopher D. Deppmann The evolutionary origins of antagonistic
neurotrophin signaling . . . . . . . . . 1223
Robert S. Molday and
Andrew F. X. Goldberg Peripherin diverts ciliary ectosome
release to photoreceptor disc
morphogenesis . . . . . . . . . . . . . 1227
Ambre J. Sala and
Laura C. Bott and
Richard I. Morimoto Shaping proteostasis at the cellular,
tissue, and organismal level . . . . . . 1231
Amanda C. Davis-Roca and
Christina C. Muscat and
Sarah M. Wignall \bionameCaenorhabditis elegans oocytes
detect meiotic errors in the absence of
canonical end-on kinetochore attachments 1243
John S. Poulton and
John C. Cuningham and
Mark Peifer Centrosome and spindle assembly
checkpoint loss leads to neural
apoptosis and reduced brain size . . . . 1255
Thomas A. Burke and
Alyssa J. Harker and
Roberto Dominguez and
David R. Kovar The bacterial virulence factors VopL and
VopF nucleate actin from the pointed end 1267
Julia König and
E. B. Frankel and
Anjon Audhya and
Thomas Müller-Reichert Membrane remodeling during embryonic
abscission in \bionameCaenorhabditis
elegans . . . . . . . . . . . . . . . . 1277
Abdelhalim Loukil and
Kati Tormanen and
Christine Sütterlin The daughter centriole controls
ciliogenesis by regulating Neurl-4
localization at the centrosome . . . . . 1287
Xuezhao Liu and
Yang Li and
Xin Wang and
Ruxiao Xing and
Kai Liu and
Qiwen Gan and
Changyong Tang and
Zhiyang Gao and
Youli Jian and
Shouqing Luo and
Weixiang Guo and
Chonglin Yang The BEACH-containing protein WDR81
coordinates p62 and LC3C to promote
aggrephagy . . . . . . . . . . . . . . . 1301
James Winsor and
David D. Hackney and
Tina H. Lee The crossover conformational shift of
the GTPase atlastin provides the energy
driving ER fusion . . . . . . . . . . . 1321
Rachel Allison and
James R. Edgar and
Guy Pearson and
Tania Rizo and
Timothy Newton and
Sven Günther and
Fiamma Berner and
Jennifer Hague and
James W. Connell and
Jürgen Winkler and
Jennifer Lippincott-Schwartz and
Christian Beetz and
Beate Winner and
Evan Reid Defects in ER--endosome contacts impact
lysosome function in hereditary spastic
paraplegia . . . . . . . . . . . . . . . 1337
Katerina E. Chatzi and
Marios Frantzeskos Sardis and
Alexandra Tsirigotaki and
Marina Koukaki and
Nikolina \vSo\vstari\'c and
Albert Konijnenberg and
Frank Sobott and
Charalampos G. Kalodimos and
Spyridoula Karamanou and
Anastassios Economou Preprotein mature domains contain
translocase targeting signals that are
essential for secretion . . . . . . . . 1357
Wei Yung Ding and
Hui Ting Ong and
Yusuke Hara and
Jantana Wongsantichon and
Yusuke Toyama and
Robert C. Robinson and
François Nédélec and
Ronen Zaidel-Bar Plastin increases cortical connectivity
to facilitate robust polarization and
timely cytokinesis . . . . . . . . . . . 1371
Sérgio Simões and
Youjin Oh and
Michael F. Z. Wang and
Rodrigo Fernandez-Gonzalez and
Ulrich Tepass Myosin II promotes the anisotropic loss
of the apical domain during
\bionameDrosophila neuroblast ingression 1387
Gantas Perez-Mockus and
Vanessa Roca and
Khalil Mazouni and
François Schweisguth Neuralized regulates Crumbs endocytosis
and epithelium morphogenesis via
specific Stardust isoforms . . . . . . . 1405
Istvan Foldi and
Niki Anthoney and
Neale Harrison and
Monique Gangloff and
Brett Verstak and
Mohanakarthik Ponnadai Nallasivan and
Samaher AlAhmed and
Bangfu Zhu and
Mark Phizacklea and
Maria Losada-Perez and
Marta Moreira and
Nicholas J. Gay and
Alicia Hidalgo Three-tier regulation of cell number
plasticity by neurotrophins and Tolls in
\bionameDrosophila . . . . . . . . . . . 1421
Chun-Ming Lai and
Kun-Yang Lin and
Shih-Han Kao and
Yi-Ning Chen and
Fu Huang and
Hwei-Jan Hsu Hedgehog signaling establishes
precursors for germline stem cell niches
by regulating cell adhesion . . . . . . 1439
Xiaofan Wei and
Xiang Wang and
Jun Zhan and
Yuhan Chen and
Weigang Fang and
Lingqiang Zhang and
Hongquan Zhang Smurf1 inhibits integrin activation by
controlling Kindlin-2 ubiquitination and
degradation . . . . . . . . . . . . . . 1455
Whitney M. Longmate and
Scott P. Lyons and
Sridar V. Chittur and
Kevin M. Pumiglia and
Livingston Van De Water and
C. Michael DiPersio Suppression of integrin $ \alpha $3$
\beta $1 by $ \alpha $9$ \beta $1 in the
epidermis controls the paracrine
resolution of wound angiogenesis . . . . 1473
Raquel Y. Salinas and
Jillian N. Pearring and
Jin-Dong Ding and
William J. Spencer and
Ying Hao and
Vadim Y. Arshavsky Photoreceptor discs form through
peripherin-dependent suppression of
ciliary ectosome release . . . . . . . . 1489
Ben Short Choosing the right response to ER stress 1501
Marie Anne O'Donnell Jonathan Kagan: a cell biologist's view
of immunity . . . . . . . . . . . . . . 1502
Tomohiro Mizutani and
Yoshiyuki Tsukamoto and
Hans Clevers Oncogene-inducible organoids as a
miniature platform to assess cancer
characteristics . . . . . . . . . . . . 1505
Margaret A. Titus and
Holly V. Goodson An evolutionary perspective on cell
migration: Digging for the roots of
amoeboid motility . . . . . . . . . . . 1509
Michael X. Zhu A well-known potassium channel plays a
critical role in lysosomes . . . . . . . 1513
Lynda M. Stuart and
Adam Lacy-Hulbert GOP-1: Helping phagosomes pass the acid
test . . . . . . . . . . . . . . . . . . 1517
Kenneth J. O'Byrne and
Derek J. Richard Nucleolar caspase-2: Protecting us from
DNA damage . . . . . . . . . . . . . . . 1521
Scott Forth and
Tarun M. Kapoor The mechanics of microtubule networks in
cell division . . . . . . . . . . . . . 1525
Jonathan Kuhn and
Sophie Dumont Spindle assembly checkpoint satisfaction
occurs via end-on but not lateral
attachments under tension . . . . . . . 1533
Assaf Zaritsky and
Yun-Yu Tseng and
M. Angeles Rabadán and
Shefali Krishna and
Michael Overholtzer and
Gaudenz Danuser and
Alan Hall Diverse roles of guanine nucleotide
exchange factors in regulating
collective cell migration . . . . . . . 1543
Richard G. Yau and
Sara Wong and
Lois S. Weisman Spatial regulation of organelle release
from myosin V transport by p21-activated
kinases . . . . . . . . . . . . . . . . 1557
Pamela Riemer and
Mattias Rydenfelt and
Matthias Marks and
Karen van Eunen and
Kathrin Thedieck and
Bernhard G. Herrmann and
Nils Blüthgen and
Christine Sers and
Markus Morkel Oncogenic $ \beta $-catenin and PIK3CA
instruct network states and cancer
phenotypes in intestinal organoids . . . 1567
Anna Malinová and
Zuzana Cva\vcková and
Daniel Mat\vej\ru and
Zuzana Ho\vrej\vsí and
Claire Abéza and
Franck Vandermoere and
Edouard Bertrand and
David Stan\vek and
Céline Verheggen Assembly of the U5 snRNP component PRPF8
is controlled by the HSP90/R2TP
chaperones . . . . . . . . . . . . . . . 1579
Travis Karg and
Mary Williard Elting and
Hannah Vicars and
Sophie Dumont and
William Sullivan The chromokinesin Klp3a and microtubules
facilitate acentric chromosome
segregation . . . . . . . . . . . . . . 1597
Vanya Vasileva and
Marek Gierlinski and
Zuojun Yue and
Nicola O'Reilly and
Etsushi Kitamura and
Tomoyuki U. Tanaka Molecular mechanisms facilitating the
initial kinetochore encounter with
spindle microtubules . . . . . . . . . . 1609
Philip Auckland and
Nicholas I. Clarke and
Stephen J. Royle and
Andrew D. McAinsh Congressing kinetochores progressively
load Ska complexes to prevent
force-dependent detachment . . . . . . . 1623
Amy E. Byrnes and
Kevin C. Slep TOG-tubulin binding specificity promotes
microtubule dynamics and mitotic spindle
formation . . . . . . . . . . . . . . . 1641
Daniel Serwas and
Tiffany Y. Su and
Max Roessler and
Shaohe Wang and
Alexander Dammermann Centrioles initiate cilia assembly but
are dispensable for maturation and
maintenance in \bionameC. elegans . . . 1659
Lillian K. Fritz-Laylin and
Samuel J. Lord and
R. Dyche Mullins WASP and SCAR are evolutionarily
conserved in actin-filled
pseudopod-based motility . . . . . . . . 1673
Cécile Leduc and
Sandrine Etienne-Manneville Regulation of microtubule-associated
motors drives intermediate filament
network polarization . . . . . . . . . . 1689
Moé Yamada and
Yohko Tanaka-Takiguchi and
Masahito Hayashi and
Momoko Nishina and
Gohta Goshima Multiple kinesin-14 family members drive
microtubule minus end--directed
transport in plant cells . . . . . . . . 1705
Wuyang Wang and
Xiaoli Zhang and
Qiong Gao and
Maria Lawas and
Lu Yu and
Xiping Cheng and
Mingxue Gu and
Nirakar Sahoo and
Xinran Li and
Ping Li and
Stephen Ireland and
Andrea Meredith and
Haoxing Xu A voltage-dependent K$^+$ channel in the
lysosome is required for refilling
lysosomal Ca$^{2+}$ stores . . . . . . . 1715
Miharu Maeda and
Toshiaki Katada and
Kota Saito TANGO1 recruits Sec16 to coordinately
organize ER exit sites for efficient
secretion . . . . . . . . . . . . . . . 1731
Amita Gorur and
Lin Yuan and
Samuel J. Kenny and
Satoshi Baba and
Ke Xu and
Randy Schekman COPII-coated membranes function as
transport carriers of intracellular
procollagen I . . . . . . . . . . . . . 1745
Tokiro Ishikawa and
Takuya Toyama and
Yuki Nakamura and
Kentaro Tamada and
Hitomi Shimizu and
Satoshi Ninagawa and
Tetsuya Okada and
Yasuhiro Kamei and
Tomoko Ishikawa-Fujiwara and
Takeshi Todo and
Eriko Aoyama and
Masaharu Takigawa and
Akihiro Harada and
Kazutoshi Mori UPR transducer BBF2H7 allows export of
type II collagen in a cargo- and
developmental stage--specific manner . . 1761
Jianhua Yin and
Yaling Huang and
Pengfei Guo and
Siqi Hu and
Sawako Yoshina and
Nan Xuan and
Qiwen Gan and
Shohei Mitani and
Chonglin Yang and
Xiaochen Wang GOP-1 promotes apoptotic cell
degradation by activating the small
GTPase Rab2 in \bionameC. elegans . . . 1775
Kiyohiro Ando and
Melissa J. Parsons and
Richa B. Shah and
Chloé I. Charendoff and
Sheré L. Paris and
Peter H. Liu and
Sara R. Fassio and
Brittany A. Rohrman and
Ruth Thompson and
Andrew Oberst and
Samuel Sidi and
Lisa Bouchier-Hayes NPM1 directs PIDDosome-dependent
caspase-2 activation in the nucleolus 1795
Junie Hovsepian and
Quentin Defenouill\`ere and
Véronique Alban\`ese and
Libu\vse Váchová and
Camille Garcia and
Zdena Palková and
Sébastien Léon Multilevel regulation of an $ \alpha
$-arrestin by glucose depletion controls
hexose transporter endocytosis . . . . . 1811
Xia Tang and
Jianan Gao and
Xinling Jia and
Wencao Zhao and
Yijie Zhang and
Weijun Pan and
Jie He Bipotent progenitors as embryonic origin
of retinal stem cells . . . . . . . . . 1833
Cataldo Schietroma and
Karine Parain and
Amrit Estivalet and
Asadollah Aghaie and
Jacques Boutet de Monvel and
Serge Picaud and
José-Alain Sahel and
Muriel Perron and
Aziz El-Amraoui and
Christine Petit Usher syndrome type $1$--associated
cadherins shape the photoreceptor outer
segment . . . . . . . . . . . . . . . . 1849
Ben Short ATF4 helps mitochondria pass the stress
test . . . . . . . . . . . . . . . . . . 1865
Melina Casadio Andrea Ventura: Decrypting noncoding
RNAs . . . . . . . . . . . . . . . . . . 1866
María Gómez A stitch in time: Replicate early and
escape dosage compensation to express
more . . . . . . . . . . . . . . . . . . 1869
Brendan D. Price KDM5A demethylase: Erasing histone
modifications to promote repair of DNA
breaks . . . . . . . . . . . . . . . . . 1871
Marie-Louise Hammarskjold and
David Rekosh SR proteins: To shuttle or not to
shuttle, that is the question . . . . . 1875
Eamonn J. Dickson RASSF4: Regulator of plasma membrane
PI(4,5)P$_2$ . . . . . . . . . . . . . . 1879
Kathrin Maedler and
Amin Ardestani mTORC in $ \beta $ cells: more Than Only
Recognizing Comestibles . . . . . . . . 1883
Jakob B. Sòrensen Ride the wave: Retrograde trafficking
becomes Ca$^{2+}$ dependent with BAIAP3 1887
Catherine Rabouille KRS: a cut away from release in exosomes 1891
Vinoy Vijayan and
Patrik Verstreken Autophagy in the presynaptic compartment
in health and disease . . . . . . . . . 1895
Carolin A. Müller and
Conrad A. Nieduszynski DNA replication timing influences gene
expression level . . . . . . . . . . . . 1907
Matthew J. Stroud and
Wei Feng and
Jianlin Zhang and
Jennifer Veevers and
Xi Fang and
Larry Gerace and
Ju Chen Nesprin 1$ \alpha $2 is essential for
mouse postnatal viability and nuclear
positioning in skeletal muscle . . . . . 1915
Oleg Milberg and
Akiko Shitara and
Seham Ebrahim and
Andrius Masedunskas and
Muhibullah Tora and
Duy T. Tran and
Yun Chen and
Mary Anne Conti and
Robert S. Adelstein and
Kelly G. Ten Hagen and
Roberto Weigert Concerted actions of distinct nonmuscle
myosin II isoforms drive intracellular
membrane remodeling in live animals . . 1925
Péter L\Horincz and
Sarolta Tóth and
Péter Benk\Ho and
Zsolt Lakatos and
Attila Boda and
Gábor Glatz and
Martina Zobel and
Sara Bisi and
Krisztina Heged\Hus and
Szabolcs Takáts and
Giorgio Scita and
Gábor Juhász Rab2 promotes autophagic and endocytic
lysosomal degradation . . . . . . . . . 1937
Bernadette Carroll and
Glyn Nelson and
Yoana Rabanal-Ruiz and
Olena Kucheryavenko and
Natasha A. Dunhill-Turner and
Charlotte C. Chesterman and
Qabil Zahari and
Tong Zhang and
Sarah E. Conduit and
Christina A. Mitchell and
Oliver D. K. Maddocks and
Penny Lovat and
Thomas von Zglinicki and
Viktor I. Korolchuk Persistent mTORC1 signaling in cell
senescence results from defects in amino
acid and growth factor sensing . . . . . 1949
Fade Gong and
Thomas Clouaire and
Marion Aguirrebengoa and
Gaëlle Legube and
Kyle M. Miller Histone demethylase KDM5A regulates the
ZMYND8--NuRD chromatin remodeler to
promote DNA repair . . . . . . . . . . . 1959
Yanxin Li and
Jianwei Jiao Histone chaperone HIRA regulates neural
progenitor cell proliferation and
neurogenesis via $ \beta $-catenin . . . 1975
Valentina Botti and
François McNicoll and
Michaela C. Steiner and
Florian M. Richter and
Anfisa Solovyeva and
Marius Wegener and
Oliver D. Schwich and
Ina Poser and
Kathi Zarnack and
Ilka Wittig and
Karla M. Neugebauer and
Michaela Müller-McNicoll Cellular differentiation state modulates
the mRNA export activity of SR proteins 1993
Yu-Ju Chen and
Chi-Lun Chang and
Wan-Ru Lee and
Jen Liou RASSF4 controls SOCE and ER--PM
junctions through regulation of
PI(4,5)P$_2$ . . . . . . . . . . . . . . 2011
Pedro M. Quirós and
Miguel A. Prado and
Nicola Zamboni and
Davide D'Amico and
Robert W. Williams and
Daniel Finley and
Steven P. Gygi and
Johan Auwerx Multi-omics analysis identifies ATF4 as
a key regulator of the mitochondrial
stress response in mammals . . . . . . . 2027
Cassi Estrem and
Colby P. Fees and
Jeffrey K. Moore Dynein is regulated by the stability of
its microtubule track . . . . . . . . . 2047
Archan Ganguly and
Xuemei Han and
Utpal Das and
Lina Wang and
Jonathan Loi and
Jichao Sun and
Daniel Gitler and
Ghislaine Caillol and
Christophe Leterrier and
John R. Yates and
Subhojit Roy Hsc70 chaperone activity is required for
the cytosolic slow axonal transport of
synapsin . . . . . . . . . . . . . . . . 2059
Natsuko Jin and
Yui Jin and
Lois S. Weisman Early protection to stress mediated by
CDK-dependent PI3,5P$_2$ signaling from
the vacuole/lysosome . . . . . . . . . . 2075
Gia Cac Chau and
Dong Uk Im and
Tong Mook Kang and
Jeong Mo Bae and
Won Kim and
Suhkneung Pyo and
Eun-Yi Moon and
Sung Hee Um mTOR controls ChREBP transcriptional
activity and pancreatic $ \beta $ cell
survival under diabetic stress . . . . . 2091
Tullio Genova and
Guillaume P. Grolez and
Chiara Camillo and
Michela Bernardini and
Alexandre Bokhobza and
Elodie Richard and
Marco Scianna and
Loic Lemonnier and
Donatella Valdembri and
Luca Munaron and
Mark R. Philips and
Virginie Mattot and
Guido Serini and
Natalia Prevarskaya and
Dimitra Gkika and
Alessandra Fiorio Pla TRPM8 inhibits endothelial cell
migration via a non-channel function by
trapping the small GTPase Rap1 . . . . . 2107
William J. Monis and
Victor Faundez and
Gregory J. Pazour BLOC-1 is required for selective
membrane protein trafficking from
endosomes to primary cilia . . . . . . . 2131
Xingmin Zhang and
Shan Jiang and
Kelly A. Mitok and
Lingjun Li and
Alan D. Attie and
Thomas F. J. Martin BAIAP3, a C2 domain--containing Munc13
protein, controls the fate of dense-core
vesicles in neuroendocrine cells . . . . 2151
Rafael Andrade Buono and
André Leier and
Julio Paez-Valencia and
Janice Pennington and
Kaija Goodman and
Nathan Miller and
Paul Ahlquist and
Tatiana T. Marquez-Lago and
Marisa S. Otegui ESCRT-mediated vesicle concatenation in
plant endosomes . . . . . . . . . . . . 2167
Yuanzheng Gu and
Peter Jukkola and
Qian Wang and
Thomas Esparza and
Yi Zhao and
David Brody and
Chen Gu Polarity of varicosity initiation in
central neuron mechanosensation . . . . 2179
Sang Bum Kim and
Hye Rim Kim and
Min Chul Park and
Seongmin Cho and
Peter C. Goughnour and
Daeyoung Han and
Ina Yoon and
YounHa Kim and
Taehee Kang and
Eunjoo Song and
Pilhan Kim and
Hyosun Choi and
Ji Young Mun and
Chihong Song and
Sangmin Lee and
Hyun Suk Jung and
Sunghoon Kim Caspase-8 controls the secretion of
inflammatory lysyl-tRNA synthetase in
exosomes from cancer cells . . . . . . . 2201
Gregoire Stik and
Simon Crequit and
Laurence Petit and
Jennifer Durant and
Pierre Charbord and
Thierry Jaffredo and
Charles Durand Extracellular vesicles of stromal origin
target and support hematopoietic stem
and progenitor cells . . . . . . . . . . 2217
Ben Short Mitochondria deliver a gut check to
intestinal stem cells . . . . . . . . . 2231
Marie Anne O'Donnell Ann Miller: Shaping cells and scientists 2232
Shambaditya Saha and
Anthony A. Hyman RNA gets in phase . . . . . . . . . . . 2235
Elma Zaganjor and
Jessica B. Spinelli and
Marcia C. Haigis Strength in numbers: Phosphofructokinase
polymerization prevails in the liver . . 2239
Dmitri Churikov and
Vincent Géli De novo telomere addition at chromosome
breaks: Dangerous Liaisons . . . . . . . 2243
Takeshi Kawauchi Tubulin isotype specificity in neuronal
migration: Tuba8 can't fill in for
Tuba1a . . . . . . . . . . . . . . . . . 2247
Natalia L. Kononenko Lysosomes convene to keep the synapse
clean . . . . . . . . . . . . . . . . . 2251
Katalin Schlett More than a mere supply of monomers:
G--Actin pools regulate actin dynamics
in dendritic spines . . . . . . . . . . 2255
Samuel Gilberto and
Matthias Peter Dynamic ubiquitin signaling in cell
cycle regulation . . . . . . . . . . . . 2259
Michelle T. Panzica and
Harold C. Marin and
Anne-Cecile Reymann and
Francis J. McNally F-actin prevents interaction between
sperm DNA and the oocyte meiotic spindle
in \bionameC. elegans . . . . . . . . . 2273
Johan Nordholm and
Jeanne Petitou and
Henrik Östbye and
Diogo V. da Silva and
Dan Dou and
Hao Wang and
Robert Daniels Translational regulation of viral
secretory proteins by the 5' coding
regions and a viral RNA-binding protein 2283
Norfadilah Hamdan and
Paraskevi Kritsiligkou and
Chris M. Grant ER stress causes widespread protein
aggregation and prion formation . . . . 2295
Bradley A. Webb and
Anne M. Dosey and
Torsten Wittmann and
Justin M. Kollman and
Diane L. Barber The glycolytic enzyme
phosphofructokinase-1 assembles into
filaments . . . . . . . . . . . . . . . 2305
Christopher L. Koehler and
Guy A. Perkins and
Mark H. Ellisman and
D. Leanne Jones Pink1 and Parkin regulate
\bionameDrosophila intestinal stem cell
proliferation during stress and aging 2315
Nicole Fehrenbacher and
Israel Tojal da Silva and
Craig Ramirez and
Yong Zhou and
Kwang-Jin Cho and
Shafi Kuchay and
Jie Shi and
Susan Thomas and
Michele Pagano and
John F. Hancock and
Dafna Bar-Sagi and
Mark R. Philips The G protein--coupled receptor GPR31
promotes membrane association of KRAS 2329
Sierra N. Cullati and
Lilian Kabeche and
Arminja N. Kettenbach and
Scott A. Gerber A bifurcated signaling cascade of
NIMA-related kinases controls distinct
kinesins in anaphase . . . . . . . . . . 2339
Faissal Ouenzar and
Maxime Lalonde and
Hadrien Laprade and
Genevi\`eve Morin and
Franck Gallardo and
Samuel Tremblay-Belzile and
Pascal Chartrand Cell cycle-dependent spatial segregation
of telomerase from sites of DNA damage 2355
Kaspar Burger and
Margarita Schlackow and
Martin Potts and
Svenja Hester and
Shabaz Mohammed and
Monika Gullerova Nuclear phosphorylated Dicer processes
double-stranded RNA in response to DNA
damage . . . . . . . . . . . . . . . . . 2373
Archana Bairavasundaram Prusty and
Rajyalakshmi Meduri and
Bhupesh Kumar Prusty and
Jens Vanselow and
Andreas Schlosser and
Utz Fischer Impaired spliceosomal UsnRNP assembly
leads to Sm mRNA down-regulation and Sm
protein degradation . . . . . . . . . . 2391
Andrew J. Bestul and
Zulin Yu and
Jay R. Unruh and
Sue L. Jaspersen Molecular model of fission yeast
centrosome assembly determined by
superresolution imaging . . . . . . . . 2409
Diana Rüthnick and
Annett Neuner and
Franziska Dietrich and
Daniel Kirrmaier and
Ulrike Engel and
Michael Knop and
Elmar Schiebel Characterization of spindle pole body
duplication reveals a regulatory role
for nuclear pore complexes . . . . . . . 2425
Richard Belvindrah and
Kathiresan Natarajan and
Preety Shabajee and
Elodie Bruel-Jungerman and
Jennifer Bernard and
Marie Goutierre and
Imane Moutkine and
Xavier H. Jaglin and
Mythili Savariradjane and
Theano Irinopoulou and
Jean-Christophe Poncer and
Carsten Janke and
Fiona Francis Mutation of the $ \alpha $-tubulin
Tuba1a leads to straighter microtubules
and perturbs neuronal migration . . . . 2443
Hui-Chia Yu-Kemp and
James P. Kemp and
William M. Brieher CRMP-1 enhances EVL-mediated actin
elongation to build lamellipodia and the
actin cortex . . . . . . . . . . . . . . 2463
Stefan Böckler and
Xenia Chelius and
Nadine Hock and
Till Klecker and
Madita Wolter and
Matthias Weiss and
Ralf J. Braun and
Benedikt Westermann Fusion, fission, and transport control
asymmetric inheritance of mitochondria
and protein aggregates . . . . . . . . . 2481
Marisa S. Goo and
Laura Sancho and
Natalia Slepak and
Daniela Boassa and
Thomas J. Deerinck and
Mark H. Ellisman and
Brenda L. Bloodgood and
Gentry N. Patrick Activity-dependent trafficking of
lysosomes in dendrites and dendritic
spines . . . . . . . . . . . . . . . . . 2499
Brian R. Graziano and
Delquin Gong and
Karen E. Anderson and
Anne Pipathsouk and
Anna R. Goldberg and
Orion D. Weiner A module for Rac temporal signal
integration revealed with optogenetics 2515
François Renault-Mihara and
Masahiko Mukaino and
Munehisa Shinozaki and
Hiromi Kumamaru and
Satoshi Kawase and
Matthieu Baudoux and
Toshiki Ishibashi and
Soya Kawabata and
Yuichiro Nishiyama and
Keiko Sugai and
Kaori Yasutake and
Seiji Okada and
Masaya Nakamura and
Hideyuki Okano Regulation of RhoA by STAT3 coordinates
glial scar formation . . . . . . . . . . 2533
Wenliang Lei and
Kenneth R. Myers and
Yanfang Rui and
Siarhei Hladyshau and
Denis Tsygankov and
James Q. Zheng Phosphoinositide-dependent enrichment of
actin monomers in dendritic spines
regulates synapse development and
plasticity . . . . . . . . . . . . . . . 2551
Kristen B. Farrell and
Seth McDonald and
Andrew K. Lamb and
Colette Worcester and
Olve B. Peersen and
Santiago M. Di Pietro Novel function of a dynein light chain
in actin assembly during
clathrin-mediated endocytosis . . . . . 2565
Chenran Wang and
Syn Yeo and
Michael A. Haas and
Jun-Lin Guan Autophagy gene FIP200 in neural
progenitors non-cell autonomously
controls differentiation by regulating
microglia . . . . . . . . . . . . . . . 2581
Jia Qu and
Wenyi Sun and
Jie Zhong and
Hao Lv and
Mingrui Zhu and
Jun Xu and
Nan Jin and
Zuoquan Xie and
Minjia Tan and
Shu-Hai Lin and
Meiyu Geng and
Jian Ding and
Min Huang Correction: Phosphoglycerate mutase 1
regulates dNTP pool and promotes
homologous recombination repair in
cancer cells . . . . . . . . . . . . . . 2597
Ben Short Centrosome signaling pathways consult on
their decision . . . . . . . . . . . . . 2599
Marie Anne O'Donnell Yaron Fuchs: Exploring the mysterious
mixture of life and death . . . . . . . 2600
Nicoletta Bobola From DNA binding to transcriptional
activation: Is the TALE complete? . . . 2603
Eman Elzeneini and
Sara A. Wickström Lipodystrophic laminopathy: Lamin A
mutation relaxes chromatin architecture
to impair adipogenesis . . . . . . . . . 2607
Anna K. Serquiña and
Joseph M. Ziegelbauer How herpesviruses pass on their genomes 2611
Jelena S. Bezbradica and
Kate Schroder Zebrafish earns its stripes for in vivo
ASC speck dynamics . . . . . . . . . . . 2615
Kinneret Keren and
Tom Shemesh Buckle up: Membrane tension drives
lamellipodial network compression and
adhesion deposition . . . . . . . . . . 2619
Sandra L. Schmid Reciprocal regulation of signaling and
endocytosis: Implications for the
evolving cancer cell . . . . . . . . . . 2623
Guiliana Soraya Victoria and
Chiara Zurzolo The spread of prion-like proteins by
lysosomes and tunneling nanotubes:
Implications for neurodegenerative
diseases . . . . . . . . . . . . . . . . 2633
A.-M. Ladouceur and
Rajesh Ranjan and
Lydia Smith and
Tanner Fadero and
Jennifer Heppert and
Bob Goldstein and
Amy Shaub Maddox and
Paul S. Maddox CENP-A and topoisomerase--II
antagonistically affect chromosome
length . . . . . . . . . . . . . . . . . 2645
Ting Gang Chew and
Junqi Huang and
Saravanan Palani and
Ruth Sommese and
Anton Kamnev and
Tomoyuki Hatano and
Ying Gu and
Snezhana Oliferenko and
Sivaraj Sivaramakrishnan and
Mohan K. Balasubramanian Actin turnover maintains actin filament
homeostasis during cytokinetic ring
contraction . . . . . . . . . . . . . . 2657
Stuart C. Howes and
Elisabeth A. Geyer and
Benjamin LaFrance and
Rui Zhang and
Elizabeth H. Kellogg and
Stefan Westermann and
Luke M. Rice and
Eva Nogales Structural differences between yeast and
mammalian microtubules revealed by
cryo--EM . . . . . . . . . . . . . . . . 2669
Andrew Murley and
Justin Yamada and
Bradley J. Niles and
Alexandre Toulmay and
William A. Prinz and
Ted Powers and
Jodi Nunnari Sterol transporters at membrane contact
sites regulate TORC1 and TORC2 signaling 2679
David Cruz-Garcia and
Nathalie Brouwers and
Juan M. Duran and
Gabriel Mora and
Amy J. Curwin and
Vivek Malhotra A diacidic motif determines
unconventional secretion of wild-type
and ALS-linked mutant SOD1 . . . . . . . 2691
Sudarshan Gadadhar and
Hala Dadi and
Satish Bodakuntla and
Anne Schnitzler and
Ivan Bi\`eche and
Filippo Rusconi and
Carsten Janke Tubulin glycylation controls primary
cilia length . . . . . . . . . . . . . . 2701
Ann-Christin Hau and
Britta Moyo Grebbin and
Zsuzsa Agoston and
Marie Anders-Maurer and
Tamara Müller and
Anja Groß and
Jasmine Kolb and
Julian D. Langer and
Claudia Döring and
Dorothea Schulte MEIS homeodomain proteins facilitate
PARP1/ARTD1-mediated eviction of histone
H1 . . . . . . . . . . . . . . . . . . . 2715
Anja Oldenburg and
Nolwenn Briand and
Anita L. Sòrensen and
Inswasti Cahyani and
Akshay Shah and
Jan Òivind Moskaug and
Philippe Collas A lipodystrophy-causing lamin A mutant
alters conformation and epigenetic
regulation of the anti-adipogenic MIR335
locus . . . . . . . . . . . . . . . . . 2731
Ya-Fang Chiu and
Arthur U. Sugden and
Kathryn Fox and
Mitchell Hayes and
Bill Sugden Kaposi's sarcoma-associated herpesvirus
stably clusters its genomes across
generations to maintain itself
extrachromosomally . . . . . . . . . . . 2745
Yili Zhu and
Xiaojing An and
Alexis Tomaszewski and
Peter K. Hepler and
Wei-Lih Lee Microtubule cross-linking activity of
She1 ensures spindle stability for
spindle positioning . . . . . . . . . . 2759
Ruben Schmidt and
Lars-Eric Fielmich and
Ilya Grigoriev and
Eugene A. Katrukha and
Anna Akhmanova and
Sander van den Heuvel Two populations of cytoplasmic dynein
contribute to spindle positioning in
\bionameC. elegans embryos . . . . . . . 2777
Kuan Yoow Chan and
Marisa Alonso-Nuñez and
Agnes Grallert and
Kayoko Tanaka and
Yvonne Connolly and
Duncan L. Smith and
Iain M. Hagan Dialogue between centrosomal entrance
and exit scaffold pathways regulates
mitotic commitment . . . . . . . . . . . 2795
Subbulakshmi Suresh and
Sarine Markossian and
Aysha H. Osmani and
Stephen A. Osmani Mitotic nuclear pore complex segregation
involves Nup2 in Aspergillus nidulans 2813
Zhao-Ying Ding and
Ying-Hsuan Wang and
Yu-Cheng Huang and
Myong-Chol Lee and
Min-Jen Tseng and
Ya-Hui Chi and
Min-Lang Huang Outer nuclear membrane protein Kuduk
modulates the LINC complex and nuclear
envelope architecture . . . . . . . . . 2827
Wei Wang and
Zhi-Jie Xia and
Jean-Claude Farré and
Suresh Subramani TRIM37, a novel E3 ligase for
PEX5-mediated peroxisomal matrix protein
import . . . . . . . . . . . . . . . . . 2843
M. Angeles Juanes and
Habib Bouguenina and
Julian A. Eskin and
Richa Jaiswal and
Ali Badache and
Bruce L. Goode Adenomatous polyposis coli nucleates
actin assembly to drive cell migration
and microtubule-induced focal adhesion
turnover . . . . . . . . . . . . . . . . 2859
Maria S. Shutova and
Sreeja B. Asokan and
Shefali Talwar and
Richard K. Assoian and
James E. Bear and
Tatyana M. Svitkina Self-sorting of nonmuscle myosins IIA
and IIB polarizes the cytoskeleton and
modulates cell motility . . . . . . . . 2877
Paola Kuri and
Nicole L. Schieber and
Thomas Thumberger and
Joachim Wittbrodt and
Yannick Schwab and
Maria Leptin Dynamics of in vivo ASC speck formation 2891
Mariana Capurro and
Tomomi Izumikawa and
Philippe Suarez and
Wen Shi and
Marzena Cydzik and
Tomoyuki Kaneiwa and
Jean Gariepy and
Luisa Bonafe and
Jorge Filmus Glypican-6 promotes the growth of
developing long bones by stimulating
Hedgehog signaling . . . . . . . . . . . 2911
Paloma Navarro Negredo and
James R. Edgar and
Antoni G. Wrobel and
Nathan R. Zaccai and
Robin Antrobus and
David J. Owen and
Margaret S. Robinson Contribution of the clathrin adaptor
AP-1 subunit $ \mu $1 to acidic cluster
protein sorting . . . . . . . . . . . . 2927
Michelle G. LeBlanc and
Ruth Lehmann Domain-specific control of germ cell
polarity and migration by multifunction
Tre1 GPCR . . . . . . . . . . . . . . . 2945
Bruno Pontes and
Pascale Monzo and
Laurent Gole and
Anabel-Lise Le Roux and
Anita Joanna Kosmalska and
Zhi Yang Tam and
Weiwei Luo and
Sophie Kan and
Virgile Viasnoff and
Pere Roca-Cusachs and
Lisa Tucker-Kellogg and
Nils C. Gauthier Membrane tension controls adhesion
positioning at the leading edge of cells 2959
Yasmine Cantaut-Belarif and
Myriam Antri and
Rocco Pizzarelli and
Sabrina Colasse and
Ilaria Vaccari and
Sylvia Soares and
Marianne Renner and
Radhouane Dallel and
Antoine Triller and
Alain Bessis Microglia control the glycinergic but
not the GABAergic synapses via
prostaglandin E2 in the spinal cord . . 2979
Ben Short Gluing together the pieces of crinophagy 05
Marie Anne O'Donnell Danica Chen: From early learning to
aging research . . . . . . . . . . . . . 07
Jeffrey B. Woodruff Phase separation of BuGZ promotes Aurora
A activation and spindle assembly . . . 09
Diana Vargas-Hurtado and
Renata Basto When E-cadherin is away, centrosomes can
play . . . . . . . . . . . . . . . . . . 11
Janos Steffen and
Carla M. Koehler ER-mitochondria contacts: Actin dynamics
at the ER control mitochondrial fission
via calcium release . . . . . . . . . . 15
Gerald R. V. Hammond DepHining membrane identity . . . . . . 19
Leonid Serebryannyy and
Tom Misteli Protein sequestration at the nuclear
periphery as a potential regulatory
mechanism in premature aging . . . . . . 21
Jennifer L. Hu and
Michael E. Todhunter and
Mark A. LaBarge and
Zev J. Gartner Opportunities for organoids as new
models of aging . . . . . . . . . . . . 39
Courtney L. Klaips and
Gopal Gunanathan Jayaraj and
F. Ulrich Hartl Pathways of cellular proteostasis in
aging and disease . . . . . . . . . . . 51
Domhnall McHugh and
Jesús Gil Senescence and aging: Causes,
consequences, and therapeutic avenues 65
Brice E. Keyes and
Elaine Fuchs Stem cells: Aging and transcriptional
fingerprints . . . . . . . . . . . . . . 79
Nicole M. Templeman and
Coleen T. Murphy Regulation of reproduction and longevity
by nutrient-sensing pathways . . . . . . 93
Yuejia Huang and
Teng Li and
Stephanie C. Ems-McClung and
Claire E. Walczak and
Claude Prigent and
Xueliang Zhu and
Xuemin Zhang and
Yixian Zheng Aurora A activation in mitosis promoted
by BuGZ . . . . . . . . . . . . . . . . 107
Nadav Segev and
Jeffrey E. Gerst Specialized ribosomes and specific
ribosomal protein paralogs control
translation of mitochondrial proteins 117
Vitor Teixeira and
Lisa Johnsen and
Fernando Martínez-Montañés and
Alexandra Grippa and
Laura Buxó and
Fatima-Zahra Idrissi and
Christer S. Ejsing and
Pedro Carvalho Regulation of lipid droplets by
metabolically controlled Ldo isoforms 127
Xi Wu and
Lanlan Li and
Hui Jiang Mitochondrial inner-membrane protease
Yme1 degrades outer-membrane proteins
Tom22 and Om45 . . . . . . . . . . . . . 139
Fabian Marc Schmid and
Kenneth Bòdtker Schou and
Martin Juel Vilhelm and
Maria Schròder Holm and
Loretta Breslin and
Pietro Farinelli and
Lars Allan Larsen and
Jens Skorstengaard Andersen and
Lotte Bang Pedersen and
Sòren Tvorup Christensen IFT20 modulates ciliary PDGFR$ \alpha $
signaling by regulating the stability of
Cbl E3 ubiquitin ligases . . . . . . . . 151
Keith F. DeLuca and
Amanda Meppelink and
Amanda J. Broad and
Jeanne E. Mick and
Olve B. Peersen and
Sibel Pektas and
Susanne M. A. Lens and
Jennifer G. DeLuca Aurora A kinase phosphorylates Hec1 to
regulate metaphase
kinetochore--microtubule dynamics . . . 163
Bernhard Strauss and
Andrew Harrison and
Paula Almeida Coelho and
Keiko Yata and
Magdalena Zernicka-Goetz and
Jonathon Pines Cyclin B1 is essential for mitosis in
mouse embryos, and its nuclear export
sets the time for mitosis . . . . . . . 179
Alexander D. Rhys and
Pedro Monteiro and
Christopher Smith and
Malti Vaghela and
Teresa Arnandis and
Takuya Kato and
Birgit Leitinger and
Erik Sahai and
Andrew McAinsh and
Guillaume Charras and
Susana A. Godinho Loss of E-cadherin provides tolerance to
centrosome amplification in epithelial
cancer cells . . . . . . . . . . . . . . 195
Maryam Izadi and
Dirk Schlobinski and
Maria Lahr and
Lukas Schwintzer and
Britta Qualmann and
Michael M. Kessels Cobl-like promotes actin filament
formation and dendritic branching using
only a single WH2 domain . . . . . . . . 211
Paolo Armando Gagliardi and
Desiana Somale and
Alberto Puliafito and
Giulia Chiaverina and
Laura di Blasio and
Michele Oneto and
Paolo Bianchini and
Federico Bussolino and
Luca Primo MRCK$ \alpha $ is activated by caspase
cleavage to assemble an apical actin
ring for epithelial cell extrusion . . . 231
Rajarshi Chakrabarti and
Wei-Ke Ji and
Radu V. Stan and
Jaime de Juan Sanz and
Timothy A. Ryan and
Henry N. Higgs INF2-mediated actin polymerization at
the ER stimulates mitochondrial calcium
uptake, inner membrane constriction, and
division . . . . . . . . . . . . . . . . 251
Michal Eisenberg-Bord and
Muriel Mari and
Uri Weill and
Eden Rosenfeld-Gur and
Ofer Moldavski and
Inês G. Castro and
Krishnakant G. Soni and
Nofar Harpaz and
Tim P. Levine and
Anthony H. Futerman and
Fulvio Reggiori and
Vytas A. Bankaitis and
Maya Schuldiner and
Maria Bohnert Identification of seipin-linked factors
that act as determinants of a lipid
droplet subpopulation . . . . . . . . . 269
Laura L. Thomas and
Aaron M. N. Joiner and
J. Christopher Fromme The TRAPPIII complex activates the
GTPase Ypt1 (Rab1) in the secretory
pathway . . . . . . . . . . . . . . . . 283
Hang Liu and
Shimin Wang and
Weijian Hang and
Jinghu Gao and
Wenjuan Zhang and
Zihang Cheng and
Chao Yang and
Jun He and
Jie Zhou and
Juan Chen and
Anbing Shi LET-413\slash Erbin acts as a RAB-5
effector to promote RAB-10 activation
during endocytic recycling . . . . . . . 299
Yingli He and
Hua She and
Ting Zhang and
Haidong Xu and
Lihong Cheng and
Manuel Yepes and
Yingren Zhao and
Zixu Mao p38 MAPK inhibits autophagy and promotes
microglial inflammatory responses by
phosphorylating ULK1 . . . . . . . . . . 315
Amriya Naufer and
Victoria E. B. Hipolito and
Suriakarthiga Ganesan and
Akriti Prashar and
Vanina Zaremberg and
Roberto J. Botelho and
Mauricio R. Terebiznik pH of endophagosomes controls
association of their membranes with
Vps34 and PtdIns(3)P levels . . . . . . 329
Jinchao Liu and
Meijiao Li and
Lin Li and
She Chen and
Xiaochen Wang Ubiquitination of the PI3-kinase VPS-34
promotes VPS-34 stability and phagosome
maturation . . . . . . . . . . . . . . . 347
Tamás Csizmadia and
Péter L\Horincz and
Krisztina Heged\Hus and
Szilvia Széplaki and
Péter L\How and
Gábor Juhász Molecular mechanisms of developmentally
programmed crinophagy in
\bionameDrosophila . . . . . . . . . . . 361
Alessandro Genna and
Stefanie Lapetina and
Nikola Lukic and
Shams Twafra and
Tomer Meirson and
Ved P. Sharma and
John S. Condeelis and
Hava Gil-Henn Pyk2 and FAK differentially regulate
invadopodia formation and function in
breast cancer cells . . . . . . . . . . 375
Jing Li and
Timothy A. Springer Energy landscape differences among
integrins establish the framework for
understanding activation . . . . . . . . 397
Stephanie O. Agbu and
Yinwen Liang and
Aimin Liu and
Kathryn V. Anderson The small GTPase RSG1 controls a final
step in primary cilia initiation . . . . 413
Hibiki Kawamata and
Giovanni Manfredi Correction: Proteinopathies and OXPHOS
dysfunction in neurodegenerative
diseases . . . . . . . . . . . . . . . . 429
Marie Anne O'Donnell Tatsushi Igaki: Flying up the research
summits . . . . . . . . . . . . . . . . 3317
Katharine Goodwin and
Celeste M. Nelson Myoepithelial crowd control of cancer
cells . . . . . . . . . . . . . . . . . 3319
Mingming Gao and
Hongyuan Yang VPS13: a lipid transfer protein making
contacts at multiple cellular locations 3322
Yun-Jin Pai and
Adrian W. Moore Dendritic actin delivery service . . . . 3325
Laura E. Newman and
Gerald S. Shadel Pink1/Parkin link inflammation,
mitochondrial stress, and
neurodegeneration . . . . . . . . . . . 3327
Tanmay P. Lele and
Richard B. Dickinson and
Gregg G. Gundersen Mechanical principles of nuclear shaping
and positioning . . . . . . . . . . . . 3330
Sara Carvalhal and
Alexandra Tavares and
Mariana B. Santos and
Mihailo Mirkovic and
Raquel A. Oliveira A quantitative analysis of cohesin decay
in mitotic fidelity . . . . . . . . . . 3343
Jin Rui Liang and
Emily Lingeman and
Saba Ahmed and
Jacob E. Corn Atlastins remodel the endoplasmic
reticulum for selective autophagy . . . 3354
Orit Katarina Sirka and
Eliah R. Shamir and
Andrew J. Ewald Myoepithelial cells are a dynamic
barrier to epithelial dissemination . . 3368
Federica M. Evangelista and
Anne Maglott-Roth and
Matthieu Stierle and
Laurent Brino and
Evi Soutoglou and
László Tora Transcription and mRNA export
machineries SAGA and TREX-2 maintain
monoubiquitinated H2B balance required
for DNA repair . . . . . . . . . . . . . 3382
Zsolt Karányi and
László Halász and
Laurent Acquaviva and
Dávid Jónás and
Szabolcs Hetey and
Beáta Boros-Oláh and
Feng Peng and
Doris Chen and
Franz Klein and
Vincent Géli and
Lóránt Székvölgyi Nuclear dynamics of the Set1C subunit
Spp1 prepares meiotic recombination
sites for break formation . . . . . . . 3398
Marion Manil-Ségalen and
Ma\lgorzata \Luksza and
Joanne Kanaan and
Véronique Marthiens and
Simon I. R. Lane and
Keith T. Jones and
Marie-Emilie Terret and
Renata Basto and
Marie-Hél\`ene Verlhac Chromosome structural anomalies due to
aberrant spindle forces exerted at gene
editing sites in meiosis . . . . . . . . 3416
Pierre Romé and
Hiroyuki Ohkura A novel microtubule nucleation pathway
for meiotic spindle assembly in oocytes 3431
Shivangi Agarwal and
Kyle Paul Smith and
Yizhuo Zhou and
Aussie Suzuki and
Richard J. McKenney and
Dileep Varma Cdt1 stabilizes kinetochore--microtubule
attachments via an Aurora B
kinase-dependent mechanism . . . . . . . 3446
Wenlong Xia and
Libo Su and
Jianwei Jiao Cold-induced protein RBM3 orchestrates
neurogenesis via modulating Yap mRNA
stability in cold stress . . . . . . . . 3464
Fang Xu and
Hironori Takahashi and
Yosuke Tanaka and
Sotaro Ichinose and
Shinsuke Niwa and
Matthew P. Wicklund and
Nobutaka Hirokawa KIF1B$ \beta $ mutations detected in
hereditary neuropathy impair IGF1R
transport and axon growth . . . . . . . 3480
Wen Lu and
Margot Lakonishok and
Anna S. Serpinskaya and
David Kirchenbüechler and
Shuo-Chien Ling and
Vladimir I. Gelfand Ooplasmic flow cooperates with transport
and anchorage in \bionameDrosophila
oocyte posterior determination . . . . . 3497
Mikael V. Garabedian and
Tatiana Stanishneva-Konovalova and
Chenyu Lou and
Thomas J. Rands and
Luther W. Pollard and
Olga S. Sokolova and
Bruce L. Goode Integrated control of formin-mediated
actin assembly by a stationary inhibitor
and a mobile activator . . . . . . . . . 3512
Shu-Zon Wu and
Magdalena Bezanilla Actin and microtubule cross talk
mediates persistent polarized growth . . 3531
Takamasa Inoue and
Pengwei Zhang and
Wei Zhang and
Kylia Goodner-Bingham and
Allison Dupzyk and
Daniel DiMaio and
Billy Tsai $ \gamma $-Secretase promotes membrane
insertion of the human papillomavirus L2
capsid protein during virus infection 3545
Marianne de la Roche and
Claire Hamilton and
Rebecca Mortensen and
A. Arockia Jeyaprakash and
Sanjay Ghosh and
Paras K. Anand Trafficking of cholesterol to the ER is
required for NLRP3 inflammasome
activation . . . . . . . . . . . . . . . 3560
Rui Dong and
Ting Zhu and
Lorena Benedetti and
Swetha Gowrishankar and
Huichao Deng and
Yiying Cai and
Xiangming Wang and
Kang Shen and
Pietro De Camilli The inositol $5$-phosphatase INPP5K
participates in the fine control of ER
organization . . . . . . . . . . . . . . 3577
Björn D. M. Bean and
Samantha K. Dziurdzik and
Kathleen L. Kolehmainen and
Claire M. S. Fowler and
Waldan K. Kwong and
Leslie I. Grad and
Michael Davey and
Cayetana Schluter and
Elizabeth Conibear Competitive organelle-specific adaptors
recruit Vps13 to membrane contact sites 3593
Natalia V. Varlakhanova and
Frances J. D. Alvarez and
Tyler M. Brady and
Bryan A. Tornabene and
Christopher J. Hosford and
Joshua S. Chappie and
Peijun Zhang and
Marijn G. J. Ford Structures of the fungal dynamin-related
protein Vps1 reveal a unique, open
helical architecture . . . . . . . . . . 3608
Nikit Kumar and
Marianna Leonzino and
William Hancock-Cerutti and
Florian A. Horenkamp and
PeiQi Li and
Joshua A. Lees and
Heather Wheeler and
Karin M. Reinisch and
Pietro De Camilli VPS13A and VPS13C are lipid transport
proteins differentially localized at ER
contact sites . . . . . . . . . . . . . 3625
Jakob Mejlvang and
Hallvard Olsvik and
Steingrim Svenning and
Jack-Ansgar Bruun and
Yakubu Princely Abudu and
Kenneth Bowitz Larsen and
Andreas Brech and
Tom E. Hansen and
Hanne Brenne and
Terkel Hansen and
Harald Stenmark and
Terje Johansen Starvation induces rapid degradation of
selective autophagy receptors by
endosomal microautophagy . . . . . . . . 3640
Levent Bas and
Daniel Papinski and
Mariya Licheva and
Raffaela Torggler and
Sabrina Rohringer and
Martina Schuschnig and
Claudine Kraft Reconstitution reveals Ykt6 as the
autophagosomal SNARE in
autophagosome--vacuole fusion . . . . . 3656
Jieqiong Gao and
Fulvio Reggiori and
Christian Ungermann A novel in vitro assay reveals SNARE
topology and the role of Ykt6 in
autophagosome fusion with vacuoles . . . 3670
Erica J. Hutchins and
Marianne E. Bronner Draxin acts as a molecular rheostat of
canonical Wnt signaling to control
cranial neural crest EMT . . . . . . . . 3683
Dina Aweida and
Inga Rudesky and
Alexandra Volodin and
Eitan Shimko and
Shenhav Cohen GSK3-$ \beta $ promotes
calpain-$1$--mediated desmin filament
depolymerization and myofibril loss in
atrophy . . . . . . . . . . . . . . . . 3698
William Razzell and
Maria E. Bustillo and
Jennifer A. Zallen The force-sensitive protein Ajuba
regulates cell adhesion during
epithelial morphogenesis . . . . . . . . 3715
Vanitha Nithianandam and
Cheng-Ting Chien Actin blobs prefigure dendrite branching
sites . . . . . . . . . . . . . . . . . 3731
W. Christopher Risher and
Namsoo Kim and
Sehwon Koh and
Ji-Eun Choi and
Petar Mitev and
Erin F. Spence and
Louis-Jan Pilaz and
Dongqing Wang and
Guoping Feng and
Debra L. Silver and
Scott H. Soderling and
Henry H. Yin and
Cagla Eroglu Thrombospondin receptor $ \alpha $2$
\delta $-1 promotes synaptogenesis and
spinogenesis via postsynaptic Rac1 . . . 3747
Ya-Fang Chiu and
Arthur U. Sugden and
Kathryn Fox and
Mitchell Hayes and
Bill Sugden Correction: Kaposi's sarcoma-associated
herpesvirus stably clusters its genomes
across generations to maintain itself
extrachromosomally . . . . . . . . . . . 3766
Nicole Infarinato and
Marie Anne O'Donnell BethAnn McLaughlin: Protecting neurons
and women in science . . . . . . . . . . 3769
Kia Z. Perez-Vale and
Mark Peifer Modulating apical--basal polarity by
building and deconstructing a Yurt . . . 3772
Reuben V. Philip and
Rene E. Harrison A tent pole twist on membrane ruffles 3774
Benjamin T. Goult and
Jie Yan and
Martin A. Schwartz Talin as a mechanosensitive signaling
hub . . . . . . . . . . . . . . . . . . 3776
Zsolt G. Venkei and
Yukiko M. Yamashita Emerging mechanisms of asymmetric stem
cell division . . . . . . . . . . . . . 3785
Yuntao Xia and
Irena L. Ivanovska and
Kuangzheng Zhu and
Lucas Smith and
Jerome Irianto and
Charlotte R. Pfeifer and
Cory M. Alvey and
Jiazheng Ji and
Dazhen Liu and
Sangkyun Cho and
Rachel R. Bennett and
Andrea J. Liu and
Roger A. Greenberg and
Dennis E. Discher Nuclear rupture at sites of high
curvature compromises retention of DNA
repair factors . . . . . . . . . . . . . 3796
Brian D. Alford and
Onn Brandman Quantification of Hsp90 availability
reveals differential coupling to the
heat shock response . . . . . . . . . . 3809
Keigo Morita and
Yutaro Hama and
Tamaki Izume and
Norito Tamura and
Toshihide Ueno and
Yoshihiro Yamashita and
Yuriko Sakamaki and
Kaito Mimura and
Hideaki Morishita and
Wataru Shihoya and
Osamu Nureki and
Hiroyuki Mano and
Noboru Mizushima Genome-wide CRISPR screen identifies
TMEM41B as a gene required for
autophagosome formation . . . . . . . . 3817
Marina Volin and
Maayan Zohar-Fux and
Oren Gonen and
Lilach Porat-Kuperstein and
Hila Toledano microRNAs selectively protect hub cells
of the germline stem cell niche from
apoptosis . . . . . . . . . . . . . . . 3829
Laurent Gagnoux-Palacios and
Hala Awina and
Stéphane Audebert and
Aurélie Rossin and
Magali Mondin and
Franck Borgese and
Carlota Planas-Botey and
Amel Mettouchi and
Jean-Paul Borg and
Anne-Odile Hueber Cell polarity and adherens junction
formation inhibit epithelial Fas cell
death receptor signaling . . . . . . . . 3839
Clémence L. Gamblin and
Frédérique Parent-Prévost and
Kévin Jacquet and
Cornélia Biehler and
Alexandra Jetté and
Patrick Laprise Oligomerization of the FERM--FA protein
Yurt controls epithelial cell polarity 3853
Kohei Arasaki and
Hana Kimura and
Mitsuo Tagaya and
Craig R. Roy Legionella remodels the plasma
membrane--derived vacuole by utilizing
exocyst components as tethers . . . . . 3863
Nicholas D. Condon and
John M. Heddleston and
Teng-Leong Chew and
Lin Luo and
Peter S. McPherson and
Maria S. Ioannou and
Louis Hodgson and
Jennifer L. Stow and
Adam A. Wall Macropinosome formation by tent pole
ruffling in macrophages . . . . . . . . 3873
Aida Llauró and
Hanako Hayashi and
Megan E. Bailey and
Alex Wilson and
Patryk Ludzia and
Charles L. Asbury and
Bungo Akiyoshi The kinetoplastid kinetochore protein
KKT4 is an unconventional microtubule
tip--coupling protein . . . . . . . . . 3886
Jian Li and
Ji-Xin Tang and
Jin-Mei Cheng and
Bian Hu and
Yu-Qian Wang and
Batool Aalia and
Xiao-Yu Li and
Cheng Jin and
Xiu-Xia Wang and
Shou-Long Deng and
Yan Zhang and
Su-Ren Chen and
Wei-Ping Qian and
Qing-Yuan Sun and
Xing-Xu Huang and
Yi-Xun Liu Cyclin B2 can compensate for Cyclin B1
in oocyte meiosis I . . . . . . . . . . 3901
Ke Wang and
Lantian Wang and
Jianshu Wang and
Suli Chen and
Min Shi and
Hong Cheng Intronless mRNAs transit through nuclear
speckles to gain export competence . . . 3912
Luís Pedro Resende and
Augusta Monteiro and
Rita Brás and
Tatiana Lopes and
Claudio E. Sunkel Aneuploidy in intestinal stem cells
promotes gut dysplasia in
\bionameDrosophila . . . . . . . . . . . 3930
Moushami Mallik and
Marica Catinozzi and
Clemens B. Hug and
Li Zhang and
Marina Wagner and
Julia Bussmann and
Jonas Bittern and
Sina Mersmann and
Christian Klämbt and
Hannes C. A. Drexler and
Martijn A. Huynen and
Juan M. Vaquerizas and
Erik Storkebaum Xrp1 genetically interacts with the
ALS-associated FUS orthologue caz and
mediates its toxicity . . . . . . . . . 3947
Katharine A. White and
Bree K. Grillo-Hill and
Mario Esquivel and
Jobelle Peralta and
Vivian N. Bui and
Ismahan Chire and
Diane L. Barber $ \beta $-Catenin is a pH sensor with
decreased stability at higher
intracellular pH . . . . . . . . . . . . 3965
Adam P. Williamson and
Ronald D. Vale Spatial control of Draper receptor
signaling initiates apoptotic cell
engulfment . . . . . . . . . . . . . . . 3977
Akari Hagiwara and
Yosuke Kitahara and
Chad Paul Grabner and
Christian Vogl and
Manabu Abe and
Ryo Kitta and
Keisuke Ohta and
Keiichiro Nakamura and
Kenji Sakimura and
Tobias Moser and
Akinori Nishi and
Toshihisa Ohtsuka Cytomatrix proteins CAST and ELKS
regulate retinal photoreceptor
development and maintenance . . . . . . 3993
Xian-Dong Liu and
Xiao-Na Zhu and
Michael M. Halford and
Tian-Le Xu and
Mark Henkemeyer and
Nan-Jie Xu Retrograde regulation of mossy fiber
axon targeting and terminal maturation
via postsynaptic Lnx1 . . . . . . . . . 4007
Yu Chen and
Yang Zhang and
Yuchuan Wang and
Liguo Zhang and
Eva K. Brinkman and
Stephen A. Adam and
Robert Goldman and
Bas van Steensel and
Jian Ma and
Andrew S. Belmont Mapping $3$D genome organization
relative to nuclear compartments using
TSA--Seq as a cytological ruler . . . . 4025
Jin Rui Liang and
Emily Lingeman and
Saba Ahmed and
Jacob E. Corn Correction: Atlastins remodel the
endoplasmic reticulum for selective
autophagy . . . . . . . . . . . . . . . 4049
Nicole Infarinato Beata Mierzwa: Bridging the divide
between science and art . . . . . . . . 4051
Maria Bohnert Wrapping up the fats --- a structure of
the lipid droplet biogenesis protein
seipin . . . . . . . . . . . . . . . . . 4053
Prachee Avasthi Can microtubule motors use every
available track? . . . . . . . . . . . . 4055
Francis J. McNally and
Antonina Roll-Mecak Microtubule-severing enzymes: From
cellular functions to molecular
mechanism . . . . . . . . . . . . . . . 4057
Marina Martinez-Garcia and
Veit Schubert and
Kim Osman and
Alice Darbyshire and
Eugenio Sanchez-Moran and
F. Chris H. Franklin TOPII and chromosome movement help
remove interlocks between entangled
chromosomes during meiosis . . . . . . . 4070
Xuewu Sui and
Henning Arlt and
Kelly P. Brock and
Zon Weng Lai and
Frank DiMaio and
Debora S. Marks and
Maofu Liao and
Robert V. Farese and
Tobias C. Walther Cryo--electron microscopy structure of
the lipid droplet--formation protein
seipin . . . . . . . . . . . . . . . . . 4080
Stéphanie Torrino and
Wei-Wei Shen and
Cédric M. Blouin and
Satish Kailasam Mani and
Christine Viaris de Lesegno and
Pierre Bost and
Alexandre Grassart and
Darius Köster and
Cesar Augusto Valades-Cruz and
Valérie Chambon and
Ludger Johannes and
Paolo Pierobon and
Vassili Soumelis and
Catherine Coirault and
Stéphane Vassilopoulos and
Christophe Lamaze EHD2 is a mechanotransducer connecting
caveolae dynamics with gene
transcription . . . . . . . . . . . . . 4092
Haytham Mehsen and
Vincent Boudreau and
Damien Garrido and
Mohammed Bourouh and
Myreille Larouche and
Paul S. Maddox and
Andrew Swan and
Vincent Archambault PP2A-B55 promotes nuclear envelope
reformation after mitosis in
\bionameDrosophila . . . . . . . . . . . 4106
Anthony Khong and
Roy Parker mRNP architecture in translating and
stress conditions reveals an ordered
pathway of mRNP compaction . . . . . . . 4124
Jason C. Collins and
Homa Ghalei and
Joanne R. Doherty and
Haina Huang and
Rebecca N. Culver and
Katrin Karbstein Ribosome biogenesis factor Ltv1
chaperones the assembly of the small
subunit head . . . . . . . . . . . . . . 4141
Hideki Shigematsu and
Tsuyoshi Imasaki and
Chihiro Doki and
Takuya Sumi and
Mari Aoki and
Tomomi Uchikubo-Kamo and
Ayako Sakamoto and
Kiyotaka Tokuraku and
Mikako Shirouzu and
Ryo Nitta Structural insight into microtubule
stabilization and kinesin inhibition by
Tau family MAPs . . . . . . . . . . . . 4155
Tomohiro Shima and
Manatsu Morikawa and
Junichi Kaneshiro and
Taketoshi Kambara and
Shinji Kamimura and
Toshiki Yagi and
Hiroyuki Iwamoto and
Sotaro Uemura and
Hideki Shigematsu and
Mikako Shirouzu and
Taro Ichimura and
Tomonobu M. Watanabe and
Ryo Nitta and
Yasushi Okada and
Nobutaka Hirokawa Kinesin-binding--triggered conformation
switching of microtubules contributes to
polarized transport . . . . . . . . . . 4164
James Winsor and
Ursula Machi and
Qixiu Han and
David D. Hackney and
Tina H. Lee GTP hydrolysis promotes disassembly of
the atlastin crossover dimer during ER
fusion . . . . . . . . . . . . . . . . . 4184
Pawan Kishor Singh and
Anjali Kapoor and
Richa Madan Lomash and
Kamal Kumar and
Sukrut C. Kamerkar and
Thomas J. Pucadyil and
Amitabha Mukhopadhyay Salmonella SipA mimics a cognate SNARE
for host Syntaxin8 to promote fusion
with early endosomes . . . . . . . . . . 4199
Daniela Gallo Castro and
Sophie G. Martin Differential GAP requirement for
Cdc42-GTP polarization during
proliferation and sexual reproduction 4215
Jonathan B. Michaux and
François B. Robin and
William M. McFadden and
Edwin M. Munro Excitable RhoA dynamics drive pulsed
contractions in the early \bionameC.
elegans embryo . . . . . . . . . . . . . 4230
Hannes Maib and
Filipe Ferreira and
Stéphane Vassilopoulos and
Elizabeth Smythe Cargo regulates clathrin-coated pit
invagination via clathrin light chain
phosphorylation . . . . . . . . . . . . 4253
Lara Carvalho and
Pedro Patricio and
Susana Ponte and
Carl-Philipp Heisenberg and
Luis Almeida and
André S. Nunes and
Nuno A. M. Araújo and
Antonio Jacinto Occluding junctions as novel regulators
of tissue mechanics during wound repair 4267
Elo\"\ise Bertiaux and
Adeline Mallet and
Cécile Fort and
Thierry Blisnick and
Serge Bonnefoy and
Jamin Jung and
Moara Lemos and
Sergio Marco and
Sue Vaughan and
Sylvain Trépout and
Jean-Yves Tinevez and
Philippe Bastin Bidirectional intraflagellar transport
is restricted to two sets of microtubule
doublets in the trypanosome flagellum 4284
Panagiota Louka and
Krishna Kumar Vasudevan and
Mayukh Guha and
Ewa Joachimiak and
Dorota Wloga and
Raphaël F.-X. Tomasi and
Charles N. Baroud and
Pascale Dupuis-Williams and
Domenico F. Galati and
Chad G. Pearson and
Luke M. Rice and
James J. Moresco and
John R. Yates and
Yu-Yang Jiang and
Karl Lechtreck and
William Dentler and
Jacek Gaertig Proteins that control the geometry of
microtubules at the ends of cilia . . . 4298
Fengrong Wang and
Song Chen and
Hans B. Liu and
Carole A. Parent and
Pierre A. Coulombe Keratin 6 regulates collective
keratinocyte migration by altering
cell--cell and cell--matrix adhesion . . 4314
Ben Short The proteasome helps epithelial cells
set up KAMPs . . . . . . . . . . . . . . 431
Marie Anne O'Donnell Bao-Liang Song: Loving biology in the
time of cholesterol . . . . . . . . . . 433
Nicola J. Allen and
Richard Daneman In Memoriam: Ben Barres . . . . . . . . 435
Marta Giacomello and
Luca Scorrano The INs and OUTs of mitofusins . . . . . 439
Rachel J. O'Neill and
Michael J. O'Neill Replication timing kept in LINE . . . . 441
Hyungsoo Kim and
Ze'ev A. Ronai Rewired Notch/p53 by Numb'ing Mdm2 . . . 445
Campbell D. Lawson and
Anne J. Ridley Rho GTPase signaling complexes in cell
migration and invasion . . . . . . . . . 447
David V. Hansen and
Jesse E. Hanson and
Morgan Sheng Microglia in Alzheimer's disease . . . . 459
Gajendra Kumar Azad and
Kenji Ito and
Badi Sri Sailaja and
Alva Biran and
Malka Nissim-Rafinia and
Yasuhiro Yamada and
David T. Brown and
Takumi Takizawa and
Eran Meshorer PARP1-dependent eviction of the linker
histone H1 mediates immediate early gene
expression during neuronal activation 473
Byung Ho Lee and
Françoise Schwager and
Patrick Meraldi and
Monica Gotta p37/UBXN2B regulates spindle orientation
by limiting cortical NuMA recruitment
via PP1/Repo--Man . . . . . . . . . . . 483
Francisco Piña and
Fumi Yagisawa and
Keisuke Obara and
J. D. Gregerson and
Akio Kihara and
Maho Niwa Sphingolipids activate the endoplasmic
reticulum stress surveillance pathway 495
Sevan Mattie and
Jan Riemer and
Jeremy G. Wideman and
Heidi M. McBride A new mitofusin topology places the
redox-regulated C terminus in the
mitochondrial intermembrane space . . . 507
Suxia Ren and
Zengyi Huang and
Yuqiang Jiang and
Tao Wang dTBC1D7 regulates systemic growth
independently of TSC through insulin
signaling . . . . . . . . . . . . . . . 517
Shalaka Chitale and
Holger Richly DICER- and MMSET-catalyzed H4K20me2
recruits the nucleotide excision repair
factor XPA to DNA damage sites . . . . . 527
Emily J. Platt and
Leslie Smith and
Mathew J. Thayer L1 retrotransposon antisense RNA within
ASAR lncRNAs controls chromosome-wide
replication timing . . . . . . . . . . . 541
Aya Sato-Carlton and
Chihiro Nakamura-Tabuchi and
Stephane Kazuki Chartrand and
Tomoki Uchino and
Peter Mark Carlton Phosphorylation of the synaptonemal
complex protein SYP-1 promotes meiotic
chromosome segregation . . . . . . . . . 555
Joshua Kavaler and
Hong Duan and
Rajaguru Aradhya and
Luis F. de Navas and
Brian Joseph and
Boris Shklyar and
Eric C. Lai miRNA suppression of a Notch repressor
directs non-neuronal fate in
\bionameDrosophila mechanosensory organs 571
Yi-Shi Liu and
Xin-Yu Guo and
Tetsuya Hirata and
Yao Rong and
Daisuke Motooka and
Toshihiko Kitajima and
Yoshiko Murakami and
Xiao-Dong Gao and
Shota Nakamura and
Taroh Kinoshita and
Morihisa Fujita N -Glycan-dependent protein folding and
endoplasmic reticulum retention regulate
GPI-anchor processing . . . . . . . . . 585
Falko Riedel and
Antonio Galindo and
Nadine Muschalik and
Sean Munro The two TRAPP complexes of metazoans
have distinct roles and act on different
Rab GTPases . . . . . . . . . . . . . . 601
Kanji Okumoto and
Tatsuaki Ono and
Ryusuke Toyama and
Ayako Shimomura and
Aiko Nagata and
Yukio Fujiki New splicing variants of mitochondrial
Rho GTPase-1 (Miro1) transport
peroxisomes . . . . . . . . . . . . . . 619
Zhenwei Gong and
Inmaculada Tasset and
Antonio Diaz and
Jaime Anguiano and
Emir Tas and
Lingguang Cui and
Regina Kuliawat and
Honghai Liu and
Bernhard Kühn and
Ana Maria Cuervo and
Radhika Muzumdar Humanin is an endogenous activator of
chaperone-mediated autophagy . . . . . . 635
Julien Villeneuve and
Laia Bassaganyas and
Sebastien Lepreux and
Marioara Chiritoiu and
Pierre Costet and
Jean Ripoche and
Vivek Malhotra and
Randy Schekman Unconventional secretion of FABP4 by
endosomes and secretory lysosomes . . . 649
Hsin-Fang Chang and
Stefanie Mannebach and
Andreas Beck and
Keerthana Ravichandran and
Elmar Krause and
Katja Frohnweiler and
Claudia Fecher-Trost and
Claudia Schirra and
Varsha Pattu and
Veit Flockerzi and
Jens Rettig Cytotoxic granule endocytosis depends on
the Flower protein . . . . . . . . . . . 667
Voahangy Randrianarison-Huetz and
Aikaterini Papaefthymiou and
Gaëlle Herledan and
Chiara Noviello and
Ulduz Faradova and
Laura Collard and
Alessandra Pincini and
Emilie Schol and
Jean François Decaux and
Pascal Maire and
Stéphane Vassilopoulos and
Athanassia Sotiropoulos Srf controls satellite cell fusion
through the maintenance of actin
architecture . . . . . . . . . . . . . . 685
Andrew J. Davidson and
Clelia Amato and
Peter A. Thomason and
Robert H. Insall WASP family proteins and formins compete
in pseudopod- and bleb-based migration 701
Michael Wigerius and
Dylan Quinn and
Antonios Diab and
Leanne Clattenburg and
Annette Kolar and
Jiansong Qi and
Stefan R. Krueger and
James P. Fawcett The polarity protein Angiomotin p130
controls dendritic spine maturation . . 715
Jonathan K. L. Chan and
Don Yuen and
Priscilla Hiu-Mei Too and
Yan Sun and
Belinda Willard and
David Man and
Connie Tam Keratin 6a reorganization for
ubiquitin--proteasomal processing is a
direct antimicrobial response . . . . . 731
Ivan Nicola Colaluca and
Andrea Basile and
Lee Freiburger and
Veronica D'Uva and
Davide Disalvatore and
Manuela Vecchi and
Stefano Confalonieri and
Daniela Tosoni and
Valentina Cecatiello and
Maria Grazia Malabarba and
Chun-Jiun Yang and
Masatsune Kainosho and
Michael Sattler and
Marina Mapelli and
Salvatore Pece and
Pier Paolo Di Fiore A Numb--Mdm2 fuzzy complex reveals an
isoform-specific involvement of Numb in
breast cancer . . . . . . . . . . . . . 745
Manuel Viotti and
Catherine Wilson and
Mark McCleland and
Hartmut Koeppen and
Benjamin Haley and
Suchit Jhunjhunwala and
Christiaan Klijn and
Zora Modrusan and
David Arnott and
Marie Classon and
Jean-Philippe Stephan and
Ira Mellman SUV420H2 is an epigenetic regulator of
epithelial/mesenchymal states in
pancreatic cancer . . . . . . . . . . . 763
Rebecca C. Adikes and
Ryan A. Hallett and
Brian F. Saway and
Brian Kuhlman and
Kevin C. Slep Control of microtubule dynamics using an
optogenetic microtubule plus
end--F-actin cross-linker . . . . . . . 779
Ben Short How mitotic spindles point to the exit 795
Marie Anne O'Donnell Laura Lackner: Passing on the scientific
baton . . . . . . . . . . . . . . . . . 797
Rhoda J. Hawkins Do migrating cells need a nucleus? . . . 799
Sharon A. Tooze SNAREing an ARP requires a LIR . . . . . 803
Florence Janody The Big Bang of tissue growth: Apical
cell constriction turns into tissue
expansion . . . . . . . . . . . . . . . 807
Helge Ewers Open-source recombinant monoclonal
secondary nanobodies . . . . . . . . . . 809
Ken Cadwell and
Jayanta Debnath Beyond self-eating: The control of
nonautophagic functions and signaling
pathways by autophagy-related proteins 813
Jadranka Loncarek and
Mónica Bettencourt-Dias Building the right centriole for each
cell type . . . . . . . . . . . . . . . 823
Sriyash Mangal and
Jennifer Sacher and
Taekyung Kim and
Daniel Sampaio Osório and
Fumio Motegi and
Ana Xavier Carvalho and
Karen Oegema and
Esther Zanin TPXL-1 activates Aurora A to clear
contractile ring components from the
polar cortex during cytokinesis . . . . 837
Joshua C. Sandquist and
Matthew E. Larson and
Sarah Woolner and
Zhiwei Ding and
William M. Bement An interaction between myosin-10 and the
cell cycle regulator Wee1 links spindle
dynamics to mitotic progression in
epithelia . . . . . . . . . . . . . . . 849
Eleni Petsalaki and
Maria Dandoulaki and
George Zachos The ESCRT protein Chmp4c regulates
mitotic spindle checkpoint signaling . . 861
Wanlu Zhang and
Annett Neuner and
Diana Rüthnick and
Timo Sachsenheimer and
Christian Lüchtenborg and
Britta Brügger and
Elmar Schiebel Brr6 and Brl1 locate to nuclear pore
complex assembly sites to promote their
biogenesis . . . . . . . . . . . . . . . 877
David M. Graham and
Tomas Andersen and
Lisa Sharek and
Gunes Uzer and
Katheryn Rothenberg and
Brenton D. Hoffman and
Janet Rubin and
Martial Balland and
James E. Bear and
Keith Burridge Enucleated cells reveal differential
roles of the nucleus in cell migration,
polarity, and mechanotransduction . . . 895
Masayoshi Nakamura and
Jelmer J. Lindeboom and
Marco Saltini and
Bela M. Mulder and
David W. Ehrhardt SPR2 protects minus ends to promote
severing and reorientation of plant
cortical microtubule arrays . . . . . . 915
Jaime Fernández-Barrera and
Miguel Bernabé-Rubio and
Javier Casares-Arias and
Laura Rangel and
Laura Fernández-Martín and
Isabel Correas and
Miguel A. Alonso The actin--MRTF--SRF transcriptional
circuit controls tubulin acetylation via
$ \alpha $-TAT1 gene expression . . . . 929
Peter A. C. van Gisbergen and
Shu-Zon Wu and
Mingqin Chang and
Kelli A. Pattavina and
Madelaine E. Bartlett and
Magdalena Bezanilla An ancient Sec10--formin fusion provides
insights into actin-mediated regulation
of exocytosis . . . . . . . . . . . . . 945
Shin Kawano and
Yasushi Tamura and
Rieko Kojima and
Siqin Bala and
Eri Asai and
Agn\`es H. Michel and
Beno\^\it Kornmann and
Isabelle Riezman and
Howard Riezman and
Yoshitake Sakae and
Yuko Okamoto and
Toshiya Endo Structure--function insights into direct
lipid transfer between membranes by
Mmm1--Mdm12 of ERMES . . . . . . . . . . 959
Dijin Xu and
Yuqi Li and
Lizhen Wu and
Ying Li and
Dongyu Zhao and
Jinhai Yu and
Tuozhi Huang and
Charles Ferguson and
Robert G. Parton and
Hongyuan Yang and
Peng Li Rab18 promotes lipid droplet (LD) growth
by tethering the ER to LDs through SNARE
and NRZ interactions . . . . . . . . . . 975
Suresh Kumar and
Ashish Jain and
Farzin Farzam and
Jingyue Jia and
Yuexi Gu and
Seong Won Choi and
Michal H. Mudd and
Aurore Claude-Taupin and
Michael J. Wester and
Keith A. Lidke and
Tor-Erik Rusten and
Vojo Deretic Mechanism of Stx17 recruitment to
autophagosomes via IRGM and mammalian
Atg8 proteins . . . . . . . . . . . . . 997
Igor Kova\vcevi\'c and
Tomohisa Sakaue and
Jisca Majoleé and
Manon C. Pronk and
Masashi Maekawa and
Dirk Geerts and
Mar Fernandez-Borja and
Shigeki Higashiyama and
Peter L. Hordijk The Cullin-3--Rbx1--KCTD10 complex
controls endothelial barrier function
via K63 ubiquitination of RhoB . . . . . 1015
Giorgos Tsoumpekos and
Linda Nemetschke and
Elisabeth Knust Drosophila Big bang regulates the apical
cytocortex and wing growth through
junctional tension . . . . . . . . . . . 1033
Elodie Forest and
Rémi Logeay and
Charles Géminard and
Diala Kantar and
Florence Frayssinoux and
Lisa Heron-Milhavet and
Alexandre Djiane The apical scaffold big bang binds to
spectrins and regulates the growth of
\bionameDrosophila melanogaster wing
discs . . . . . . . . . . . . . . . . . 1047
Charl\`ene Gayrard and
Clément Bernaudin and
Théophile Déjardin and
Cynthia Seiler and
Nicolas Borghi Src- and confinement-dependent FAK
activation causes E-cadherin relaxation
and $ \beta $-catenin activity . . . . . 1063
Hamze Beati and
Irina Peek and
Paulina Hordowska and
Mona Honemann-Capito and
Jade Glashauser and
Fabian A. Renschler and
Parisa Kakanj and
Andreas Ramrath and
Maria Leptin and
Stefan Luschnig and
Silke Wiesner and
Andreas Wodarz The adherens junction--associated LIM
domain protein Smallish regulates
epithelial morphogenesis . . . . . . . . 1079
Antonino Schepis and
Adrian Barker and
Yoga Srinivasan and
Eaman Balouch and
Yaowu Zheng and
Ian Lam and
Hilary Clay and
Chung-Der Hsiao and
Shaun R. Coughlin Protease signaling regulates apical cell
extrusion, cell contacts, and
proliferation in epithelia . . . . . . . 1097
Fabio L. Urbina and
Shawn M. Gomez and
Stephanie L. Gupton Spatiotemporal organization of
exocytosis emerges during neuronal shape
change . . . . . . . . . . . . . . . . . 1113
Frederik Johannes Verweij and
Maarten P. Bebelman and
Connie R. Jimenez and
Juan J. Garcia-Vallejo and
Hans Janssen and
Jacques Neefjes and
Jaco C. Knol and
Richard de Goeij-de Haas and
Sander R. Piersma and
S. Rubina Baglio and
Matthijs Verhage and
Jaap M. Middeldorp and
Anoek Zomer and
Jacco van Rheenen and
Marc G. Coppolino and
Ilse Hurbain and
Graça Raposo and
Martine J. Smit and
Ruud F. G. Toonen and
Guillaume van Niel and
D. Michiel Pegtel Quantifying exosome secretion from
single cells reveals a modulatory role
for GPCR signaling . . . . . . . . . . . 1129
Tino Pleiner and
Mark Bates and
Dirk Görlich A toolbox of anti-mouse and anti-rabbit
IgG secondary nanobodies . . . . . . . . 1143
Nadav Segev and
Jeffrey E. Gerst Correction: Specialized ribosomes and
specific ribosomal protein paralogs
control translation of mitochondrial
proteins . . . . . . . . . . . . . . . . 1155
Frederik Johannes Verweij and
Maarten P. Bebelman and
Connie R. Jimenez and
Juan J. Garcia-Vallejo and
Hans Janssen and
Jacques Neefjes and
Jaco C. Knol and
Richard de Goeij-de Haas and
Sander R. Piersma and
S. Rubina Baglio and
Matthijs Verhage and
Jaap M. Middeldorp and
Anoek Zomer and
Jacco van Rheenen and
Marc G. Coppolino and
Ilse Hurbain and
Graça Raposo and
Martine J. Smit and
Ruud F. G. Toonen and
Guillaume van Niel and
D. Michiel Pegtel Correction: Quantifying exosome
secretion from single cells reveals a
modulatory role for GPCR signaling . . . 1157
Ben Short Src turns FHL1 to the dark side . . . . 1159
Marie Anne O'Donnell Tamas Balla: Leading the way with
phosphoinositides . . . . . . . . . . . 1161
Blobel Laboratory Trainees Günter Blobel: Pioneer of molecular cell
biology (1936--2018) . . . . . . . . . . 1163
Simon Gemble and
Renata Basto Fast and furious \ldots or not, Plk4
dictates the pace . . . . . . . . . . . 1169
Edgar E. Boczek and
Simon Alberti One domain fits all: Using disordered
regions to sequester misfolded proteins 1173
Dana Branzei and
Michele Giannattasio SIRFing the replication fork: Assessing
protein interactions with nascent DNA 1177
Zhe Liu and
Robert Tjian Visualizing transcription factor
dynamics in living cells . . . . . . . . 1181
Victoria E. Deneke and
Stefano Di Talia Chemical waves in cell and developmental
biology . . . . . . . . . . . . . . . . 1193
Yetunde Adesanya Ogungbenro and
Teresa Casar Tena and
David Gaboriau and
Pierce Lalor and
Peter Dockery and
Melanie Philipp and
Ciaran G. Morrison Centrobin controls primary ciliogenesis
in vertebrates . . . . . . . . . . . . . 1205
Tiffany A. McLamarrah and
Daniel W. Buster and
Brian J. Galletta and
Cody J. Boese and
John M. Ryniawec and
Natalie Ann Hollingsworth and
Amy E. Byrnes and
Christopher W. Brownlee and
Kevin C. Slep and
Nasser M. Rusan and
Gregory C. Rogers An ordered pattern of Ana2
phosphorylation by Plk4 is required for
centriole assembly . . . . . . . . . . . 1217
Mustafa G. Aydogan and
Alan Wainman and
Saroj Saurya and
Thomas L. Steinacker and
Anna Caballe and
Zsofia A. Novak and
Janina Baumbach and
Nadine Muschalik and
Jordan W. Raff A homeostatic clock sets daughter
centriole size in flies . . . . . . . . 1233
Clara Gomis-Coloma and
Sergio Velasco-Aviles and
Jose A. Gomez-Sanchez and
Angeles Casillas-Bajo and
Johannes Backs and
Hugo Cabedo Class IIa histone deacetylases link cAMP
signaling to the myelin transcriptional
program of Schwann cells . . . . . . . . 1249
Tomas Grousl and
Sophia Ungelenk and
Stephanie Miller and
Chi-Ting Ho and
Maria Khokhrina and
Matthias P. Mayer and
Bernd Bukau and
Axel Mogk A prion-like domain in Hsp42 drives
chaperone-facilitated aggregation of
misfolded proteins . . . . . . . . . . . 1269
Yuichi Tsuchiya and
Michiko Saito and
Hiroshi Kadokura and
Jun-ichi Miyazaki and
Fumi Tashiro and
Yusuke Imagawa and
Takao Iwawaki and
Kenji Kohno IRE1--XBP1 pathway regulates oxidative
proinsulin folding in pancreatic $ \beta
$ cells . . . . . . . . . . . . . . . . 1287
Benedikt Niewidok and
Maxim Igaev and
Abel Pereira da Graca and
Andre Strassner and
Christine Lenzen and
Christian P. Richter and
Jacob Piehler and
Rainer Kurre and
Roland Brandt Single-molecule imaging reveals dynamic
biphasic partition of RNA-binding
proteins in stress granules . . . . . . 1303
Yang Yue and
T. Lynne Blasius and
Stephanie Zhang and
Shashank Jariwala and
Benjamin Walker and
Barry J. Grant and
Jared C. Cochran and
Kristen J. Verhey Altered chemomechanical coupling causes
impaired motility of the kinesin-4
motors KIF27 and KIF7 . . . . . . . . . 1319
Xiang Wang and
Xiaofan Wei and
Yang Yuan and
Qingrui Sun and
Jun Zhan and
Jing Zhang and
Yan Tang and
Feng Li and
Lihua Ding and
Qinong Ye and
Hongquan Zhang Src-mediated phosphorylation converts
FHL1 from tumor suppressor to tumor
promoter . . . . . . . . . . . . . . . . 1335
Laura Montani and
Jorge A. Pereira and
Camilla Norrmén and
Hartmut B. F. Pohl and
Elisa Tinelli and
Martin Trötzmüller and
Gianluca Figlia and
Penelope Dimas and
Belinda von Niederhäusern and
Rachel Schwager and
Sebastian Jessberger and
Clay F. Semenkovich and
Harald C. Köfeler and
Ueli Suter De novo fatty acid synthesis by Schwann
cells is essential for peripheral
nervous system myelination . . . . . . . 1353
Sandra Backes and
Steffen Hess and
Felix Boos and
Michael W. Woellhaf and
Sabrina Gödel and
Martin Jung and
Timo Mühlhaus and
Johannes M. Herrmann Tom70 enhances mitochondrial preprotein
import efficiency by binding to internal
targeting sequences . . . . . . . . . . 1369
Dominic B. Bernkopf and
Kowcee Jalal and
Martina Brückner and
Karl X. Knaup and
Marc Gentzel and
Alexandra Schambony and
Jürgen Behrens Pgam5 released from damaged mitochondria
induces mitochondrial biogenesis via Wnt
signaling . . . . . . . . . . . . . . . 1383
Jaehak Oh and
Justin S. A. Perry and
Heather Pua and
Nicole Irgens-Möller and
Satoshi Ishido and
Chyi-Song Hsieh and
Jeoung-Sook Shin MARCH1 protects the lipid raft and
tetraspanin web from MHCII
proteotoxicity in dendritic cells . . . 1395
Maria Yurchenko and
Astrid Skjesol and
Liv Ryan and
Gabriel Mary Richard and
Richard Kumaran Kandasamy and
Ninghai Wang and
Cox Terhorst and
Harald Husebye and
Terje Espevik SLAMF1 is required for TLR4-mediated
TRAM--TRIF-dependent signaling in human
macrophages . . . . . . . . . . . . . . 1411
Ling Guo and
Ting Cai and
Keng Chen and
Rong Wang and
Jiaxin Wang and
Chunhong Cui and
Jifan Yuan and
Kuo Zhang and
Zhongzhen Liu and
Yi Deng and
Guozhi Xiao and
Chuanyue Wu Kindlin-2 regulates mesenchymal stem
cell differentiation through control of
YAP1/TAZ . . . . . . . . . . . . . . . . 1431
Hao Sun and
Frederic Lagarrigue and
Alexandre R. Gingras and
Zhichao Fan and
Klaus Ley and
Mark H. Ginsberg Transmission of integrin $ \beta $7
transmembrane domain topology enables
gut lymphoid tissue development . . . . 1453
Laura Merlini and
Bita Khalili and
Omaya Dudin and
Laetitia Michon and
Vincent Vincenzetti and
Sophie G. Martin Inhibition of Ras activity coordinates
cell fusion with cell--cell contact
during yeast mating . . . . . . . . . . 1467
Tim B. Fessenden and
Yvonne Beckham and
Mathew Perez-Neut and
Guillermina Ramirez-San Juan and
Aparajita H. Chourasia and
Kay F. Macleod and
Patrick W. Oakes and
Margaret L. Gardel Dia1-dependent adhesions are required by
epithelial tissues to initiate invasion 1485
Hebatullah Laban and
Andreas Weigert and
Joana Zink and
Amro Elgheznawy and
Christoph Schürmann and
Lea Günther and
Randa Abdel Malik and
Sabrina Bothur and
Susanne Wingert and
Rolf Bremer and
Michael A. Rieger and
Bernhard Brüne and
Ralf P. Brandes and
Ingrid Fleming and
Peter M. Benz VASP regulates leukocyte infiltration,
polarization, and vascular repair after
ischemia . . . . . . . . . . . . . . . . 1503
Sunetra Roy and
Jessica W. Luzwick and
Katharina Schlacher SIRF: Quantitative in situ analysis of
protein interactions at DNA replication
forks . . . . . . . . . . . . . . . . . 1521
Sascha Conic and
Dominique Desplancq and
Alexia Ferrand and
Veronique Fischer and
Vincent Heyer and
Bernardo Reina San Martin and
Julien Pontabry and
Mustapha Oulad-Abdelghani and
Kishore Babu N. and
Graham D. Wright and
Nacho Molina and
Etienne Weiss and
László Tora Imaging of native transcription factors
and histone phosphorylation at high
resolution in live cells . . . . . . . . 1537
Sunetra Roy and
Jessica W. Luzwick and
Katharina Schlacher Correction: SIRF: Quantitative in situ
analysis of protein interactions at DNA
replication forks . . . . . . . . . . . 1553
Ben Short Seeing the insulin receptor in action 1555
Nicole Infarinato Johan Auwerx:o Sowing the seeds of
translational research . . . . . . . . . 1557
Veneta Gerganova and
Sophie G. Martin Dynamic visits of cortical structures
probe for cell size . . . . . . . . . . 1559
Hilary A. Coller DNA replication licensing in stem cells:
Gatekeeping the commitment to
proliferation . . . . . . . . . . . . . 1563
Simon C. Watkins and
Claudette M. St. Croix Light sheet imaging comes of age . . . . 1567
Florence Broders-Bondon and
Thanh Huong Nguyen Ho-Bouldoires and
Maria-Elena Fernandez-Sanchez and
Emmanuel Farge Mechanotransduction in tumor
progression: The dark side of the force 1571
Corey A. H. Allard and
Hannah E. Opalko and
Ko-Wei Liu and
Uche Medoh and
James B. Moseley Cell size-dependent regulation of Wee1
localization by Cdr2 cortical nodes . . 1589
Tânia Catarina Medeiros and
Ryan Lee Thomas and
Ruben Ghillebert and
Martin Graef Autophagy balances mtDNA synthesis and
degradation by DNA polymerase POLG
during starvation . . . . . . . . . . . 1601
Juliette J. Lee and
Alvaro Sanchez-Martinez and
Aitor Martinez Zarate and
Cristiane Benincá and
Ugo Mayor and
Michael J. Clague and
Alexander J. Whitworth Basal mitophagy is widespread in
\bionameDrosophila but minimally
affected by loss of Pink1 or Parkin . . 1613
Sho W. Suzuki and
Scott D. Emr Membrane protein recycling from the
vacuole/lysosome membrane . . . . . . . 1623
Sun K. Kim and
Siwei Zhang and
Michael E. Werner and
Eva J. Brotslaw and
Jennifer W. Mitchell and
Mohamed M. Altabbaa and
Brian J. Mitchell CLAMP\slash Spef1 regulates planar cell
polarity signaling and asymmetric
microtubule accumulation in the
\bionameXenopus ciliated epithelia . . . 1633
Theresia Gutmann and
Kelly H. Kim and
Michal Grzybek and
Thomas Walz and
Ünal Coskun Visualization of ligand-induced
transmembrane signaling in the
full-length human insulin receptor . . . 1643
Anne-Clémence Vion and
Silvanus Alt and
Alexandra Klaus-Bergmann and
Anna Szymborska and
Tuyu Zheng and
Tijana Perovic and
Adel Hammoutene and
Marta Bastos Oliveira and
Eireen Bartels-Klein and
Irene Hollfinger and
Pierre-Emmanuel Rautou and
Miguel O. Bernabeu and
Holger Gerhardt Primary cilia sensitize endothelial
cells to BMP and prevent excessive
vascular regression . . . . . . . . . . 1651
Thomas D. Carroll and
Ian P. Newton and
Yu Chen and
J. Julian Blow and
Inke Näthke Lgr5$^+$ intestinal stem cells reside in
an unlicensed G$_1$ phase . . . . . . . 1667
Itziar Ibarlucea-Benitez and
Luke S. Ferro and
David G. Drubin and
Georjana Barnes Kinesins relocalize the chromosomal
passenger complex to the midzone for
spindle disassembly . . . . . . . . . . 1687
Natalia Papadopoulos and
Johan Lennartsson and
Carl-Henrik Heldin PDGFR$ \beta $ translocates to the
nucleus and regulates chromatin
remodeling via TATA element--modifying
factor 1 . . . . . . . . . . . . . . . . 1701
Coralie Fassier and
Amélie Fréal and
La\"\ila Gasmi and
Christian Delphin and
Daniel Ten Martin and
Stéphanie De Gois and
Monica Tambalo and
Christophe Bosc and
Philippe Mailly and
Céline Revenu and
Leticia Peris and
Susanne Bolte and
Sylvie Schneider-Maunoury and
Corinne Houart and
Fatiha Nothias and
Jean-Christophe Larcher and
Annie Andrieux and
Jamilé Hazan Motor axon navigation relies on
Fidgetin-like $1$--driven microtubule
plus end dynamics . . . . . . . . . . . 1719
Chih-Hang Anthony Tang and
Shiun Chang and
Adrienne W. Paton and
James C. Paton and
Dmitry I. Gabrilovich and
Hidde L. Ploegh and
Juan R. Del Valle and
Chih-Chi Andrew Hu Phosphorylation of IRE1 at S729
regulates RIDD in B cells and antibody
production after immunization . . . . . 1739
Zhe Sha and
Helena M. Schnell and
Kerstin Ruoff and
Alfred Goldberg Rapid induction of p62 and GABARAPL1
upon proteasome inhibition promotes
survival before autophagy activation . . 1757
Tomoaki Sobajima and
Shin-ichiro Yoshimura and
Tomomi Maeda and
Haruhiko Miyata and
Eiji Miyoshi and
Akihiro Harada The Rab11-binding protein RELCH/KIAA1468
controls intracellular cholesterol
distribution . . . . . . . . . . . . . . 1777
Mira Sohn and
Marek Korzeniowski and
James P. Zewe and
Rachel C. Wills and
Gerald R. V. Hammond and
Jana Humpolickova and
Lukas Vrzal and
Dominika Chalupska and
Vaclav Veverka and
Gregory D. Fairn and
Evzen Boura and
Tamas Balla PI(4,5)P$_2$ controls plasma membrane
PI4P and PS levels via ORP5/8
recruitment to ER--PM contact sites . . 1797
Dagan Segal and
Assaf Zaritsky and
Eyal D. Schejter and
Ben-Zion Shilo Feedback inhibition of actin on Rho
mediates content release from large
secretory vesicles . . . . . . . . . . . 1815
Nadia Efimova and
Tatyana M. Svitkina Branched actin networks push against
each other at adherens junctions to
maintain cell--cell adhesion . . . . . . 1827
Fan Ye and
Andrew R. Nager and
Maxence V. Nachury BBSome trains remove activated GPCRs
from cilia by enabling passage through
the transition zone . . . . . . . . . . 1847
Tanner C. Fadero and
Therese M. Gerbich and
Kishan Rana and
Aussie Suzuki and
Matthew DiSalvo and
Kristina N. Schaefer and
Jennifer K. Heppert and
Thomas C. Boothby and
Bob Goldstein and
Mark Peifer and
Nancy L. Allbritton and
Amy S. Gladfelter and
Amy S. Maddox and
Paul S. Maddox LITE microscopy: Tilted light-sheet
excitation of model organisms offers
high resolution and low photobleaching 1869
Ben Short A cell-free screen of caveolae
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Marie Anne O'Donnell Victoria Sanz--Moreno: Rho together for
cancer research . . . . . . . . . . . . 1885
Motoko Takahashi and
Toru Hirota Dynamics of sister chromatids through
the cell cycle: Together and apart . . . 1887
Daniel Brayson and
Chin Yee Ho and
Catherine M. Shanahan Muscle tensions merge to cause a DNA
replication crisis . . . . . . . . . . . 1891
F. Donelson Smith and
John D. Scott Protein kinase A activation: Something
new under the sun? . . . . . . . . . . . 1895
Qiao-Chu Wang and
Xi Wang and
Tie-Shan Tang EB1 traps STIM1 and regulates local
store-operated Ca$^{2+}$ entry . . . . . 1899
Ki-Jun Yoon and
Caroline Vissers and
Guo-li Ming and
Hongjun Song Epigenetics and epitranscriptomics in
temporal patterning of cortical neural
progenitor competence . . . . . . . . . 1901
Ying Wang and
Robyn Branicky and
Alycia Noë and
Siegfried Hekimi Superoxide dismutases: Dual roles in
controlling ROS damage and regulating
ROS signaling . . . . . . . . . . . . . 1915
Matthias Spiess and
Pablo Hernandez-Varas and
Anna Oddone and
Helene Olofsson and
Hans Blom and
Dominic Waithe and
John G. Lock and
Melike Lakadamyali and
Staffan Strömblad Active and inactive $ \beta $1 integrins
segregate into distinct nanoclusters in
focal adhesions . . . . . . . . . . . . 1929
Zhao Wang and
Lindsey W. Plasschaert and
Shivani Aryal and
Nicole A. Renaud and
Zinger Yang and
Rayman Choo-Wing and
Angelica D. Pessotti and
Nathaniel D. Kirkpatrick and
Nadire R. Cochran and
Walter Carbone and
Rob Maher and
Alicia Lindeman and
Carsten Russ and
John Reece-Hoyes and
Gregory McAllister and
Gregory R. Hoffman and
Guglielmo Roma and
Aron B. Jaffe TRRAP is a central regulator of human
multiciliated cell formation . . . . . . 1941
Georg O. M. Bobkov and
Nick Gilbert and
Patrick Heun Centromere transcription allows CENP--A
to transit from chromatin association to
stable incorporation . . . . . . . . . . 1957
Wanqing Xiang and
M. Julia Roberti and
Jean-Karim Hériché and
Sébastien Huet and
Stephanie Alexander and
Jan Ellenberg Correlative live and super-resolution
imaging reveals the dynamic structure of
replication domains . . . . . . . . . . 1973
Rugile Stanyte and
Johannes Nuebler and
Claudia Blaukopf and
Rudolf Hoefler and
Roman Stocsits and
Jan-Michael Peters and
Daniel W. Gerlich Dynamics of sister chromatid resolution
during cell cycle progression . . . . . 1985
Shuoshuo Wang and
Elizabeth Stoops and
Unnikannan C. P. and
Barak Markus and
Adriana Reuveny and
Elly Ordan and
Talila Volk Mechanotransduction via the LINC complex
regulates DNA replication in myonuclei 2005
Rupali Prasad and
Chengchao Xu and
Davis T. W. Ng Hsp40\slash 70/110 chaperones adapt
nuclear protein quality control to serve
cytosolic clients . . . . . . . . . . . 2019
Olga Iuliano and
Azumi Yoshimura and
Marie-Thér\`ese Prospéri and
René Martin and
Hans-Joachim Knölker and
Evelyne Coudrier Myosin 1b promotes axon formation by
regulating actin wave propagation and
growth cone dynamics . . . . . . . . . . 2033
Chi-Lun Chang and
Yu-Ju Chen and
Carlo Giovanni Quintanilla and
Ting-Sung Hsieh and
Jen Liou EB1 binding restricts STIM1
translocation to ER--PM junctions and
regulates store-operated Ca$^{2+}$ entry 2047
Gi Young Lee and
Deok-gyun You and
Hye-Ra Lee and
Sun Wook Hwang and
C. Justin Lee and
Young Do Yoo Romo1 is a mitochondrial nonselective
cation channel with viroporin-like
characteristics . . . . . . . . . . . . 2059
Keiko Saegusa and
Miyuki Sato and
Nobukatsu Morooka and
Taichi Hara and
Ken Sato SFT-4\slash Surf4 control ER export of
soluble cargo proteins and participate
in ER exit site organization . . . . . . 2073
Fred D. Mast and
Thurston Herricks and
Kathleen M. Strehler and
Leslie R. Miller and
Ramsey A. Saleem and
Richard A. Rachubinski and
John D. Aitchison ESCRT-III is required for scissioning
new peroxisomes from the endoplasmic
reticulum . . . . . . . . . . . . . . . 2087
Fengyi Gao and
Guoping Li and
Chao Liu and
Hui Gao and
Hao Wang and
Weixiao Liu and
Min Chen and
Yongliang Shang and
Lina Wang and
Jian Shi and
Wenlong Xia and
Jianwei Jiao and
Fei Gao and
Jian Li and
Liang Chen and
Wei Li Autophagy regulates testosterone
synthesis by facilitating cholesterol
uptake in Leydig cells . . . . . . . . . 2103
Dan Chen and
Chao Yang and
Sha Liu and
Weijian Hang and
Xianghong Wang and
Juan Chen and
Anbing Shi SAC-1 ensures epithelial endocytic
recycling by restricting ARF-6 activity 2121
WooRam Jung and
Emma Sierecki and
Michele Bastiani and
Ailis O'Carroll and
Kirill Alexandrov and
James Rae and
Wayne Johnston and
Dominic J. B. Hunter and
Charles Ferguson and
Yann Gambin and
Nicholas Ariotti and
Robert G. Parton Cell-free formation and interactome
analysis of caveolae . . . . . . . . . . 2141
Jörg Isensee and
Melanie Kaufholz and
Matthias J. Knape and
Jan Hasenauer and
Hanna Hammerich and
Humberto Gonczarowska-Jorge and
René P. Zahedi and
Frank Schwede and
Friedrich W. Herberg and
Tim Hucho PKA-RII subunit phosphorylation precedes
activation by cAMP and regulates
activity termination . . . . . . . . . . 2167
Jaimee E. Hoefert and
Glen A. Bjerke and
Dongmei Wang and
Rui Yi The microRNA-200 family coordinately
regulates cell adhesion and
proliferation in hair morphogenesis . . 2185
Markus Brown and
Louise A. Johnson and
Dario A. Leone and
Peter Majek and
Kari Vaahtomeri and
Daniel Senfter and
Nora Bukosza and
Helga Schachner and
Gabriele Asfour and
Brigitte Langer and
Robert Hauschild and
Katja Parapatics and
Young-Kwon Hong and
Keiryn L. Bennett and
Renate Kain and
Michael Detmar and
Michael Sixt and
David G. Jackson and
Dontscho Kerjaschki Lymphatic exosomes promote dendritic
cell migration along guidance cues . . . 2205
Marie Anne O'Donnell Erika Pearce: Fitting metabolism and
immunity together, to a T . . . . . . . 2223
Susan T. Lovett Between sisters: Watching
replication-associated recombinational
DNA repair . . . . . . . . . . . . . . . 2225
Kazuhiro Maeshima and
Kayo Hibino and
Damien F. Hudson Condensins under the microscope . . . . 2229
Jennifer L. Gerton A transcription factor primes the
condensin pump . . . . . . . . . . . . . 2233
Gary Yellen Fueling thought: Management of
glycolysis and oxidative phosphorylation
in neuronal metabolism . . . . . . . . . 2235
Juan Manuel Schvartzman and
Craig B. Thompson and
Lydia W. S. Finley Metabolic regulation of chromatin
modifications and gene expression . . . 2247
Wessel van Leeuwen and
Felix van der Krift and
Catherine Rabouille Modulation of the secretory pathway by
amino-acid starvation . . . . . . . . . 2261
Victoria L. Tokarz and
Patrick E. MacDonald and
Amira Klip The cell biology of systemic insulin
function . . . . . . . . . . . . . . . . 2273
Ankita Bansal and
M. Celeste Simon Glutathione metabolism in cancer
progression and treatment resistance . . 2291
Vincent Amarh and
Martin A. White and
David R. F. Leach Dynamics of RecA-mediated repair of
replication-dependent DNA breaks . . . . 2299
Nike Walther and
M. Julius Hossain and
Antonio Z. Politi and
Birgit Koch and
Moritz Kueblbeck and
Òyvind Òdegård-Fougner and
Marko Lampe and
Jan Ellenberg A quantitative map of human Condensins
provides new insights into mitotic
chromosome architecture . . . . . . . . 2309
Metin Aksu and
Tino Pleiner and
Samir Karaca and
Christin Kappert and
Heinz-Jürgen Dehne and
Katharina Seibel and
Henning Urlaub and
Markus T. Bohnsack and
Dirk Görlich Xpo7 is a broad-spectrum exportin and a
nuclear import receptor . . . . . . . . 2329
Yutaka Ogawa and
Naoko Imamoto Nuclear transport adapts to varying heat
stress in a multistep mechanism . . . . 2341
Carla A. M. Lopes and
Marta Mesquita and
Ana Isabel Cunha and
Joana Cardoso and
Sara Carapeta and
Cátia Laranjeira and
António E. Pinto and
José B. Pereira-Leal and
António Dias-Pereira and
Mónica Bettencourt-Dias and
Paula Chaves Centrosome amplification arises before
neoplasia and increases upon p53 loss in
tumorigenesis . . . . . . . . . . . . . 2353
Jose Reina and
Marco Gottardo and
Maria G. Riparbelli and
Salud Llamazares and
Giuliano Callaini and
Cayetano Gonzalez Centrobin is essential for C-tubule
assembly and flagellum development in
\bionameDrosophila melanogaster
spermatogenesis . . . . . . . . . . . . 2365
Kenta Shigetomi and
Yumiko Ono and
Tetsuichiro Inai and
Junichi Ikenouchi Adherens junctions influence tight
junction formation via changes in
membrane lipid composition . . . . . . . 2373
Christoph Schiklenk and
Boryana Petrova and
Marc Kschonsak and
Markus Hassler and
Carlo Klein and
Toby J. Gibson and
Christian H. Haering Control of mitotic chromosome
condensation by the fission yeast
transcription factor Zas1 . . . . . . . 2383
Toni McHugh and
Agata A. Gluszek and
Julie P. I. Welburn Microtubule end tethering of a
processive kinesin-8 motor Kif18b is
required for spindle positioning . . . . 2403
Jae-Geun Song and
Matthew R. King and
Rui Zhang and
Rachel S. Kadzik and
Akanksha Thawani and
Sabine Petry Mechanism of how augmin directly targets
the $ \gamma $-tubulin ring complex to
microtubules . . . . . . . . . . . . . . 2417
Gabriel M. Gihana and
Tiffany R. Musser and
Oscar Thompson and
Soni Lacefield Prolonged cyclin-dependent kinase
inhibition results in septin
perturbations during return to growth
and mitosis . . . . . . . . . . . . . . 2429
Tina L. Sing and
Minnie P. Hung and
Shinsuke Ohnuki and
Godai Suzuki and
Bryan-Joseph San Luis and
Melainia McClain and
Jay R. Unruh and
Zulin Yu and
Jiongwen Ou and
Jesse Marshall-Sheppard and
Won-Ki Huh and
Michael Costanzo and
Charles Boone and
Yoshikazu Ohya and
Sue L. Jaspersen and
Grant W. Brown The budding yeast RSC complex maintains
ploidy by promoting spindle pole body
insertion . . . . . . . . . . . . . . . 2445
Kan Yaguchi and
Takahiro Yamamoto and
Ryo Matsui and
Yuki Tsukada and
Atsuko Shibanuma and
Keiko Kamimura and
Toshiaki Koda and
Ryota Uehara Uncoordinated centrosome cycle underlies
the instability of non-diploid somatic
cells in mammals . . . . . . . . . . . . 2463
Lai Kuan Dionne and
Kyuhwan Shim and
Masato Hoshi and
Tao Cheng and
Jinzhi Wang and
Veronique Marthiens and
Amanda Knoten and
Renata Basto and
Sanjay Jain and
Moe R. Mahjoub Centrosome amplification disrupts renal
development and causes cystogenesis . . 2485
Stephanie Biedka and
Jelena Micic and
Daniel Wilson and
Hailey Brown and
Luke Diorio-Toth and
John L. Woolford Hierarchical recruitment of ribosomal
proteins and assembly factors remodels
nucleolar pre-60S ribosomes . . . . . . 2503
Sandip Dey and
Chiranjit Biswas and
Jayati Sengupta The universally conserved GTPase HflX is
an RNA helicase that restores
heat-damaged \bionameEscherichia coli
ribosomes . . . . . . . . . . . . . . . 2519
Michael T. Kelliher and
Yang Yue and
Ashley Ng and
Daichi Kamiyama and
Bo Huang and
Kristen J. Verhey and
Jill Wildonger Autoinhibition of kinesin-1 is essential
to the dendrite-specific localization of
Golgi outposts . . . . . . . . . . . . . 2531
Ewan MacDonald and
Louise Brown and
Arnaud Selvais and
Han Liu and
Thomas Waring and
Daniel Newman and
Jessica Bithell and
Douglas Grimes and
Sylvie Urbé and
Michael J. Clague and
Tobias Zech HRS--WASH axis governs actin-mediated
endosomal recycling and cell invasion 2549
Zhengpeng Wan and
Chenguang Xu and
Xiangjun Chen and
Hengyi Xie and
Zongyu Li and
Jing Wang and
Xingyu Ji and
Haodong Chen and
Qinghua Ji and
Samina Shaheen and
Yang Xu and
Fei Wang and
Zhuo Tang and
Ji-Shen Zheng and
Wei Chen and
Jizhong Lou and
Wanli Liu PI(4,5)P2 determines the threshold of
mechanical force--induced B cell
activation . . . . . . . . . . . . . . . 2565
Petra zur Lage and
Panagiota Stefanopoulou and
Katarzyna Styczynska-Soczka and
Niall Quinn and
Girish Mali and
Alex von Kriegsheim and
Pleasantine Mill and
Andrew P. Jarman Ciliary dynein motor preassembly is
regulated by Wdr92 in association with
HSP90 co-chaperone, R2TP . . . . . . . . 2583
Marie Anne O'Donnell and
Nicole Infarinato Jerry Edward Chipuk: a powerhouse for
mitochondrial biology . . . . . . . . . 2599
Marie-Hél\`ene Verlhac An actin shell delays oocyte chromosome
capture by microtubules . . . . . . . . 2601
Pauline Verlhac and
Fulvio Reggiori Sorting the trash: Micronucleophagy gets
selective . . . . . . . . . . . . . . . 2605
Luke M. Rice A new look for the growing microtubule
end? . . . . . . . . . . . . . . . . . . 2609
Bong Hwan Sung and
Alissa M. Weaver Directed migration: Cells navigate by
extracellular vesicles . . . . . . . . . 2613
Kai P. Hoefig and
Vigo Heissmeyer Posttranscriptional regulation of T
helper cell fate decisions . . . . . . . 2615
Takahide Matsui and
Peidu Jiang and
Saori Nakano and
Yuriko Sakamaki and
Hayashi Yamamoto and
Noboru Mizushima Autophagosomal YKT6 is required for
fusion with lysosomes independently of
syntaxin 17 . . . . . . . . . . . . . . 2633
Vitali Sikirzhytski and
Fioranna Renda and
Irina Tikhonenko and
Valentin Magidson and
Bruce F. McEwen and
Alexey Khodjakov Microtubules assemble near most
kinetochores during early prometaphase
in human cells . . . . . . . . . . . . . 2647
Mariia Burdyniuk and
Andrea Callegari and
Masashi Mori and
François Nédélec and
Péter Lénárt F-Actin nucleated on chromosomes
coordinates their capture by
microtubules in oocyte meiosis . . . . . 2661
Md. Golam Mostofa and
Muhammad Arifur Rahman and
Naoki Koike and
Akter M. S. T. Yeasmin and
Nafisa Islam and
Talukdar Muhammad Waliullah and
Shun Hosoyamada and
Mitsugu Shimobayashi and
Takehiko Kobayashi and
Michael N. Hall and
Takashi Ushimaru CLIP and cohibin separate rDNA from
nucleolar proteins destined for
degradation by nucleophagy . . . . . . . 2675
J. Richard McIntosh and
Eileen O'Toole and
Garry Morgan and
Jotham Austin and
Evgeniy Ulyanov and
Fazoil Ataullakhanov and
Nikita Gudimchuk Microtubules grow by the addition of
bent guanosine triphosphate tubulin to
the tips of curved protofilaments . . . 2691
Léa Ripoll and
Xavier Heiligenstein and
Ilse Hurbain and
Lia Domingues and
Florent Figon and
Karl J. Petersen and
Megan K. Dennis and
Anne Houdusse and
Michael S. Marks and
Graça Raposo and
Cédric Delevoye Myosin VI and branched actin filaments
mediate membrane constriction and
fission of melanosomal tubule carriers 2709
Yun-Fen Hung and
Chiung-Ya Chen and
Yi-Chun Shih and
Hsin-Yu Liu and
Chiao-Ming Huang and
Yi-Ping Hsueh Endosomal TLR3, TLR7, and TLR8 control
neuronal morphology through different
transcriptional programs . . . . . . . . 2727
Rubén Gómez-Sánchez and
Jaqueline Rose and
Rodrigo Guimarães and
Muriel Mari and
Daniel Papinski and
Ester Rieter and
Willie J. Geerts and
Ralph Hardenberg and
Claudine Kraft and
Christian Ungermann and
Fulvio Reggiori Atg9 establishes Atg2-dependent contact
sites between the endoplasmic reticulum
and phagophores . . . . . . . . . . . . 2743
Jin Meng and
Shawn M. Ferguson GATOR1-dependent recruitment of
FLCN--FNIP to lysosomes coordinates Rag
GTPase heterodimer nucleotide status in
response to amino acids . . . . . . . . 2765
Rocío G. Sampayo and
Andrés M. Toscani and
Matthew G. Rubashkin and
Kate Thi and
Luciano A. Masullo and
Ianina L. Violi and
Jonathon N. Lakins and
Alfredo Cáceres and
William C. Hines and
Federico Coluccio Leskow and
Fernando D. Stefani and
Dante R. Chialvo and
Mina J. Bissell and
Valerie M. Weaver and
Marina Simian Fibronectin rescues estrogen receptor $
\alpha $ from lysosomal degradation in
breast cancer cells . . . . . . . . . . 2777
ShiHui Wang and
ChenYu Wu and
YueBin Zhang and
QingLu Zhong and
Hao Sun and
WenPeng Cao and
GaoXiang Ge and
GuoHui Li and
X. Frank Zhang and
JianFeng Chen Integrin $ \alpha $4$ \beta $7 switches
its ligand specificity via distinct
conformer-specific activation . . . . . 2799
Georg Hilfenhaus and
Dai Phuong Nguyen and
Jonathan Freshman and
Divya Prajapati and
Feiyang Ma and
Dana Song and
Safiyyah Ziyad and
Myriam Cuadrado and
Matteo Pellegrini and
Xosé R. Bustelo and
M. Luisa Iruela-Arispe Vav3-induced cytoskeletal dynamics
contribute to heterotypic properties of
endothelial barriers . . . . . . . . . . 2813
Sungsu Lee and
Han Yen Tan and
Ivayla I. Geneva and
Aleksandr Kruglov and
Peter D. Calvert Actin filaments partition primary cilia
membranes into distinct fluid corrals 2831
Rachayata Dharmat and
Aiden Eblimit and
Michael A. Robichaux and
Zhixian Zhang and
Thanh-Minh T. Nguyen and
Sung Yun Jung and
Feng He and
Antrix Jain and
Yumei Li and
Jun Qin and
Paul Overbeek and
Ronald Roepman and
Graeme Mardon and
Theodore G. Wensel and
Rui Chen SPATA7 maintains a novel
photoreceptor-specific zone in the
distal connecting cilium . . . . . . . . 2851
Teruki Funabashi and
Yohei Katoh and
Misato Okazaki and
Maho Sugawa and
Kazuhisa Nakayama Interaction of heterotrimeric
kinesin--II with IFT--B--connecting
tetramer is crucial for ciliogenesis . . 2867
Scott W. Messenger and
Sang Su Woo and
Zhongze Sun and
Thomas F. J. Martin A Ca$^{2+}$-stimulated exosome release
pathway in cancer cells is regulated by
Munc13-4 . . . . . . . . . . . . . . . . 2877
Paul W. Kriebel and
Ritankar Majumdar and
Lisa M. Jenkins and
Hiroshi Senoo and
Weiye Wang and
Sonia Ammu and
Song Chen and
Kedar Narayan and
Miho Iijima and
Carole A. Parent Extracellular vesicles direct migration
by synthesizing and releasing
chemotactic signals . . . . . . . . . . 2891
Julia Pfanzelter and
Serge Mostowy and
Michael Way Septins suppress the release of vaccinia
virus from infected cells . . . . . . . 2911
David Bending and
Paz Prieto Martín and
Alina Paduraru and
Catherine Ducker and
Erik Marzaganov and
Marie Laviron and
Satsuki Kitano and
Hitoshi Miyachi and
Tessa Crompton and
Masahiro Ono A timer for analyzing temporally dynamic
changes in transcription during
differentiation in vivo . . . . . . . . 2931
Alison E. Casey and
Ankit Sinha and
Rajat Singhania and
Julie Livingstone and
Paul Waterhouse and
Pirashaanthy Tharmapalan and
Jennifer Cruickshank and
Mona Shehata and
Erik Drysdale and
Hui Fang and
Hyeyeon Kim and
Ruth Isserlin and
Swneke Bailey and
Tiago Medina and
Genevieve Deblois and
Yu-Jia Shiah and
Dalia Barsyte-Lovejoy and
Stefan Hofer and
Gary Bader and
Mathieu Lupien and
Cheryl Arrowsmith and
Stefan Knapp and
Daniel De Carvalho and
Hal Berman and
Paul C. Boutros and
Thomas Kislinger and
Rama Khokha Mammary molecular portraits reveal
lineage-specific features and progenitor
cell vulnerabilities . . . . . . . . . . 2951
Nicole Infarinato Dan Davis: Up close and personal with
immune cells . . . . . . . . . . . . . . 2975
Vineet Vinay Kulkarni and
Sandra Maday Neuronal endosomes to lysosomes: a
journey to the soma . . . . . . . . . . 2977
Ronen Zaidel-Bar Cell cycle pacemaker keeps adhesion in
step with division . . . . . . . . . . . 2981
James H. Felce and
Michael L. Dustin Natural killers shed attachments to kill
again . . . . . . . . . . . . . . . . . 2983
Aravind Sivakumar and
Natasza A. Kurpios Transcriptional regulation of cell shape
during organ morphogenesis . . . . . . . 2987
Anna A. Ye and
Vikash Verma and
Thomas J. Maresca NOD is a plus end--directed motor that
binds EB1 via a new microtubule tip
localization sequence . . . . . . . . . 3007
Caitlin L. Wynne and
Richard B. Vallee Cdk1 phosphorylation of the dynein
adapter Nde1 controls cargo binding from
G2 to anaphase . . . . . . . . . . . . . 3019
Chiara De Pascalis and
Carlos Pérez-González and
Shailaja Seetharaman and
Batiste Boëda and
Benoit Vianay and
Mithila Burute and
Cécile Leduc and
Nicolas Borghi and
Xavier Trepat and
Sandrine Etienne-Manneville Intermediate filaments control
collective migration by restricting
traction forces and sustaining
cell--cell contacts . . . . . . . . . . 3031
Leila Thuma and
Deborah Carter and
Helen Weavers and
Paul Martin Drosophila immune cells extravasate from
vessels to wounds using Tre1 GPCR and
Rho signaling . . . . . . . . . . . . . 3045
Ihsan Zulkipli and
Joanna Clark and
Madeleine Hart and
Roshan L. Shrestha and
Parveen Gul and
David Dang and
Tami Kasichiwin and
Izabela Kujawiak and
Nishanth Sastry and
Viji M. Draviam Spindle rotation in human cells is
reliant on a MARK2-mediated equatorial
spindle-centering mechanism . . . . . . 3057
Maria Dandoulaki and
Eleni Petsalaki and
David Sumpton and
Sara Zanivan and
George Zachos Src activation by Chk1 promotes actin
patch formation and prevents chromatin
bridge breakage in cytokinesis . . . . . 3071
Tobias Jores and
Jannis Lawatscheck and
Viktor Beke and
Mirita Franz-Wachtel and
Kaori Yunoki and
Julia C. Fitzgerald and
Boris Macek and
Toshiya Endo and
Hubert Kalbacher and
Johannes Buchner and
Doron Rapaport Cytosolic Hsp70 and Hsp40 chaperones
enable the biogenesis of mitochondrial $
\beta $-barrel proteins . . . . . . . . 3091
Harald F. Hofbauer and
Michael Gecht and
Sabine C. Fischer and
Anja Seybert and
Achilleas S. Frangakis and
Ernst H. K. Stelzer and
Roberto Covino and
Gerhard Hummer and
Robert Ernst The molecular recognition of
phosphatidic acid by an amphipathic
helix in Opi1 . . . . . . . . . . . . . 3109
Xiu-Tang Cheng and
Yu-Xiang Xie and
Bing Zhou and
Ning Huang and
Tamar Farfel-Becker and
Zu-Hang Sheng Characterization of LAMP1-labeled
nondegradative lysosomal and endocytic
compartments in neurons . . . . . . . . 3127
Chan Choo Yap and
Laura Digilio and
Lloyd P. McMahon and
A. Denise R. Garcia and
Bettina Winckler Degradation of dendritic cargos requires
Rab7-dependent transport to somatic
lysosomes . . . . . . . . . . . . . . . 3141
Martina Zobel and
Andrea Disanza and
Francesca Senic-Matuglia and
Michel Franco and
Ivan Nicola Colaluca and
Stefano Confalonieri and
Sara Bisi and
Elisa Barbieri and
Giusi Caldieri and
Sara Sigismund and
Salvatore Pece and
Philippe Chavrier and
Pier Paolo Di Fiore and
Giorgio Scita A NUMB--EFA6B--ARF6 recycling route
controls apically restricted cell
protrusions and mesenchymal motility . . 3161
Scott R. Frank and
Clemens P. Köllmann and
Phi Luong and
Giorgio G. Galli and
Lihua Zou and
André Bernards and
Gad Getz and
Raffaele A. Calogero and
Morten Frödin and
Steen H. Hansen p190 RhoGAP promotes contact inhibition
in epithelial cells by repressing YAP
activity . . . . . . . . . . . . . . . . 3183
Matthew C. Jones and
Janet A. Askari and
Jonathan D. Humphries and
Martin J. Humphries Cell adhesion is regulated by CDK1
during the cell cycle . . . . . . . . . 3203
Chen Yuan Kam and
Adi D. Dubash and
Elisa Magistrati and
Simona Polo and
Karla J. F. Satchell and
Farah Sheikh and
Paul D. Lampe and
Kathleen J. Green Desmoplakin maintains gap junctions by
inhibiting Ras/MAPK and lysosomal
degradation of connexin-43 . . . . . . . 3219
Christopher R. Donnelly and
Nicole A. Gabreski and
Esther B. Suh and
Monzurul Chowdhury and
Brian A. Pierchala Non-canonical Ret signaling augments
p75-mediated cell death in developing
sympathetic neurons . . . . . . . . . . 3237
Michael L. Drummond and
Mischa Li and
Eric Tarapore and
Tuyen T. L. Nguyen and
Baina J. Barouni and
Shaun Cruz and
Kevin C. Tan and
Anthony E. Oro and
Scott X. Atwood Actin polymerization controls
cilia-mediated signaling . . . . . . . . 3255
Katja Srpan and
Ashley Ambrose and
Alexandros Karampatzakis and
Mezida Saeed and
Adam N. R. Cartwright and
Karolin Guldevall and
Gabriela Dos Santos Cruz De Matos and
Björn Önfelt and
Daniel M. Davis Shedding of CD16 disassembles the NK
cell immune synapse and boosts serial
engagement of target cells . . . . . . . 3267
Sebastian Wissel and
Heike Harzer and
François Bonnay and
Thomas R. Burkard and
Ralph A. Neumüller and
Juergen A. Knoblich Time-resolved transcriptomics in neural
stem cells identifies a v-ATPase\slash
Notch regulatory loop . . . . . . . . . 3285
Daphné Dambournet and
Kem A. Sochacki and
Aaron T. Cheng and
Matthew Akamatsu and
Justin W. Taraska and
Dirk Hockemeyer and
David G. Drubin Genome-edited human stem cells
expressing fluorescently labeled
endocytic markers allow quantitative
analysis of clathrin-mediated
endocytosis during differentiation . . . 3301
Scott R. Frank and
Clemens P. Köllmann and
Phi Luong and
Giorgio G. Galli and
Lihua Zou and
André Bernards and
Gad Getz and
Raffaele A. Calogero and
Morten Frödin and
Steen H. Hansen Correction: p190 RhoGAP promotes contact
inhibition in epithelial cells by
repressing YAP activity . . . . . . . . 3313
Wanqing Xiang and
M. Julia Roberti and
Jean-Karim Hériché and
Sébastien Huet and
Stephanie Alexander and
Jan Ellenberg Correction: Correlative live and
super-resolution imaging reveals the
dynamic structure of replication domains 3315
Marie Anne O'Donnell Gustavo Silva: Translating the ubiquitin
code . . . . . . . . . . . . . . . . . . 3
Shannon M. McNulty and
Beth A. Sullivan Going the distance: Neocentromeres make
long-range contacts with heterochromatin 5
Béatrice Benoit and
Christian Poüs Microtubule reorientation in the blue
spotlight: Cutting and CLASPing at
dynamic hot spots . . . . . . . . . . . 8
Julia Tischer and
Fanni Gergely Anti-mitotic therapies in cancer . . . . 10
Marit W. Vermunt and
Di Zhang and
Gerd A. Blobel The interdependence of gene-regulatory
elements and the $3$D genome . . . . . . 12
Philipp G. Maass and
A. Rasim Barutcu and
John L. Rinn Interchromosomal interactions: a genomic
love story of kissing chromosomes . . . 27
Shweta Mendiratta and
Alberto Gatto and
Genevieve Almouzni Histone supply: Multitiered regulation
ensures chromatin dynamics throughout
the cell cycle . . . . . . . . . . . . . 39
Valerio Di Carlo and
Ivano Mocavini and
Luciano Di Croce Polycomb complexes in normal and
malignant hematopoiesis . . . . . . . . 55
Sabrina Ladstätter and
Kikuë Tachibana Genomic insights into chromatin
reprogramming to totipotency in embryos 70
Lena K. Schroeder and
Andrew E. S. Barentine and
Holly Merta and
Sarah Schweighofer and
Yongdeng Zhang and
David Baddeley and
Joerg Bewersdorf and
Shirin Bahmanyar Dynamic nanoscale morphology of the ER
surveyed by STED microscopy . . . . . . 83
Liang Wang and
Ziyi Yan and
Helena Vihinen and
Ove Eriksson and
Weihuan Wang and
Rabah Soliymani and
Yao Lu and
Yaxin Xue and
Eija Jokitalo and
Jing Li and
Hongxia Zhao FAM92A1 is a BAR domain protein required
for mitochondrial ultrastructure and
function . . . . . . . . . . . . . . . . 97
Nilaj Chakrabarty and
Pankaj Dubey and
Yong Tang and
Archan Ganguly and
Kelsey Ladt and
Christophe Leterrier and
Peter Jung and
Subhojit Roy Processive flow by biased polymerization
mediates the slow axonal transport of
actin . . . . . . . . . . . . . . . . . 112
Nathaniel Noblett and
Zilu Wu and
Zhao Hua Ding and
Seungmee Park and
Tony Roenspies and
Stephane Flibotte and
Andrew D. Chisholm and
Yishi Jin and
Antonio Colavita DIP-2 suppresses ectopic neurite
sprouting and axonal regeneration in
mature neurons . . . . . . . . . . . . . 125
Kohei Nishimura and
Masataka Komiya and
Tetsuya Hori and
Takehiko Itoh and
Tatsuo Fukagawa $3$D genomic architecture reveals that
neocentromeres associate with
heterochromatin regions . . . . . . . . 134
Jennifer L. Brace and
Matthew D. Doerfler and
Eric L. Weiss A cell separation checkpoint that
enforces the proper order of late
cytokinetic events . . . . . . . . . . . 150
Kyle D. Moran and
Hui Kang and
Ana V. Araujo and
Trevin R. Zyla and
Koji Saito and
Denis Tsygankov and
Daniel J. Lew Cell-cycle control of cell polarity in
yeast . . . . . . . . . . . . . . . . . 171
Jelmer J. Lindeboom and
Masayoshi Nakamura and
Marco Saltini and
Anneke Hibbel and
Ankit Walia and
Tijs Ketelaar and
Anne Mie C. Emons and
John C. Sedbrook and
Viktor Kirik and
Bela M. Mulder and
David W. Ehrhardt CLASP stabilization of plus ends created
by severing promotes microtubule
creation and reorientation . . . . . . . 190
Stephen Gilmore-Hall and
Jennifer Kuo and
Jacqueline M. Ward and
Rabaab Zahra and
Richard S. Morrison and
Guy Perkins and
Albert R. La Spada CCP1 promotes mitochondrial fusion and
motility to prevent Purkinje cell neuron
loss in pcd mice . . . . . . . . . . . . 206
Mara A. Olenick and
Roberto Dominguez and
Erika L. F. Holzbaur Dynein activator Hook1 is required for
trafficking of BDNF-signaling endosomes
in neurons . . . . . . . . . . . . . . . 220
Richa Sardana and
Lu Zhu and
Scott D. Emr Rsp5 Ubiquitin ligase--mediated quality
control system clears membrane proteins
mistargeted to the vacuole membrane . . 234
Xiaohua Hu and
R. Dyche Mullins LC3 and STRAP regulate actin filament
assembly by JMY during autophagosome
formation . . . . . . . . . . . . . . . 251
Ruoxi Wang and
Jieqiong Tan and
Tingting Chen and
Hailong Han and
Runyi Tian and
Ya Tan and
Yiming Wu and
Jingyi Cui and
Fang Chen and
Jie Li and
Lu Lv and
Xinjie Guan and
Shuai Shang and
Jiahong Lu and
Zhuohua Zhang ATP13A2 facilitates HDAC6 recruitment to
lysosome to promote
autophagosome--lysosome fusion . . . . . 267
Colin D. H. Ratcliffe and
Nadeem Siddiqui and
Paula P. Coelho and
Nancy Laterreur and
Tumini N. Cookey and
Nahum Sonenberg and
Morag Park HGF-induced migration depends on the
PI(3,4,5)P$_3$-binding microexon-spliced
variant of the Arf6 exchange factor
cytohesin-1 . . . . . . . . . . . . . . 285
Kevin Kruse and
Quinn S. Lee and
Ying Sun and
Jeff Klomp and
Xiaoyan Yang and
Fei Huang and
Mitchell Y. Sun and
Shuangping Zhao and
Zhigang Hong and
Stephen M. Vogel and
Jae-Won Shin and
Deborah E. Leckband and
Leon M. Tai and
Asrar B. Malik and
Yulia A. Komarova N-cadherin signaling via Trio assembles
adherens junctions to restrict
endothelial permeability . . . . . . . . 299
Li Qiang and
Hong Cao and
Jing Chen and
Shaun G. Weller and
Eugene W. Krueger and
Lizhi Zhang and
Gina L. Razidlo and
Mark A. McNiven Pancreatic tumor cell metastasis is
restricted by MT1-MMP binding protein
MTCBP-1 . . . . . . . . . . . . . . . . 317
Henrik J. Jürgensen and
Kirstine S. Nòrregaard and
Megan M. Sibree and
Eric Santoni-Rugiu and
Daniel H. Madsen and
Katharina Wassilew and
Dorrit Krustrup and
Peter Garred and
Thomas H. Bugge and
Lars H. Engelholm and
Niels Behrendt Immune regulation by fibroblasts in
tissue injury depends on uPARAP-mediated
uptake of collectins . . . . . . . . . . 333
Maria M. Bagonis and
Ludovico Fusco and
Olivier Pertz and
Gaudenz Danuser Automated profiling of growth cone
heterogeneity defines relations between
morphology and motility . . . . . . . . 350
Nicole Infarinato Xiaochen Wang: Building up our
understanding of breaking down . . . . . 381
Sharon Cantor TPX2 joins 53BP1 to maintain DNA repair
and fork stability . . . . . . . . . . . 383
Takeshi Shimi and
Hiroshi Kimura A mosaic of old and young nucleoporins 385
Florence Niedergang Dendritic cells mature to resist lamin
degradation and herpes virus release . . 387
Soni Lacefield Detaching the tether: Remodeling
mitochondrial localization during
meiosis . . . . . . . . . . . . . . . . 389
João Leandro and
Sander M. Houten Saccharopine, a lysine degradation
intermediate, is a mitochondrial toxin 391
Yekaterina A. Miroshnikova and
Tim Hammesfahr and
Sara A. Wickström Cell biology and mechanopathology of
laminopathic cardiomyopathies . . . . . 393
Jakob Nilsson Protein phosphatases in the regulation
of mitosis . . . . . . . . . . . . . . . 395
Kenichiro Taniguchi and
Idse Heemskerk and
Deborah L. Gumucio Opening the black box: Stem cell--based
modeling of human post-implantation
development . . . . . . . . . . . . . . 410
Andrea K. Byrum and
Denisse Carvajal-Maldonado and
Miranda C. Mudge and
David Valle-Garcia and
Mona C. Majid and
Romil Patel and
Mathew E. Sowa and
Steven P. Gygi and
J. Wade Harper and
Yang Shi and
Alessandro Vindigni and
Nima Mosammaparast Mitotic regulators TPX2 and Aurora A
protect DNA forks during replication
stress by counteracting 53BP1 function 422
Brandon H. Toyama and
Rafael Arrojo e Drigo and
Varda Lev-Ram and
Ranjan Ramachandra and
Thomas J. Deerinck and
Claude Lechene and
Mark H. Ellisman and
Martin W. Hetzer Visualization of long-lived proteins
reveals age mosaicism within nuclei of
postmitotic cells . . . . . . . . . . . 433
Aleksandra S. Chikina and
Tatyana M. Svitkina and
Antonina Y. Alexandrova Time-resolved ultrastructure of the
cortical actin cytoskeleton in dynamic
membrane blebs . . . . . . . . . . . . . 445
Cai Tong Ng and
Li Deng and
Chen Chen and
Hong Hwa Lim and
Jian Shi and
Uttam Surana and
Lu Gan Electron cryotomography analysis of
Dam1C/DASH at the kinetochore--spindle
interface in situ . . . . . . . . . . . 455
Tomoya Edzuka and
Gohta Goshima Drosophila kinesin-8 stabilizes the
kinetochore--microtubule interaction . . 474
Soumitra Mitra and
Poonam Sharma and
Simran Kaur and
Mohammad Anwar Khursheed and
Shivangi Gupta and
Mansi Chaudhary and
Akshai J. Kurup and
Rajesh Ramachandran Dual regulation of lin28a by Myc is
necessary during zebrafish retina
regeneration . . . . . . . . . . . . . . 489
Aykut Turan and
Linda Grosche and
Adalbert Krawczyk and
Petra Mühl-Zürbes and
Christina Drassner and
Alexandra Düthorn and
Mirko Kummer and
Mike Hasenberg and
Sylvia Voortmann and
Holger Jastrow and
Jan Dörrie and
Niels Schaft and
Max Kraner and
Katinka Döhner and
Beate Sodeik and
Alexander Steinkasserer and
Christiane Silke Heilingloh Autophagic degradation of lamins
facilitates the nuclear egress of herpes
simplex virus type 1 . . . . . . . . . . 508
Jonathan N. Rosen and
Mafalda Azevedo and
David B. Soffar and
Vitaly P. Boyko and
Matthew B. Brendel and
Victoria K. Schulman and
Mary K. Baylies The \bionameDrosophila Ninein homologue
Bsg25D cooperates with Ensconsin in
myonuclear positioning . . . . . . . . . 524
Khaled Hached and
Perrine Goguet and
Sophie Charrasse and
Suzanne Vigneron and
Maria P. Sacristan and
Thierry Lorca and
Anna Castro ENSA and ARPP19 differentially control
cell cycle progression and development 541
Eric M. Sawyer and
Pallavi R. Joshi and
Victoria Jorgensen and
Julius Yunus and
Luke E. Berchowitz and
Elçin Ünal Developmental regulation of an organelle
tether coordinates mitochondrial
remodeling in meiosis . . . . . . . . . 559
Junxiang Zhou and
Xin Wang and
Min Wang and
Yuwei Chang and
Fengxia Zhang and
Zhaonan Ban and
Ruofeng Tang and
Qiwen Gan and
Shaohuan Wu and
Ye Guo and
Qian Zhang and
Fengyang Wang and
Liyuan Zhao and
Yudong Jing and
Wenfeng Qian and
Guodong Wang and
Weixiang Guo and
Chonglin Yang The lysine catabolite saccharopine
impairs development by disrupting
mitochondrial homeostasis . . . . . . . 580
Frank Richter and
Sven Dennerlein and
Miroslav Nikolov and
Daniel C. Jans and
Nataliia Naumenko and
Abhishek Aich and
Thomas MacVicar and
Andreas Linden and
Stefan Jakobs and
Henning Urlaub and
Thomas Langer and
Peter Rehling ROMO1 is a constituent of the human
presequence translocase required for
YME1L protease import . . . . . . . . . 598
Yi Cui and
Julian M. Carosi and
Zhe Yang and
Nicholas Ariotti and
Markus C. Kerr and
Robert G. Parton and
Timothy J. Sargeant and
Rohan D. Teasdale Retromer has a selective function in
cargo sorting via endosome transport
carriers . . . . . . . . . . . . . . . . 615
Nitin Mohan and
Elena M. Sorokina and
Ione Vilanova Verdeny and
Angel Sandoval Alvarez and
Melike Lakadamyali Detyrosinated microtubules spatially
constrain lysosomes facilitating
lysosome--autophagosome fusion . . . . . 632
Lei Liu and
Li Ding and
Matteo Rovere and
Michael S. Wolfe and
Dennis J. Selkoe A cellular complex of BACE1 and $ \gamma
$-secretase sequentially generates A$
\beta $ from its full-length precursor 644
Wilton T. Snead and
Wade F. Zeno and
Grace Kago and
Ryan W. Perkins and
J. Blair Richter and
Chi Zhao and
Eileen M. Lafer and
Jeanne C. Stachowiak BAR scaffolds drive membrane fission by
crowding disordered domains . . . . . . 664
Eleni Dimou and
Katia Cosentino and
Evgenia Platonova and
Uris Ros and
Mohsen Sadeghi and
Purba Kashyap and
Taxiarchis Katsinelos and
Sabine Wegehingel and
Frank Noé and
Ana J. García-Sáez and
Helge Ewers and
Walter Nickel Single event visualization of
unconventional secretion of FGF2 . . . . 683
Fang Niu and
Ke Liao and
Guoku Hu and
Susmita Sil and
Shannon Callen and
Ming-lei Guo and
Lu Yang and
Shilpa Buch Cocaine-induced release of CXCL10 from
pericytes regulates monocyte
transmigration into the CNS . . . . . . 700
Shannon M. McNulty and
Beth A. Sullivan Correction: Going the distance:
Neocentromeres make long-range contacts
with heterochromatin . . . . . . . . . . 722
Béatrice Benoit and
Christian Poüs Correction: Microtubule reorientation in
the blue spotlight: Cutting and CLASPing
at dynamic hot spots . . . . . . . . . . 723
Nicole Infarinato Mahak Sharma: Weaving through traffic 725
Joshua Alper and
Marija Zanic Resistance is futile: Centering forces
yield for asymmetric cell division . . . 727
Maria Livia Sassano and
Patrizia Agostinis Staying in touch: Taking a closer look
at ER--Golgi contact sites . . . . . . . 729
Katharina Schlacher Sense and sensibility: ATM oxygen stress
signaling manages brain cell energetics 732
Ivan Yudushkin TAPPing into PIPs: a new reporter
reveals the origin of plasma membrane
PI(3,4)P$_2$ . . . . . . . . . . . . . . 735
Ishier Raote and
Vivek Malhotra Protein transport by vesicles and
tunnels . . . . . . . . . . . . . . . . 737
Enfu Hui Immune checkpoint inhibitors . . . . . . 740
Teresa T. Bonello and
Mark Peifer Scribble: a master scaffold in polarity,
adhesion, synaptogenesis, and
proliferation . . . . . . . . . . . . . 742
Yan G. Zhao and
Hong Zhang Autophagosome maturation: an epic
journey from the ER to lysosomes . . . . 757
Jérémy Sallé and
Jing Xie and
Dmitry Ershov and
Milan Lacassin and
Serge Dmitrieff and
Nicolas Minc Asymmetric division through a reduction
of microtubule centering forces . . . . 771
Rossella Venditti and
Maria Chiara Masone and
Laura Rita Rega and
Giuseppe Di Tullio and
Michele Santoro and
Elena Polishchuk and
Ivan Castello Serrano and
Vesa M. Olkkonen and
Akihiro Harada and
Diego L. Medina and
Raffaele La Montagna and
Maria Antonietta De Matteis The activity of Sac1 across ER--TGN
contact sites requires the
four-phosphate-adaptor-protein-$1$ . . . 783
Victoria Riccio and
Nicholas Demers and
Rong Hua and
Miluska Vissa and
Derrick T. Cheng and
Amy Wong Strilchuk and
Yuqing Wang and
G. Angus McQuibban and
Peter Kijun Kim Deubiquitinating enzyme USP30 maintains
basal peroxisome abundance by regulating
pexophagy . . . . . . . . . . . . . . . 798
João Carlos Gonçalves and
Tiago J. Dantas and
Richard B. Vallee Distinct roles for dynein light
intermediate chains in neurogenesis,
migration, and terminal somal
translocation . . . . . . . . . . . . . 808
Colin E. Delaney and
Stephen P. Methot and
Micol Guidi and
Iskra Katic and
Susan M. Gasser and
Jan Padeken Heterochromatic foci and transcriptional
repression by an unstructured
MET-2/SETDB1 co-factor LIN-65 . . . . . 820
Bailey A. Koch and
Hui Jin and
Robert J. Tomko and
Hong-Guo Yu The anaphase-promoting complex regulates
the degradation of the inner nuclear
membrane protein Mps3 . . . . . . . . . 839
Bowen Xing and
Jian Ma and
Zongzhe Jiang and
Zijie Feng and
Sunbin Ling and
Katy Szigety and
Wen Su and
Longmei Zhang and
Ruirui Jia and
Yanmei Sun and
Lin Zhang and
Xiangchen Kong and
Xiaosong Ma and
Xianxin Hua GLP-1 signaling suppresses menin's
transcriptional block by phosphorylation
in $ \beta $ cells . . . . . . . . . . . 855
Devashish Dwivedi and
Amrita Kumari and
Siddhi Rathi and
Sivaram V. S. Mylavarapu and
Mahak Sharma The dynein adaptor Hook2 plays essential
roles in mitotic progression and
cytokinesis . . . . . . . . . . . . . . 871
Eric S. Schiffhauer and
Yixin Ren and
Vicente A. Iglesias and
Priyanka Kothari and
Pablo A. Iglesias and
Douglas N. Robinson Myosin IIB assembly state determines its
mechanosensitive dynamics . . . . . . . 895
Hei-Man Chow and
Aifang Cheng and
Xuan Song and
Mavis R. Swerdel and
Ronald P. Hart and
Karl Herrup ATM is activated by ATP depletion and
modulates mitochondrial function through
NRF1 . . . . . . . . . . . . . . . . . . 909
Janine McCaughey and
Nicola L. Stevenson and
Stephen Cross and
David J. Stephens ER-to-Golgi trafficking of procollagen
in the absence of large carriers . . . . 929
Munechika Sugihara and
Daisuke Morito and
Shiori Ainuki and
Yoshinobu Hirano and
Kazutoyo Ogino and
Akira Kitamura and
Hiromi Hirata and
Kazuhiro Nagata The AAA+ ATPase/ubiquitin ligase
mysterin stabilizes cytoplasmic lipid
droplets . . . . . . . . . . . . . . . . ??
Melissa N. Locke and
Jeremy Thorner Rab5 GTPases are required for optimal
TORC2 function . . . . . . . . . . . . . 961
Sora Lee and
Hsuan-Chung Ho and
Jessica M. Tumolo and
Pi-Chiang Hsu and
Jason A. MacGurn Methionine triggers Ppz-mediated
dephosphorylation of Art1 to promote
cargo-specific endocytosis . . . . . . . 977
Lilian A. Patrón and
Kei Nagatomo and
David Tyler Eves and
Mays Imad and
Kimberly Young and
Meaghan Torvund and
Xiufang Guo and
Gregory C. Rogers and
Konrad E. Zinsmaier Cul4 ubiquitin ligase cofactor DCAF12
promotes neurotransmitter release and
homeostatic plasticity . . . . . . . . . 993
Nicole Scholz and
Nadine Ehmann and
Divya Sachidanandan and
Cordelia Imig and
Benjamin H. Cooper and
Olaf Jahn and
Kerstin Reim and
Nils Brose and
Jutta Meyer and
Marius Lamberty and
Steffen Altrichter and
Anne Bormann and
Stefan Hallermann and
Martin Pauli and
Manfred Heckmann and
Christian Stigloher and
Tobias Langenhan and
Robert J. Kittel Complexin cooperates with Bruchpilot to
tether synaptic vesicles to the active
zone cytomatrix . . . . . . . . . . . . 1011
J. Bernard Heymann and
Camasamudram Vijayasarathy and
Rick K. Huang and
Altaira D. Dearborn and
Paul A. Sieving and
Alasdair C. Steven Cryo-EM of retinoschisin branched
networks suggests an intercellular
adhesive scaffold in the retina . . . . 1027
Felix Gunawan and
Alessandra Gentile and
Ryuichi Fukuda and
Ayele Taddese Tsedeke and
Vanesa Jiménez-Amilburu and
Radhan Ramadass and
Atsuo Iida and
Atsuko Sehara-Fujisawa and
Didier Y. R. Stainier Focal adhesions are essential to drive
zebrafish heart valve morphogenesis . . 1039
Rossella Venditti and
Laura Rita Rega and
Maria Chiara Masone and
Michele Santoro and
Elena Polishchuk and
Daniela Sarnataro and
Simona Paladino and
Sabato D'Auria and
Antonio Varriale and
Vesa M. Olkkonen and
Giuseppe Di Tullio and
Roman Polishchuk and
Maria Antonietta De Matteis Molecular determinants of ER--Golgi
contacts identified through a new
FRET--FLIM system . . . . . . . . . . . 1055
Brady D. Goulden and
Jonathan Pacheco and
Allyson Dull and
James P. Zewe and
Alexander Deiters and
Gerald R. V. Hammond A high-avidity biosensor reveals plasma
membrane PI(3,4)P$_2$ is predominantly a
class I PI3K signaling product . . . . . 1066
Marie Anne O'Donnell Lillian Fritz--Laylin: Keeping up to
speed with evolutionary cell biology . . 1081
Michael A. McMurray The long and short of membrane curvature
sensing by septins . . . . . . . . . . . 1083
Bernardo Orr and
Helder Maiato No chromosome left behind: The
importance of metaphase alignment for
mitotic fidelity . . . . . . . . . . . . 1086
Truc B. Nguyen and
James A. Olzmann Getting a handle on lipid droplets:
Insights into ER--lipid droplet
tethering . . . . . . . . . . . . . . . 1089
Praful R. Nair and
Denis Wirtz Enabling migration by moderation:
YAP/TAZ are essential for persistent
migration . . . . . . . . . . . . . . . 1092
Yoo Jin Park and
Minna Woo Pancreatic $ \beta $ cells: Gatekeepers
of type 2 diabetes . . . . . . . . . . . 1094
Kimberly Rickman and
Agata Smogorzewska Advances in understanding DNA processing
and protection at stalled replication
forks . . . . . . . . . . . . . . . . . 1096
Tatiana Alfonso-Pérez and
Daniel Hayward and
James Holder and
Ulrike Gruneberg and
Francis A. Barr MAD1-dependent recruitment of CDK1-CCNB1
to kinetochores promotes spindle
checkpoint signaling . . . . . . . . . . 1108
Donghwi Bae and
Kristin A. Moore and
Jessica M. Mella and
Samantha Y. Hayashi and
Julie Hollien Degradation of Blos1 mRNA by IRE1
repositions lysosomes and protects cells
from stress . . . . . . . . . . . . . . 1118
Kevin S. Cannon and
Benjamin L. Woods and
John M. Crutchley and
Amy S. Gladfelter An amphipathic helix enables septins to
sense micrometer-scale membrane
curvature . . . . . . . . . . . . . . . 1128
Ross T. A. Pedersen and
David G. Drubin Type I myosins anchor actin assembly to
the plasma membrane during
clathrin-mediated endocytosis . . . . . 1138
Cindy L. Fonseca and
Heidi L. H. Malaby and
Leslie A. Sepaniac and
Whitney Martin and
Candice Byers and
Anne Czechanski and
Dana Messinger and
Mary Tang and
Ryoma Ohi and
Laura G. Reinholdt and
Jason Stumpff Mitotic chromosome alignment ensures
mitotic fidelity by promoting
interchromosomal compaction during
anaphase . . . . . . . . . . . . . . . . 1148
Markus Seibert and
Marcus Krüger and
Nikolaus A. Watson and
Onur Sen and
John R. Daum and
Johan A. Slotman and
Thomas Braun and
Adriaan B. Houtsmuller and
Gary J. Gorbsky and
Ralf Jacob and
Michael Kracht and
Jonathan M. G. Higgins and
M. Lienhard Schmitz CDK1-mediated phosphorylation at H2B
serine 6 is required for mitotic
chromosome segregation . . . . . . . . . 1164
Daniel Hayward and
Tatiana Alfonso-Pérez and
Michael J. Cundell and
Michael Hopkins and
James Holder and
James Bancroft and
Lukas H. Hutter and
Bela Novak and
Francis A. Barr and
Ulrike Gruneberg CDK1-CCNB1 creates a spindle
checkpoint--permissive state by enabling
MPS1 kinetochore localization . . . . . 1182
Maribel Franco and
Ana Carmena Eph signaling controls mitotic spindle
orientation and cell proliferation in
neuroepithelial cells . . . . . . . . . 1200
Heidi L. H. Malaby and
Megan E. Dumas and
Ryoma Ohi and
Jason Stumpff Kinesin-binding protein ensures accurate
chromosome segregation by buffering
KIF18A and KIF15 . . . . . . . . . . . . 1218
Thomas E. Bass and
David Cortez Quantitative phosphoproteomics reveals
mitotic function of the ATR activator
ETAA1 . . . . . . . . . . . . . . . . . 1235
Ingrid E. Adriaans and
Angika Basant and
Bas Ponsioen and
Michael Glotzer and
Susanne M. A. Lens PLK1 plays dual roles in centralspindlin
regulation during cytokinesis . . . . . 1250
Mehmet E. Karasu and
Nora Bouftas and
Scott Keeney and
Katja Wassmann Cyclin B3 promotes anaphase I onset in
oocyte meiosis . . . . . . . . . . . . . 1265
Ryan L. Hanson and
Joshua R. Porter and
Eric Batchelor Protein stability of p53 targets
determines their temporal expression
dynamics in response to p53 pulsing . . 1282
Peter Jan Hooikaas and
Maud Martin and
Tobias Mühlethaler and
Gert-Jan Kuijntjes and
Cathelijn A. E. Peeters and
Eugene A. Katrukha and
Luca Ferrari and
Riccardo Stucchi and
Daan G. F. Verhagen and
Wilhelmina E. van Riel and
Ilya Grigoriev and
A. F. Maarten Altelaar and
Casper C. Hoogenraad and
Stefan G. D. Rüdiger and
Michel O. Steinmetz and
Lukas C. Kapitein and
Anna Akhmanova MAP7 family proteins regulate kinesin-1
recruitment and activation . . . . . . . 1298
Hanaa Hariri and
Natalie Speer and
Jade Bowerman and
Sean Rogers and
Gang Fu and
Evan Reetz and
Sanchari Datta and
J. Ryan Feathers and
Rupali Ugrankar and
Daniela Nicastro and
W. Mike Henne Mdm1 maintains endoplasmic reticulum
homeostasis by spatially regulating
lipid droplet biogenesis . . . . . . . . 1319
Sanchari Datta and
Yang Liu and
Hanaa Hariri and
Jade Bowerman and
W. Mike Henne Cerebellar ataxia disease--associated
Snx14 promotes lipid droplet growth at
ER--droplet contacts . . . . . . . . . . 1335
Kelly Subramanian and
Adam Jochem and
Maxence Le Vasseur and
Samantha Lewis and
Brett R. Paulson and
Thiruchelvi R. Reddy and
Jason D. Russell and
Joshua J. Coon and
David J. Pagliarini and
Jodi Nunnari Coenzyme Q biosynthetic proteins
assemble in a substrate-dependent manner
into domains at ER--mitochondria
contacts . . . . . . . . . . . . . . . . 1353
Devon E. Mason and
Joseph M. Collins and
James H. Dawahare and
Trung Dung Nguyen and
Yang Lin and
Sherry L. Voytik-Harbin and
Pinar Zorlutuna and
Mervin C. Yoder and
Joel D. Boerckel YAP and TAZ limit cytoskeletal and focal
adhesion maturation to enable persistent
cell motility . . . . . . . . . . . . . 1369
Jonathan Cohen and
Shaul Raviv and
Orit Adir and
Krishnanand Padmanabhan and
Arad Soffer and
Chen Luxenburg The Wave complex controls epidermal
morphogenesis and proliferation by
suppressing Wnt--Sox9 signaling . . . . 1390
Xiaohui Liu and
Jiazhou Li and
Heyu Zhao and
Boyang Liu and
Thomas Günther-Pomorski and
Shaolin Chen and
Johannes Liesche Novel tool to quantify cell wall
porosity relates wall structure to cell
growth and drug uptake . . . . . . . . . 1408
Chiara Francavilla and
Paola Cattaneo and
Vladimir Berezin and
Elisabeth Bock and
Diletta Ami and
Ario de Marco and
Gerhard Christofori and
Ugo Cavallaro Correction: The binding of NCAM to FGFR1
induces a specific cellular response
mediated by receptor trafficking . . . . 1422
Scott W. Messenger and
Sang Su Woo and
Zhongze Sun and
Thomas F. J. Martin Correction: A Ca$^{2+}$-stimulated
exosome release pathway in cancer cells
is regulated by Munc13-4 . . . . . . . . 1423
Marie Anne O'Donnell Gabriel Muhire Gihana: a candle loses
nothing by lighting other candles . . . 1425
Hodaya Hochberg-Laufer and
Yaron Shav-Tal Active RNA polymerase II curbs chromatin
movement . . . . . . . . . . . . . . . . 1427
Mahak Sharma and
Devashish Dwivedi A CRACker of an adaptor connects
dynein-mediated transport to calcium
signaling . . . . . . . . . . . . . . . 1429
Oren Shatz and
Zvulun Elazar ATG9 raises the BAR for PI4P in
autophagy . . . . . . . . . . . . . . . 1432
Karen L. Cunningham and
J. Troy Littleton Neurons regulate synaptic strength
through homeostatic scaling of active
zones . . . . . . . . . . . . . . . . . 1434
Nicolas G. Brukman and
Berna Uygur and
Benjamin Podbilewicz and
Leonid V. Chernomordik How cells fuse . . . . . . . . . . . . . 1436
Anna Payne-Tobin Jost and
Jennifer C. Waters Designing a rigorous microscopy
experiment: Validating methods and
avoiding bias . . . . . . . . . . . . . 1452
Hanhui Ma and
Li-Chun Tu and
Yu-Chieh Chung and
Ardalan Naseri and
David Grunwald and
Shaojie Zhang and
Thoru Pederson Cell cycle-- and genomic
distance-dependent dynamics of a
discrete chromosomal region . . . . . . 1467
Jingjing Chen and
Jennifer M. Gardner and
Zulin Yu and
Sarah E. Smith and
Sean McKinney and
Brian D. Slaughter and
Jay R. Unruh and
Sue L. Jaspersen Yeast centrosome components form a
noncanonical LINC complex at the nuclear
envelope insertion site . . . . . . . . 1478
Mindong Ren and
Yang Xu and
Hediye Erdjument-Bromage and
Alec Donelian and
Colin K. L. Phoon and
Naohiro Terada and
Douglas Strathdee and
Thomas A. Neubert and
Michael Schlame Extramitochondrial cardiolipin suggests
a novel function of mitochondria in
spermatogenesis . . . . . . . . . . . . 1491
Takayuki Shima and
Hiromi Kirisako and
Hitoshi Nakatogawa COPII vesicles contribute to
autophagosomal membranes . . . . . . . . 1503
Ryosuke Nagashima and
Kayo Hibino and
S. S. Ashwin and
Michael Babokhov and
Shin Fujishiro and
Ryosuke Imai and
Tadasu Nozaki and
Sachiko Tamura and
Tomomi Tani and
Hiroshi Kimura and
Michael Shribak and
Masato T. Kanemaki and
Masaki Sasai and
Kazuhiro Maeshima Single nucleosome imaging reveals loose
genome chromatin networks via active RNA
polymerase II . . . . . . . . . . . . . 1511
John K. Eykelenboom and
Marek Gierli\'nski and
Zuojun Yue and
Nadia Hegarat and
Hilary Pollard and
Tatsuo Fukagawa and
Helfrid Hochegger and
Tomoyuki U. Tanaka Live imaging of marked chromosome
regions reveals their dynamic resolution
and compaction in mitosis . . . . . . . 1531
Yufei Li and
Leyun Wang and
Linlin Zhang and
Zhengquan He and
Guihai Feng and
Hao Sun and
Jiaqiang Wang and
Zhikun Li and
Chao Liu and
Jiabao Han and
Junjie Mao and
Pengcheng Li and
Xuewei Yuan and
Liyuan Jiang and
Ying Zhang and
Qi Zhou and
Wei Li Cyclin B3 is required for metaphase to
anaphase transition in oocyte meiosis I 1553
Mariavittoria Pizzinga and
Christian Bates and
Jennifer Lui and
Gabriella Forte and
Fabián Morales-Polanco and
Emma Linney and
Barbora Knotkova and
Beverley Wilson and
Clara A. Solari and
Luke E. Berchowitz and
Paula Portela and
Mark P. Ashe Translation factor mRNA granules direct
protein synthetic capacity to regions of
polarized growth . . . . . . . . . . . . 1564
Jason C. Casler and
Effrosyni Papanikou and
Juan J. Barrero and
Benjamin S. Glick Maturation-driven transport and
AP-1-dependent recycling of a secretory
cargo in the Golgi . . . . . . . . . . . 1582
Kazuo Kurokawa and
Hiroko Osakada and
Tomoko Kojidani and
Miho Waga and
Yasuyuki Suda and
Haruhiko Asakawa and
Tokuko Haraguchi and
Akihiko Nakano Visualization of secretory cargo
transport within the Golgi apparatus . . 1602
Yuxiao Wang and
Walter Huynh and
Taylor D. Skokan and
Wen Lu and
Arthur Weiss and
Ronald D. Vale CRACR2a is a calcium-activated dynein
adaptor protein that regulates endocytic
traffic . . . . . . . . . . . . . . . . 1619
Delphine Judith and
Harold B. J. Jefferies and
Stefan Boeing and
David Frith and
Ambrosius P. Snijders and
Sharon A. Tooze ATG9A shapes the forming autophagosome
through Arfaptin 2 and
phosphatidylinositol $4$-kinase III$
\beta $ . . . . . . . . . . . . . . . . 1634
Alex Sohr and
Lijuan Du and
Ruofan Wang and
Li Lin and
Sougata Roy Drosophila FGF cleavage is required for
efficient intracellular sorting and
intercellular dispersal . . . . . . . . 1653
Mei-Chun Chuang and
Shan-Shan Lin and
Ryosuke L. Ohniwa and
Gang-Hui Lee and
You-An Su and
Yu-Chen Chang and
Ming-Jer Tang and
Ya-Wen Liu Tks5 and Dynamin-2 enhance actin bundle
rigidity in invadosomes to promote
myoblast fusion . . . . . . . . . . . . 1670
Julien Oury and
Yun Liu and
Ana Töpf and
Slobodanka Todorovic and
Esthelle Hoedt and
Veeramani Preethish-Kumar and
Thomas A. Neubert and
Weichun Lin and
Hanns Lochmüller and
Steven J. Burden MACF1 links Rapsyn to microtubule- and
actin-binding proteins to maintain
neuromuscular synapses . . . . . . . . . 1686
Pragya Goel and
Dominique Dufour Bergeron and
Mathias A. Böhme and
Luke Nunnelly and
Martin Lehmann and
Christopher Buser and
Alexander M. Walter and
Stephan J. Sigrist and
Dion Dickman Homeostatic scaling of active zone
scaffolds maintains global synaptic
strength . . . . . . . . . . . . . . . . 1706
Vanessa V. Juettner and
Kevin Kruse and
Arkaprava Dan and
Vinh H. Vu and
Yousaf Khan and
Jonathan Le and
Deborah Leckband and
Yulia Komarova and
Asrar B. Malik VE-PTP stabilizes VE-cadherin junctions
and the endothelial barrier via a
phosphatase-independent mechanism . . . 1725
Arthur Marivin and
Veronika Morozova and
Isha Walawalkar and
Anthony Leyme and
Dmitry A. Kretov and
Daniel Cifuentes and
Isabel Dominguez and
Mikel Garcia-Marcos GPCR-independent activation of G
proteins promotes apical cell
constriction in vivo . . . . . . . . . . 1743
Yuichi Tsuchiya and
Michiko Saito and
Hiroshi Kadokura and
Jun-ichi Miyazaki and
Fumi Tashiro and
Yusuke Imagawa and
Takao Iwawaki and
Kenji Kohno Correction: IRE1--XBP1 pathway regulates
oxidative proinsulin folding in
pancreatic $ \beta $ cells . . . . . . . 1764
Marie Anne O'Donnell Kota Saito: Getting out and about . . . 1765
Nicholas T. Ktistakis Who plays the ferryman: ATG2 channels
lipids into the forming autophagosome 1767
Ludo Van Den Bosch HDAC6 and Miro1: Another interaction
causing trouble in neurons . . . . . . . 1769
Roxanne Toivanen and
Luc Furic A balancing act: PHLPP2 fine tunes AKT
activity and MYC stability in prostate
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Ting Zhang and
Siddharth Balachandran Bayonets over bombs: RIPK3 and MLKL
restrict \bionameListeria without
triggering necroptosis . . . . . . . . . 1773
Lei Song and
Zhao-Qing Luo Post-translational regulation of
ubiquitin signaling . . . . . . . . . . 1776
Diana P. Valverde and
Shenliang Yu and
Venkata Boggavarapu and
Nikit Kumar and
Joshua A. Lees and
Thomas Walz and
Karin M. Reinisch and
Thomas J. Melia ATG2 transports lipids to promote
autophagosome biogenesis . . . . . . . . 1787
Alexandre R. Gingras and
Frederic Lagarrigue and
Monica N. Cuevas and
Andrew J. Valadez and
Marcus Zorovich and
Wilma McLaughlin and
Miguel Alejandro Lopez-Ramirez and
Nicolas Seban and
Klaus Ley and
William B. Kiosses and
Mark H. Ginsberg Rap1 binding and a lipid-dependent helix
in talin F1 domain promote integrin
activation in tandem . . . . . . . . . . 1799
Hanae Sato and
Bin Wu and
Fabien Delahaye and
Robert H. Singer and
John M. Greally Retargeting of macroH2A following
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heterochromatic domains . . . . . . . . 1810
Yu-ichiro Nakajima and
Zachary T. Lee and
Sean A. McKinney and
Selene K. Swanson and
Laurence Florens and
Matthew C. Gibson Junctional tumor suppressors interact
with 14-3-3 proteins to control planar
spindle alignment . . . . . . . . . . . 1824
Metin Aksu and
Sergei Trakhanov and
Arturo Vera Rodriguez and
Dirk Görlich Structural basis for the nuclear import
and export functions of the biportin
Pdr6/Kap122 . . . . . . . . . . . . . . 1839
Tatjana Holzer and
Kristina Probst and
Julia Etich and
Markus Auler and
Veronika S. Georgieva and
Björn Bluhm and
Christian Frie and
Juliane Heilig and
Anja Niehoff and
Julian Nüchel and
Markus Plomann and
Jens M. Seeger and
Hamid Kashkar and
Olivier R. Baris and
Rudolf J. Wiesner and
Bent Brachvogel Respiratory chain inactivation links
cartilage-mediated growth retardation to
mitochondrial diseases . . . . . . . . . 1853
Ashley L. Kalinski and
Amar N. Kar and
John Craver and
Andrew P. Tosolini and
James N. Sleigh and
Seung Joon Lee and
Alicia Hawthorne and
Paul Brito-Vargas and
Sharmina Miller-Randolph and
Ryan Passino and
Liang Shi and
Victor S. C. Wong and
Cristina Picci and
Deanna S. Smith and
Dianna E. Willis and
Leif A. Havton and
Giampietro Schiavo and
Roman J. Giger and
Brett Langley and
Jeffery L. Twiss Deacetylation of Miro1 by HDAC6 blocks
mitochondrial transport and mediates
axon growth inhibition . . . . . . . . . 1871
Yanrong Zheng and
Xiangnan Zhang and
Xiaoli Wu and
Lei Jiang and
Anil Ahsan and
Shijia Ma and
Ziyu Xiao and
Feng Han and
Zheng-Hong Qin and
Weiwei Hu and
Zhong Chen Somatic autophagy of axonal mitochondria
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Fan Zhou and
Zulin Wu and
Mengzhu Zhao and
Rakhilya Murtazina and
Juan Cai and
Ao Zhang and
Rui Li and
Dan Sun and
Wenjing Li and
Lei Zhao and
Qunli Li and
Jing Zhu and
Xiaoxia Cong and
Yiting Zhou and
Zhiping Xie and
Valeriya Gyurkovska and
Liuju Li and
Xiaoshuai Huang and
Yanhong Xue and
Liangyi Chen and
Hui Xu and
Haiqian Xu and
Yongheng Liang and
Nava Segev Rab5-dependent autophagosome closure by
ESCRT . . . . . . . . . . . . . . . . . 1908
Ashley M. Lakoduk and
Philippe Roudot and
Marcel Mettlen and
Heather M. Grossman and
Sandra L. Schmid and
Ping-Hung Chen Mutant p53 amplifies a dynamin-1/APPL1
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Dawid G. Nowak and
Ksenya Cohen Katsenelson and
Kaitlin E. Watrud and
Muhan Chen and
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Vincent D. D'Andrea and
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Manojit Mosur Swamynathan and
Irene Casanova-Salas and
Megan C. Jibilian and
Caroline L. Buckholtz and
Alexandra J. Ambrico and
Chun-Hao Pan and
John E. Wilkinson and
Alexandra C. Newton and
Lloyd C. Trotman The PHLPP2 phosphatase is a druggable
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Hannah K. Campbell and
Alicia M. Salvi and
Timothy O'Brien and
Richard Superfine and
Kris A. DeMali PAK2 links cell survival to
mechanotransduction and metabolism . . . 1958
Manish Sharma and
Srinivasa Subramaniam Rhes travels from cell to cell and
transports Huntington disease protein
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Kazuhito Sai and
Cameron Parsons and
John S. House and
Sophia Kathariou and
Jun Ninomiya-Tsuji Necroptosis mediators RIPK3 and MLKL
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Dirk Görlich Engineered SUMO/protease system
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Tom A. Rapoport Peroxisome protein import recapitulated
in \bionameXenopus egg extracts . . . . 2021
Yuta Homma and
Riko Kinoshita and
Yoshihiko Kuchitsu and
Paulina S. Wawro and
Soujiro Marubashi and
Mai E. Oguchi and
Morié Ishida and
Naonobu Fujita and
Mitsunori Fukuda Comprehensive knockout analysis of the
Rab family GTPases in epithelial cells 2035
Lei Zhao and
Yuqing Hou and
Tyler Picariello and
Branch Craige and
George B. Witman Proteome of the central apparatus of a
ciliary axoneme . . . . . . . . . . . . 2051
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Julie Lacombe and
Amélie Germain and
Franck Oury and
Gérard Karsenty Correction: GGCX and VKORC1 inhibit
osteocalcin endocrine functions . . . . 2071
Marie Anne O'Donnell Greg Alushin: The shape of things to
come . . . . . . . . . . . . . . . . . . 2073
Yanira Gonzalez-Rodriguez and
Samuel F. Bunting XLF extends its range from DNA repair to
replication . . . . . . . . . . . . . . 2075
Megan C. King and
C. Patrick Lusk Loss of nuclear envelope integrity? No
probLEM --- BAF has it covered . . . . . 2077
J. Julian Blow Defects in the origin licensing
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Steven J. Del Signore and
Avital A. Rodal The enemy of my enemy: PTEN and PLCXD
collude to fight endosomal
PtdIns(4,5)P$_2$ . . . . . . . . . . . . 2082
Heather T. Broihier Expecto Patronin for slow and persistent
minus end microtubule growth in
dendrites . . . . . . . . . . . . . . . 2084
John G. Lock and
Francesco Baschieri and
Matthew C. Jones and
Jonathan D. Humphries and
Guillaume Montagnac and
Staffan Strömblad and
Martin J. Humphries Clathrin-containing adhesion complexes 2086
Ryan J. Schulze and
Micah B. Schott and
Carol A. Casey and
Pamela L. Tuma and
Mark A. McNiven The cell biology of the hepatocyte: a
membrane trafficking machine . . . . . . 2096
Bo-Ruei Chen and
Annabel Quinet and
Andrea K. Byrum and
Jessica Jackson and
Matteo Berti and
Saravanabhavan Thangavel and
Andrea L. Bredemeyer and
Issa Hindi and
Nima Mosammaparast and
Jessica K. Tyler and
Alessandro Vindigni and
Barry P. Sleckman XLF and H2AX function in series to
promote replication fork stability . . . 2113
Karthik Dhatchinamoorthy and
Jay R. Unruh and
Jeffrey J. Lange and
Michaella Levy and
Brian D. Slaughter and
Jennifer L. Gerton The stoichiometry of the outer
kinetochore is modulated by
microtubule-proximal regulatory factors 2124
Charles T. Halfmann and
Rhiannon M. Sears and
Aditya Katiyar and
Brook W. Busselman and
London K. Aman and
Qiao Zhang and
Christopher S. O'Bryan and
Thomas E. Angelini and
Tanmay P. Lele and
Kyle J. Roux Repair of nuclear ruptures requires
barrier-to-autointegration factor . . . 2136
Ana F. David and
Philippe Roudot and
Wesley R. Legant and
Eric Betzig and
Gaudenz Danuser and
Daniel W. Gerlich Augmin accumulation on long-lived
microtubules drives amplification and
kinetochore-directed growth . . . . . . 2150
Jacob Peter Matson and
Amy M. House and
Gavin D. Grant and
Huaitong Wu and
Joanna Perez and
Jeanette Gowen Cook Intrinsic checkpoint deficiency during
cell cycle re-entry from quiescence . . 2169
Andrew Kodani and
Tyler Moyer and
Allen Chen and
Andrew Holland and
Christopher A. Walsh and
Jeremy F. Reiter SFI1 promotes centriole duplication by
recruiting USP9X to stabilize the
microcephaly protein STIL . . . . . . . 2185
Virginie E. Mondin and
Khaled Ben El Kadhi and
Clothilde Cauvin and
Anthony Jackson-Crawford and
Emilie Bélanger and
Barbara Decelle and
Rémi Salomon and
Martin Lowe and
Arnaud Echard and
Sébastien Carréno PTEN reduces endosomal PtdIns(4,5)P$_2$
in a phosphatase-independent manner via
a PLC pathway . . . . . . . . . . . . . 2198
Lou Fourriere and
Amal Kasri and
Nelly Gareil and
Sabine Bardin and
Hugo Bousquet and
David Pereira and
Franck Perez and
Bruno Goud and
Gaelle Boncompain and
Stéphanie Miserey-Lenkei RAB6 and microtubules restrict protein
secretion to focal adhesions . . . . . . 2215
Katarina T. Miteva and
Lucia Pedicini and
Lesley A. Wilson and
Izzy Jayasinghe and
Raphael G. Slip and
Katarzyna Marszalek and
Hannah J. Gaunt and
Fiona Bartoli and
Shruthi Deivasigamani and
Diego Sobradillo and
David J. Beech and
Lynn McKeown Rab46 integrates Ca$^{2+}$ and histamine
signaling to regulate selective cargo
release from Weibel--Palade bodies . . . 2232
Juan José Sáez and
Jheimmy Diaz and
Jorge Ibañez and
Juan Pablo Bozo and
Fernanda Cabrera Reyes and
Martina Alamo and
François-Xavier Gobert and
Dorian Obino and
María Rosa Bono and
Ana-María Lennon-Duménil and
Charles Yeaman and
María-Isabel Yuseff The exocyst controls lysosome secretion
and antigen extraction at the immune
synapse of B cells . . . . . . . . . . . 2247
Margot Riggi and
Clélia Bourgoint and
Mariano Macchione and
Stefan Matile and
Robbie Loewith and
Aurélien Roux TORC2 controls endocytosis through
plasma membrane tension . . . . . . . . 2265
Jongho Choi and
Regina B. Troyanovsky and
Indrajyoti Indra and
Brian J. Mitchell and
Sergey M. Troyanovsky Scribble, Erbin, and Lano redundantly
regulate epithelial polarity and apical
adhesion complex . . . . . . . . . . . . 2277
Marta Carrasco-Rando and
Silvia Prieto-Sánchez and
Joaquim Culi and
Antonio S. Tutor and
Mar Ruiz-Gómez A specific isoform of Pyd/ZO-1 mediates
junctional remodeling and formation of
slit diaphragms . . . . . . . . . . . . 2294
Chengye Feng and
Pankajam Thyagarajan and
Matthew Shorey and
Dylan Y. Seebold and
Alexis T. Weiner and
Richard M. Albertson and
Kavitha S. Rao and
Alvaro Sagasti and
Daniel J. Goetschius and
Melissa M. Rolls Patronin-mediated minus end growth is
required for dendritic microtubule
polarity . . . . . . . . . . . . . . . . 2309
Xiao-Feng Zhang and
Visar Ajeti and
Nicole Tsai and
Arash Fereydooni and
William Burns and
Michael Murrell and
Enrique M. De La Cruz and
Paul Forscher Regulation of axon growth by myosin
II--dependent mechanocatalysis of
cofilin activity . . . . . . . . . . . . 2329
Andrea Ommer and
Gianluca Figlia and
Jorge A. Pereira and
Anna Lena Datwyler and
Joanne Gerber and
Jonathan DeGeer and
Giovanna Lalli and
Ueli Suter Ral GTPases in Schwann cells promote
radial axonal sorting in the peripheral
nervous system . . . . . . . . . . . . . 2350
Jorge Galino and
Ilaria Cervellini and
Ning Zhu and
Nina Stöberl and
Meike Hütte and
Florence R. Fricker and
Garrett Lee and
Lucy McDermott and
Giovanna Lalli and
David L. H. Bennett RalGTPases contribute to Schwann cell
repair after nerve injury via regulation
of process formation . . . . . . . . . . 2370
Liliana Osório and
Xuewei Wu and
Linsheng Wang and
Zhixin Jiang and
Carlos Neideck and
Guojun Sheng and
Zhongjun Zhou ISM1 regulates NODAL signaling and
asymmetric organ morphogenesis during
development . . . . . . . . . . . . . . 2388
Liakot A. Khan and
Gholamali Jafari and
Nan Zhang and
Edward Membreno and
Siyang Yan and
Hongjie Zhang and
Verena Gobel A tensile trilayered cytoskeletal
endotube drives capillary-like
lumenogenesis . . . . . . . . . . . . . 2403
Marc D. Panas and
Nancy Kedersha and
Tim Schulte and
Rui M. Branca and
Pavel Ivanov and
Paul Anderson Phosphorylation of G3BP1-S149 does not
influence stress granule assembly . . . 2425
Hél\`ene Tourri\`ere and
Jamal Tazi Reply to ``Phosphorylation of G3BP1-S149
does not influence stress granule
assembly'' . . . . . . . . . . . . . . . 2433
Marie Anne O'Donnell Efraín E. Rivera--Serrano: Personal
training for scientists . . . . . . . . 2435
Patrícia Pereira and
Cecília M. Arraiano A precision RNA degradation machinery
shapes stem cell development . . . . . . 2437
W. Mike Henne Spastin joins LDs and peroxisomes in the
interorganelle contact ballet . . . . . 2439
Daichi Kawaguchi and
Yukiko Gotoh Neurexin nanoclusters: a novel structure
at presynaptic terminals . . . . . . . . 2442
Benjamin Schrank and
Jean Gautier Assembling nuclear domains: Lessons from
DNA repair . . . . . . . . . . . . . . . 2444
Julie Chang and
Ovijit Chaudhuri Beyond proteases: Basement membrane
mechanics and cancer invasion . . . . . 2456
Federica G. Centonze and
Veronika Reiterer and
Karsten Nalbach and
Kota Saito and
Krzysztof Pawlowski and
Christian Behrends and
Hesso Farhan LTK is an ER-resident receptor tyrosine
kinase that regulates secretion . . . . 2470
Abhishek Kumar and
Maria S. Shutova and
Keiichiro Tanaka and
Daniel V. Iwamoto and
David A. Calderwood and
Tatyana M. Svitkina and
Martin A. Schwartz Filamin A mediates isotropic
distribution of applied force across the
actin network . . . . . . . . . . . . . 2481
Tamara A. Potapova and
Jay R. Unruh and
Zulin Yu and
Giulia Rancati and
Hua Li and
Martha R. Stampfer and
Jennifer L. Gerton Superresolution microscopy reveals
linkages between ribosomal DNA on
heterologous chromosomes . . . . . . . . 2492
Qianhui Qu and
Qian Zhang and
Lu Yang and
Yujue Chen and
Hong Liu SET binding to Sgo1 inhibits
Sgo1--cohesin interactions and promotes
chromosome segregation . . . . . . . . . 2514
Melissa C. Pamula and
Lina Carlini and
Scott Forth and
Priyanka Verma and
Subbulakshmi Suresh and
Wesley R. Legant and
Alexey Khodjakov and
Eric Betzig and
Tarun M. Kapoor High-resolution imaging reveals how the
spindle midzone impacts chromosome
movement . . . . . . . . . . . . . . . . 2529
Yuntao Xia and
Charlotte R. Pfeifer and
Kuangzheng Zhu and
Jerome Irianto and
Dazhen Liu and
Kalia Pannell and
Emily J. Chen and
Lawrence J. Dooling and
Michael P. Tobin and
Mai Wang and
Irena L. Ivanovska and
Lucas R. Smith and
Roger A. Greenberg and
Dennis E. Discher Rescue of DNA damage after constricted
migration reveals a mechano-regulated
threshold for cell cycle . . . . . . . . 2545
Cedric Belair and
Soyeong Sim and
Kun-Yong Kim and
Yoshiaki Tanaka and
In-Hyun Park and
Sandra L. Wolin The RNA exosome nuclease complex
regulates human embryonic stem cell
differentiation . . . . . . . . . . . . 2564
Chi-Lun Chang and
Aubrey V. Weigel and
Maria S. Ioannou and
H. Amalia Pasolli and
C. Shan Xu and
David R. Peale and
Gleb Shtengel and
Melanie Freeman and
Harald F. Hess and
Craig Blackstone and
Jennifer Lippincott-Schwartz Spastin tethers lipid droplets to
peroxisomes and directs fatty acid
trafficking through ESCRT--III . . . . . 2583
ShiYu Wang and
Zechuan Zhao and
Avital A. Rodal Higher-order assembly of Sorting Nexin
16 controls tubulation and distribution
of neuronal endosomes . . . . . . . . . 2600
Qiwen Gan and
Xin Wang and
Qian Zhang and
Qiuyuan Yin and
Youli Jian and
Yubing Liu and
Nan Xuan and
Jinglin Li and
Junxiang Zhou and
Kai Liu and
Yudong Jing and
Xiaochen Wang and
Chonglin Yang The amino acid transporter SLC-36.1
cooperates with PtdIns3P $5$-kinase to
control phagocytic lysosome reformation 2619
Junya Zhang and
Shan Wu and
Susan K. Boehlein and
Donald R. McCarty and
Gaoyuan Song and
Justin W. Walley and
Alan Myers and
A. Mark Settles Maize defective kernel5 is a bacterial
TamB homologue required for chloroplast
envelope biogenesis . . . . . . . . . . 2638
Moonsup Lee and
Yoo-Seok Hwang and
Jaeho Yoon and
Jian Sun and
Adam Harned and
Kunio Nagashima and
Ira O. Daar Developmentally regulated GTP-binding
protein 1 modulates ciliogenesis via an
interaction with Dishevelled . . . . . . 2659
Justin H. Trotter and
Junjie Hao and
Stephan Maxeiner and
Theodoros Tsetsenis and
Zhihui Liu and
Xiaowei Zhuang and
Thomas C. Südhof Synaptic neurexin-1 assembles into
dynamically regulated active zone
nanoclusters . . . . . . . . . . . . . . 2677
Sahezeel Awadia and
Farah Huq and
Torey R. Arnold and
Silvia M. Goicoechea and
Young Joo Sun and
Titus Hou and
Gabriel Kreider-Letterman and
Paola Massimi and
Lawrence Banks and
Ernesto J. Fuentes and
Ann L. Miller and
Rafael Garcia-Mata SGEF forms a complex with Scribble and
Dlg1 and regulates epithelial junctions
and contractility . . . . . . . . . . . 2699
Clint S. Ko and
Vardges Tserunyan and
Adam C. Martin Microtubules promote intercellular
contractile force transmission during
tissue folding . . . . . . . . . . . . . 2726
Daniel Krueger and
Theresa Quinkler and
Simon Arnold Mortensen and
Carsten Sachse and
Stefano De Renzis Cross-linker--mediated regulation of
actin network organization controls
tissue morphogenesis . . . . . . . . . . 2743
Kassiani Skouloudaki and
Ioannis Christodoulou and
Dilan Khalili and
Vasilios Tsarouhas and
Christos Samakovlis and
Pavel Tomancak and
Elisabeth Knust and
Dimitrios K. Papadopoulos Yorkie controls tube length and apical
barrier integrity during airway
development . . . . . . . . . . . . . . 2762
Natalia A. Cherepanova and
Sergey V. Venev and
John D. Leszyk and
Scott A. Shaffer and
Reid Gilmore Quantitative glycoproteomics reveals new
classes of STT3A- and STT3B-dependent
N-glycosylation sites . . . . . . . . . 2782
Yury S. Bykov and
Nir Cohen and
Natalia Gabrielli and
Hetty Manenschijn and
Sonja Welsch and
Petr Chlanda and
Wanda Kukulski and
Kiran R. Patil and
Maya Schuldiner and
John A. G. Briggs High-throughput ultrastructure screening
using electron microscopy and
fluorescent barcoding . . . . . . . . . 2797
Andrea Marat Early Career Advisory Board: Q&A on
career and publishing . . . . . . . . . 2815
Elisabeth Knust and
Kai Simons Suzanne Eaton (1959--2019): a pioneer in
quantitative tissue morphogenesis . . . 2819
Linda Wordeman GTP-tubulin loves microtubule plus ends
but marries the minus ends . . . . . . . 2822
Jiaxing Li and
Kelly R. Monk Healthy attachments: Cell adhesion
molecules collectively control myelin
integrity . . . . . . . . . . . . . . . 2824
Chiara Mozzetta and
Francesco Saverio Tedesco Challenging the ``chromatin hypothesis''
of cardiac laminopathies with LMNA
mutant iPS cells . . . . . . . . . . . . 2826
Vikash Verma and
Thomas J. Maresca Direct observation of branching MT
nucleation in living animal cells . . . 2829
Claire Strothman and
Veronica Farmer and
Göker Arpa\ug and
Nicole Rodgers and
Marija Podolski and
Stephen Norris and
Ryoma Ohi and
Marija Zanic Microtubule minus-end stability is
dictated by the tubulin off-rate . . . . 2841
Mariana F. A. Costa and
Hiroyuki Ohkura The molecular architecture of the
meiotic spindle is remodeled during
metaphase arrest in oocytes . . . . . . 2854
Jone Michelena and
Marco Gatti and
Federico Teloni and
Ralph Imhof and
Matthias Altmeyer Basal CHK1 activity safeguards its
stability to maintain intrinsic S-phase
checkpoint functions . . . . . . . . . . 2865
Sho W. Suzuki and
Ya-Shan Chuang and
Ming Li and
Matthew N. J. Seaman and
Scott D. Emr A bipartite sorting signal ensures
specificity of retromer complex in
membrane protein recycling . . . . . . . 2876
Nimrod Elazar and
Anya Vainshtein and
Katya Rechav and
Michael Tsoory and
Yael Eshed-Eisenbach and
Elior Peles Coordinated internodal and paranodal
adhesion controls accurate myelination
by oligodendrocytes . . . . . . . . . . 2887
Nathan Palmer and
S. Zakiah A. Talib and
Chandrahas Koumar Ratnacaram and
Diana Low and
Xavier Bisteau and
Joanna Hui Si Lee and
Elisabeth Pfeiffenberger and
Heike Wollmann and
Joel Heng Loong Tan and
Sheena Wee and
Radoslaw Sobota and
Jayantha Gunaratne and
Daniel M. Messerschmidt and
Ernesto Guccione and
Philipp Kaldis CDK2 regulates the NRF1/Ehmt1 axis
during meiotic prophase I . . . . . . . 2896
Alessandro Bertero and
Paul A. Fields and
Alec S. T. Smith and
Andrea Leonard and
Kevin Beussman and
Nathan J. Sniadecki and
Deok-Ho Kim and
Hung-Fat Tse and
Lil Pabon and
Jay Shendure and
William S. Noble and
Charles E. Murry Chromatin compartment dynamics in a
haploinsufficient model of cardiac
laminopathy . . . . . . . . . . . . . . 2919
Terra M. Kuhn and
Pau Pascual-Garcia and
Alejandro Gozalo and
Shawn C. Little and
Maya Capelson Chromatin targeting of nuclear pore
proteins induces chromatin
decondensation . . . . . . . . . . . . . 2945
Rakefet Ben-Yishay and
Amir Mor and
Amit Shraga and
Asaf Ashkenazy-Titelman and
Noa Kinor and
Avital Schwed-Gross and
Avi Jacob and
Noga Kozer and
Pramod Kumar and
Yuval Garini and
Yaron Shav-Tal Imaging within single NPCs reveals
NXF1's role in mRNA export on the
cytoplasmic side of the pore . . . . . . 2962
Agnieszka A. Kendrick and
Andrea M. Dickey and
William B. Redwine and
Phuoc Tien Tran and
Laura Pontano Vaites and
Monika Dzieciatkowska and
J. Wade Harper and
Samara L. Reck-Peterson Hook3 is a scaffold for the
opposite-polarity microtubule-based
motors cytoplasmic dynein-1 and KIF1C 2982
Fei-Yun Chen and
Min-Yu Huang and
Yu-Min Lin and
Chi-Huan Ho and
Shu-Yu Lin and
Hsin-Yi Chen and
Mien-Chie Hung and
Ruey-Hwa Chen BIK ubiquitination by the E3 ligase
Cul5-ASB11 determines cell fate during
cellular stress . . . . . . . . . . . . 3002
Arunas Kvainickas and
Heike Nägele and
Wenjing Qi and
Ladislav Dokládal and
Ana Jimenez-Orgaz and
Luca Stehl and
Dipak Gangurde and
Qian Zhao and
Zehan Hu and
Jörn Dengjel and
Claudio De Virgilio and
Ralf Baumeister and
Florian Steinberg Retromer and TBC1D5 maintain late
endosomal RAB7 domains to enable amino
acid--induced mTORC1 signaling . . . . . 3019
Matthias Klose and
Johann E. Salloum and
Hannes Gonschior and
Stefan Linder SNX3 drives maturation of
\bionameBorrelia phagosomes by forming a
hub for PI(3)P, Rab5a, and galectin-9 3039
Brajendra K. Tripathi and
Meghan F. Anderman and
Xiaolan Qian and
Ming Zhou and
Dunrui Wang and
Alex G. Papageorge and
Douglas R. Lowy SRC and ERK cooperatively phosphorylate
DLC1 and attenuate its Rho--GAP and
tumor suppressor functions . . . . . . . 3060
Mihai L. Azoitei and
Jungsik Noh and
Daniel J. Marston and
Philippe Roudot and
Christopher B. Marshall and
Timothy A. Daugird and
Sidney L. Lisanza and
María-José Sandí and
Mitsu Ikura and
John Sondek and
Robert Rottapel and
Klaus M. Hahn and
Gaudenz Danuser Spatiotemporal dynamics of GEF--H1
activation controlled by microtubule-
and Src-mediated pathways . . . . . . . 3077
Ranjay Jayadev and
Qiuyi Chi and
Daniel P. Keeley and
Eric L. Hastie and
Laura C. Kelley and
David R. Sherwood $ \alpha $-Integrins dictate distinct
modes of type IV collagen recruitment to
basement membranes . . . . . . . . . . . 3098
Frank van Drogen and
Ranjan Mishra and
Fabian Rudolf and
Michal J. Walczak and
Sung Sik Lee and
Wolfgang Reiter and
Björn Hegemann and
Serge Pelet and
Ilse Dohnal and
Andres Binolfi and
Zinaida Yudina and
Philipp Selenko and
Gerhard Wider and
Gustav Ammerer and
Matthias Peter Mechanical stress impairs pheromone
signaling via Pkc1-mediated regulation
of the MAPK scaffold Ste5 . . . . . . . 3117
Sanjay Saw and
Alison Aiken and
Hui Fang and
Trevor D. McKee and
Sarah Bregant and
Otto Sanchez and
Yan Chen and
Ashley Weiss and
Brendan C. Dickson and
Bertrand Czarny and
Ankit Sinha and
Amanda Fosang and
Vincent Dive and
Paul D. Waterhouse and
Thomas Kislinger and
Rama Khokha Metalloprotease inhibitor TIMP proteins
control FGF-2 bioavailability and
regulate skeletal growth . . . . . . . . 3134
Ellen C. O'Shaughnessy and
Orrin J. Stone and
Paul K. LaFosse and
Mihai L. Azoitei and
Denis Tsygankov and
John M. Heddleston and
Wesley R. Legant and
Erika S. Wittchen and
Keith Burridge and
Timothy C. Elston and
Eric Betzig and
Teng-Leong Chew and
David Adalsteinsson and
Klaus M. Hahn Software for lattice light-sheet imaging
of FRET biosensors, illustrated with a
new Rap1 biosensor . . . . . . . . . . . 3153
Marie Anne O'Donnell Brajendra Tripathi: Keeping an eye out
for translational research . . . . . . . 3161
Denise Gay and
Mayumi Ito Adult hair follicles keep oncogenic
growth in check . . . . . . . . . . . . 3163
Hongquan Zhang Kindlin-3 stokes the life span of
podosomes . . . . . . . . . . . . . . . 3166
Elena B. Pasquale Eph receptors and ephrins engage in
cellular cannibalism . . . . . . . . . . 3168
Zhihao Sun and
Jeffrey L. Brodsky Protein quality control in the secretory
pathway . . . . . . . . . . . . . . . . 3171
Daniel Hayward and
James Bancroft and
Davinderpreet Mangat and
Tatiana Alfonso-Pérez and
Sholto Dugdale and
Julia McCarthy and
Francis A. Barr and
Ulrike Gruneberg Checkpoint signaling and error
correction require regulation of the
MPS1 T-loop by PP2A--B56 . . . . . . . . 3188
Yan Chen and
Jeffery Yong and
Antonio Martínez-Sánchez and
Yang Yang and
Yumei Wu and
Pietro De Camilli and
Rubén Fernández-Busnadiego and
Min Wu Dynamic instability of clathrin assembly
provides proofreading control for
endocytosis . . . . . . . . . . . . . . 3200
Cristiana M. Pineda and
David G. Gonzalez and
Catherine Matte-Martone and
Jonathan Boucher and
Elizabeth Lathrop and
Sara Gallini and
Nathan R. Fons and
Tianchi Xin and
Karen Tai and
Edward Marsh and
Don X. Nguyen and
Kathleen C. Suozzi and
Slobodan Beronja and
Valentina Greco Hair follicle regeneration suppresses
Ras-driven oncogenic growth . . . . . . 3212
Yuichiro Asai and
Koh Fukuchi and
Yuji Tanno and
Saki Koitabashi-Kiyozuka and
Tatsuyuki Kiyozuka and
Yuko Noda and
Rieko Matsumura and
Tetsuo Koizumi and
Atsushi Watanabe and
Kyosuke Nagata and
Yoshinori Watanabe and
Yasuhiko Terada Aurora B kinase activity is regulated by
SET/TAF1 on Sgo2 at the inner centromere 3223
Mary Kate Bonner and
Julian Haase and
Jason Swinderman and
Hyunmi Halas and
Lisa M. Miller Jenkins and
Alexander E. Kelly Enrichment of Aurora B kinase at the
inner kinetochore controls outer
kinetochore assembly . . . . . . . . . . 3237
Charnese Bowes and
Michael Redd and
Malika Yousfi and
Muriel Tauzin and
Emi Murayama and
Philippe Herbomel Coronin 1A depletion restores the
nuclear stability and viability of
Aip1/Wdr1-deficient neutrophils . . . . 3258
Iskra Yanakieva and
Anna Erzberger and
Marija Matej\vci\'c and
Carl D. Modes and
Caren Norden Cell and tissue morphology determine
actin-dependent nuclear migration
mechanisms in neuroepithelia . . . . . . 3272
Melody Atkins and
La\"\ila Gasmi and
Valérie Bercier and
Céline Revenu and
Filippo Del Bene and
Jamilé Hazan and
Coralie Fassier FIGNL1 associates with KIF1B$ \beta $
and BICD1 to restrict dynein transport
velocity during axon navigation . . . . 3290
Yu-Hsien Hwang Fu and
Sowmya Chandrasekar and
Jae Ho Lee and
Shu-ou Shan A molecular recognition feature mediates
ribosome-induced SRP-receptor assembly
during protein targeting . . . . . . . . 3307
Micah B. Schott and
Shaun G. Weller and
Ryan J. Schulze and
Eugene W. Krueger and
Kristina Drizyte-Miller and
Carol A. Casey and
Mark A. McNiven Lipid droplet size directs lipolysis and
lipophagy catabolism in hepatocytes . . 3320
Yoshinori Takahashi and
Xinwen Liang and
Tatsuya Hattori and
Zhenyuan Tang and
Haiyan He and
Han Chen and
Xiaoming Liu and
Thomas Abraham and
Yuka Imamura-Kawasawa and
Nicholas J. Buchkovich and
Megan M. Young and
Hong-Gang Wang VPS37A directs ESCRT recruitment for
phagophore closure . . . . . . . . . . . 3336
Takuya Miyagawa and
Kana Hasegawa and
Yoko Aoki and
Takuya Watanabe and
Yuka Otagiri and
Kohei Arasaki and
Yuichi Wakana and
Kenichi Asano and
Masato Tanaka and
Hideki Yamaguchi and
Mitsuo Tagaya and
Hiroki Inoue MT1-MMP recruits the ER--Golgi SNARE
Bet1 for efficient MT1-MMP transport to
the plasma membrane . . . . . . . . . . 3355
Tetsuhisa Otani and
Thanh Phuong Nguyen and
Shinsaku Tokuda and
Kei Sugihara and
Taichi Sugawara and
Kyoko Furuse and
Takashi Miura and
Klaus Ebnet and
Mikio Furuse Claudins and JAM--A coordinately
regulate tight junction formation and
epithelial polarity . . . . . . . . . . 3372
Jordan T. Silver and
Frederik Wirtz-Peitz and
Sérgio Simões and
Milena Pellikka and
Dong Yan and
Richard Binari and
Takashi Nishimura and
Yan Li and
Tony J. C. Harris and
Norbert Perrimon and
Ulrich Tepass Apical polarity proteins recruit the
RhoGEF Cysts to promote junctional
myosin assembly . . . . . . . . . . . . 3397
M. Angeles Juanes and
Daniel Isnardon and
Ali Badache and
Sophie Brasselet and
Manos Mavrakis and
Bruce L. Goode The role of APC-mediated actin assembly
in microtubule capture and focal
adhesion turnover . . . . . . . . . . . 3415
Sarah Klapproth and
Thomas Bromberger and
Clara Türk and
Marcus Krüger and
Markus Moser A kindlin-$3$--leupaxin--paxillin
signaling pathway regulates podosome
stability . . . . . . . . . . . . . . . 3436
Jingyi Gong and
Thomas N. Gaitanos and
Olivia Luu and
Yunyun Huang and
Louise Gaitanos and
Jana Lindner and
Rudolf Winklbauer and
Rüdiger Klein Gulp1 controls Eph\slash ephrin
trogocytosis and is important for cell
rearrangements during development . . . 3455
Nicolas A. Perez-Gonzalez and
Nash D. Rochman and
Kai Yao and
Jiaxiang Tao and
Minh-Tam Tran Le and
Shannon Flanary and
Lucia Sablich and
Ben Toler and
Eliana Crentsil and
Felipe Takaesu and
Bram Lambrus and
Jessie Huang and
Vivian Fu and
Pragati Chengappa and
Tia M. Jones and
Andrew J. Holland and
Steven An and
Denis Wirtz and
Ryan J. Petrie and
Kun-Liang Guan and
Sean X. Sun YAP and TAZ regulate cell volume . . . . 3472
Chien-Hui Lo and
I-Hsuan Lin and
T. Tony Yang and
Yen-Chun Huang and
Barbara E. Tanos and
Po-Chun Chou and
Chih-Wei Chang and
Yeou-Guang Tsay and
Jung-Chi Liao and
Won-Jing Wang Phosphorylation of CEP83 by TTBK2 is
necessary for cilia initiation . . . . . 3489
Kuniyuki Nakamura and
Tomoko Ikeuchi and
Kazuki Nara and
Craig S. Rhodes and
Peipei Zhang and
Yuta Chiba and
Saiko Kazuno and
Yoshiki Miura and
Tetsuro Ago and
Eri Arikawa-Hirasawa and
Yoh-suke Mukouyama and
Yoshihiko Yamada Perlecan regulates pericyte dynamics in
the maintenance and repair of the
blood--brain barrier . . . . . . . . . . 3506
Devashish Dwivedi and
Amrita Kumari and
Siddhi Rathi and
Sivaram V. S. Mylavarapu and
Mahak Sharma Correction: The dynein adaptor Hook2
plays essential roles in mitotic
progression and cytokinesis . . . . . . 3526
Marie Anne O'Donnell Kazuhiro Maeshima: Excitement under the
microscope . . . . . . . . . . . . . . . 3529
Dhananjay Chaturvedi and
K. VijayRaghavan From a syncytium to mononucleate cells
and back: Yki and JNK in symphony . . . 3531
Aidan I. Brown and
Elena F. Koslover Drive, filter, and stick: a protein
sorting conspiracy in photoreceptors . . 3533
Marco Napoli and
Elsa R. Flores Beware of thy neighbor: Senescent cancer
cells feast on adjacent cells to persist 3535
Daisuke Takao and
Shohei Yamamoto and
Daiju Kitagawa A theory of centriole duplication based
on self-organized spatial pattern
formation . . . . . . . . . . . . . . . 3537
Saravanan Palani and
Darius V. Köster and
Tomoyuki Hatano and
Anton Kamnev and
Taishi Kanamaru and
Holly R. Brooker and
Juan Ramon Hernandez-Fernaud and
Alexandra M. E. Jones and
Jonathan B. A. Millar and
Daniel P. Mulvihill and
Mohan K. Balasubramanian Phosphoregulation of tropomyosin is
crucial for actin cable turnover and
division site placement . . . . . . . . 3548
Leeba Ann Chacko and
Kritika Mehta and
Vaishnavi Ananthanarayanan Cortical tethering of mitochondria by
the anchor protein Mcp5 enables
uniparental inheritance . . . . . . . . 3560
Christoph Schaub and
Marcel Rose and
Manfred Frasch Yorkie and JNK revert syncytial muscles
into myoblasts during Org-1--dependent
lineage reprogramming . . . . . . . . . 3572
Jonathan Kuhn and
Sophie Dumont Mammalian kinetochores count attached
microtubules in a sensitive and
switch-like manner . . . . . . . . . . . 3583
Daisaku Hiraoka and
Enako Hosoda and
Kazuyoshi Chiba and
Takeo Kishimoto SGK phosphorylates Cdc25 and Myt1 to
trigger cyclin B--Cdk1 activation at the
meiotic G2/M transition . . . . . . . . 3597
Enako Hosoda and
Daisaku Hiraoka and
Noritaka Hirohashi and
Saki Omi and
Takeo Kishimoto and
Kazuyoshi Chiba SGK regulates pH increase and cyclin
B--Cdk1 activation to resume meiosis in
starfish ovarian oocytes . . . . . . . . 3612
Rongde Qiu and
Jun Zhang and
Xin Xiang LIS1 regulates cargo-adapter--mediated
activation of dynein by overcoming its
autoinhibition in vivo . . . . . . . . . 3630
Amy C. Engevik and
Izumi Kaji and
Meagan M. Postema and
James J. Faust and
Anne R. Meyer and
Janice A. Williams and
Gillian N. Fitz and
Matthew J. Tyska and
Jean M. Wilson and
James R. Goldenring Loss of myosin Vb promotes apical bulk
endocytosis in neonatal enterocytes . . 3647
Wei-Cheng Su and
Yi-Hsiu Lin and
Martin Pagac and
Chao-Wen Wang Seipin negatively regulates sphingolipid
production at the ER--LD contact site 3663
Morié Ishida and
Juan S. Bonifacino ARFRP1 functions upstream of ARL1 and
ARL5 to coordinate recruitment of
distinct tethering factors to the
trans-Golgi network . . . . . . . . . . 3681
Mukesh Kumar and
Srikant Ojha and
Priyanka Rai and
Alaumy Joshi and
Siddhesh S. Kamat and
Roop Mallik Insulin activates intracellular
transport of lipid droplets to release
triglycerides from the liver . . . . . . 3697
Phuoc My Nguyen and
Nikhil R. Gandasi and
Beichen Xie and
Sari Sugahara and
Yingke Xu and
Olof Idevall-Hagren The PI(4)P phosphatase Sac2 controls
insulin granule docking and release . . 3714
Xin Wang and
Wei Tian and
Bryan T. Banh and
Bethanie-Michelle Statler and
Jie Liang and
David E. Stone Mating yeast cells use an intrinsic
polarity site to assemble a
pheromone-gradient tracking machine . . 3730
Nycole A. Maza and
William E. Schiesser and
Peter D. Calvert An intrinsic compartmentalization code
for peripheral membrane proteins in
photoreceptor neurons . . . . . . . . . 3753
Ling Guo and
Rong Wang and
Kuo Zhang and
Jifan Yuan and
Jiaxin Wang and
Xiaoxia Wang and
Jianfei Ma and
Chuanyue Wu A PINCH-1--Smurf1 signaling axis
mediates mechano-regulation of BMPR2 and
stem cell differentiation . . . . . . . 3773
Adina Gerson-Gurwitz and
Carolyn A. Worby and
Kian-Yong Lee and
Renat Khaliullin and
Jeff Bouffard and
Dhanya Cheerambathur and
Karen Oegema and
Erin J. Cram and
Jack E. Dixon and
Arshad Desai Ancestral roles of the Fam20C family of
secreted protein kinases revealed in
\bionameC. elegans . . . . . . . . . . . 3795
Kossay Zaoui and
Charles V. Rajadurai and
Stéphanie Duhamel and
Morag Park Arf6 regulates RhoB subcellular
localization to control cancer cell
invasion . . . . . . . . . . . . . . . . 3812
Crystal A. Tonnessen-Murray and
Wesley D. Frey and
Sonia G. Rao and
Ashkan Shahbandi and
Nathan A. Ungerleider and
Joy O. Olayiwola and
Lucas B. Murray and
Benjamin T. Vinson and
Douglas B. Chrisey and
Christopher J. Lord and
James G. Jackson Chemotherapy-induced senescent cancer
cells engulf other cells to enhance
their survival . . . . . . . . . . . . . 3827
Hui Miao and
Timothy E. Vanderleest and
Cayla E. Jewett and
Dinah Loerke and
J. Todd Blankenship Cell ratcheting through the Sbf RabGEF
directs force balancing and stepped
apical constriction . . . . . . . . . . 3845
Laia Bassaganyas and
Stephanie J. Popa and
Max Horlbeck and
Claudia Puri and
Sarah E. Stewart and
Felix Campelo and
Anupama Ashok and
Cristian M. Butnaru and
Nathalie Brouwers and
Kartoosh Heydari and
Jean Ripoche and
Jonathan Weissman and
David C. Rubinsztein and
Randy Schekman and
Vivek Malhotra and
Kevin Moreau and
Julien Villeneuve New factors for protein transport
identified by a genome-wide CRISPRi
screen in mammalian cells . . . . . . . 3861
Morié Ishida and
Juan S. Bonifacino Correction: ARFRP1 functions upstream of
ARL1 and ARL5 to coordinate recruitment
of tethering factors to the trans-Golgi
network . . . . . . . . . . . . . . . . 3880
Marie Anne O'Donnell Michael Lazarou: Building a body of
research . . . . . . . . . . . . . . . . 3881--3882
Marina Alejandra González Besteiro and
Vanesa Gottifredi ETAA1 ensures proper chromosome
segregation: a matter of S phase or
mitosis? . . . . . . . . . . . . . . . . 3883--3884
Caroline Kumsta and
Malene Hansen Getting under the skin: Cuticle damage
elicits systemic autophagy response in
\bionameC. elegans . . . . . . . . . . . 3885--3887
Uri Kahanovitch and
Michelle L. Olsen Glial SIK3: a central player in ion and
volume homeostasis in \bionameDrosophila
peripheral nerves . . . . . . . . . . . 3888--3889
Stephanie M. Cologna A calcium message for Niemann--Pick type
C . . . . . . . . . . . . . . . . . . . 3890--3891
Bennie Lemmens and
Arne Lindqvist DNA replication and mitotic entry: a
brake model for cell cycle progression 3892--3902
Eric Peterman and
Rytis Prekeris The postmitotic midbody: Regulating
polarity, stemness, and proliferation 3903--3911
Maria A. Abad and
Jan G. Ruppert and
Lana Buzuk and
Martin Wear and
Juan Zou and
Kim M. Webb and
David A. Kelly and
Philipp Voigt and
Juri Rappsilber and
William C. Earnshaw and
A. Arockia Jeyaprakash Borealin--nucleosome interaction secures
chromosome association of the
chromosomal passenger complex . . . . . 3912--3925
Babhrubahan Roy and
Vikash Verma and
Janice Sim and
Adrienne Fontan and
Ajit P. Joglekar Delineating the contribution of
Spc105-bound PP1 to spindle checkpoint
silencing and kinetochore microtubule
attachment regulation . . . . . . . . . 3926--3942
Divya Achuthankutty and
Roshan Singh Thakur and
Peter Haahr and
Saskia Hoffmann and
Alexandros P. Drainas and
Anna H. Bizard and
Joachim Weischenfeldt and
Ian D. Hickson and
Niels Mailand Regulation of ETAA1-mediated ATR
activation couples DNA replication
fidelity and genome stability . . . . . 3943--3953
Rachel Curnock and
Alessia Calcagni and
Andrea Ballabio and
Peter J. Cullen TFEB controls retromer expression in
response to nutrient availability . . . 3954--3966
Carina Patrizia Derrer and
Roberta Mancini and
Pascal Vallotton and
Sébastien Huet and
Karsten Weis and
Elisa Dultz The RNA export factor Mex67 functions as
a mobile nucleoporin . . . . . . . . . . 3967--3976
Johannes Baumgart and
Marcel Kirchner and
Stefanie Redemann and
Alec Bond and
Jeffrey Woodruff and
Jean-Marc Verbavatz and
Frank Jülicher and
Thomas Müller-Reichert and
Anthony A. Hyman and
Jan Brugués Soluble tubulin is significantly
enriched at mitotic centrosomes . . . . 3977--3985
Yuhan Hu and
Wanqing Lyu and
Laura Anne Lowery and
Anthony J. Koleske Regulation of MT dynamics via direct
binding of an Abl family kinase . . . . 3986--3997
Yujie Zhang and
Linxiang Qi and
Hong Zhang TGF$ \beta $-like DAF-7 acts as a
systemic signal for autophagy regulation
in \bionameC. elegans . . . . . . . . . 3998--4006
Rachel J. Hunt and
Lucy Granat and
Gregory S. McElroy and
Ramya Ranganathan and
Navdeep S. Chandel and
Joseph M. Bateman Mitochondrial stress causes neuronal
dysfunction via an ATF4-dependent
increase in L-2-hydroxyglutarate . . . . 4007--4016
Hailun Li and
Alexandra Russo and
Aaron DiAntonio SIK3 suppresses neuronal
hyperexcitability by regulating the
glial capacity to buffer K$^+$ and water 4017--4029
Guang Wang and
Huai-Bin Hu and
Yan Chang and
Yan Huang and
Zeng-Qing Song and
Shi-Bo Zhou and
Liang Chen and
Yu-Cheng Zhang and
Min Wu and
Hai-Qing Tu and
Jin-Feng Yuan and
Na Wang and
Xin Pan and
Ai-Ling Li and
Tao Zhou and
Xue-Min Zhang and
Kun He and
Hui-Yan Li Rab7 regulates primary cilia disassembly
through cilia excision . . . . . . . . . 4030--4041
Reito Watanabe and
Masatoshi Hara and
Ei-ichi Okumura and
Sol\`ene Hervé and
Daniele Fachinetti and
Mariko Ariyoshi and
Tatsuo Fukagawa CDK1-mediated CENP-C phosphorylation
modulates CENP-A binding and mitotic
kinetochore localization . . . . . . . . 4042--4062
Pan Chen and
Miroslav Tomschik and
Katherine M. Nelson and
John Oakey and
Jesse C. Gatlin and
Daniel L. Levy Nucleoplasmin is a limiting component in
the scaling of nuclear size with
cytoplasmic volume . . . . . . . . . . . 4063--4078
Alison E. Patteson and
Amir Vahabikashi and
Katarzyna Pogoda and
Stephen A. Adam and
Kalpana Mandal and
Mark Kittisopikul and
Suganya Sivagurunathan and
Anne Goldman and
Robert D. Goldman and
Paul A. Janmey Vimentin protects cells against nuclear
rupture and DNA damage during migration 4079--4092
Panagiotis Mistriotis and
Emily O. Wisniewski and
Kaustav Bera and
Jeremy Keys and
Yizeng Li and
Soontorn Tuntithavornwat and
Robert A. Law and
Nicolas A. Perez-Gonzalez and
Eda Erdogmus and
Yuqi Zhang and
Runchen Zhao and
Sean X. Sun and
Petr Kalab and
Jan Lammerding and
Konstantinos Konstantopoulos Confinement hinders motility by inducing
RhoA-mediated nuclear influx, volume
expansion, and blebbing . . . . . . . . 4093--4111
Alexandra Bondaz and
Luca Cirillo and
Patrick Meraldi and
Monica Gotta Cell polarity-dependent centrosome
separation in the \bionameC. elegans
embryo . . . . . . . . . . . . . . . . . 4112--4126
Haiyan An and
Jing Tong Tan and
Tatyana A. Shelkovnikova Stress granules regulate stress-induced
paraspeckle assembly . . . . . . . . . . 4127--4140
Scott A. Tiscione and
Oscar Vivas and
Kenneth S. Ginsburg and
Donald M. Bers and
Daniel S. Ory and
Luis F. Santana and
Rose E. Dixon and
Eamonn J. Dickson Disease-associated mutations in
Niemann--Pick type C1 alter ER calcium
signaling and neuronal plasticity . . . 4141--4156
Rachel C. Gomez and
Paulina Wawro and
Pawel Lis and
Dario R. Alessi and
Suzanne R. Pfeffer Membrane association but not identity is
required for LRRK2 activation and
phosphorylation of Rab GTPases . . . . . 4157--4170
Mariona Ramos and
Juan Carlos G. Cortés and
Mamiko Sato and
Sergio A. Rincón and
M. Belén Moreno and
José Ángel Clemente-Ramos and
Masako Osumi and
Pilar Pérez and
Juan Carlos Ribas Two \bionameS. pombe septation phases
differ in ingression rate, septum
structure, and response to F-actin loss 4171--4194
Tao Jiang and
Tony J. C. Harris Par-1 controls the composition and
growth of cortical actin caps during
\bionameDrosophila embryo cleavage . . . 4195--4214
Julieann I. Puleo and
Sara S. Parker and
Mackenzie R. Roman and
Adam W. Watson and
Kiarash Rahmani Eliato and
Leilei Peng and
Kathylynn Saboda and
Denise J. Roe and
Robert Ros and
Frank B. Gertler and
Ghassan Mouneimne Mechanosensing during directed cell
migration requires dynamic actin
polymerization at focal adhesions . . . 4215--4235
Gang Fu and
Lei Zhao and
Erin Dymek and
Yuqing Hou and
Kangkang Song and
Nhan Phan and
Zhiguo Shang and
Elizabeth F. Smith and
George B. Witman and
Daniela Nicastro Structural organization of the C1a-e-c
supercomplex within the ciliary central
apparatus . . . . . . . . . . . . . . . 4236--4251
Nancy Kedersha and
Marc D. Panas and
Christopher A. Achorn and
Shawn Lyons and
Sarah Tisdale and
Tyler Hickman and
Marshall Thomas and
Judy Lieberman and
Gerald M. McInerney and
Pavel Ivanov and
Paul Anderson Correction: G3BP Caprin1 USP10 complexes
mediate stress granule condensation and
associate with 40S subunits . . . . . . e20150802809202019c
Kassiani Skouloudaki and
Ioannis Christodoulou and
Dilan Khalili and
Vasilios Tsarouhas and
Christos Samakovlis and
Pavel Tomancak and
Elisabeth Knust and
Dimitrios K. Papadopoulos Correction: Yorkie controls tube length
and apical barrier integrity during
airway development . . . . . . . . . . . e20180912104072023c